137 lines
No EOL
36 KiB
HTML
137 lines
No EOL
36 KiB
HTML
<!DOCTYPE html>
|
||
<html lang="en" id="medmono" class="nojs us" data-root="https://medlineplus.gov"><head><meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/><meta http-equiv="window-target" content="_top"/><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/><meta charset="utf-8"/><meta property="fb:app_id" content="1042245625821448"/><meta name="expires" content="2025-03-08T12:59:27+05:00"/><meta name="ac-dictionary" content="medlineplus-ac-dictionary"/><link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon"/><meta name="viewport" content="width=device-width, initial-scale=1"/><link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?tk=1682610665830"/><link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css?tk=121212"/><!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"> <![endif]--><link rel="stylesheet" href="https://medlineplus.gov/css/drug.css"/><!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/drug_ie8.css"> <![endif]--><script type="text/javascript">document.querySelector("html").className = document.querySelector("html").className.replace(/nojs[\s]*/g, '');</script><script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript">
|
||
</script><script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MMVM77');</script><link rel="canonical" href="https://medlineplus.gov/druginfo/meds/a618045.html"/><meta name="description" content="Darunavir, Cobicistat, Emtricitabine, and Tenofovir: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="og:description" content="Darunavir, Cobicistat, Emtricitabine, and Tenofovir: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="twitter:description" content="Darunavir, Cobicistat, Emtricitabine, and Tenofovir: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="og:title" content="Darunavir, Cobicistat, Emtricitabine, and Tenofovir: MedlinePlus Drug Information"/><meta property="og:url" content="https://medlineplus.gov/druginfo/meds/a618045.html"/><meta property="twitter:title" content="Darunavir, Cobicistat, Emtricitabine, and Tenofovir: MedlinePlus Drug Information"/><meta name="twitter:card" content="summary_large_image"/><meta property="og:image" content="https://medlineplus.gov/images/share_drugs_1.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_drugs_2.jpg"/><meta property="twitter:image" content="https://medlineplus.gov/images/share_drugs_1.jpg"/><meta name="twitter:site" content="@medlineplus"/><meta content="@medlineplus" name="twitter:creator"/><link href="https://medlineplus.gov/druginfo/meds/a618045.html" hreflang="en" rel="alternate"/><link href="https://medlineplus.gov/spanish/druginfo/meds/a618045-es.html" hreflang="es" rel="alternate"/><title>Darunavir, Cobicistat, Emtricitabine, and Tenofovir: MedlinePlus Drug Information</title></head><body><!-- Google Tag Manager --><noscript><iframe title="googletagmanager" src="//www.googletagmanager.com/ns.html?id=GTM-MMVM77" height="0" width="0" style="display:none;visibility:hidden">
|
||
</iframe>
|
||
</noscript><a name="top" id="top">
|
||
</a><a class="hide-offscreen" href="#start">Skip navigation</a><section class="usa-banner" aria-label="Official website of the United States government"><div class="usa-accordion"><header class="usa-banner__header"><div class="usa-banner__inner"><div class="grid-col-auto"><img aria-hidden="true" class="usa-banner__header-flag" src="https://medlineplus.gov/uswds/img/us_flag_small.png" alt=""/>
|
||
</div><div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true"><p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p><p class="usa-banner__header-action">Here’s how you know</p></div><button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default"><span class="usa-banner__button-text">Here’s how you know</span></button></div></header><div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default"><div class="grid-row grid-gap-lg"><div class="usa-banner__guidance tablet:grid-col-6"><img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/><div class="usa-media-block__body"><p><strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong> website belongs to an official government organization in the United States.
