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</div><div><span>Talimogene Laherparepvec Injection</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a616006.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Talimogene Laherparepvec Injection</h1><span class="alsocalled" id="d-pronunciation">pronounced as (tal im' oh jeen la her'' pa rep' vek)
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li><li><a href="#other-name">Other names</a>
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</li></ul></div><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Talimogene laherparepvec injection is used to treat certain melanoma (a type of skin cancer) tumors that cannot be removed surgically or that came back after being treated with surgery. Talimogene laherparepvec is in a class of medications called oncolytic viruses. It is a weakened and changed form of Herpes Simplex Virus Type I (HSV-1 'cold sore virus') that works by helping to kill cancer cells.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Talimogene laherparepvec injection comes as a suspension (liquid) to be injected by a doctor or nurse in a medical office. Your doctor will inject the medicine directly into tumors that are on your skin, just below your skin, or in your lymph nodes. You will receive a second treatment 3 weeks after the first treatment, and then every 2 weeks afterwards. The length of treatment depends on how well your tumors respond to treatment. Your doctor may not inject all of the tumors at each visit.</p><p>Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with talimogene laherparepvec and each time you receive the injections. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (<a target="_blank" href="https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm">https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm</a>) or the manufacturer's website to obtain the Medication Guide.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-precautions"><h3>Before receiving talimogene laherparepvec injection,</h3><ul><li>tell your doctor and pharmacist if you are allergic to talimogene laherparepvec, any other medications, or any of the ingredients in the talimogene laherparepvec injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.</li><li>some medications should not be taken with talimogene laherparepvec injection. Other medications may cause dosing changes or extra monitoring when taken with talimogene laherparepvec injection. Make sure you have discussed any medications you are currently taking or plan to take before receiving talimogene laherparepvec with your doctor and pharmacist. Before starting, stopping, or changing any medications while receiving talimogene laherparepvec, please get the advice of your doctor or pharmacist. </li><li>tell your doctor if you have or have ever had leukemia (cancer of the white blood cells), lymphoma (cancer of a part of the immune system), human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), or any other condition that causes a weakened immune system. Your doctor will probably not want you not to receive talimogene laherparepvec injection.</li><li>tell your doctor if you have or have ever had radiation treatment in the area of the melanoma tumors, multiple myeloma (cancer of the plasma cells in the bone marrow), any type of autoimmune disease (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage), or if you have close contact with someone who is pregnant or has a weakened immune system.</li><li>tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not become pregnant during your treatment with talimogene laherparepvec injection. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while receiving talimogene laherparepvec injection, call your doctor immediately. Talimogene laherparepvec injection may harm the fetus.</li><li>you should know that talimogene laherparepvec injection contains a virus that could spread and infect other people. You should be careful to cover all the injection sites with airtight and watertight bandages for at least 1 week after each treatment, or longer if the injection site is oozing. If the bandages become loose or fall off, be sure to replace them right away. You should use rubber or latex gloves when bandaging the injection sites. You should be sure to put all cleaning materials, gloves, and bandages that were used for the injection sites into a sealed plastic bag and throw them away into the garbage.</li><li>you should not touch or scratch the injection sites or bandages. This can spread the virus in the talimogene laherparepvec medication to other parts of your body. The people around you should be careful not to come into direct contact with your injections sites, bandages, or bodily fluids. Call your doctor immediately if you, or anyone around you, develops signs of a herpes infection;: pain, burning, or tingling in a blister by your mouth, genitals, fingers, or ears; eye pain, redness, or tearing; blurry vision; sensitivity to light; weakness in arms or legs; extreme drowsiness; or mental confusion.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-side-effects"><h3>Talimogene laherparepvec injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>unusual tiredness</li><li>nausea</li><li>vomiting</li><li>diarrhea</li><li>constipation</li><li>abdominal pain</li><li>headache</li><li>dizziness</li><li>weight loss</li><li>dry, cracked, itching, burning skin</li><li>muscle or joint pain</li><li>pain in arms or legs</li><li>slowed healing of injection sites</li><li>pain at the injection sites</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:
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</h3><ul><li>shortness of breath or other breathing problems</li><li>cough</li><li>pink, cola colored, or foamy urine</li><li>swelling of face, hands, feet, or stomach</li><li>losing color in your skin, hair, or eyes</li><li>warm, red, swollen, or painful skin around injection area</li><li>fever, sore throat, chills, or other signs of infection</li><li>dead tissue or open sores on the injected tumors</li></ul><p>Talimogene laherparepvec injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-7"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-8"><p>Keep all appointments with your doctor.</p><p>Ask your pharmacist any questions you have about talimogene laherparepvec injection.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Imlygic<sup>®</sup></li></ul></div></div></section><section><div id="other-name" class="section"><div class="section-header"><div class="section-title"><h2>Other names</h2></div><div class="section-button"><button type="submit" aria-controls="section-other-name" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-other-name"><ul><li>T-Vec</li></ul></div></div></section><span>Last Revised - </span><span>02/15/2016</span>
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