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</div><div><span>Bullous pemphigoid</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Bullous pemphigoid</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Bullous pemphigoid is a skin disorder characterized by <a test="test" href="./003939.htm">blisters</a>.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Bullous pemphigoid is an <a test="test" href="./000816.htm">autoimmune disorder</a> that occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.</p><p>This disorder usually occurs in older persons and is rare in young people. Symptoms come and go. The condition often goes away within 5 years.</p><p>In some cases, the condition is triggered by a medicine.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Most people with this disorder have itchy skin that may be severe. In most cases, there are blisters, called <a test="test" href="./003239.htm">bullae</a>.</p><ul><li>Blisters are usually located on the arms, legs, or middle of the body. In rare cases, blisters can form in the mouth.</li><li>The blisters may break open and form open sores (<a test="test" href="./003228.htm">ulcers</a>). </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will examine the skin and ask about the symptoms. They will review your list of medicines.</p><p>Tests that may be done to help diagnose this condition include:</p><ul><li>Blood tests</li><li><a test="test" href="./003840.htm">Skin biopsy</a> of the blister or the area next to it
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</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Anti-inflammatory medicines called corticosteroids may be prescribed. They may be taken by mouth or applied to the skin. More powerful medicines may be used to help suppress the immune system if steroids do not work, or to allow lower steroid doses to be used.</p><p>Antibiotics in the tetracycline family may be useful. <a test="test" href="./002409.htm">Niacin</a> (a B complex vitamin) is sometimes given along with tetracycline.</p><p>Your provider may suggest self-care measures. These may include:</p><ul><li>Applying anti-inflammatory creams to the skin</li><li>Using mild soaps and applying moisturizer to the skin after bathing</li><li>Protecting the affected skin from sun exposure and injury </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Bullous pemphigoid usually responds well to treatment. The medicine can often be stopped after several years. The disease sometimes returns after treatment is stopped.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Skin infection is the most common complication.</p><p>Complications resulting from treatment may also occur, especially from taking corticosteroids.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Contact your provider if you have: </p><ul><li>Unexplained blisters on your skin</li><li>An itchy rash that continues despite home treatment</li></ul></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1531t.jpg" alt="Bullous pemphigoid - close-up of tense blisters" title="Bullous pemphigoid - close-up of tense blisters" class="side-img"/><a href="../imagepages/1531.htm">Bullous pemphigoid - close-up of tense blisters</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Bilgic A, Murrell DF. Bullous pemphigoid. In: Lebwohl MG, Heymann WR, Coulson IH, Murrell DF, eds. <em>Treatment of Skin Disease: Comprehensive Therapeutic Strategies</em>. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 32.</p><p>Dinulos JGH. Vesicular and bullous diseases. In: Dinulos JGH, ed. <em>Habif's Clinical Dermatology</em>. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 16.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 5/31/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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</div></div><div name="Related MedlinePlus Health Topics" class="section-body" id="section-mtp"><ul class="side-nav"><li><a href="https://medlineplus.gov/pemphigus.html">Pemphigus</a></li>
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