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<span>Lipase Tests</span>
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<span class="page-url print-only">URL of this page: https://medlineplus.gov/lab-tests/lipase-tests/</span>
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<h1>Lipase Tests</h1>
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<section><div class="mp-content"><h2>What is a lipase test?</h2>
<p>Lipase is a type of digestive enzyme or "digestive juice." It helps your body digest <a data-tid="3593" href="https://medlineplus.gov/dietaryfats.html">fats</a>. Most of your lipase is made in your pancreas, an organ located behind the lower part of your stomach. Lipase is also made in your salivary (spit) glands and in your stomach.</p>
<p>It's normal to have a small amount of lipase in your blood. But if the cells of your pancreas are damaged, they will release larger amounts of lipase. So high levels of lipase in your blood may mean you have <a data-tid="5876" href="https://medlineplus.gov/pancreatitis.html">pancreatitis</a>, (an inflamed, swollen pancreas) or another type of <a data-tid="110" href="https://medlineplus.gov/pancreaticdiseases.html">pancreatic disease</a>. A lipase tests can help diagnose these conditions and others.</p>
<p>Other names: serum lipase, lipase, LPS</p></div>
</section>
<section><div class="mp-content"><h2>What is it used for?</h2>
<p>A lipase test may be used to:</p>
<ul>
<li>Help diagnose diseases of the pancreas, especially acute (sudden) pancreatitis</li>
<li>Check to see if treatment for pancreatic diseases is working</li>
<li>Help diagnose and monitor chronic diseases that affect the pancreas, including:
<ul>
<li><a data-tid="203" href="https://medlineplus.gov/cysticfibrosis.html">Cystic fibrosis</a></li>
<li><a data-tid="119" href="https://medlineplus.gov/crohnsdisease.html">Crohn disease</a></li>
<li><a data-tid="897" href="https://medlineplus.gov/celiacdisease.html">Celiac disease</a></li>
</ul>
</li>
</ul></div>
</section>
<section><div class="mp-content"><h2>Why do I need a lipase test?</h2>
<p>You may need a lipase test if you have symptoms that may be caused by a problem with your pancreas. These include:</p>
<ul>
<li>Pain in your upper belly that may spread to your back</li>
<li><a data-tid="489" href="https://medlineplus.gov/nauseaandvomiting.html">Nausea and vomiting</a></li>
<li><a data-tid="211" href="https://medlineplus.gov/diarrhea.html">Diarrhea</a></li>
<li>Swollen or <a data-tid="3061" href="https://medlineplus.gov/abdominalpain.html">tender belly</a></li>
<li><a data-tid="511" href="https://medlineplus.gov/fever.html">Fever</a></li>
<li>Fast heartbeat</li>
</ul></div>
</section>
<section><div class="mp-content"><h2>What happens during a lipase test?</h2>
<p>Lipase is measured with a blood test. During a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.</p></div>
</section>
<section><div class="mp-content"><h2>Will I need to do anything to prepare for the test?</h2>
<p>You may need to <a data-pid="858" href="https://medlineplus.gov/lab-tests/fasting-for-a-blood-test/">fast</a> (not eat or drink) for 8-12 hours before a lipase blood test.</p></div>
</section>
<section><div class="mp-content"><h2>Are there any risks to the test?</h2>
<p>There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.</p></div>
</section>
<section><div class="mp-content"><h2>What do the results mean?</h2>
<p><strong>A very high level of lipase</strong> is usually a sign of acute pancreatitis.</p>
<p><strong>Higher than normal levels of lipase</strong> may be caused by:</p>
<ul>
<li>Diseases of the pancreas, including a blocked duct (tube), or <a data-tid="469" href="https://medlineplus.gov/pancreaticcancer.html">pancreatic cancer</a></li>
<li><a data-tid="5987" href="https://medlineplus.gov/chronickidneydisease.html">Chronic kidney disease</a></li>
<li><a data-tid="357" href="https://medlineplus.gov/pepticulcer.html">Peptic ulcer</a></li>
<li><a data-tid="259" href="https://medlineplus.gov/gallbladderdiseases.html">Gallbladder disease</a></li>
<li>Intestinal problems, such as a <a data-tid="5275" href="https://medlineplus.gov/intestinalobstruction.html">blocked intestine</a></li>
<li><a data-tid="4" href="https://medlineplus.gov/diabetes.html">Diabetes</a></li>
<li><a data-tid="388" href="https://medlineplus.gov/salivaryglanddisorders.html">Salivary (spit) gland disorders</a>, such as infection or <a data-tid="5331" href="https://medlineplus.gov/salivaryglandcancer.html">cancer</a></li>
<li><a data-tid="120" href="https://medlineplus.gov/alcoholusedisorderaud.html">Alcohol use disorder</a></li>
</ul>
<p><strong>Low levels of lipase</strong> may be a sign of permanent damage to cells in your pancreas that make lipase. This may happen in certain chronic (long-lasting) diseases, such as cystic fibrosis and chronic pancreatitis.</p>
<p>If your lipase levels are not normal, it doesn't always mean you have a medical condition that needs treatment. Many medicines, including codeine, diuretics ("water pills"), certain <a data-tid="6811" href="https://medlineplus.gov/cholesterolmedicines.html">cholesterol medicines</a>, and <a data-tid="160" href="https://medlineplus.gov/birthcontrol.html">birth control</a> pills, can affect your lipase levels.</p>
<p>If you have questions about your lipase test results, talk with your health care provider.</p>
<p>Learn more about <a data-pid="806" href="https://medlineplus.gov/lab-tests/how-to-understand-your-lab-results/">laboratory tests, reference ranges, and understanding results</a>.</p></div>
</section>
