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<span>Creatine Kinase</span>
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<h1>Creatine Kinase</h1>
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<section><div class="mp-content"><h2>What is a creatine kinase (CK) test?</h2>
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<p>This test measures the amount of creatine kinase (CK) in a sample of your blood. CK is also called creatine phosphokinase (CPK).</p>
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<p>CK is an enzyme. An enzyme is a protein that speeds up certain chemical reactions in your body. CK helps make energy. Most of the CK in your body is in your skeletal muscles. These are the muscles you use to move. You also have CK in your heart muscle and small amounts in your brain.</p>
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<p>Normally, a small amount of CK gets into your blood from the usual wear and tear on your muscles. But if your muscles, heart, or brain tissues are damaged, larger amounts of CK leak out of your cells into your bloodstream.</p>
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<p>A CK test is mainly used to help diagnose and monitor injuries and diseases that damage skeletal muscles and cause high levels of CK in your blood. But it may also be used for conditions that damage the heart muscle and the brain.</p>
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<p>Other names: CK, total CK, creatine phosphokinase, CPK</p></div>
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</section>
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<section><div class="mp-content"><h2>What is it used for?</h2>
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<p>A CK test is most often used to help diagnose and monitor:</p>
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<ul>
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<li><strong><a data-tid="510" href="https://medlineplus.gov/muscledisorders.html">Muscle injuries</a></strong>, including injuries from accidents, serious <a data-tid="176" href="https://medlineplus.gov/burns.html">burns</a>, or extreme exercise.</li>
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<li><strong>Muscle diseases</strong>, including:
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<ul>
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<li><strong><a data-tid="335" href="https://medlineplus.gov/musculardystrophy.html">Muscular dystrophy</a></strong>, a group of inherited muscle diseases that weaken muscles over time.</li>
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<li><strong>Rhabdomyolysis</strong>, or "rhabdo," a rapid breakdown of muscle tissue which releases proteins and <a data-tid="4224" href="https://medlineplus.gov/fluidandelectrolytebalance.html">electrolytes</a> into the blood. This uncommon condition can damage the heart and lead to sudden<a data-tid="302" href="https://medlineplus.gov/kidneyfailure.html"> kidney failure</a>. Rhabdo has many causes, including serious injuries, working in very hot places, overusing muscles, and certain medicines and medical conditions that affect the muscles.</li>
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<li><strong><a data-tid="1617" href="https://medlineplus.gov/myositis.html">Myositis</a></strong>, a group of rare diseases that involve long-term muscle inflammation (swelling), weakness, and sometimes pain.</li>
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</ul>
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</li>
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</ul>
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<p>In certain cases, a CK test may be used to help diagnose a heart attack. Another blood test, called a <a data-pid="5379" href="https://medlineplus.gov/lab-tests/troponin-test/">troponin test</a> is used more often. That's because troponin testing is better at finding damage to the heart muscle from a <a data-tid="5" href="https://medlineplus.gov/heartattack.html">heart attack</a>.</p>
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<p>If you've had a <a data-tid="8" href="https://medlineplus.gov/stroke.html">stroke</a>, a CK test may be done to find out how severe it was. The test may also help predict the chance that you may have another stroke.</p></div>
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</section>
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<section><div class="mp-content"><h2>Why do I need a CK test?</h2>
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<p>You may need a CK test if you have symptoms of a muscular disorder. These include:</p>
