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<h1>Ceruloplasmin Test</h1>
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<section><div class="mp-content"><h2>What is a ceruloplasmin test?</h2>
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<p>A ceruloplasmin test measures the amount of ceruloplasmin in a sample of your blood. Your liver makes ceruloplasmin by attaching copper to a protein. Your liver releases the ceruloplasmin into your bloodstream so it can carry copper to the parts of your body that need it.</p>
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<p>Copper is a <a data-tid="4298" href="https://medlineplus.gov/minerals.html">mineral</a> that your body uses for many important processes, including making energy, blood vessels, and melanin (the substance that gives your skin and eyes their color). Copper helps your body use <a data-tid="5542" href="https://medlineplus.gov/iron.html">iron</a>, and it supports brain development. It helps keep your nervous and immune systems healthy, too.</p>
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<p>You need only small amounts of copper to stay healthy. Most people get enough copper from the foods they eat. Good sources of copper include shellfish, nuts and seeds, beef liver and other organ meats, wheat-bran cereals, and chocolate.</p>
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<p>Normally, most of the copper in your blood is part of ceruloplasmin. So, ceruloplasmin testing can help diagnose conditions that involve having too much or too little copper in your body.</p>
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<p>Other names: CP, ceruloplasmin blood test, ceruloplasmin, serum, copper oxidase, ferroxidase</p></div>
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</section>
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<section><div class="mp-content"><h2>What is it used for?</h2>
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<p>A ceruloplasmin test is most often used with other tests to help diagnose <a data-tid="1691" href="https://medlineplus.gov/wilsondisease.html">Wilson disease</a>. Wilson disease is a rare <a data-tid="33" href="https://medlineplus.gov/geneticdisorders.html">genetic disorder</a> that prevents the body from removing extra copper.</p>
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<p>Wilson disease can lead to a harmful buildup of copper in the liver, brain, eyes, and other organs. The high levels of copper can severely damage organs and become life-threatening</p>
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<p>Ceruloplasmin tests may also be used to help diagnose conditions that cause low levels of copper. Although low levels of copper are uncommon, they may be caused by conditions such as:</p>
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<ul>
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<li><a data-tid="5461" href="https://medlineplus.gov/malnutrition.html">Malnutrition</a>, a condition that happens if your diet doesn't include enough vitamins, minerals, and other key nutrients.</li>
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<li><a data-tid="5459" href="https://medlineplus.gov/malabsorptionsyndromes.html">Malabsorption</a>, a condition in which your body has trouble absorbing nutrients from the food you eat. Many diseases can cause malabsorption, including <a data-tid="897" href="https://medlineplus.gov/celiacdisease.html">celiac disease.</a></li>
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<a data-tid="897" href="https://medlineplus.gov/celiacdisease.html">
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</a>
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<li>Menkes syndrome, also called <a data-pid="14529" href="https://medlineplus.gov/genetics/condition/menkes-syndrome/">Menkes disease</a>, a rare, incurable genetic disease that affects the body's ability to use copper. Symptoms usually show up in the first few months of life.</li>
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<li>Taking too many zinc supplements, which can affect how well your body can use copper</li>
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</ul>
