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</div><div><span>Cri du chat syndrome</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Cri du chat syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Cri du chat syndrome is a group of symptoms that result from missing a piece of <a test="test" href="./002327.htm">chromosome</a> number 5. The syndrome's name is based on the infant's cry, which is high-pitched and sounds like a cat.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Cri du chat syndrome is rare. It is caused by a missing piece of chromosome 5.</p><p>Most cases are believed to occur during the development of the egg or sperm. A small number of cases occur when a parent passes a different, rearranged form of the chromosome to their child.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms include:</p><ul><li>Cry that is high-pitched and may sound like a cat</li><li>Downward slant to the eyes</li><li><a test="test" href="./003030.htm">Epicanthal folds</a>, an extra fold of skin over the inner corner of the eye</li><li>
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Low birth weight and slow growth</li><li><a test="test" href="./003303.htm">Low-set or abnormally shaped ears</a></li><li>Hearing loss</li><li>Heart defects</li><li><a test="test" href="./001523.htm">Intellectual disability</a></li><li>Partial webbing or fusing of fingers or toes</li><li>Curvature of the spine (scoliosis)</li><li>Single line in the palm of the hand</li><li>Skin tags just in front of the ear</li><li>Slow or incomplete development of motor skills</li><li>Small head (<a test="test" href="./003272.htm">microcephaly</a>)</li><li>Small jaw (<a test="test" href="./003306.htm">micrognathia</a>)</li><li>Wide-set eyes</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will perform a physical exam. This may show:</p><ul><li><a test="test" href="./000960.htm">Inguinal hernia</a></li><li><a test="test" href="./001602.htm">Diastasis recti</a> (separation of the muscles in the belly area)</li><li>Low muscle tone</li><li>Characteristic facial features</li></ul><p>Genetic tests can show a missing part of chromosome 5. Skull x-ray may reveal any problems with the shape of the base of the skull.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>There is no specific treatment. Your provider will suggest ways to treat or manage the symptoms.</p><p>Parents of a child with this syndrome should have genetic counseling and testing to determine if one parent has a change in chromosome 5.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with Cri du chat syndrome and their families can be found at:</p><ul><li>5P- Society -- <a class="extln" target="_blank" href="https://fivepminus.org/">fivepminus.org</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Intellectual disability is common. One half of children with this syndrome learn enough verbal skills to communicate. The cat-like cry becomes less noticeable over time.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Complications depend on the amount of intellectual disability and physical problems. Symptoms may affect the person's ability to care for themselves.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>This syndrome is most often diagnosed at birth. Your provider will discuss your baby's symptoms with you. It is important to continue regular visits with the child's providers after leaving the hospital.</p><p>Genetic counseling and testing is recommended for all people with a family history of this syndrome.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>There is no known prevention. Couples with a family history of this syndrome who wish to become pregnant may consider genetic counseling.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Chromosome 5p deletion syndrome; 5p minus syndrome; Cat cry syndrome</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Bacino CA, Lee B. Cytogenetics. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. <em>Nelson Textbook of Pediatrics. </em>21st ed. Philadelphia, PA: Elsevier; 2020:chap 98.</p><p>Madan-Khetarpal S, Arnold G, Ortiz D. Genetic disorders and dysmorphic conditions. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Physical Diagnosis.</em> 8th ed. Philadelphia, PA: Elsevier; 2023:chap 1.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 9/18/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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