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</div><div><span>Myocardial biopsy</span></div></div>
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</noscript></div><div class="main"><div id="ency_summary"><p>Myocardial biopsy is the removal of a small piece of heart muscle for examination.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Myocardial biopsy is done through a catheter that is threaded into your heart (<a test="test" href="./003419.htm">cardiac catheterization</a>). The procedure will take place in a hospital radiology department, special procedures room, or cardiac diagnostics laboratory. </p><p>To have the procedure:</p><ul><li>You may be given medicine to help you relax (sedative) before the procedure. However, you will remain awake and able to follow instructions during the test.</li><li>You will lie flat on a stretcher or table while the test is being done.</li><li>The skin is scrubbed and a local numbing medicine (anesthetic) is given.</li><li>The doctor inserts a thin tube (catheter) through a vein or artery, depending on whether tissue will be taken from the right or left side of the heart.</li><li>If the biopsy is done without another procedure, the catheter is most often placed through a vein in the neck and then carefully threaded into the heart. The doctor will use moving <a test="test" href="./003337.htm">x-ray</a> images (fluoroscopy) or echocardiography (ultrasound) to guide the catheter to the correct area.</li><li>Once the catheter is in position, a special device with small jaws on the tip is used to remove small pieces of tissue from the heart muscle.</li><li>The procedure may last 1 or more hours. </li></ul><img title="Biopsy catheter" alt="Biopsy catheter" src="//medlineplus.gov/ency/images/ency/fullsize/8904.jpg" class="img-e" itemprop="image"/></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>You will be told not to eat or drink anything for 6 to 8 hours before the test. The procedure takes place in the hospital. Most often, you will be admitted the morning of the procedure, but in some cases, you may need to be admitted the night before.</p><p>A health care provider will explain the procedure and its risks. You must sign a consent form.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>You may feel some pressure at the biopsy site. You may have some discomfort due to lying still for a long period of time.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>This procedure is routinely done after heart transplantation to watch for signs of rejection. </p><p>Your provider may also order this procedure if you have signs of:</p><ul><li>Alcoholic cardiomyopathy</li><li><a test="test" href="./000193.htm">Cardiac amyloidosis</a></li><li><a test="test" href="./001105.htm">Cardiomyopathy</a></li><li><a test="test" href="./000192.htm">Hypertrophic cardiomyopathy</a></li><li>Idiopathic cardiomyopathy</li><li>Ischemic cardiomyopathy</li><li><a test="test" href="./000149.htm">Myocarditis</a></li><li><a test="test" href="./000188.htm">Peripartum cardiomyopathy</a></li><li><a test="test" href="./000189.htm">Restrictive cardiomyopathy</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>A normal result means no abnormal heart muscle tissue was discovered. However, it does not necessarily mean your heart is normal because sometimes the biopsy can miss abnormal tissue.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>An abnormal result means abnormal tissue was found. This test may reveal the cause of cardiomyopathy. Abnormal tissue may be due to:</p><ul><li>Amyloidosis</li><li>Myocarditis</li><li>Sarcoidosis</li><li><a test="test" href="./000815.htm">Transplant (heart) rejection</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Risks are moderate and include:</p><ul><li><a test="test" href="./001124.htm">Blood clots</a></li><li>Bleeding from the biopsy site</li><li>Cardiac <a test="test" href="./001101.htm">arrhythmias</a></li><li>Infection</li><li>Injury to the recurrent laryngeal nerve</li><li>Injury to the vein or artery</li><li>Pneumothorax</li><li>Rupture of the heart (very rare)</li><li>Tricuspid regurgitation </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Heart biopsy; Biopsy - heart</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1097t.jpg" alt="Heart - front view" title="Heart - front view" class="side-img"/><a href="../imagepages/1097.htm">Heart - front view</a></li>
<li><img src="//medlineplus.gov/ency/images/ency/tnails/8904t.jpg" alt="Biopsy catheter" title="Biopsy catheter" class="side-img"/><a href="../imagepages/8904.htm">Biopsy catheter</a></li>
</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Kliger CA, Sorajja P. Special techniques. In: Sorajja P, Lim MJ, Kern MJ, eds. <em>Kern's Cardiac Catheterization Handbook</em>. 7th ed. Philadelphia, PA: Elsevier; 2020:chap 9.</p><p>Miller DV. Cardiovascular system. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. <em>Rosai and Ackerman's Surgical Pathology</em>. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 42.</p><p>Rogers JG, O'Connor CM. Heart failure: epidemiology, pathobiology, and diagnosis. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 45.</p></div></div></section>
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 5/8/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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