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<p>If a person has been diagnosed with too much or too little copper in their blood, regular ceruloplasmin testing may be used to monitor their condition and to check whether treatment is working.</p>
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<p>Ceruloplasmin tests are mostly used with tests that measure copper levels in blood and/or urine (pee).</p></div>
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</section>
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<section><div class="mp-content"><h2>Why do I need a ceruloplasmin test?</h2>
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<p>Your health care provider may order a ceruloplasmin test if you have symptoms of Wilson disease. Even though people are born with the disease, the symptoms don't appear until copper builds up in your liver, brain, or other organs. This usually happens between ages 4 and 40, but symptoms can appear earlier or later in life.</p>
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<p>Wilson disease can cause many types of symptoms depending on which parts of your body are affected. For example:</p>
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<ul>
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<li><a data-tid="489" href="https://medlineplus.gov/nauseaandvomiting.html">Nausea and vomiting</a></li>
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<li><a data-tid="3061" href="https://medlineplus.gov/abdominalpain.html">Pain in your upper abdomen</a> (belly)</li>
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<li>Urine that's a darker color than usual and/or stool (poop) that's a lighter color</li>
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<li><a data-tid="4452" href="https://medlineplus.gov/jaundice.html">Jaundice</a>, a condition that causes your skin and eyes to turn yellow</li>
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<li>A type of <a data-tid="139" href="https://medlineplus.gov/anemia.html">anemia</a>, called hemolytic anemia, that destroys red blood cells faster than your body can make them</li>
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<li>Swelling from fluid buildup in your belly, lower legs, or feet</li>
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<li>Itchy skin</li>
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<li><a data-tid="409" href="https://medlineplus.gov/speechandcommunicationdisorders.html">Trouble with speech</a>, <a data-tid="1309" href="https://medlineplus.gov/swallowingdisorders.html">swallowing</a>, or physical coordination</li>
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<li>Tremors</li>
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<li>Stiff muscles and/or sudden jerky movements you can't control</li>
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<li><a data-tid="5676" href="https://medlineplus.gov/mentaldisorders.html">Mental health disorders</a>, including <a data-tid="144" href="https://medlineplus.gov/anxiety.html">anxiety</a>, <a data-tid="113" href="https://medlineplus.gov/depression.html">depression</a>, or <a data-tid="4180" href="https://medlineplus.gov/psychoticdisorders.html">psychosis</a></li>
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<li>Green, gold, or brown rings around your irises (the colored part of your eyes)</li>
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</ul>
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<p>If you have a family history of Wilson disease, you may need a test even if you don't have symptoms.</p>
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<p>You may also need this test if you have symptoms that could be a sign of too little copper, such as:</p>
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<ul>
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<li>Abnormally low levels of white blood cells called neutrophils</li>
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<li><a data-tid="37" href="https://medlineplus.gov/osteoporosis.html">Osteoporosis</a>, a condition that causes bones to become weak and break easily</li>
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<li><a data-tid="5324" href="https://medlineplus.gov/fatigue.html">Fatigue</a></li>
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<li>Tingling in your hands and feet</li>
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<li>Pale skin</li>
