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</div><div><span>Fenfluramine</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a620045.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Fenfluramine</h1><span class="alsocalled" id="d-pronunciation">pronounced as (fen flur' a meen )
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
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</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li></ul></div><section><div id="boxed-warning" class="section"><div class="section-header"><div class="section-title"><h2>IMPORTANT WARNING: </h2></div><div class="section-button"><button type="submit" aria-controls="section-warning" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-warning"><p>Fenfluramine may cause serious heart and lung problems. Tell your doctor if you have or have ever had heart or lung disease. Your doctor will perform an echocardiogram (test that uses sound waves to measure your heart's ability to pump blood) before you start taking fenfluramine, every 6 months during treatment, and one time 3 to 6 months after your final dose of fenfluramine. Call your doctor right away if you have any of these signs and symptoms during treatment: shortness of breath, chest pain, tiredness or weakness, rapid or pounding heartbeat especially with increased activity, lightheadedness, fainting, irregular pulse, swollen ankles or feet, or bluish color to lips and skin.</p><p>Because of the risks with this medication, fenfluramine is available only through a special restricted distribution program. A program called Fintepla Risk Evaluation and Mitigation Strategies (REMS) program. You, your doctor, and your pharmacy must be enrolled in the Fintepla REMS program before you can receive it.</p><p>Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to fenfluramine. Your doctor will probably monitor your blood pressure during your treatment with fenfluramine.</p><p>Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with fenfluramine and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (<a target="_blank" href="https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm">https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm</a>) or the manufacturer's website to obtain the Medication Guide.</p></div></div></section><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Fenfluramine is used to control seizures in children from 2 years of age and older with Dravet syndrome (a disorder that begins in early childhood and causes seizures and later may lead to developmental delays and changes in eating, balance, and walking) and Lennox-Gastaut syndrome (LGS) (a disorder that causes seizures and developmental delays). Fenfluramine is in a class of medications called anticonvulsants. It is not known exactly how fenfluramine works, but it increases the amount of natural substances in the brain that may reduce seizure activity.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Fenfluramine comes as a solution (liquid) to take by mouth. It is usually taken two times a day with or without food. Take fenfluramine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fenfluramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.</p><p>Your doctor will probably start you on a low dose of fenfluramine and gradually increase your dose, not more than once every week.</p><p>Use the oral syringe that came with the medication for measuring the solution. Do not use a household spoon to measure your dose. Household teaspoons are not accurate measuring devices, and you may receive too much medication or not enough medication if you measure your dose with a household teaspoon. Rinse the oral syringe with clean tap water and allow it to air dry after each use. Use a dry oral syringe each time that you take the medication.</p><p>If you have a nasogastric (NG) or gastric tube, your doctor or pharmacist will explain how to prepare fenfluramine to administer it.</p><p>Fenfluramine helps to control seizures, but does not cure them. Continue to take fenfluramine even if you feel well. Do not stop taking fenfluramine without talking to your doctor. If you suddenly stop taking fenfluramine, you may experience withdrawal symptoms such as new or worsening seizures. Your doctor will probably decrease your dose gradually.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-precautions"><h3>Before taking fenfluramine,</h3><ul><li>tell your doctor and pharmacist if you are allergic to fenfluramine, any other medications, or any of the ingredients in fenfluramine oral solution. Ask your pharmacist or check the Medication Guide for a list of the ingredients.</li><li>Some medications should not be taken with fenfluramine. Make sure you have discussed any medications you are currently taking or plan to take before starting fenfluramine with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking fenfluramine, please get the advice of your doctor or pharmacist. Some medications may need to have their dose adjusted or require extra monitoring while receiving fenfluramine.</li><li>The following nonprescription or herbal products may interact with fenfluramine: dextromethorphan (in cough medications), St. John's Wort, and tryptophan. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking fenfluramine. Do not start any of these medications while taking fenfluramine without discussing it with your healthcare provider.</li><li>tell your doctor if you have or have ever had have glaucoma (increased pressure in the eye that may cause vision loss) or high blood pressure. Also, tell your doctor if you have or have ever had depression, mood problems, suicidal thoughts or behavior or kidney or liver disease.</li><li>tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking fenfluramine, call your doctor.</li><li>you should know that fenfluramine may make you drowsy and make it difficult for you to perform activities that require alertness or physical coordination. Do not drive a car or operate machinery until you know how this medication affects you.</li><li>ask your doctor about the safe use of alcoholic beverages and medications containing alcohol (cough and cold products, such as Nyquil, and other liquid products) while you are taking fenfluramine. Alcohol can add to the drowsiness caused by this medication.</li><li>you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking fenfluramine. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants, such as fenfluramine, to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as one week after they started taking the medication. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); thinking about harming or killing yourself, or planning or trying to do so; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-side-effects"><h3>Fenfluramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>diarrhea</li><li>constipation</li><li>vomiting</li><li>unsteadiness or problems with walking</li><li>drooling or excessive saliva</li><li>difficulty falling asleep or staying asleep</li><li>falls</li><li>fever, cough, or other signs of infection</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, stop taking fenfluramine and call your doctor immediately or get emergency medical treatment:
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</h3><ul><li>agitation, hallucinations, fever, sweating, confusion, fast heartbeat, chills, muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea</li><li>blurred vision or vision changes, including seeing halos (blurred outline around objects) or colored dots</li></ul><p>Fenfluramine can cause loss of appetite and weight loss. If you notice your child is losing weight, call your doctor. Your doctor will watch your child's growth and weight carefully. Talk to your doctor if you have concerns about your child's growth or weight while he or she is taking this medication.</p><p>Fenfluramine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the oral solution at room temperature and away from excess heat and moisture (not in the bathroom). Do not refrigerate or freeze the solution. Discard any unused oral solution that remains 3 months after first opening the bottle or after the "discard after" date on the label, whichever date is sooner.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p><h3>Symptoms of overdose may include:
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||
</h3><ul><li>dilated pupils</li><li>back arching</li><li>fast or irregular heartbeat</li><li>flushing</li><li>restlessness</li><li>anxiety</li><li>tremors</li><li>seizure</li><li>coma (loss of consciousness for a period of time)</li></ul></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-10"><p>Do not let anyone else take your medication. Fenfluramine is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Fintepla<sup>®</sup></li></ul></div></div></section><span>Last Revised - </span><span>03/15/2023</span>
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