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</div><div><span>Isavuconazonium</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a615031.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Isavuconazonium</h1><span class="alsocalled" id="d-pronunciation">pronounced as (eye'' sa vue koe'' na zoe' nee um)
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
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</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li></ul></div><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Isavuconazonium is used to treat serious fungal infections such as invasive aspergillosis (a fungal infection that begins in the lungs and spreads through the bloodstream to other organs) and invasive mucormycosis (a fungal infection that usually begins in the sinuses, brain, or lungs) in adults and children 6 years of age and older who weigh at least 35 pounds (16 kg). Isavuconazonium is in a class of medications called azole antifungals. It works by slowing the growth of fungi that cause infection.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Isavuconazonium comes as a capsule to take by mouth. It is usually taken with or without food every 8 hours for the first six doses and then once a day. Take isavuconazonium at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take isavuconazonium exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.</p><p>Swallow the capsules whole; do not open, chew, dissolve, or crush them.</p><p>The length of your treatment depends on your general health, the type of infection you have, and how well you respond to the medication. Continue to take isavuconazonium even if you feel well. Do not stop taking isavuconazonium without talking to your doctor.</p><p>Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-precautions"><h3>Before taking isavuconazonium,</h3><ul><li>tell your doctor and pharmacist if you are allergic to isavuconazonium, fluconazole (Diflucan), itraconazole (Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), voriconazole (Vfend), any other medications, or any of the ingredients in isavuconazonium capsules. Ask your pharmacist for a list of the ingredients.</li><li>Some medications should not be taken with isavuconazonium. Other medications may cause dosing changes or extra monitoring when taken with isavuconazonium. Make sure you have discussed any medications you are currently taking or plan to take before starting isavuconazonium with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking isavuconazonium, please get the advice of your doctor or pharmacist.</li><li>tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.</li><li>the following nonprescription or herbal products may interact with isavuconazonium injection: St. John's wort. You should not take this medication while taking isavuconazonium.</li><li>tell your doctor if you or anyone in your family has or has ever had short QT syndrome (condition that increases the risk of irregular heartbeat, dizziness, fainting, or sudden death). Your doctor will probably tell you not to take isavuconazonium.</li><li>tell your doctor if you have or have ever had an arrhythmia (abnormal heart rate or rhythm) or other heart problems, a low level of potassium in your blood, cancer of the blood cells, or liver problems.</li><li>tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant during your treatment with isavuconazonium and for 28 days after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking isavuconazonium, call your doctor. Isavuconazonium may harm the fetus.</li><li>tell your doctor if you are breastfeeding or plan to breastfeed. Your doctor may tell you not to breastfeed during your treatment with isavuconazonium.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-6"><p>Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-side-effects"><h3>Isavuconazonium may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>diarrhea</li><li>constipation</li><li>headache</li><li>back pain</li><li>cough</li><li>difficulty falling asleep or staying asleep</li><li>anxiety</li><li>agitation</li><li>confusion</li><li>nausea</li><li>vomiting</li><li>stomach pain</li><li>heartburn or indigestion</li><li>decreased appetite</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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</h3><ul><li>rash; hives; itching; swelling of the face, throat, tongue, lips, or eyes; hoarseness; difficulty breathing or swallowing; fast or irregular heartbeat; dizziness; sweating; or fainting</li><li>peeling or blistering skin</li><li>nausea; vomiting; yellowing of the skin or eyes; extreme tiredness; or flu-like symptoms</li><li>irregular heartbeat</li><li>swelling of the hands, feet, arms or legs</li></ul><p>Isavuconazonium may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Keep this medication in the container it came in, tightly closed, and out of reach of children. Isavuconazonium comes in blister packaging and each blister section has two pockets. The left pocket has a desiccant (small packet that contains a substance that absorbs moisture to keep the medication dry) and the right pocket has the medication. Only open the isavuconazonium pocket and leave the desiccant in the packaging. Do not remove isavuconazonium from the original packaging until you are ready to take your dose. Do not put isavuconazonium in pill boxes or pill organizers. Store it at room temperature and away from excess heat and moisture (not in the bathroom).</p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p><h3>Symptoms of overdose may include the following:
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</h3><ul><li>headache</li><li>dizziness</li><li>pain, burning, or tingling in the hands or feet</li><li>drowsiness</li><li>difficulty focusing</li><li>change in sense of taste</li><li>dry mouth</li><li>numbness in the mouth</li><li>diarrhea</li><li>vomiting</li><li>sudden reddening of the face, neck, or upper chest</li><li>anxiety</li><li>restlessness</li><li>pounding or fast heartbeat</li><li>sensitivity of the eyes to light</li><li>joint pain</li></ul></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-10"><p>Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to isavuconazonium.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Cresemba<sup>®</sup></li></ul></div></div></section><span>Last Revised - </span><span>05/20/2024</span>
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</p>
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