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<span>Preclinical Research Toolbox</span>
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<h1>Preclinical Research Toolbox</h1>
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We collaborate with other NIH institutes and centers to develop tools and resources that accelerate preclinical research.
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<h2 class="section-heading">About Preclinical Research Toolbox</h2>
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<p>We have tools and resources to help scientists carry out preclinical research. Selected resources and software tools are listed below.</p>
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<h2 class="section-heading">Small Molecules, Compounds and Probes</h2>
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||
<div class="row mb-4 three-pic-cards">
|
||
|
||
|
||
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|
||
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|
||
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|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Assay Guidance Manual </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>This resource contains detailed information on developing appropriate assays for high-throughput screening projects.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
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<a href="/research/research-resources/agm">Learn More</a>
|
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|
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|
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|
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<div class="card border-0 p-0 radius-10 h-100">
|
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|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Compound Management</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our compound management team uses sophisticated and automated techniques to supply chemicals for NCATS screening experiments to uncover new treatments for diseases.</p>
|
||
|
||
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<a href="/research/research-activities/compound-management">Learn More</a>
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|
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<div class="card border-0 p-0 radius-10 h-100">
|
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<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">NCATS Pharmaceutical Collection </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>This publicly available, web-based application provides complete information on active pharmaceutical ingredients.</p>
|
||
|
||
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|
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<a href="/research/research-resources/preclinical-research-toolbox/npc">Learn More</a>
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|
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|
||
<div class="row mb-4 three-pic-cards">
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|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">PubChem </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>PubChem is a freely accessible database of small organic molecules and their activities against biological assays.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
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<a href="https://pubchem.ncbi.nlm.nih.gov/docs/about">Learn More</a>
|
||
</div>
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||
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||
|
||
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|
||
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||
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|
||
<div class="col-xl-4 ps-xl-3 mb-4">
|
||
<div class="card border-0 p-0 radius-10 h-100">
|
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<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Probes </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>We identify and optimize small molecule probes of novel, unexplored cellular targets. Probes are freely accessible to the scientific community.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
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<a href="https://www.ncbi.nlm.nih.gov/books/NBK47352/">Learn More</a>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
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|
||
|
||
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||
</div>
|
||
<div class="row mb-4 three-pic-cards">
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<div class="card border-0 p-0 radius-10 h-100">
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<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">BioPlanet </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>BioPlanet is a publicly available, comprehensive database that details the body’s biological pathways. Researchers can use it to study gene activity, disease mechanisms, cell toxicity and more.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
||
<a href="https://tripod.nih.gov/bioplanet/">Learn More</a>
|
||
</div>
|
||
</div>
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||
|
||
</div>
|
||
</div>
|
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|
||
|
||
|
||
</div>
|
||
|
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<hr class="section-divider">
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</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
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<h2 class="section-heading">Biomarkers</h2>
|
||
|
||
|
||
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|
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|
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|
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<div class="col-xl-4 ps-xl-3 mb-4">
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<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">BEST (Biomarkers, EndpointS, and other Tools) Resource </h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>This resource is an online glossary developed by a U.S. Food and Drug Administration and NIH joint committee to clarify terms used in translational science and medical product development, with a focus on study endpoints and biomarkers. </p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
||
<a href="http://www.ncbi.nlm.nih.gov/books/NBK326791/">Learn More</a>
|
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</div>
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|
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<section>
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<div class="container news-content Advancing">
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<h2 class="section-heading"> Informatics Tools & Information Systems</h2>
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<div class="card-body px-0 pt-0">
|
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<h3 class="">Global Ingredient Archival System</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>The registration system for the ingredients in medicinal products makes it easier for stakeholders to exchange information about substances in medicines, supporting scientific research on the use and safety of these products.</p>
|
||
|
||
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|
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<h3 class="">Additional Software and Informatics Tools </h3>
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|
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<p>These tools including specialized browsers, are available under “Software” in the right-hand column of the Tripod server.</p>
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</section>
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<section>
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<div class="container news-content Advancing">
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<h2 class="section-heading">Patents</h2>
|
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|
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|
||
|
||
|
||
<p>We have <a href="/research/alliances/licensing-opportunities">filed patent applications</a> on several technologies developed by center investigators. To ensure that these new technologies are further developed and commercialized, we seek collaboration and licensing partners.</p>
|
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|
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|
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<section>
|
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<div class="container news-content Advancing">
|
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<h2 class="section-heading">Therapy Development</h2>
|
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|
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|
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<div class="row mb-4 three-pic-cards">
|
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|
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<div class="col-xl-4 ps-xl-3 mb-4">
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<h3 class="">NCATS Toolkit for Patient-Focused Therapy Development </h3>
|
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<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Toolkit is a centralized collection of online resources that can help patient groups progress through the research and development process for new treatments.</p>
|
||
|
||
</p>
|
||
</div>
|
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<div class="card-footer bg-white border-0 p-0">
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<a href="/research/research-resources/ncats-toolkit">Learn More</a>
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