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<ul>
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<li>Muscle pain and/or <a data-tid="1707" href="https://medlineplus.gov/musclecramps.html">cramps</a></li>
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<li>Muscle weakness</li>
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<li><a data-tid="5953" href="https://medlineplus.gov/balanceproblems.html">Balance problems</a> and/or <a data-tid="1661" href="https://medlineplus.gov/falls.html">falling</a> a lot</li>
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<li>Numbness or tingling</li>
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<li>Dark colored urine (pee)</li>
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<li>Swollen legs or feet</li>
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</ul>
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<p>You may also need this test if you:</p>
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<ul>
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<li>Have had an injury that crushed or tore your muscles</li>
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<li>Have had serious burns</li>
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<li>Take certain medicines that may cause muscle damage, such as <a data-tid="4909" href="https://medlineplus.gov/statins.html">statins</a> to lower blood <a data-tid="26" href="https://medlineplus.gov/cholesterol.html">cholesterol</a></li>
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<li>Have had a stroke or <a data-tid="271" href="https://medlineplus.gov/traumaticbraininjury.html">traumatic brain injury (TBI)</a></li>
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</ul></div>
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</section>
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<section><div class="mp-content"><h2>What happens during a CK test?</h2>
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<p>A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.</p></div>
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</section>
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<section><div class="mp-content"><h2>Will I need to do anything to prepare for the test?</h2>
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<p>You don't need any special preparations for a CK test. To help make sure your results are accurate, your provider may ask you to avoid intense exercise and drinking alcohol for a few days before your test.</p></div>
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</section>
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<section><div class="mp-content"><h2>Are there any risks to the test?</h2>
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<p>There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.</p></div>
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</section>
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<section><div class="mp-content"><h2>What do the results mean?</h2>
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<p>Normal CK levels for you will depend on:</p>
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<ul>
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<li>Your age, sex, and race</li>
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<li>How much muscle you have</li>
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<li>How physically active you are</li>
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</ul>
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<p>If your CK level is higher than normal, it usually means you have some type of muscle damage. CK levels may not reach their highest until up to two days after certain injuries. So, you may have more than one CK test to see if your levels go up or down. CK levels that stay high or increase may mean that muscle damage is continuing to happen.</p>
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<p>But a CK test result can't show where the damage is or what's causing it. Your provider will consider your symptoms and medical history to understand what your test results mean.</p>
|
||
<p>If the source of high or increasing CK levels isn't clear, you may need a more specific type of CK test to find out if the CK is coming from your muscles, heart, or brain. This more specific test is called a CK isoenzymes test.</p>
|
||
<p>A CK isoenzymes test measures three different types of CK:</p>
|
||
<ul>
|
||
<li><strong>High levels of CK-MM enzymes</strong> are most likely from damage to your skeletal muscles. The damage may be from disease, sudden injury, certain medicines, or recent intense exercise.</li>