<section><div class="mp-content"><h2>Is there anything else I need to know about a lipase test?</h2>
<p>A lipase test is commonly used to diagnose pancreatitis. Pancreatitis can be acute or chronic. Acute pancreatitis is a sudden, short-term condition can usually be cured with treatment. Chronic pancreatitis is a long-lasting condition that gets worse over time. But it can be managed with medicine and lifestyle changes, such as not drinking <a data-tid="1558" href="https://medlineplus.gov/alcohol.html">alcohol</a> or <a data-tid="1359" href="https://medlineplus.gov/quittingsmoking.html">smoking</a> and being at a <a data-tid="480" href="https://medlineplus.gov/weightcontrol.html">healthy weight</a>. In certain cases, your provider may recommend surgery if other treatments don't help enough.</p></div>
</section>
<section><div class="mp-refs mp-content"><h2>References</h2>
<ol>
<li>Hinkle J, Cheever K. Brunner &amp; Suddarth's Handbook of Laboratory and Diagnostic Tests. 2nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams &amp; Wilkins; c2014. Lipase, Serum; 358 p.</li>
<li>Johns Hopkins Medicine [Internet]. Johns Hopkins Medicine; c2022. Health Library: Chronic Pancreatitis; [cited 2022 May 11 ]; [about 5 screens]. Available from: <a href="https://www.hopkinsmedicine.org/health/conditions-and-diseases/chronic-pancreatitis" target="bibliowin">https://www.hopkinsmedicine.org/health/conditions-and-diseases/chronic-pancreatitis</a></li>
<li>Junglee D, Penketh A, Katrak A, Hodson ME, Batten JC, Dandona P. Serum pancreatic lipase activity in cystic fibrosis. Br Med J [Internet]. 1983 May 28 [cited 2022 May 11]; 286(6379):1693–4. Available from: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1548188/pdf/bmjcred00555-0017.pdf" target="bibliowin">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1548188/pdf/bmjcred00555-0017.pdf</a></li>
<li>LabCorp [Internet]. Burlington (NC): Laboratory Corporation of America® Holdings; c2022. Patient Test Information: Lipase; [cited 2022 May 13]; [about 5 screens]. Available from: <a href="https://www.labcorp.com/help/patient-test-info/lipase" target="bibliowin">https://www.labcorp.com/help/patient-test-info/lipase</a></li>
<li>Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995–2022. Test ID: FLIPR: Lipase, Random Urine: Specimen; [cited 2022 May 11]; [about 3 screens]. Available from: <a href="https://www.mayocliniclabs.com/test-catalog/overview/90347#Specimen" target="bibliowin">https://www.mayocliniclabs.com/test-catalog/overview/90347#Specimen</a></li>
<li>Mt. Sinai [Internet]. New York (NY): Icahn School of Medicine at Mt. Sinai; c2022. Health Library:Lipase; [cited 2022 May 13]; [about 5 screens]. Available from: <a href="https://www.mountsinai.org/health-library/supplement/lipase" target="bibliowin">https://www.mountsinai.org/health-library/supplement/lipase</a></li>
<li>National Cancer Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; NCI Dictionary of Cancer Terms: pancreas; [cited 2022 May 11]; [about 1 screen]. Available from: <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/pancreas" target="bibliowin">https://www.cancer.gov/publications/dictionaries/cancer-terms/def/pancreas</a></li>
<li>National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Blood Tests; [updated 2022 Mar 24; cited 2022 May 11]; [about 7 screens]. Available from: <a href="https://www.nhlbi.nih.gov/health/blood-tests" target="bibliowin">https://www.nhlbi.nih.gov/health/blood-tests</a></li>
<li>National Institute of Diabetes and Digestive and Kidney Diseases [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Definitions &amp; Facts for Pancreatitis;[reviewed 2017 Nov; cited 2022 May 11]; [about 4 screens]. Available from: <a href="https://www.niddk.nih.gov/health-information/digestive-diseases/pancreatitis/definition-facts" target="bibliowin">https://www.niddk.nih.gov/health-information/digestive-diseases/pancreatitis/definition-facts</a></li>
<li>National Institute of Diabetes and Digestive and Kidney Diseases [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Treatment for Pancreatitis; [updated 2017 Nov; cited 2022 May 11]; [about 4 screens]. Available from: <a href="https://www.niddk.nih.gov/health-information/digestive-diseases/pancreatitis/treatment" target="bibliowin">https://www.niddk.nih.gov/health-information/digestive-diseases/pancreatitis/treatment</a></li>
<li>Pirahanchi Y, Sharma S. Biochemistry, Lipase. [Updated 2021 Jul 22; cited 2022 May 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK537346/" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK537346/</a></li>
<li>Testing.com [Internet]. Seattle (WA): OneCare Media; c2022. Lipase; [modified 2022 Feb 7; cited 2022 May 11]; [about 9 screens]. Available from: <a href="https://www.testing.com/tests/lipase/" target="bibliowin">https://www.testing.com/tests/lipase/</a></li>
<li>University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c2022. Health Encyclopedia: Lipase; [cited 2022 May 11]; [about 3 screens]. Available from: <a href="https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&amp;contentid=lipase" target="bibliowin">https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&amp;contentid=lipase</a></li>
<li>UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2022. Health Information: Lipase Blood Test; [updated 2021 Dec 27; cited 2022 May 11]; [about 3 screens]. Available from: <a href="https://patient.uwhealth.org/healthwise/article/en-us/hw7976" target="bibliowin">https://patient.uwhealth.org/healthwise/article/en-us/hw7976</a></li>
</ol></div>
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