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</div><div><span>C-reactive protein</span></div></div>
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</a><h1 class="with-also" itemprop="name">C-reactive protein</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>C-reactive protein (CRP) is produced by the liver. The level of CRP rises when there is inflammation in the body. It is one of a group of proteins, called acute phase reactants that go up in response to inflammation. The levels of acute phase reactants increase in response to certain inflammatory proteins called cytokines. These proteins are produced by white blood cells during inflammation.</p><p>This article discusses the blood test done to measure the amount of CRP in your blood.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A blood sample is needed. This is most often taken from a vein. The procedure is called a <a test="test" href="./003423.htm">venipuncture</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>No special steps are needed to prepare for this test.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>When the needle is inserted to draw blood, some people feel moderate pain. Others may feel only a prick or stinging sensation. Afterward, there may be some throbbing.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>The CRP test is a general test to check for inflammation in the body. It is not a specific test. This means it can reveal that you have inflammation somewhere in your body, but it cannot pinpoint the exact location or reason. The CRP test is often done with the <a test="test" href="./003638.htm">ESR</a> (erythrocyte or sedimentation rate) test which also looks for inflammation.</p><p>You may have this test to:</p><ul><li>Check for flare-ups of inflammatory diseases such as <a test="test" href="./000431.htm">rheumatoid arthritis</a>, lupus, or vasculitis.</li><li>Determine if anti-inflammatory medicine is working to treat a disease or condition.</li></ul><p>A more sensitive CRP test, called a high-sensitivity C-reactive protein (hs-CRP) assay, is available to determine a person's risk for heart disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Normal CRP values vary from lab to lab. The levels often increase slightly with age, female sex and in African Americans. The majority of healthy adults have levels less than 0.3 mg/dL.</p><p>However, a low CRP level does not always mean that there is no inflammation present. Levels of CRP may not be increased in people with rheumatoid arthritis and lupus. The reason for this is unknown.</p><p>Note: Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.</p><p>The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>It is unclear if a minor rise of 0.3 to 1 mg/dL in CRP levels is a cause for concern. The hs-CRP is more precise and may be used to further understand these results.</p><ul><li>CRP levels from 1 mg/dL to 10 mg/dL are thought to be a moderate increase.</li><li>CRP Levels greater than 10 mg/dL are considered a marked increase.</li></ul><p>A positive test means you have inflammation in the body. The cause of a high CRP cannot always be determined. Some include:</p><ul><li><a test="test" href="./001289.htm">Cancer</a></li><li><a test="test" href="./000195.htm">Heart attack</a></li><li>Infection</li><li>Inflammatory bowel disease (IBD)</li><li>Rheumatoid arthritis, <a test="test" href="./000435.htm">lupus</a>, and related diseases</li><li><a test="test" href="./003940.htm">Rheumatic fever</a></li></ul><p>According to the American Heart Association, results of the hs-CRP can be interpreted as follows:</p><ul><li>You are at low risk of developing cardiovascular disease if your hs-CRP level is lower than 1.0 mg/L.</li><li>You are at average risk of developing cardiovascular disease if your levels are between 1.0 mg/L and 3.0 mg/L.</li><li>You are at high risk for cardiovascular disease if your hs-CRP level is higher than 3.0 mg/L.</li></ul><p>Note: Positive CRP results also occur during the last half of pregnancy or with the use of birth control pills (oral contraceptives).</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Risks associated with having blood drawn are slight, but may include:</p><ul><li>Excessive bleeding</li><li>Fainting or feeling lightheaded</li><li>Hematoma (blood accumulating under the skin)</li><li>Infection (a slight risk any time the skin is broken) </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Acute phase reactants - CRP</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/10026t.jpg" alt="Blood test" title="Blood test" class="side-img"/><a href="../imagepages/10026.htm">Blood test</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Dietzen DJ, Willrich MAV. Amino acids, peptides, and proteins. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. <em>Tietz Textbook of Laboratory Medicine</em>. 7th ed. St Louis, MO: Elsevier; 2023:chap 31.</p><p>Haberman R, Fors Nieves CE, Cronstein BN, Saxena A. Acute phase reactants. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. <em>Firestein & Kelley's Textbook of Rheumatology</em>. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 60.</p><p>Mora S, Libby P, Ridker PM. Primary prevention of cardiovascular disease. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. <em>Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine</em>. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 25.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 1/25/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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