|
||
<li><strong>High levels of CK-MB enzymes</strong> are most likely from damage to your heart muscle. The damage is often caused by heart attack or inflammation in your heart muscle (myocarditis). But other conditions can also cause high levels of CK-MB, such as:
|
||
<ul>
|
||
<li><a data-tid="377" href="https://medlineplus.gov/pulmonaryembolism.html">A blood clot in the lung</a></li>
|
||
<li><a data-tid="4119" href="https://medlineplus.gov/heartsurgery.html">Heart surgery</a></li>
|
||
<li><a data-tid="199" href="https://medlineplus.gov/heartfailure.html">Congestive heart failure</a></li>
|
||
<li><a data-tid="6175" href="https://medlineplus.gov/hypothyroidism.html">Hypothyroidism</a></li>
|
||
<li>Kidney failure</li>
|
||
</ul>
|
||
</li>
|
||
<li><strong>Higher than normal CK-BB enzymes</strong> may mean you had a stroke or brain injury. But conditions that affect smooth muscles can also increase CK-BB levels. Smooth muscles are muscles you can't control, for example, the muscles in your digestive system.</li>
|
||
</ul>
|
||
<p>To diagnose the condition causing high CK levels, you may need other types of tests, too. The tests you have will depend on which types of CK enzymes are high as well as your symptoms and medical history.</p>
|
||
<p>If you have questions about any of your test results or diagnosis, talk with your provider.</p>
|
||
<p>Learn more about <a data-pid="806" href="https://medlineplus.gov/lab-tests/how-to-understand-your-lab-results/">laboratory tests, reference ranges, and understanding results</a>.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"></div>
|
||
</section>
|
||
|
||
<section><div class="mp-refs mp-content"><h2>References</h2>
|
||
<ol>
|
||
<li>Aujla RS, Patel R. Creatine Phosphokinase. [Updated 2022 Oct 24; cited 2023 Mar 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK546624/#_article-20105_s7_" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK546624/#_article-20105_s7_</a></li>
|
||
<li>Centers for Disease Control and Prevention [Internet]. Atlanta: U.S. Department of Health and Human Services; Rhabdomyolysis and Work; [reviewed 2023 Feb 8; cited 2023 Mar 24]; [about 2 screens]. Available from: <a href="https://www.cdc.gov/niosh/rhabdo/about/" target="bibliowin">https://www.cdc.gov/niosh/rhabdo/about/</a></li>
|
||
<li>Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2023. CK-MB Test; [reviewed 2022 Apr 11; cited 2023 Nov 5]; [about 17 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diagnostics/24519-ck-mb-test" target="bibliowin">https://my.clevelandclinic.org/health/diagnostics/24519-ck-mb-test</a></li>
|
||
<li>Cleveland Clinic: Health Library: Diagnostics & Testing [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Creatine Kinase (CK); [reviewed 2022 Apr 11; cited 2023 Nov 5]; [about 17 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diagnostics/22692-creatine-kinase-ck" target="bibliowin">https://my.clevelandclinic.org/health/diagnostics/22692-creatine-kinase-ck</a></li>
|
||
<li>Kurapati R, Soos MP. CPK-MB. [Updated 2022 Apr 21; cited 2023 Mar 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK557591/#_article-36627_s6_" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK557591/#_article-36627_s6_</a></li>
|
||
<li>Li S, Wang A, Zhang Y, Tian X, Meng X, Wang Y, Li H, Wang Y. Creatine Kinase Is Associated With Recurrent Stroke and Functional Outcomes of Ischemic Stroke or Transient Ischemic Attack. J Am Heart Assoc. 2022 Mar 15 [cited 2023 Mar 24];11(6):e022279. doi: 10.1161/JAHA.121.022279. Epub 2022 Mar 4. PMID: 35243903; PMCID: PMC9075278. Available from: <a href="https://pubmed.ncbi.nlm.nih.gov/35243903/" target="bibliowin">https://pubmed.ncbi.nlm.nih.gov/35243903/</a></li>
|
||
<li>Merck Manual Consumer Version [Internet]. Kenilworth (NJ): Merck & Co., Inc.; c2023. Tests for Musculoskeletal Disorders; [revised 2022 May; cited 2023 Mar 24]; [about 6 screens]. Available from: <a href="https://www.merckmanuals.com/home/bone-joint-and-muscle-disorders/diagnosis-of-musculoskeletal-disorders/tests-for-musculoskeletal-disorders" target="bibliowin">https://www.merckmanuals.com/home/bone-joint-and-muscle-disorders/diagnosis-of-musculoskeletal-disorders/tests-for-musculoskeletal-disorders</a></li>
|
||
<li>Muscular Dystrophy Association [Internet]. Chicago: Muscular Dystrophy Association; c2023. Simply Stated: The Creatine Kinase Test; 2022 Dec 12 [cited 2023 Mar 24]; [about 8 screens]. Available from: <a href="https://mdaquest.org/simply-stated-the-creatine-kinase-test/" target="bibliowin">https://mdaquest.org/simply-stated-the-creatine-kinase-test/</a></li>
