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</div><div><span>Eruptive xanthomatosis</span></div></div>
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</a><h1 class="with-also" itemprop="name">Eruptive xanthomatosis</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Eruptive xanthomatosis is a skin condition that causes small yellow-red bumps to appear on the body. It can occur in people who have a very high blood triglyceride level. These people also frequently have diabetes.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p> Eruptive xanthomatosis is a rare skin condition caused by an excessively high triglyceride level in the blood. It can occur in people with poorly-controlled <a test="test" href="./001214.htm">diabetes</a> or in people who take some medicines, such as isotretinoin, estrogens, and cyclosporine, which can increase the triglyceride levels.</p><p>Cholesterol and triglycerides are types of fats that naturally occur in your blood. High levels increase the risk for heart disease and other health problems.</p><p>When diabetes is not well-controlled, the insufficient insulin level makes it harder for the body to break down fats in the blood. This increases the level of fats in the blood. The extra fat can collect under the skin to form small bumps which are xanthomas.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p> The skin bumps may vary in color from yellow, orange-yellow, red-yellow, to red. A small red halo may form around the bump. The bumps are:</p><ul><li>Pea-sized</li><li>Waxy</li><li>Firm</li></ul><p>While harmless by themselves, the bumps may be itchy and tender. They tend to appear on the:</p><ul><li>Buttocks</li><li>Shoulders</li><li>Arms</li><li>Thighs</li><li>Legs</li></ul><img title="Xanthoma, eruptive - close-up" alt="Xanthoma, eruptive - close-up" src="//medlineplus.gov/ency/images/ency/fullsize/1554.jpg" class="img-e" itemprop="image"/></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p> Your health care provider will take your medical history and examine your skin. You may have the following blood tests:</p><ul><li>Blood test for <a test="test" href="../patientinstructions/000386.htm">cholesterol</a> and triglycerides</li><li><a test="test" href="./003482.htm">Blood sugar test</a> for diabetes</li><li><a test="test" href="./003892.htm">Pancreatic function test</a></li></ul><p>A <a test="test" href="./003840.htm">skin biopsy</a> may be done to help diagnose the condition.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p> Treatment for eruptive xanthomatosis involves lowering:</p><ul><li>Blood triglyceride</li><li>Blood sugar</li><li>Stopping or decreasing the dose of culprit medicines</li></ul><p>Your provider will ask you to make changes in your lifestyle and diet. This can help lower <a test="test" href="../patientinstructions/000099.htm">high blood fats</a>.</p><p>If you have diabetes, your provider will ask you to <a test="test" href="../patientinstructions/000086.htm">manage your blood sugar</a> through diet, exercise, and medicines.</p><p>If lifestyle changes do not work, your provider may ask you to take medicines to help lower blood fat levels, such as:</p><ul><li><a test="test" href="../patientinstructions/000748.htm">Statins</a></li><li><a test="test" href="../patientinstructions/000789.htm">Fibrates</a></li><li>Lipid-lowering antioxidants</li><li><a test="test" href="../patientinstructions/000788.htm">Niacin</a></li><li><a test="test" href="../patientinstructions/000787.htm">Bile acid resins</a></li></ul><p>The skin bumps go away by themselves after few weeks. They clear once the blood sugar and fat levels are under control.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>If not treated, high triglyceride levels can lead to <a test="test" href="./000287.htm">pancreatitis</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Contact your health care provider if you:</p><ul><li>Have poor control of diabetes</li><li>Notice yellowish-red bumps on your skin</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Control of blood fats and blood sugar can help prevent this condition. Follow your provider's treatment recommendations.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Eruptive xanthoma; Eruptive xanthomata; Xanthoma - eruptive; Diabetes - xanthoma</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1554t.jpg" alt="Xanthoma, eruptive - close-up" title="Xanthoma, eruptive - close-up" class="side-img"/><a href="../imagepages/1554.htm">Xanthoma, eruptive - close-up</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Ahn CS, Yosipovitch G, Huang WW. Diabetes and the skin. In: Callen JP, Jorizzo JL, Zone JJ, Piette WW, Rosenbach MA, Vleugels RA, eds. <em>Dermatological Signs of Systemic Disease.</em> 5th ed. Philadelphia, PA: Elsevier; 2017:chap 24.</p><p>Braunstein I. Cutaneous manifestations of lipid disorders. In: Callen JP, Jorizzo JL, Zone JJ, Piette WW, Rosenbach MA, Vleugels RA, eds. <em>Dermatological Signs of Systemic Disease.</em> 5th ed. Philadelphia, PA: Elsevier; 2017:chap 26.</p><p>Fitzpatrick JE, High WA, Kyle WL. Yellow lesions. In: Fitzpatrick JE, High WA, Kyle WL, eds. <em>Urgent Care Dermatology: Symptom-Based Diagnosis. </em>Philadelphia, PA: Elsevier; 2018:chap 33.</p><p>Patterson JW. Cutaneous infiltrates - nonlymphoid. In: Patterson JW, ed. <em>Weedon's Skin Pathology.</em> 5th ed. Philadelphia, PA: Elsevier; 2021:chap 41.</p><p>White LE, Horenstein MG, Shea CR. Xanthomas. In: Lebwohl MG, Heymann WR, Coulson IH, Murrell DF, eds. <em>Treatment of Skin Disease</em>. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 256.</p></div></div></section>
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