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</ul>
|
||
<p>Your baby may need a ceruloplasmin test if they have symptoms of Menkes syndrome. Symptoms usually show up when babies are about two or three months old. They may include:</p>
|
||
<ul>
|
||
<li>Hair that is colorless, thin, breaks easily, and becomes unusually tangled</li>
|
||
<li>Floppy muscles</li>
|
||
<li><a data-tid="396" href="https://medlineplus.gov/seizures.html">Seizures</a></li>
|
||
<li>Slow weight gain and growth</li>
|
||
</ul>
|
||
<p>Without treatment, most children with Menkes syndrome die within the first few years of life. If treatment is given in the first month after birth, some children may live longer. But even with treatment, the disease still tends to get worse over time.</p>
|
||
<p>If you have been diagnosed with abnormal copper levels, you may need regular ceruloplasmin testing to check your condition and to see how well your treatment is working.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>What happens during a ceruloplasmin test?</h2>
|
||
<p>A health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>Will I need to do anything to prepare for the test?</h2>
|
||
<p>You don't need any special preparations for a ceruloplasmin test.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>Are there any risks to the test?</h2>
|
||
<p>There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"><h2>What do the results mean?</h2>
|
||
<p>The results of a ceruloplasmin test alone cannot diagnose any conditions. The meaning of your test results will depend on the results of other tests, including tests that measure the amount of copper in your blood and/or urine.</p>
|
||
<p>To make a diagnosis, your provider will consider all your test results along with your symptoms, medical history, and family history. Ask your provider to explain what your ceruloplasmin levels say about your health.</p>
|
||
<p>In general, <strong>lower than normal ceruloplasmin levels</strong> may mean your body is not able to use copper properly. Low ceruloplasmin may be a sign of:</p>
|
||
<ul>
|
||
<li>Wilson disease, although ceruloplasmin levels are sometimes normal with this disease</li>
|
||
<li>Menkes syndrome</li>
|
||
<li>Severe <a data-tid="310" href="https://medlineplus.gov/liverdiseases.html">liver disease</a></li>
|
||
<li><a data-tid="91" href="https://medlineplus.gov/kidneydiseases.html">Kidney disease</a></li>
|
||
<li>A lack of copper caused by malnutrition and/or malabsorption</li>
|
||
</ul>
|
||
<p><strong>Higher than normal ceruloplasmin levels</strong> may be linked to:</p>
|
||
<ul>
|
||
<li><a data-tid="277" href="https://medlineplus.gov/heartdiseases.html">Heart disease</a></li>
|
||
<li><a data-tid="1232" href="https://medlineplus.gov/rheumatoidarthritis.html">Rheumatoid arthritis</a></li>
|
||
<li><a data-tid="5620" href="https://medlineplus.gov/leukemia.html">Leukemia</a></li>
|
||
<li><a data-tid="1262" href="https://medlineplus.gov/hodgkinlymphoma.html">Hodgkin lymphoma</a></li>
|
||
<li>Infection, inflammation, or injury</li>
|
||
</ul>
|
||
<p>But high levels of ceruloplasmin don't always mean you have a condition that needs medical treatment. <a data-tid="368" href="https://medlineplus.gov/pregnancy.html">Pregnancy</a>, <a data-tid="160" href="https://medlineplus.gov/birthcontrol.html">birth control pills</a>, and certain medicines, including <a data-tid="1610" href="https://medlineplus.gov/hormonereplacementtherapy.html">estrogen therapy</a> to treat <a data-tid="62" href="https://medlineplus.gov/menopause.html">menopause</a>, may cause high blood ceruloplasmin. Too much copper in your diet rarely causes high ceruloplasmin.</p>
|
||
<p>If you have questions about your results, talk with your provider.</p>
|
||
<p>Learn more about <a data-pid="806" href="https://medlineplus.gov/lab-tests/how-to-understand-your-lab-results/">laboratory tests, reference ranges, and understanding results</a>.</p></div>
|
||
</section>
|
||
|
||
<section><div class="mp-content"></div>
|
||
</section>
|
||
|
||
<section><div class="mp-refs mp-content"><h2>References</h2>
|
||
<ol>
|
||
<li>Biology Dictionary [Internet]. Biology Dictionary; c2023. Ceruloplasmin; [updated 2017 Jul 4; cited 2023 Apr 20]; [about 3 screens]. Available from: <a href="https://biologydictionary.net/ceruloplasmin" target="bibliowin">https://biologydictionary.net/ceruloplasmin</a></li>