|
||
</p></div></div><div class="usa-banner__guidance tablet:grid-col-6"><img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/><div class="usa-media-block__body"><p><strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong> (
|
||
<span class="icon-lock"><svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false"><title id="banner-lock-title-default">Lock</title><desc id="banner-lock-description-default">Locked padlock icon</desc><path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z">
|
||
</path></svg></span>) or <strong>https://</strong> means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
|
||
</p></div></div></div></div></div></section><!-- End Google Tag Manager --><div id="mplus-wrap"><header><div id="mplus-header"><div id="mplus-orgs"><a href="http://www.nih.gov/" class="nih-org" target="_blank" title="National Institutes of Health"><img class="nihlogo" src="https://medlineplus.gov/images/nihlogo.png" alt="National Institutes of Health"/>
|
||
</a><a href="https://www.nlm.nih.gov/" target="_blank"> National Library of Medicine</a></div><div id="mplus-logo" class="years-25"><a href="https://medlineplus.gov/"><img alt="MedlinePlus Trusted Health Information for You" title="MedlinePlus Trusted Health Information for You" src="https://medlineplus.gov/images/m_logo_25.png"/>
|
||
</a>
|
||
</div><div id="mplus-nav"><div aria-live="polite" class="sm-live-area hide-offscreen">
|
||
</div><button id="sm-menu-btn" class="navmenu-btn" title="Menu" role="button" aria-controls="mplus-menu-list" type="submit">Menu<span class="icon icon-nav-menu">
|
||
</span></button><ul id="mplus-menu-list" class="nav-list"><li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li><li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li></ul><button id="sm-search-btn" class="navmenu-btn" title="Search" role="button" aria-controls="mplus-search" type="submit"><span class="hide-offscreen">
|
||
</span>Search<span class="icon icon-nav-search">
|
||
</span></button><div class="top-1"><form id="mplus-search" method="get" action="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" title="Search MedlinePlus" target="_self"><input type="hidden" name="v:project" value="medlineplus"/><input type="hidden" name="v:sources" value="medlineplus-bundle"/><div class="form-box text-combo"><div class="form-area"><label class="hide-offscreen" for="searchtext_primary">Search MedlinePlus</label><input id="searchtext_primary" class="form-text" type="text" placeholder="Search MedlinePlus" alt="#Site Search input" title="Site Search input" maxlength="400" size="40" name="query" autocomplete="off" role="textbox" aria-autocomplete="list" aria-haspopup="true"/></div><div class="button-area"><button class="form-btn" title="Search MedlinePlus" alt="Search MedlinePlus" type="submit">GO</button></div></div></form><div class="secondarynav"><ul class="nav-list"><li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li><li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li><li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li><li><a href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from=https%3A//medlineplus.gov/skincancer.html" target="_blank"><span>Customer Support</span></a></li></ul></div></div><div id="mplus-nav-bar"><ul class="nav-list"><li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li></ul></div><a title="Español" id="mplus-lang-toggle" href="../../spanish/druginfo/meds/a618045-es.html">Español</a></div></div></header><div id="mplus-content"><!-- Breadrcumbs --><div id="breadcrumbs"><div itemtype="http://schema.org/BreadcrumbList" itemscope="" itemprop="breadcrumb"><span class="hide-offscreen">You Are Here:</span>
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov" itemprop="item"><span itemprop="name">Home</span></a>
|
||
→
|
||
<meta itemprop="position" content="1"/>
|
||
</div>
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov/druginformation.html" itemprop="item"><span itemprop="name">Drugs, Herbs and Supplements</span></a>
|
||
→
|
||
<meta itemprop="position" content="2"/>
|
||
</div>
|
||
</div><div><span>Darunavir, Cobicistat, Emtricitabine, and Tenofovir</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a618045.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
|
||
</a><h1 class="with-also">Darunavir, Cobicistat, Emtricitabine, and Tenofovir</h1><span class="alsocalled" id="d-pronunciation">pronounced as (da roon' a veer) (koe bik' i stat)
|
||
</span>
|
||
</div><div class="page-actions">
|
||
</div>
|
||
<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
|
||
</li><li><a href="#how">How should this medicine be used?</a>
|
||
</li><li><a href="#other-uses">Other uses for this medicine</a>
|
||
</li><li><a href="#precautions">What special precautions should I follow?</a>
|
||
</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
|
||
</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
|
||
</li><li><a href="#side-effects">What side effects can this medication cause?</a>
|
||
</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
|
||
</li><li><a href="#overdose">In case of emergency/overdose</a>
|
||
</li><li><a href="#other-information">What other information should I know?</a>
|
||
</li><li><a href="#brand-name-1">Brand names</a>
|
||
