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</div><div><span>Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a616040.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir</h1><span class="alsocalled" id="d-pronunciation">pronounced as (da sa' bue vir) (om bit' as vir) (par'' i ta' pre vir) (ri toe' na vir)
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
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</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li></ul></div><section><div id="boxed-notice" class="section"><div class="section-header"><div class="section-title"><h2>Notice:</h2></div><div class="section-button"><button type="submit" aria-controls="section-notification" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-notification"><p>Dasabuvir, ombitasvir, paritaprevir, and ritonavir is no longer available in the United States.</p></div></div></section><section><div id="boxed-warning" class="section"><div class="section-header"><div class="section-title"><h2>IMPORTANT WARNING: </h2></div><div class="section-button"><button type="submit" aria-controls="section-warning" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-warning"><p>You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. In this case, taking the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or ever had a hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine.</p><p>Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir.</p><p>Talk to your doctor about the risk(s) of taking the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir.</p></div></div></section><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Dasabuvir, ombitasvir, paritaprevir, and ritonavir is used alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Dasabuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of HCV in the body. Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-2"><p>The combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir comes as extended-release (long-acting) tablets to take by mouth. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dasabuvir, ombitasvir, paritaprevir, and ritonavir at around the same time every day. Do not take more or less of it or take it more often than prescribed by your doctor.</p><p>The extended-release tablets come in a package with 28 days of medication. Each daily dose pack contains 3 tablets that each contain a combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir. Take dasabuvir, ombitasvir, paritaprevir, and ritonavir (3 tablets) every morning with food. Follow the instructions on each daily dose pack about how to remove the tablets.</p><p>Swallow the extended-release tablets whole; do not split, chew, or crush them.</p><p>Continue to take dasabuvir, ombitasvir, paritaprevir, and ritonavir even if you feel well. The length of your treatment (12 to 24 weeks) depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking dasabuvir, ombitasvir, paritaprevir, and ritonavir without talking to your doctor.</p><p>Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-precautions"><h3>Before taking dasabuvir, ombitasvir, paritaprevir, and ritonavir,</h3><ul><li>tell your doctor and pharmacist if you are allergic to dasabuvir, ombitasvir, paritaprevir, and ritonavir, any other medications, or any of the ingredients in dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets. If you have had a serious or life-threatening reaction to ritonavir (rash, blistering or peeling of the skin), your doctor will probably tell not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir. Ask your pharmacist or check the Medication Guide for a list of the ingredients.</li><li>some medications should not be taken with dasabuvir, ombitasvir, paritaprevir, and ritonavir. Other medications may cause dosing changes or extra monitoring when taken with dasabuvir, ombitasvir, paritaprevir, and ritonavir. Make sure you have discussed any medications you are currently taking or plan to take before starting dasabuvir, ombitasvir, paritaprevir, and ritonavir with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking dasabuvir, ombitasvir, paritaprevir, and ritonavir, please get the advice of your doctor or pharmacist. s </li><li>the following herbal product may interact with dasabuvir, ombitasvir, paritaprevir, and ritonavir: St. John's wort. Be sure to let your doctor and pharmacist know that you are taking this medication before you start taking dasabuvir, ombitasvir, paritaprevir, and ritonavir. Do not start this medication while taking dasabuvir, ombitasvir, paritaprevir, and ritonavir without discussing with your healthcare provider. </li><li>tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir.</li><li>tell your doctor if you have ever had a liver transplant, diabetes, or human immunodeficiency virus (HIV).</li><li>tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking dasabuvir, ombitasvir, paritaprevir, and ritonavir, call your doctor.</li><li>you should know that dasabuvir, ombitasvir, paritaprevir, and ritonavir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking dasabuvir, ombitasvir, paritaprevir, and ritonavir and for 2 weeks after your final dose. Talk to your doctor about types of birth control that will work for you during and after your treatment with dasabuvir, ombitasvir, paritaprevir, and ritonavir.</li><li>remember not to drink alcohol within 4 hours of taking dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-6"><p>It is important not to miss or skip any doses. Do not take a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-side-effects"><h3>Dasabuvir, ombitasvir, paritaprevir, and ritonavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>difficulty falling asleep or staying asleep</li><li>cough</li><li>irritability</li><li>headache</li><li>diarrhea</li><li>muscle spasms</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately
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</h3><ul><li>rash</li><li>reddening of the skin</li><li>itching</li><li>hives</li><li>fatigue or lack of energy</li><li>weakness</li><li>confusion</li></ul><p>Dasabuvir, ombitasvir, paritaprevir, and ritonavir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Keep this medication in the carton it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not remove the tablets from the daily dose pack provided by the manufacturer until ready to take them.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-10"><p>Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Viekira XR<sup>®</sup> (as a combination product containing Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir)</li></ul></div></div></section><span>Last Revised - </span><span>08/15/2020</span>
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