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<span>IGF-1 (Insulin-like Growth Factor 1) Test</span>
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<h1>IGF-1 (Insulin-like Growth Factor 1) Test</h1>
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<section><div class="mp-content"><h2>What is an IGF-1 test?</h2>
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<p>This test measures the amount of IGF-1 (insulin-like growth factor 1) in your blood. IGF-1 is a <a data-tid="1499" href="https://medlineplus.gov/hormones.html">hormone</a>, a chemical messenger in your bloodstream that controls the actions of certain cells or organs. IGF-1 manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues.</p>
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<p>GH levels in the blood change throughout the day, depending on your diet and activity levels. But IGF-1 levels are more stable. So, a reliable way to track GH in your body is by measuring the level of IGF-I in the blood.</p>
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<p>Levels of IGF-1 and GH change throughout your life. They:</p>
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<ul>
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<li>Are normally low when you are a child</li>
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<li>Increase until they peak during <a data-tid="5569" href="https://medlineplus.gov/puberty.html">puberty</a></li>
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<li>Decrease once you are an adult</li>
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</ul>
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<p>Besides growth, GH also helps control your metabolism (the process your body uses to make energy from the food you eat). Some conditions, such as <a data-tid="5328" href="https://medlineplus.gov/pituitarytumors.html">pituitary tumors</a>, can cause your body to make too much or too little GH.</p>
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<p>Other names: somatomedin C test</p></div>
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</section>
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<section><div class="mp-content"><h2>What is it used for?</h2>
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<p>An IGF-1 test is used to detect and monitor <a data-tid="265" href="https://medlineplus.gov/growthdisorders.html">growth hormone disorders</a>, including:</p>
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<ul>
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<li><strong>GH deficiency.</strong> In children, GH is essential for normal growth and development. A GH deficiency can cause a child to grow more slowly and be much shorter than children of the same age. In adults, GH deficiency can lead to low <a data-tid="5935" href="https://medlineplus.gov/bonedensity.html">bone density</a> and reduced muscle mass.</li>
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<li><strong>GH insensitivity, also known as <a data-pid="16475" href="https://medlineplus.gov/genetics/condition/laron-syndrome/">Laron syndrome</a>.</strong> This is a rare <a data-tid="33" href="https://medlineplus.gov/geneticdisorders.html">genetic disorder</a> in which your body is unable to use the growth hormone it produces. It causes a slowed growth rate in children and shorter than normal height.</li>
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<li><strong>Gigantism.</strong> This rare childhood disorder causes your body to produce too much growth hormone. Children with gigantism are very tall for their age and have large hands and feet.</li>
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<li><strong>Acromegaly.</strong> This condition affects adults and causes your body to produce too much growth hormone. Adults with acromegaly have thicker than normal bones and enlarged hands, feet, and facial features.</li>
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</ul></div>
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</section>
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<section><div class="mp-content"><h2>Why do I need an IGF-1 test?</h2>
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<p>Your health care provider may order an IGF-1 test if you or your child has symptoms of a GH disorder or to monitor treatment for a GH disorder.</p>
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<p><strong>Symptoms of GH deficiency or GH insensitivity in children include:</strong></p>
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<ul>
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<li>Slowed growth rate compared with children of the same age</li>
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<li>Shorter height, arms, and legs, and lower weight than children of the same age</li>
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<li>Small penis in males</li>
