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</div><div><span>Enfuvirtide Injection</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a603023.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also">Enfuvirtide Injection</h1><span class="alsocalled" id="d-pronunciation">pronounced as (en fyoo' vir tide)
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</div><div class="page-actions">
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<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
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</li><li><a href="#how">How should this medicine be used?</a>
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</li><li><a href="#other-uses">Other uses for this medicine</a>
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</li><li><a href="#precautions">What special precautions should I follow?</a>
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</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
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</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
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</li><li><a href="#side-effects">What side effects can this medication cause?</a>
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</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
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</li><li><a href="#overdose">In case of emergency/overdose</a>
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</li><li><a href="#other-information">What other information should I know?</a>
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</li><li><a href="#brand-name-1">Brand names</a>
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</li><li><a href="#other-name">Other names</a>
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</li></ul></div><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Enfuvirtide injection is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who weigh at least 24 pounds (11 kg) who have been treated with several other HIV medications in the past and whose HIV could not be successfully be treated with other medications, including their current therapy. Enfuvirtide is in a class of medications called HIV entry and fusion inhibitors. It works by decreasing the amount of HIV in the blood. Although enfuvirtide does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Enfuvirtide injection comes as a powder to be mixed with sterile water and injected subcutaneously (under the skin). It is usually injected twice a day. To help you remember to inject enfuvirtide, inject it at about the same times each day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use enfuvirtide injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.</p><p>Enfuvirtide injection controls HIV but does not cure it. Continue to use enfuvirtide injection even if you feel well. Do not stop using enfuvirtide injection without talking to your doctor. If you miss doses or stop using enfuvirtide injection, your condition may become more difficult to treat.</p><p>Your doctor or nurse will show you or a caregiver how to mix and inject a dose of enfuvirtide injection at home. Before you use enfuvirtide injection for the first time, you and the person who will be giving the injections should read the manufacturer's information for the patient that comes with it. These instructions describe how to mix and inject a dose of enfuvirtide. Be sure that you understand these directions. Ask your healthcare provider if you have any questions about when you should use the medication, where on your body you should inject the medication, how to give the injection, or what type of syringe and needle to use.</p><p>You can inject enfuvirtide anywhere in the front of your thighs or in your lower stomach except for the 2-inch (5-centimeter) area around the the navel (belly button) If someone else is giving you the injection, it can be injected into the outer area of your upper arms. Do not inject enfuvirtide in any area directly under a belt or waistband; near the elbow, knee, groin, the lower or inner buttocks; or directly over a blood vessel. To reduce the chances of soreness, choose a different area for each injection. Keep track of the areas where you inject enfuvirtide, and do not give an injection into the same area two times in a row. Use your fingertips to check your chosen area for hard bumps under the skin. Do not inject enfuvirtide into an area of skin that has a tattoo, scar, bruise, mole, a burn site, or has had a reaction to a previous injection of enfuvirtide.</p><p>Never reuse needles, syringes, vials of enfuvirtide, or vials of sterile water. Dispose of used needles and syringes in a puncture-resistant container. Do not put them in a trash can. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container. Ask you doctor how to dispose of used alcohol pads and vials.</p><p>Before preparing an enfuvirtide dose, wash your hands with soap and water. After you wash your hands, do not touch anything except the medication, supplies, and the area where you will inject the medication.</p><p>Ask your pharmacist or doctor for a copy of the manufacturer's injection information for the patient. Carefully read the manufacturer's instructions to learn how to prepare and inject your dose. Ask your doctor or pharmacist if you have questions about how to inject enfuvirtide.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-precautions"><h3>Before using enfuvirtide,</h3><ul><li>tell your doctor and pharmacist if you are allergic to enfuvirtide, mannitol, any other medications, or any ingredient in enfuvirtide injection. Ask your pharmacist for a list of the ingredients.</li><li>tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.</li><li>tell your doctor if you smoke, if you use or have ever used intravenous (injected into the vein) street drugs, and if you have or have ever had hemophilia or any other blood-clotting or bleeding condition, a low CD4 count (low number of a certain type of infection-fighting cell in your blood), or lung disease.</li><li>tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using enfuvirtide, call your doctor. You should not breast-feed if you are infected with HIV or if you are using enfuvirtide.</li><li>Do not drive a car or operate machinery until you know how this medication affects you.</li><li>you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms after starting treatment with enfuvirtide injection, be sure to tell your doctor.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Inject the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-side-effects"><h3>Enfuvirtide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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</h3><ul><li>itching, swelling, pain, tingling, discomfort, tenderness, redness, bruising, hardened area of skin, or bumps at the injection site</li><li>red bumps or pimples around hair follicles</li><li>tiredness</li><li>muscle pain</li><li>nausea</li><li>decreased appetite</li><li>weight loss</li><li>diarrhea</li><li>arm and leg pain</li><li>stomach pain</li><li>flu-like symptoms</li><li>nasal congestion</li><li>cold sores</li><li>dry mouth</li><li>painful, itchy, red, or teary eyes</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical help:
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</h3><ul><li>worsening pain, oozing, swelling, warmth, or redness in a place you injected enfuvirtide</li><li>rash; hives; itching; difficulty breathing or swallowing; nausea; vomiting; or swelling of your face, eyes, lips or mouth</li><li>fever</li><li>chills</li><li>cough with fever, fast breathing, or shortness of breath</li><li>decreased urination; foamy, pink, or brown colored urine; swelling in hands, face, feet or stomach</li><li>pain, burning, numbness, or tingling in feet or legs</li><li>ongoing pain that begins in the upper left or middle of the stomach but may spread to the back with or without vomiting</li><li>pale or fatty stools</li><li>yellowing of skin or eyes, pain in the upper right part of the stomach, itching, loss of appetite, dark (tea-colored) urine, extreme tiredness, nausea, or vomiting </li></ul><p>Enfuvirtide may cause other side effects. Call your doctor if you have any unusual problems while using this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Keep this medication and the sterile water that comes with it in the containers they came in, tightly closed, and out of reach of children. Store them at room temperature and away from excess heat and moisture (not in the bathroom). If they can not be stored at room temperature, put them in the refrigerator. If you mix the medication and sterile water in advance, store the mixture in the vial in the refrigerator for up to 24 hours. Never store mixed medication in the syringe.</p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-10"><p>Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to enfuvirtide injection.</p><p>Before having any laboratory test, tell your doctor and the laboratory personnel that you are using enfuvirtide injection.</p><p>Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-brandname-1"><ul><li>Fuzeon<sup>®</sup></li></ul></div></div></section><section><div id="other-name" class="section"><div class="section-header"><div class="section-title"><h2>Other names</h2></div><div class="section-button"><button type="submit" aria-controls="section-other-name" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-other-name"><ul><li>T-20</li><li>Pentafuside</li></ul></div></div></section><span>Last Revised - </span><span>09/15/2023</span>
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