</li></ul></div><section><div id="boxed-warning" class="section"><div class="section-header"><div class="section-title"><h2>IMPORTANT WARNING: </h2></div><div class="section-button"><button type="submit" aria-controls="section-warning" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-warning"><p>Darunavir, cobicistat, emtricitabine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin and during your treatment with darunavir, cobicistat, emtricitabine, and tenofovir. If you have HBV and you take darunavir, cobicistat, emtricitabine, and tenofovir, your condition may suddenly worsen when you stop taking this medication. Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened.</p><p>Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to darunavir, cobicistat, emtricitabine, and tenofovir.</p><p>Talk to your doctor about the risks of taking darunavir, cobicistat, emtricitabine, and tenofovir.</p></div></div></section><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-1"><p>The combination of darunavir, cobicistat, emtricitabine, and tenofovir is used to treat human immunodeficiency virus (HIV) infection in adults and children weighing at least 88 pounds (40 kg) who have not been treated with other HIV medications or to replace current medication therapy in certain people already taking HIV medications. The combination of darunavir, cobicistat, emtricitabine, and tenofovir is in a class of medications called antivirals. Darunavir, emtricitabine, and tenofovir work by decreasing the amount of HIV in the blood. Cobicistat helps to keep darunavir in the body longer so that the medication will have a greater effect. Although the combination of darunavir, cobicistat, emtricitabine, and tenofovir will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting the HIV virus to other people.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-2"><p>The combination of darunavir, cobicistat, emtricitabine, and tenofovir comes as a tablet to take by mouth. It is usually taken with food once a day. Take darunavir, cobicistat, emtricitabine, and tenofovir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take darunavir, cobicistat, emtricitabine, and tenofovir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.</p><p>If you have trouble swallowing the tablets, you can split them into two pieces with a tablet-cutter. Take the split tablets right after cutting them. Do not save them for future use.</p><p>The combination of darunavir, cobicistat, emtricitabine, and tenofovir helps to control HIV infection but does not cure it. Continue to take darunavir, cobicistat, emtricitabine, and tenofovir even if you feel well. Do not stop taking darunavir, cobicistat, emtricitabine, and tenofovir without talking to your doctor.</p><p>Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-precautions"><h3>Before taking darunavir, cobicistat, emtricitabine, and tenofovir,</h3><ul><li>tell your doctor and pharmacist if you are allergic to darunavir, cobicistat, emtricitabine, and tenofovir, any other medications, sulfa medications, or any of the other ingredients in darunavir, cobicistat, emtricitabine, and tenofovir tablets. Ask your pharmacist for a list of the ingredients.</li><li>tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, others); cisapride (Propulsid) (not available in the U.S.); colchicine (Colcyrs, Mitigare) in people with kidney or liver disease; dronedarone (Multaq); elbasvir and grazoprevir (Zepatier); ergot medications such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ivabradine (Corlanor); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam by mouth; naloxegol (Movantik); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); St. John's wort; sildenafil (only Revatio, brand used for lung disease); simvastatin (Simcor, Zocor, in Vytorin); or triazolam (Halcion). Your doctor will probably tell you not to take darunavir, cobicistat, emtricitabine, and tenofovir if you are taking one or more of these medications.</li><li>tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as gentamicin; antifungal medications such as isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); antiviral medications such as acyclovir (Sitavig, Zovirax), cidofovir, ganciclovir (Cytovene, Valcyte), valacyclovir (Valtrex), and valganciclovir (Valcyte); antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S, Eryc, Ery-Tab), and telithromycin (no longer available in U.S., Ketek); apixaban (Eliquis); artemether and lumefantrine (Coartem); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); benzodiazepines such as clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, midazolam given intravenously (into a vein), and zolpidem (Ambien, Zolpmist); beta blockers such as arvedilol (Coreg), metoprolol (Lopressor, Toprol-XL, in Dutoprol), and timolol; bosentan (Tracleer); buprenorphine (Belbuca, Buprenex, others); buprenorphine and naloxone (Bunavail, Suboxone); buspirone; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, others), felodipine, nifedipine (Adalat CC, Afeditab CR, Procardia), and verapamil (Calan, Verelan, in Tarka); carvedilol (Coreg); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), and rosuvastatin (Crestor); dasatinib (Sprycel); medications for depression such as amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), and trazodone; digoxin (Lanoxin); eslicarbazepine (Aptiom); everolimus (Afinitor, Zortress); fentanyl (Duragesic, Subsys); fesoterodine (Toviaz); irinotecan (Camptosar); medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), and quinidine (in Nuedexta); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf); methadone (Methadose); nilotinib (Tasigna); oral contraceptives ('birth control pills'); oxcarbazepine (Trileptal); oxycodone (Xtampza, in Percodan); perphenazine; quetiapine (Seroquel); phosphodiesterase (PDE5) inhibitors such as avanafil (Stendra), avanafil (Stendra);sildenafil (Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); rivaroxaban (Xarelto); salmeterol (Serevent, in Advair); simeprevir (Olysio; no longer available in US); solifenacin (Vesicare); oral or inhaled steroids such as betamethasone, budesonide (Pulmicort), ciclesonide (Alvesco, Omnaris, Zetonna) dexamethasone, fluticasone (Flonase, Flovent, in Advair), methylprednisolone, mometasone (Asmanex, in Dulera), and triamcinolone; thioridazine; ticagrelor (Brilinta); tramadol (Conzip, Ultram); vinblastine; vincristine; and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with darunavir, cobicistat, emtricitabine, and tenofovir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.