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</div><div><span>Prune belly syndrome</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Prune belly syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Prune belly syndrome is a group of rare birth defects that involves these three main problems:</p><ul><li>Poor development of the abdominal muscles, causing the skin of the belly area to wrinkle like a prune</li><li><a test="test" href="./000973.htm">Undescended testicles</a></li><li>Urinary tract problems</li></ul></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The exact causes of prune belly syndrome are unknown. The condition affects mostly boys.</p><p>While in the womb (uterus), the developing baby's abdomen swells with fluid. Often, the cause is a problem in the urinary tract. The fluid disappears after birth, leading to a wrinkled abdomen that looks like a prune. This appearance is more noticeable due to the lack of abdominal muscles.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Weak abdominal muscles can cause:</p><ul><li><a test="test" href="./003125.htm">Constipation</a></li><li>Delay in sitting and walking</li><li>Difficulties coughing</li></ul><p>Urinary tract problems can cause difficulty urinating.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A woman who is pregnant with a baby who has prune belly syndrome may not have enough amniotic fluid (the fluid that surrounds the fetus). This can cause the infant to have lung problems from being compressed in the womb.</p><p>An <a test="test" href="./003778.htm">ultrasound done during pregnancy</a> may show that the baby has a swollen bladder or enlarged kidney.</p><p>In some cases, a pregnancy ultrasound may also help determine if the baby has:</p><ul><li><div>Heart problems</div></li><li>Abnormal bones or muscles</li><li>Stomach and intestinal problems</li><li>Underdeveloped lungs </li></ul><p>The following tests may be performed on the baby after birth to diagnose the condition:</p><ul><li>Blood tests</li><li><a test="test" href="./003782.htm">Intravenous pyelogram</a> (IVP)</li><li><a test="test" href="./003336.htm">Ultrasound</a></li><li><a test="test" href="./003784.htm">Voiding cystourethrogram</a> (VCUG)</li><li><a test="test" href="./003337.htm">X-ray</a></li><li><a test="test" href="./003330.htm">CT scan</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Early surgery is recommended to fix weak abdominal muscles, urinary tract problems, and undescended testicles.</p><p>The baby may be given antibiotics to treat or help prevent urinary tract infections.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with prune belly syndrome and their families can be found at:</p><ul><li>Prune Belly Syndrome Network -- <a class="extln" target="_blank" href="https://prunebelly.org">prunebelly.org</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Prune belly syndrome is a serious and often life-threatening problem.</p><p>Many infants with this condition are either <a test="test" href="../patientinstructions/000626.htm">stillborn</a> or die within the first few weeks of life. The cause of death is from severe lung or kidney problems, or from a combination of birth problems.</p><p>Some newborns survive and can develop normally. Others continue to have many medical and developmental problems.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Complications depend on the related problems. The most common are:</p><ul><li>Constipation</li><li>Bone deformities (<a test="test" href="./001228.htm">clubfoot</a>, dislocated hip, missing limb, finger, or toe, <a test="test" href="./003320.htm">funnel chest</a>)</li><li>Disease of the urinary tract (may need <a test="test" href="./007434.htm">dialysis</a> and a kidney transplant)</li></ul><p>Undescended testicles can lead to <a test="test" href="./001191.htm">infertility</a> or cancer.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Prune belly syndrome is usually diagnosed before birth or when the baby is born.</p><p>If you have a child with diagnosed prune belly syndrome, contact your health care provider at the first sign of a urinary tract infection or other urinary symptoms.</p><p>If a pregnancy ultrasound shows that your baby has a swollen bladder or enlarged kidneys, talk to a specialist in high-risk pregnancy or perinatology.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>There is no known way to prevent this condition. If the baby is diagnosed with a urinary tract obstruction before birth, in rare cases, surgery during the pregnancy may help prevent the problem from progressing to prune belly syndrome.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Eagle-Barrett syndrome; Triad syndrome</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Denes FT, Lopes RI. Prune-belly syndrome. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. <em>Campbell-Walsh-Wein Urology</em>. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 32.</p><p>Di Carlo HN, Crigger CB. Obstruction of the urinary tract. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 577.</p><p>Rowe CK, Merguerian PA. Developmental abnormalities of the genitourinary system. In: Gleason CA, Sawyer T, eds. <em>Avery's Diseases of the Newborn</em>. 11th ed. Philadelphia, PA: Elsevier; 2024:chap 76.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 12/31/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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