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<li>Thin hair</li>
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<li>Poor nail growth</li>
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</ul>
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<p>Adults with GH deficiency may have symptoms such as <a data-tid="5324" href="https://medlineplus.gov/fatigue.html">fatigue</a> and decreased bone density and muscle mass. But IGF-1 testing isn't common for adults, as other disorders are much more likely to cause these symptoms.</p>
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<p><strong>Symptoms of GH excess (gigantism) in children include:</strong></p>
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<ul>
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<li>Excessive growth compared with children of the same age</li>
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<li>Overly large head</li>
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<li>Larger than normal hands and feet</li>
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<li>Mild to moderate <a data-tid="61" href="https://medlineplus.gov/obesity.html">obesity</a></li>
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</ul>
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<p><strong>Symptoms of GH excess (acromegaly) in adults include:</strong></p>
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<ul>
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<li>Deep, husky voice</li>
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<li>Larger than normal facial features such as lips, nose, and tongue</li>
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<li>Excessive <a data-tid="1344" href="https://medlineplus.gov/sweat.html">sweating</a> and body odor</li>
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<li>Thickening of bones</li>
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<li>Coarse, oily skin</li>
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<li>Irregular <a data-tid="325" href="https://medlineplus.gov/menstruation.html">menstrual cycles</a> in women</li>
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<li><a data-tid="118" href="https://medlineplus.gov/erectiledysfunction.html">Erectile dysfunction</a> in men</li>
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</ul></div>
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</section>
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<section><div class="mp-content"><h2>What happens during an IGF-1 test?</h2>
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<p>A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.</p></div>
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</section>
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<section><div class="mp-content"><h2>Will I need to do anything to prepare for this test?</h2>
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<p>You don't need any special preparations for an IGF-1 test.</p></div>
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</section>
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<section><div class="mp-content"><h2>Are there any risks to this test?</h2>
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<p>There is very little risk to you or your child in having a blood test. There may be slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>What do the results mean?</h2>
|
||
<p>If <strong>your child's results show lower than normal levels of IGF-1</strong>, it probably means they have a GH deficiency or insensitivity to GH. In a child, this may be caused by a genetic disorder or <a data-tid="174" href="https://medlineplus.gov/braindiseases.html">brain disease</a>. Your child may benefit from treatment with GH supplementation. GH supplementation is an injected medicine that contains manufactured human growth hormone. When GH deficiency is diagnosed and treated early, some children can grow several inches in the first year of treatment. Others grow less and more slowly but still benefit from treatment.</p>
|
||
<p>If <strong>your results show lower than normal IGF-1</strong>, it may be due to a normal age-related decrease in the hormone or other conditions. Your provider may order more tests to help make a diagnosis.</p>
|
||
<p><strong>Higher than normal levels of IGF-1</strong> may mean gigantism in children or acromegaly in adults. Gigantism and acromegaly are most often caused by a tumor in the pituitary gland, a small organ in the base of the brain that controls many functions, including growth. Treatment for the tumor may include <a data-tid="2724" href="https://medlineplus.gov/radiationtherapy.html">radiation therapy</a>, surgery, and/or medicines. But if the cause is not a tumor, you or your child may need more tests to identify the cause.</p>
|
||
