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</a><h1 class="with-also" itemprop="name">Chloride test - blood</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Chloride is a type of <a test="test" href="./002350.htm">electrolyte</a>. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance.</p><p>This article is about the laboratory test used to measure the amount of chloride in the fluid portion (serum) of the blood.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A blood sample is needed. Most of the time blood is <a test="test" href="./003423.htm">drawn from a vein</a> located on the inside of the elbow or the back of the hand.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Many medicines can interfere with blood test results.</p><ul><li>Your health care provider will tell you if you need to stop taking any medicines before you have this test.</li><li>DO NOT stop or change your medicines without talking to your provider first. </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>You may have this test if you have signs that your body's fluid level or acid-base balance is disturbed.</p><p>This test is most often ordered with other blood tests, such as a basic or comprehensive metabolic panel.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>A typical normal range is 96 to 106 milliequivalents per liter (mEq/L) or 96 to 106 millimoles per liter (millimol/L).</p><p>Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.</p><p>The example above shows the common measurement range for results for these tests. Some laboratories use different measurements or may test different specimens.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>A greater-than-normal level of chloride is called hyperchloremia. It may be due to:</p><ul><li><a test="test" href="./000378.htm">Addison disease</a></li><li>Carbonic anhydrase inhibitors (used to treat glaucoma)</li><li>Diarrhea</li><li>Ethylene glycol poisoning</li><li>Ketoacidosis</li><li>Kidney disease</li><li>Lactic acidosis</li><li><a test="test" href="./000335.htm">Metabolic acidosis</a></li><li>Methanol poisoning</li><li>Renal tubular acidosis - distal</li><li>Renal tubular acidosis - proximal</li><li><a test="test" href="./000111.htm">Respiratory alkalosis</a> (compensated)</li><li>Salicylate toxicity (such as aspirin overdose)</li><li>Ureteral diversion</li></ul><p>A lower-than-normal level of chloride is called hypochloremia. It may be due to:</p><ul><li><a test="test" href="./000308.htm">Bartter syndrome</a></li><li>Burns</li><li><a test="test" href="./000158.htm">Congestive heart failure</a></li><li>Cushing syndrome</li><li>Dehydration</li><li>Excessive sweating</li><li><a test="test" href="./000330.htm">Hyperaldosteronism</a></li><li>Metabolic alkalosis</li><li><a test="test" href="./000092.htm">Respiratory acidosis</a> (compensated)</li><li>Syndrome of inappropriate diuretic hormone secretion (<a test="test" href="./003702.htm">SIADH</a>)</li><li>Vomiting </li></ul><p>This test may also be done to help rule out or diagnose:</p><ul><li><a test="test" href="./000399.htm">Multiple endocrine neoplasia (MEN) II</a></li><li>Primary hyperparathyroidism </li></ul><p>Delirium may also alter chloride levels.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Serum chloride test</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/10026t.jpg" alt="Blood test" title="Blood test" class="side-img"/><a href="../imagepages/10026.htm">Blood test</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Bansal A. Respiratory acidosis, respiratory alkalosis, and mixed acid-base disorders. In: Johnson RJ, Floege J, Tonelli M, eds. <em>Comprehensive Clinical Nephrology</em>. 7th ed. Philadelphia, PA: Elsevier; 2024:chap 15.</p><p>Seifter JR. Acid-base disorders. In: Goldman L, Schafer AI, eds. <em>Goldman-Cecil Medicine</em>. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 110.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/20/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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