|
||
<li>Cleveland Clinic [Internet]. Cleveland (OH): Cleveland Clinic; c2023.Ceruloplasmin Test; [reviewed 2021 Nov 24; cited 2023 Apr 24]; [about 10 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diagnostics/22153-ceruloplasmin-test" target="bibliowin">https://my.clevelandclinic.org/health/diagnostics/22153-ceruloplasmin-test</a></li>
|
||
<li>Cleveland Clinic [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Menkes Disease; [reviewed 2022 Apr 18; cited 2023 Apr 24]; [about 11 screens]. Available from: <a href="https://my.clevelandclinic.org/health/articles/6068-menkes-disease" target="bibliowin">https://my.clevelandclinic.org/health/articles/6068-menkes-disease</a></li>
|
||
<li>Cleveland Clinic [Internet]. Cleveland (OH): Cleveland Clinic; c2023. Wilson Disease; [reviewed 2022 Oct 26; cited 2023 Apr 20]; [about 22 screens]. Available from: <a href="https://my.clevelandclinic.org/health/diseases/5957-wilson-disease" target="bibliowin">https://my.clevelandclinic.org/health/diseases/5957-wilson-disease</a></li>
|
||
<li>Hinkle J, Cheever K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Ceruloplasmin; p. 146.</li>
|
||
<li>Kaler SG, Holmes CS, Goldstein DS, Tang J, Godwin SC, Donsante A, Liew CJ, Sato S, Patronas N. Neonatal diagnosis and treatment of Menkes Disease. N Engl J Med [Internet]. 2008 Feb 7 [cited 2023 Apr 23]; 358(6):605-14. Available from: <a href="https://www.ncbi.nlm.nih.gov/pubmed/18256395" target="bibliowin">https://www.ncbi.nlm.nih.gov/pubmed/18256395</a></li>
|
||
<li>Lopez MJ, Royer A, Shah NJ. Biochemistry, Ceruloplasmin. [Updated 2023 Feb 24; cited 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: <a href="https://www.ncbi.nlm.nih.gov/books/NBK554422/" target="bibliowin">https://www.ncbi.nlm.nih.gov/books/NBK554422/</a></li>
|
||
<li>MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); Menkes syndrome; [updated 2019 Dec 1; cited 2023 Apr 20]; [about 5 screens]. Available from: <a href="https://medlineplus.gov/genetics/condition/menkes-syndrome/#definition" target="bibliowin">https://medlineplus.gov/genetics/condition/menkes-syndrome/#definition</a></li>
|
||
<li>Mayo Clinic [Internet]. Mayo Foundation for Medical Education and Research; c1998-2023. Wilson's disease: Symptoms and causes; [cited 2023 Apr 20]; [about 5 screens]. Available from: <a href="https://www.mayoclinic.org/diseases-conditions/wilsons-disease/symptoms-causes/syc-20353251" target="bibliowin">https://www.mayoclinic.org/diseases-conditions/wilsons-disease/symptoms-causes/syc-20353251</a></li>
|
||
<li>Mayo Clinic: Mayo Medical Laboratories [Internet]. Mayo Foundation for Medical Education and Research; c1995-2023. Test ID: CER: Ceruloplasmin, Serum: Clinical and Interpretive; [cited 2023 Apr 24]; [about 3 screens]. Available from: <a href="https://www.mayocliniclabs.com/test-catalog/overview/614504#Clinical-and-Interpretive" target="bibliowin">https://www.mayocliniclabs.com/test-catalog/overview/614504#Clinical-and-Interpretive</a></li>
|
||
<li>National Institute of Diabetes and Digestive and Kidney Diseases [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Wilson Disease; [updated 2018 Nov; cited 2023 Apr 24]; [about 17 screens]. Available from: <a href="https://www.niddk.nih.gov/health-information/liver-disease/wilson-disease/all-content" target="bibliowin">https://www.niddk.nih.gov/health-information/liver-disease/wilson-disease/all-content</a></li>
|
||
<li>National Institutes of Health: Office of Dietary Supplements [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Copper: Fact Sheet for Consumers [updated 2022 Oct 18; cited 2023 Apr 24]; [about 7 screens]. Available from: <a href="https://ods.od.nih.gov/factsheets/Copper-Consumer/" target="bibliowin">https://ods.od.nih.gov/factsheets/Copper-Consumer/</a></li>
|
||
<li>National Institute of Neurological Disorders and Stroke [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Menkes Disease; [reviewed 2023 Jan 20; cited 2023 Apr 24]; [about 2 screens]. Available from: <a href="https://www.ninds.nih.gov/health-information/disorders/menkes-disease" target="bibliowin">https://www.ninds.nih.gov/health-information/disorders/menkes-disease</a></li>
|
||
