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</div><div><span>Phenothiazine overdose</span></div></div>
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</a><h1 class="with-also" itemprop="name">Phenothiazine overdose</h1>
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</noscript></div><div class="main-single"><div id="ency_summary"><p>Phenothiazines are medicines used to treat serious mental and emotional disorders, and to reduce nausea. This article discusses an overdose of phenothiazines. <a test="test" href="./007287.htm">Overdose</a> occurs when someone takes more than the normal or recommended amount of a certain substance. This can be by accident or on purpose.</p><p>This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with overdoses, call your local emergency number (such as 911), or your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Poisonous Ingredient</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The poisonous ingredient is phenothiazine, which may be found in many medicines.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Where Found</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>These medicines contain phenothiazine or a medicine that has a similar action:</p><ul><li>Chlorpromazine</li><li>Clozapine</li><li>Fluphenazine</li><li>Haloperidol</li><li>Loxapine</li><li>Molindone</li><li>Perphenazine</li><li>Pimozide</li><li>Prochlorperazine</li><li>Thioridazine</li><li>Thiothixene</li><li>Trifluoperazine</li><li>Promethazine </li></ul><p>Other medicines may also contain phenothiazine.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Below are symptoms of a phenothiazine overdose in different parts of the body.</p><p>AIRWAYS AND LUNGS</p><ul><li>No breathing</li><li>Rapid breathing</li><li>Shallow breathing </li></ul><p>BLADDER AND KIDNEYS</p><ul><li>Difficult or slow urination</li><li>Inability to completely empty the bladder (urinary retention) </li></ul><p>EYES, EARS, NOSE, MOUTH, AND THROAT</p><ul><li><a test="test" href="./003029.htm">Blurred vision</a></li><li>Difficulty swallowing</li><li>Drooling</li><li>Dry mouth</li><li>Nasal congestion</li><li>Small or large pupils</li><li>Sores in the mouth, on the tongue or in the throat</li><li>Yellow eyes (icterus) </li></ul><p>HEART AND BLOOD</p><ul><li>Low blood pressure (severe)</li><li>Pounding heartbeat</li><li>Rapid heartbeat </li></ul><p>MUSCLES AND JOINTS</p><ul><li>Muscle spasms</li><li>Muscle stiffness</li><li>Rapid, involuntary movements of the face (chewing, blinking, grimaces, and tongue movements) </li></ul><p>NERVOUS SYSTEM</p><ul><li>Agitation, irritability, <a test="test" href="./003205.htm">confusion</a></li><li>Convulsions (seizures)</li><li>Disorientation, <a test="test" href="./003202.htm">coma</a> (lack of responsiveness)</li><li>Drowsiness</li><li>Fever</li><li>Low body temperature</li><li>Restlessness linked with repeated foot shuffling, rocking, or pacing (<a test="test" href="./000807.htm">akathisia</a>)</li><li>Tremor, motor tics that the person cannot control (<a test="test" href="./003197.htm">dystonia</a>)</li><li>Uncoordinated movement, slow movement, or shuffling (with long-term use or overuse)</li><li>Weakness </li></ul><p>REPRODUCTIVE SYSTEM</p><ul><li>Changes in menstrual patterns </li></ul><p>SKIN</p><ul><li>Rash</li><li>Sun sensitivity, rapid sunburn</li><li>Skin color changes </li></ul><p>STOMACH AND INTESTINES</p><ul><li><a test="test" href="./003125.htm">Constipation</a></li><li>Loss of appetite</li><li>Nausea</li></ul><p>Some of these symptoms may occur, even when the medicine is taken properly.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Home Care</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Seek medical help right away. </p><p>DO NOT make a person throw up unless poison control or a health care provider tells you to.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Before Calling Emergency</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Have this information ready:</p><ul><li>The person's age, weight, and condition</li><li>The name of the medicine, and strength, if known</li><li>The amount swallowed</li><li>The time it was swallowed</li><li>If the medicine was prescribed for the person</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Poison Control</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Your <a test="test" href="./002724.htm">local poison control center</a> can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.</p><p>This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What to Expect at the Emergency Room</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Take the container with you to the hospital, if possible.</p><p>Your provider will measure and monitor your vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated.</p><p>Tests may include:</p><ul><li>Blood and urine tests</li><li>Chest x-ray</li><li>CT scan (advanced imaging) of the brain for neurologic symptoms</li><li><a test="test" href="./003868.htm">Electrocardiogram</a> (ECG)</li></ul><p>Treatment may include:</p><ul><li>Activated charcoal</li><li>Breathing support, including oxygen, tube through the mouth into the lungs, and breathing machine (ventilator)</li><li>Fluids through a vein (IV)</li><li>Laxative</li><li>Medicines to treat symptoms</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Recovery depends on the amount of damage. Survival past 2 days is usually a good sign. Nervous system symptoms may be permanent. The most serious side effects are usually due to damage to the heart. If heart damage can be stabilized, recovery is likely. Life threatening heart rhythm disturbances may be difficult to treat, and may result in death.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Aronson JK. Neuroleptic drugs. In: Aronson JK, ed. <em>Meyler's Side Effects of Drugs</em>. 16th ed. Waltham, MA: Elsevier; 2016:53-119.</p><p>Monas J, Skolnik AB. Antipsychotics. In: Walls RM, ed. <em>Rosen's Emergency Medicine: Concepts and Clinical Practice</em>. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 150.</p></div></div></section>
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