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</div><div><span>Smallpox/Mpox Vaccine</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a622052.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Smallpox/Mpox Vaccine</h1>
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#app1">Why get vaccinated?
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</a></li><li><a href="#app2">What is Smallpox/Mpox vaccine?
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</a></li><li><a href="#app3">Talk with your healthcare provider
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</a></li><li><a href="#app4">What are the risks of a vaccine reaction?
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</a></li><li><a href="#app5">What if there is a serious problem?
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</a></li><li><a href="#app6">The National Vaccine Injury Compensation Program
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</a></li><li><a href="#app7">How can I learn more?
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</a></li><li><a href="#brand-name-1">Brand names</a>
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</li></ul></div><section><div id="boxed-notice" class="section"><div class="section-header"><div class="section-title"><h2>Notice:</h2></div><div class="section-button"><button type="submit" aria-controls="section-notification" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-notification"><p>Smallpox/Mpox vaccine is approved by the FDA as a primary (2-dose) series to prevent infection caused by smallpox or mpox vaccine in people 18 years of age and older. The FDA has also approved an Emergency Use Authorization (EUA) for the Smallpox/Mpox vaccine (Jynneos) to allow:</p><ul><li>2 doses of smallpox/Mpox vaccine given 4 weeks apart in children and adolescents younger than 18 years of age.</li></ul></div></div></section><section><div id="app1" class="section"><div class="section-header"><div class="section-title"><h2>Why get vaccinated?</h2></div><div class="section-button"><button type="submit" aria-controls="section-app1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-app1"><p>Smallpox/Mpox vaccine can prevent infection with some types of orthopoxviruses including Smallpox, Mpox, and Vaccinia viruses.</p><p>Smallpox infection can cause a serious illness characterized by rash and fever that may result in death, for some.</p><p>Mpox infection can cause an illness similar to Smallpox. Although generally milder, it can still cause death.</p><p>Vaccinia virus infection can occur after someone is exposed to a person or an animal who has been exposed to the virus. It generally causes a self-limiting illness.</p></div></div></section><section><div id="app2" class="section"><div class="section-header"><div class="section-title"><h2>What is Smallpox/Mpox vaccine?</h2></div><div class="section-button"><button type="submit" aria-controls="section-app2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-app2"><h3>Smallpox/Mpox vaccine is approved to prevent Smallpox or Mpox disease in adults at high risk for Smallpox or mpox infection. The Center for Diseases Control and Prevention recommend:
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</h3><ul><li>giving the vaccine to certain laboratory workers and emergency response team members who may be exposed to any of the covered orthopox viruses</li><li>consider giving the vaccine to people who administer ACAM2000 (Smallpox vaccine) or who care for people that are infected with an orthopox virus</li></ul><p>Smallpox/Mpox vaccine is given as 2 doses 4 weeks apart. If you have already received another Smallpox vaccine, you may only need 1 dose.</p><p>Booster doses are recommended every 2 to 10 years to people who remain at high risk of exposure to orthopox viruses.</p><p>Smallpox/Mpox vaccine can be administered at the same time as other vaccines.</p></div></div></section><section><div id="app3" class="section"><div class="section-header"><div class="section-title"><h2>Talk with your healthcare provider</h2></div><div class="section-button"><button type="submit" aria-controls="section-app3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-app3"><h3>Tell your vaccination provider if the person getting the vaccine:
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</h3><ul><li>Has had an allergic reaction after a previous dose of Smallpox vaccine, or has any severe life-threatening allergies.</li><li>Is pregnant or thinks they might be pregnant or is breastfeeding.</li><li>Has a weakened immune system.</li></ul><p>In some cases, your healthcare provider may decide to postpone pre-exposure Smallpox/Mpox vaccination until a future visit.</p><p>People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting pre-exposure Smallpox/Mpox vaccine.</p><p>If you have been recommended to receive Smallpox/Mpox vaccine due to an exposure to Mpox vaccine, you should receive it regardless of concurrent illness, pregnancy, breastfeeding or weakened immune system.</p><p>Your healthcare provider can give you more information.</p></div></div></section><section><div id="app4" class="section"><div class="section-header"><div class="section-title"><h2>What are the risks of a vaccine reaction?</h2></div><div class="section-button"><button type="submit" aria-controls="section-app4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-app4"><ul><li>Soreness, redness, itching or swelling where the shot is given can happen after Smallpox/Mpox vaccination.</li><li>Fatigue, headache and muscle pain can also happen after Smallpox/Mpox vaccination.</li></ul><p>People sometimes faint after medical procedures, including vaccination. Tell your doctor if you feel dizzy, or have vision changes or ringing in the ears.</p><p>As with any medication, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.</p></div></div></section><section><div id="app5" class="section"><div class="section-header"><div class="section-title"><h2>What if there is a serious problem?</h2></div><div class="section-button"><button type="submit" aria-controls="section-app5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-app5"><p>An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital.</p><p>For other signs that concern you, call your health care provider.</p><p>Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your health care provider will usually file this report, or you can do it yourself. Visit the VAERS website at <a target="_blank" href="http://www.vaers.hhs.gov">http://www.vaers.hhs.gov</a> or call <a href="tel:1-800-822-7967">1-800-822-7967</a>. <em>VAERS is only for reporting reactions, and VAERS staff members do not give medical advice</em>.</p></div></div></section><section><div id="app6" class="section"><div class="section-header"><div class="section-title"><h2>The National Vaccine Injury Compensation Program</h2></div><div class="section-button"><button type="submit" aria-controls="section-app6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-app6"><p>The National Vaccine Injury Compensation Program (VICP) is a federal program that was created to compensate people who may have been injured by certain vaccines. Claims regarding alleged injury or death due to vaccination have a time limit for filing, which may be as short as two years. Visit the VICP website at <a target="_blank" href="http://www.hrsa.gov/vaccinecompensation">http://www.hrsa.gov/vaccinecompensation</a> or call <a href="tel:1-800-338-2382">1-800-338-2382</a> to learn about the program and about filing a claim.</p></div></div></section><section><div id="app7" class="section"><div class="section-header"><div class="section-title"><h2>How can I learn more?</h2></div><div class="section-button"><button type="submit" aria-controls="section-app7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-app7"><ul><li>Ask your healthcare provider.</li><li>Call your local or state health department.</li><li>Visit the website of the Food and Drug Administration (FDA) for vaccine package inserts and additional information at <a target="_blank" href="https://www.fda.gov/vaccines-blood-biologics/vaccines">https://www.fda.gov/vaccines-blood-biologics/vaccines</a>.</li><li>Contact the Centers for Disease Control and Prevention (CDC): call <a href="tel:1-800-232-4636 (1-800-CDC-INFO)">1-800-232-4636 (1-800-CDC-INFO)</a> or visit CDC's website at <a target="_blank" href="https://www.cdc.gov/vaccines">https://www.cdc.gov/vaccines</a>.Visit CDC's website at www.cdc.gov/poxvirus/mpox</li></ul></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Jynneos<sup>®</sup></li></ul></div></div></section><span>Last Revised - </span><span>04/15/2023</span>
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