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</div><div><span>Nalmefene Injection</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a623029.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Nalmefene Injection</h1><span class="alsocalled" id="d-pronunciation">pronounced as (nal' me feen)
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li></ul></div><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Nalmefene injection is to reverse the effects of a known or suspected opiate (narcotic) overdose that may result in death. Nalmefene injection is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Nalmefene injection comes as a solution (liquid) to be injected intravenously (into a vein), intramuscularly (into a muscle), or subcutaneously (just under the skin). Nalmefene also comes as an autoinjector (a pre-filled syringe that can be available for quick and easy administration) to be injected intramuscularly or subcutaneously. It is usually given as needed to treat opiate overdoses.</p><p>To safely administer nalmefene using the autoinjector, inspect solution in the window of the autoinjector every 30 days. If the solution is discolored, cloudy or has particles floating in it, do not use it and obtain a new autoinjector, Nalmefene autoinjector should be stored in a place where it can be obtained easily. If a person is unresponsive and an overdose on opiates is known or suspected, give nalmefene via the autoinjector directly into the outer thigh. Press the needle directly into the injection site (through clothing, if needed) and then firmly press and hold the button at the other end for 3 seconds. Once all of the nalmefene has been given, the viewing window on the autoinjector will turn orange. Immediately after giving, call 911 and then move the person to the recovery position by rolling them onto their side. Watch the person for 2 to 5 minutes to see if they wake up. If the person does not respond or becomes unresponsive again after waking, administer an additional dose of nalmefene using a new autoinjector. Autoinjectors are only intended for one-time use and should not be used if the expiration date has passed.</p><p>Nalmefene injection may not reverse the effects of certain opiates such as buprenorphine (Belbuca, Buprenex, Butrans, Sublocade) and pentazocine (Talwin), and additional nalmefene doses may be required.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-precautions"><h3>Before receiving nalmefene injection,</h3><ul><li>tell your doctor and pharmacist if you are allergic to nalmefene injection, related drugs, any other medications, or any of the ingredients in nalmefene injection or nalmefene autoinjector. Ask your pharmacist for a list of the ingredients.</li><li>tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.</li><li>tell your doctor if you have recently had surgery or if you have or have ever had seizures, or heart, liver, or kidney disease.</li></ul></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-side-effects"><h3>Nalmefene injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>nausea</li><li>vomiting</li><li>headache</li><li>fever</li><li>chills</li><li>dizziness</li><li>tiredness</li><li>feeling of rapid heart beat</li><li>ringing in ear</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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</h3><ul><li>signs of opiate withdrawal such as body aches; diarrhea; fast, pounding, or irregular heartbeat; fever; runny nose; sneezing; sweating; yawning; nausea; vomiting; nervousness; restlessness; irritability; shivering or trembling; stomach cramps; weakness; and the appearance of hair on the skin standing on end</li><li>seizures</li></ul><p>Nalmefene injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-6"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-7"><p>Keep all appointments with your doctor.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p><p/></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Revex<sup>®</sup><a href="#discontinued"><sup>¶</sup></a></li><li>Zurnai<sup>®</sup><a href="#discontinued"><sup>¶</sup></a></li></ul></div></div></section><div id="footnote"><p><sup id="discontinued">¶</sup> This branded product is no longer on the market. Generic alternatives may be available.</p></div><span>Last Revised - </span><span>09/20/2024</span>
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