<p>Learn more about <a data-pid="806" href="https://medlineplus.gov/lab-tests/how-to-understand-your-lab-results/">laboratory tests, references ranges, understanding results</a>.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>Is there anything else I need to know about an IGF-1 test?</h2>
|
||
<p>Your provider may order <a data-pid="31841" href="https://medlineplus.gov/lab-tests/growth-hormone-tests/">growth hormone tests</a> to help diagnose a GH disorder. These include:</p>
|
||
<ul>
|
||
<li><strong>A GH stimulation test</strong>, which helps diagnose a GH deficiency or insensitivity.</li>
|
||
<li><strong>A GH suppression test</strong>, which helps diagnose a GH excess (too much GH).</li>
|
||
<li><strong>IGBP-3 test.</strong> IGBP-3 is a protein that is the main carrier of IGF-1. This test can help diagnose a GH deficiency, GH insensitivity, or GH excess.</li>
|
||
</ul></div>
|
||
</section>
|
||
|
||
<section><div class="mp-refs mp-content"><h2>References</h2>
|
||
<ol>
|
||
<li>Brinkman JE, Tariq MA, Leavitt L, et al. Physiology, Growth Hormone. [Updated 2023 May 1; cited 2024 May 24]; [about 4 screens]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK482141/" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK482141/</a></li>
|
||
<li>Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2024. Acromegaly; [reviewed 2022 Jun 20; cited 2024 May 24]; [about 12 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diseases/17743-acromegaly" target="bibliowin">https://my.clevelandclinic.org/health/diseases/17743-acromegaly</a></li>
|
||
<li>Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2024. Blood Tests; [reviewed 2022 Dec 06; cited 2024 May 24]; [about 16 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diagnostics/24508-blood-tests" target="bibliowin">https://my.clevelandclinic.org/health/diagnostics/24508-blood-tests</a></li>
|
||
<li>Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2024. Human Growth Hormone (HGH); [reviewed 2022 Jun 21; cited 2024 May 24]; [about 11 screens]. Available from: <a href="https://my.clevelandclinic.org/health/articles/23309-human-growth-hormone-hgh" target="bibliowin">https://my.clevelandclinic.org/health/articles/23309-human-growth-hormone-hgh</a></li>
|
||
<li>Hormone Health Network [Internet]. Endocrine Society; c2024. Acromegaly; [updated 2022 Jan 25; cited 2024 May 24]; [about 5 screens]. Available from: <a href="https://www.hormone.org/diseases-and-conditions/acromegaly" target="bibliowin">https://www.hormone.org/diseases-and-conditions/acromegaly</a></li>
|
||
<li>Hormone Health Network [Internet]. Endocrine Society; c2024. Growth Hormone Deficiency; [updated 2022 Jan 24; cited 2024 May 24]; [about 6 screens]. Available from: <a href="https://www.hormone.org/diseases-and-conditions/growth-hormone-deficiency" target="bibliowin">https://www.hormone.org/diseases-and-conditions/growth-hormone-deficiency</a></li>
|
||
<li>MAGIC Foundation [Internet]. Warrenville (IL): Magic Foundation; c1989–2024. Insulin-like Growth Factor-1 Deficiency; [cited 2024 May 24]; [about 2 screens]. Available from: <a href="https://www.magicfoundation.org/insulin-like-growth-factor-deficiency" target="bibliowin">https://www.magicfoundation.org/insulin-like-growth-factor-deficiency</a></li>
|
||
<li>Mayo Clinic [Internet]. Mayo Foundation for Medical Education and Research; c1998-2024. Acromegaly: Diagnosis and treatment; [cited 2024 May 24]; [about 6 screens]. Available from: <a href="https://www.mayoclinic.org/diseases-conditions/acromegaly/diagnosis-treatment/drc-20351226" target="bibliowin">https://www.mayoclinic.org/diseases-conditions/acromegaly/diagnosis-treatment/drc-20351226</a></li>
|
||
<li>Mayo Clinic [Internet]. Mayo Foundation for Medical Education and Research; c1998-2024. Acromegaly: Symptoms and causes; [cited 2024 May 24]; [about 5 screens]. Available from: <a href="https://www.mayoclinic.org/diseases-conditions/acromegaly/symptoms-causes/syc-20351222" target="bibliowin">https://www.mayoclinic.org/diseases-conditions/acromegaly/symptoms-causes/syc-20351222</a></li>
|
||
<li>Mayo Clinic Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995-2024. Test ID: IGFMS: Insulin-Like Growth Factor-1, LC-MS, Serum: Clinical and Interpretive; [cited 2024 May 24]; [about 5 screens]. Available from: <a href="https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/62750" target="bibliowin">https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/62750</a></li>
|
||
<li>Merck Manual Consumer Version [Internet]. Kenilworth (NJ): Merck & Co., Inc.; c2024. Growth Hormone Deficiency in Children; [reviewed 2024 Apr; cited 2024 May 24]; [about 5 screens]. Available from: <a href="https://www.merckmanuals.com/home/children-s-health-issues/hormonal-disorders-in-children/growth-hormone-deficiency-in-children" target="bibliowin">https://www.merckmanuals.com/home/children-s-health-issues/hormonal-disorders-in-children/growth-hormone-deficiency-in-children</a></li>
|
||