<li>National Organization for Rare Disorders [Internet]. Danbury (CT): National Organization for Rare Disorders; c2023. Menkes Disease; [updated 2020 Mar 24; cited 2023 Apr 20]; [about 3 screens]. Available from: <a href="https://rarediseases.org/rare-diseases/menkes-disease" target="bibliowin">https://rarediseases.org/rare-diseases/menkes-disease</a></li>
|
||
<li>Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Ceruloplasmin; [modified 2021 Nov 9; cited 2023 Apr 20]; [about 9 screens]. Available from: <a href="https://www.testing.com/tests/ceruloplasmin/" target="bibliowin">https://www.testing.com/tests/ceruloplasmin/</a></li>
|
||
<li>Testing.com [Internet]. Seattle (WA): OneCare Media; c2023. Copper; [modified 2021 Nov 9; cited 2023 Apr 20]; [about 11 screens]. Available from: <a href="https://www.testing.com/tests/copper/" target="bibliowin">https://www.testing.com/tests/copper/</a></li>
|
||
<li>UF Health: University of Florida Health [Internet]. Gainesville (FL): University of Florida Health; c2023. Ceruloplasmin blood test: Overview; [updated 2021 Jan 24; cited 2023 Apr 20]; [about 3 screens]. Available from: <a href="https://ufhealth.org/ceruloplasmin-blood-test" target="bibliowin">https://ufhealth.org/ceruloplasmin-blood-test</a></li>
|
||
<li>UF Health: University of Florida Health [Internet]. Gainesville (FL): University of Florida Health; c2023. Malabsorption: Overview; [updated 2020 Apr 30; cited 2023 Apr 20]; [about 3 screens]. Available from: <a href="https://ufhealth.org/malabsorption" target="bibliowin">https://ufhealth.org/malabsorption</a></li>
|
||
<li>UF Health: University of Florida Health [Internet]. University of Florida; c2023. Malnutrition: Overview; [updated 2019 May 13; cited 2023 Apr 20]; [about 3 screens]. Available from: <a href="https://ufhealth.org/malnutrition" target="bibliowin">https://ufhealth.org/malnutrition</a></li>
|
||
<li>University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c2023. Health Encyclopedia: Ceruloplasmin (Blood); [cited 2023 Apr 20]; [about 5 screens]. Available from: <a href="https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=ceruloplasmin_blood" target="bibliowin">https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=ceruloplasmin_blood</a></li>
|
||
<li>University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; c2023. Health Encyclopedia: Total Copper (Blood); [cited 2023 Apr 20]; [about 6 screens]. Available from: <a href="https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=total_copper_blood" target="bibliowin">https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=total_copper_blood</a></li>
|
||
<li>UR Medicine: Conditions & Treatments [Internet]. Rochester (NY): University of Rochester Medical Center; c2023. Osteoporosis; [cited 2023 Apr 20]. [about 5 screens]. Available from: <a href="https://www.urmc.rochester.edu/conditions-and-treatments/osteoporosis#overview" target="bibliowin">https://www.urmc.rochester.edu/conditions-and-treatments/osteoporosis#overview</a></li>
|
||
</ol></div>
|
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"@context": "http://schema.org",
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"headline": "Ceruloplasmin Test",
|
||
"description": "A ceruloplasmin test measures the amount of ceruloplasmin in a sample of your blood. Your liver makes ceruloplasmin by attaching copper to a protein. Your liver releases the ceruloplasmin into your bloodstream so it can carry copper to the parts of your body that need it. Copper is a mineral that your body uses for many important processes, including making energy, blood vessels, and melanin (the substance that gives your skin and eyes their color). Copper helps your body use iron, and it supports brain development. It helps keep your nervous and immune systems healthy, too. You need only small amounts of copper to stay healthy. Most people get enough copper from the foods they eat. Good sources of copper include shellfish, nuts and seeds, beef liver and other organ meats, wheat-bran cereals, and chocolate. Normally, most of the copper in your blood is part of ceruloplasmin. So, ceruloplasmin testing can help diagnose conditions that involve having too much or too little copper in your body. Other names: CP, ceruloplasmin blood test, ceruloplasmin, serum, copper oxidase, ferroxidase",
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