|
||
<li>National Institute of Neurological Disorders and Stroke [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Inflammatory Myopathies; [reviewed 2023 Jan 20; cited 2023 Mar 24]; [about 2 screens]. Available from: <a href="https://www.ninds.nih.gov/health-information/disorders/inflammatory-myopathies?search-term=myositis" target="bibliowin">https://www.ninds.nih.gov/health-information/disorders/inflammatory-myopathies?search-term=myositis</a></li>
|
||
<li>National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Blood Tests; [cited 2023 Mar 24]; [about 9 screens]. Available from: <a href="https://www.nhlbi.nih.gov/health/blood-tests" target="bibliowin">https://www.nhlbi.nih.gov/health/blood-tests</a></li>
|
||
<li>National Institute of Neurological Disorders and Stroke [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Muscular Dystrophy;[reviewed 2023 Jan 20; cited 2023 Mar 24]; [about 12 screens]. Available from: <a href="https://www.ninds.nih.gov/health-information/disorders/muscular-dystrophy" target="bibliowin">https://www.ninds.nih.gov/health-information/disorders/muscular-dystrophy</a></li>
|
||
<li>Nemours KidsHealth [Internet]. The Nemours Foundation; c1995-2023. Your Muscles; [updated 2023 Jan; cited 2023 Mar 24]; [about 4 screens]. Available from: <a href="https://kidshealth.org/en/kids/muscles.html" target="bibliowin">https://kidshealth.org/en/kids/muscles.html</a></li>
|
||
<li>Patibandla S, Gupta K, Alsayouri K. Cardiac Enzymes. [Updated 2022 Aug 8; cited 2023 Mar 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK545216/" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK545216/</a></li>
|
||
<li>Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Creatine Kinase (CK) Blood Test; [modified 2022 Sep 13; cited 2023 Mar 24]; [about 10 screens]. Available from: <a href="https://www.testing.com/tests/creatine-kinase-ck/" target="bibliowin">https://www.testing.com/tests/creatine-kinase-ck/</a></li>
|
||
<li>UF Health: University of Florida Health [Internet]. Gainesville (FL): University of Florida Health; c2023. Creatine phosphokinase test: Overview; [reviewed 2019 Jan 28; cited 2023 Mar 24]; [about 3 screens]. Available from: <a href="https://ufhealth.org/creatine-phosphokinase-test" target="bibliowin">https://ufhealth.org/creatine-phosphokinase-test</a></li>
|
||
<li>University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c20239. Health Encyclopedia: Creatine Kinase (Blood); [cited 2023 Mar 24]; [about 3 screens]. Available from: <a href="https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=creatine_kinase_blood" target="bibliowin">https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=creatine_kinase_blood</a></li>
|
||
<li>University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c20239. Health Encyclopedia: Creatine Kinase with Isoenzymes (Blood); [cited 2023 Mar 24]; [about 4 screens]. Available from: <a href="https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=creatine_kinase_isoenzyme_serum" target="bibliowin">https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=creatine_kinase_isoenzyme_serum</a></li>
|
||
<li>UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2019. Health Information: Creatine Kinase; [updated 2022 Sep 8; cited 2023 Mar 24]; [about 3 screens]. Available from: <a href="https://patient.uwhealth.org/healthwise/article/en-us/abq5121" target="bibliowin">https://patient.uwhealth.org/healthwise/article/en-us/abq5121</a></li>
|
||
</ol></div>
|
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"headline": "Creatine Kinase",
|
||
"description": "This test measures the amount of creatine kinase (CK) in a sample of your blood. CK is also called creatine phosphokinase (CPK). CK is an enzyme. An enzyme is a protein that speeds up certain chemical reactions in your body. CK helps make energy. Most of the CK in your body is in your skeletal muscles. These are the muscles you use to move. You also have CK in your heart muscle and small amounts in your brain. Normally, a small amount of CK gets into your blood from the usual wear and tear on your muscles. But if your muscles, heart, or brain tissues are damaged, larger amounts of CK leak out of your cells into your bloodstream. A CK test is mainly used to help diagnose and monitor injuries and diseases that damage skeletal muscles and cause high levels of CK in your blood. But it may also be used for conditions that damage the heart muscle and the brain. Other names: CK, total CK, creatine phosphokinase, CPK",
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