<li>National Cancer Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; NCI Dictionary of Cancer Terms: IGF; [cited 2024 May 24]; [about 1 screen]. Available from: <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/igf" target="bibliowin">https://www.cancer.gov/publications/dictionaries/cancer-terms/def/igf</a></li>
|
||
<li>National Center for Advancing Translational Sciences [Internet]. Gaithersburg (MD): U.S. Department of Health and Human Services; Pituitary gigantism; [updated 2024 Feb; cited 2024 May 24]; [about 7 screens]. Available from: <a href="https://rarediseases.info.nih.gov/diseases/6506/gigantism" target="bibliowin">https://rarediseases.info.nih.gov/diseases/6506/gigantism</a></li>
|
||
<li>National Center for Advancing Translational Sciences [Internet]. Gaithersburg (MD): U.S. Department of Health and Human Services; Laron syndrome; [updated 2024 Feb; cited 2024 May 24]; [about 6 screens]. Available from: <a href="https://rarediseases.info.nih.gov/diseases/6859/laron-syndrome" target="bibliowin">https://rarediseases.info.nih.gov/diseases/6859/laron-syndrome</a></li>
|
||
<li>National Institute of Diabetes and Digestive and Kidney Diseases [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Acromegaly; [reviewed 2020 Jan; cited 2024 May 26]; [about 10 screens]. Available from: <a href="https://www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly" target="bibliowin">https://www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly</a></li>
|
||
<li>Nemours KidsHealth [Internet]. Jacksonville (FL): The Nemours Foundation; c1995-2024. Getting a Blood Test; [reviewed 2021 Sep; cited 2024 May 24]; [about 4 screens]. Available from: <a href="https://kidshealth.org/en/parents/blood-tests.html" target="bibliowin">https://kidshealth.org/en/parents/blood-tests.html</a></li>
|
||
<li>Nemours KidsHealth [Internet]. Jacksonville (FL): The Nemours Foundation; c1995-2024. Blood Test: IGF Binding Protein-3 (IGFBP-3); [reviewed 2023 May; cited 2024 May 24]; [about 2 screens]. Available from: <a href="https://kidshealth.org/en/parents/test-igfbp3.html" target="bibliowin">https://kidshealth.org/en/parents/test-igfbp3.html</a></li>
|
||
<li>Nemours KidsHealth [Internet]. Jacksonville (FL): The Nemours Foundation; c1995-2024. Blood Test: Somatomedin C (IGF-1); [reviewed 2023 May; cited 2024 May 24]; [about 2 screens]. Available from: <a href="https://kidshealth.org/en/parents/somatomedin-test.html" target="bibliowin">https://kidshealth.org/en/parents/somatomedin-test.html</a></li>
|
||
<li>NORD: National Organization for Rare Disorders [Internet]. Danbury (CT): NORD: National Organization for Rare Disorders; c2024. Growth Hormone Deficiency; [updated 2016 Sept 9; cited 2024 May 24]; [about 2 screens]. Available from: <a href="https://rarediseases.org/rare-diseases/growth-hormone-deficiency" target="bibliowin">https://rarediseases.org/rare-diseases/growth-hormone-deficiency</a></li>
|
||
<li>Pathology Tests Explained [Internet]. Alexandria (Australia): Australasian Association for Clinical Biochemistry and Laboratory Medicine; c2024. Insulin-like growth factor 1 (IGF-1); [reviewed 2023 Jun 1; cited 2024 May 24]; [about 7 screens]. Available from: <a href="https://pathologytestsexplained.org.au/ptests-pro.php?q=Insulin-like+growth+factor+1+%28IGF-1%29" target="bibliowin">https://pathologytestsexplained.org.au/ptests-pro.php?q=Insulin-like+growth+factor+1+%28IGF-1%29</a></li>
|
||
<li>Testing.com [Internet]. Seattle (WA).: OneCare Media; c2024. Insulin-like Growth Factor-1 (IGF-1); [modified 2021 Nov 9; cited 2024 May 24]; [about 9 screens]. Available from: <a href="https://www.testing.com/tests/insulin-growth-factor-1-igf-1/" target="bibliowin">https://www.testing.com/tests/insulin-growth-factor-1-igf-1/</a></li>
|
||
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"headline": "IGF-1 (Insulin-like Growth Factor 1) Test",
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"description": "This test measures the amount of IGF-1 (insulin-like growth factor 1) in your blood. IGF-1 is a hormone, a chemical messenger in your bloodstream that controls the actions of certain cells or organs. IGF-1 manages the effects of growth hormone (GH) in your body. Together, IGF-1 and GH promote normal growth of bones and tissues. GH levels in the blood change throughout the day, depending on your diet and activity levels. But IGF-1 levels are more stable. So, a reliable way to track GH in your body is by measuring the level of IGF-I in the blood. Levels of IGF-1 and GH change throughout your life. They: Are normally low when you are a child; Increase until they peak during puberty; Decrease once you are an adult; Besides growth, GH also helps control your metabolism (the process your body uses to make energy from the food you eat). Some conditions, such as pituitary tumors, can cause your body to make too much or too little GH. Other names: somatomedin C test",
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