</li><li>tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section, any type of infection that does not go away or that comes and goes such as tuberculosis (TB; a type of lung infection) or cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems); diabetes; hemophilia (a disease in which the blood does not clot normally); or liver or kidney disease.</li><li>tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking darunavir, cobicistat, emtricitabine, and tenofovir, call your doctor.</li><li>tell your doctor if you are breastfeeding. You should not breastfeed if you are infected with HIV or if you are taking darunavir, cobicistat, emtricitabine, and tenofovir.</li><li>you should be aware that your body fat may increase or move to different areas of your body, such as your upper back, neck (''buffalo hump''), breasts, and around your stomach. You may notice a loss of body fat from your face, legs, and arms.</li><li>you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms during your treatment with darunavir, cobicistat, emtricitabine, and tenofovir, be sure to tell your doctor.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-6"><p>Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-side-effects"><h3>Darunavir, cobicistat, emtricitabine, and tenofovir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
|
||
</h3><ul><li>diarrhea</li><li>headache</li><li>stomach discomfort</li><li>gas</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING OR SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:
|
||
</h3><ul><li>dark yellow or brown urine; light-colored bowel movements; loss of appetite; nausea; vomiting; right upper stomach-area pain; or yellow skin or eyes</li><li>increased or decreased urination</li><li>weakness; muscle pain; shortness of breath or fast breathing; stomach pain with nausea and vomiting; cold or blue hands and feet; dizziness, lightheadedness; or fast or abnormal heartbeat</li><li>sore throat; fever; chills; cough; and other signs of infection</li><li>severe rash or rash with one or more of the following: fever, muscle or joint aches, red or swollen eyes, blisters or peeling skin, mouth sores, or swelling of face or neck</li></ul><p>Darunavir, cobicistat, emtricitabine, and tenofovir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-8"><p>Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the desiccant (drying agent) pouches from the container.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-10"><p>Keep a supply of darunavir, cobicistat, emtricitabine, and tenofovir on hand. Do not wait until you run out of medication to refill your prescription.</p><p>Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-brandname-1"><ul><li>Symtuza<sup>®</sup></li></ul></div></div></section><span>Last Revised - </span><span>04/15/2020</span>
|
||
</p>
|
||
<div id="bdme"><a href="https://medlineplus.gov/druginformation.html">Browse Drugs and Medicines</a></div><div id="citation-how-to"><button><span>Learn how to cite this page</span></button></div></article></div><footer><div class="provider-box"><img src="https://medlineplus.gov/images/ashpTM_CMYK_small.jpg" alt="ASHP Logo" title="ASHP Logo"/><a href="https://medlineplus.gov/ashpdisclaimer.html">American Society of Health-System Pharmacists, Inc. Disclaimer</a><div><p>AHFS<sup>®</sup> Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists<sup>®</sup>, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.</p></div></div>
|
||
|
||
<div id="mplus-footer">
|
||
<div class="footer1">
|
||
<ul class="secondarynav">
|
||
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
|
||
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
|
||
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
|
||
<li><a target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from="><span>Customer Support</span></a></li>
|
||
</ul>
|
||
<ul class="follow-footer">
|
||
<li>
|
||
<a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a>
|
||
</li>
|
||
<li>
|
||
<span class="follow-label">Follow us</span>
|
||
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X">
|
||
</a>
|
||
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook">
|
||
</a>
|
||
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram">
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
<div class="footer2">
|
||
<ul>
|
||
<li><a href=" https://www.nlm.nih.gov/web_policies.html" target='_blank'>NLM Web Policies</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
|
||
<li><a href="https://medlineplus.gov/accessibility.html">Accessibility</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
|
||
<li><a href="https://medlineplus.gov/plugins.html">Viewers & Players</a></li>
|
||
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
|
||
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
|
||
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
|
||
</ul>
|
||
<div class="address">
|
||
<a href="//www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
|
||
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
|
||
<a href="//www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
|
||
<a href="//www.nih.gov" target="_blank">National Institutes of Health</a>
|
||
</div>
|
||
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
|
||
</div>
|
||
</div>
|
||
|
||
</footer></div><!-- End Wrap --><script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/mplus-frontend-controls.js" type="text/javascript">
|
||
</script><!--[if lte IE 9]>
|
||
<script src="https://medlineplus.gov/jslib/jquery.placeholder.js" type="text/javascript"></script>
|
||
<![endif]--><script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/control.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/drug.js" type="text/javascript">
|
||
</script></body></html> |