136 lines
No EOL
30 KiB
HTML
136 lines
No EOL
30 KiB
HTML
<!DOCTYPE html>
|
||
<html lang="en" id="medmono" class="nojs us" data-root="https://medlineplus.gov"><head><meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/><meta http-equiv="window-target" content="_top"/><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/><meta charset="utf-8"/><meta property="fb:app_id" content="1042245625821448"/><meta name="expires" content="2025-03-08T12:59:27+05:00"/><meta name="ac-dictionary" content="medlineplus-ac-dictionary"/><link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon"/><meta name="viewport" content="width=device-width, initial-scale=1"/><link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?tk=1682610665830"/><link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css?tk=121212"/><!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"> <![endif]--><link rel="stylesheet" href="https://medlineplus.gov/css/drug.css"/><!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/drug_ie8.css"> <![endif]--><script type="text/javascript">document.querySelector("html").className = document.querySelector("html").className.replace(/nojs[\s]*/g, '');</script><script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript">
|
||
</script><script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MMVM77');</script><link rel="canonical" href="https://medlineplus.gov/druginfo/meds/a601250.html"/><meta name="description" content="Temozolomide: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="og:description" content="Temozolomide: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="twitter:description" content="Temozolomide: learn about side effects, dosage, special precautions, and more on MedlinePlus"/><meta property="og:title" content="Temozolomide: MedlinePlus Drug Information"/><meta property="og:url" content="https://medlineplus.gov/druginfo/meds/a601250.html"/><meta property="twitter:title" content="Temozolomide: MedlinePlus Drug Information"/><meta name="twitter:card" content="summary_large_image"/><meta property="og:image" content="https://medlineplus.gov/images/share_drugs_1.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_drugs_2.jpg"/><meta property="twitter:image" content="https://medlineplus.gov/images/share_drugs_1.jpg"/><meta name="twitter:site" content="@medlineplus"/><meta content="@medlineplus" name="twitter:creator"/><link href="https://medlineplus.gov/druginfo/meds/a601250.html" hreflang="en" rel="alternate"/><link href="https://medlineplus.gov/spanish/druginfo/meds/a601250-es.html" hreflang="es" rel="alternate"/><title>Temozolomide: MedlinePlus Drug Information</title></head><body><!-- Google Tag Manager --><noscript><iframe title="googletagmanager" src="//www.googletagmanager.com/ns.html?id=GTM-MMVM77" height="0" width="0" style="display:none;visibility:hidden">
|
||
</iframe>
|
||
</noscript><a name="top" id="top">
|
||
</a><a class="hide-offscreen" href="#start">Skip navigation</a><section class="usa-banner" aria-label="Official website of the United States government"><div class="usa-accordion"><header class="usa-banner__header"><div class="usa-banner__inner"><div class="grid-col-auto"><img aria-hidden="true" class="usa-banner__header-flag" src="https://medlineplus.gov/uswds/img/us_flag_small.png" alt=""/>
|
||
</div><div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true"><p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p><p class="usa-banner__header-action">Here’s how you know</p></div><button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default"><span class="usa-banner__button-text">Here’s how you know</span></button></div></header><div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default"><div class="grid-row grid-gap-lg"><div class="usa-banner__guidance tablet:grid-col-6"><img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/><div class="usa-media-block__body"><p><strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong> website belongs to an official government organization in the United States.
|
||
</p></div></div><div class="usa-banner__guidance tablet:grid-col-6"><img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/><div class="usa-media-block__body"><p><strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong> (
|
||
<span class="icon-lock"><svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false"><title id="banner-lock-title-default">Lock</title><desc id="banner-lock-description-default">Locked padlock icon</desc><path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z">
|
||
</path></svg></span>) or <strong>https://</strong> means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
|
||
</p></div></div></div></div></div></section><!-- End Google Tag Manager --><div id="mplus-wrap"><header><div id="mplus-header"><div id="mplus-orgs"><a href="http://www.nih.gov/" class="nih-org" target="_blank" title="National Institutes of Health"><img class="nihlogo" src="https://medlineplus.gov/images/nihlogo.png" alt="National Institutes of Health"/>
|
||
</a><a href="https://www.nlm.nih.gov/" target="_blank"> National Library of Medicine</a></div><div id="mplus-logo" class="years-25"><a href="https://medlineplus.gov/"><img alt="MedlinePlus Trusted Health Information for You" title="MedlinePlus Trusted Health Information for You" src="https://medlineplus.gov/images/m_logo_25.png"/>
|
||
</a>
|
||
</div><div id="mplus-nav"><div aria-live="polite" class="sm-live-area hide-offscreen">
|
||
</div><button id="sm-menu-btn" class="navmenu-btn" title="Menu" role="button" aria-controls="mplus-menu-list" type="submit">Menu<span class="icon icon-nav-menu">
|
||
</span></button><ul id="mplus-menu-list" class="nav-list"><li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li><li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li></ul><button id="sm-search-btn" class="navmenu-btn" title="Search" role="button" aria-controls="mplus-search" type="submit"><span class="hide-offscreen">
|
||
</span>Search<span class="icon icon-nav-search">
|
||
</span></button><div class="top-1"><form id="mplus-search" method="get" action="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" title="Search MedlinePlus" target="_self"><input type="hidden" name="v:project" value="medlineplus"/><input type="hidden" name="v:sources" value="medlineplus-bundle"/><div class="form-box text-combo"><div class="form-area"><label class="hide-offscreen" for="searchtext_primary">Search MedlinePlus</label><input id="searchtext_primary" class="form-text" type="text" placeholder="Search MedlinePlus" alt="#Site Search input" title="Site Search input" maxlength="400" size="40" name="query" autocomplete="off" role="textbox" aria-autocomplete="list" aria-haspopup="true"/></div><div class="button-area"><button class="form-btn" title="Search MedlinePlus" alt="Search MedlinePlus" type="submit">GO</button></div></div></form><div class="secondarynav"><ul class="nav-list"><li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li><li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li><li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li><li><a href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from=https%3A//medlineplus.gov/skincancer.html" target="_blank"><span>Customer Support</span></a></li></ul></div></div><div id="mplus-nav-bar"><ul class="nav-list"><li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li></ul></div><a title="Español" id="mplus-lang-toggle" href="../../spanish/druginfo/meds/a601250-es.html">Español</a></div></div></header><div id="mplus-content"><!-- Breadrcumbs --><div id="breadcrumbs"><div itemtype="http://schema.org/BreadcrumbList" itemscope="" itemprop="breadcrumb"><span class="hide-offscreen">You Are Here:</span>
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov" itemprop="item"><span itemprop="name">Home</span></a>
|
||
→
|
||
<meta itemprop="position" content="1"/>
|
||
</div>
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov/druginformation.html" itemprop="item"><span itemprop="name">Drugs, Herbs and Supplements</span></a>
|
||
→
|
||
<meta itemprop="position" content="2"/>
|
||
</div>
|
||
</div><div><span>Temozolomide</span></div></div><span class="page-url print-only">URL of this page: https://medlineplus.gov/druginfo/meds/a601250.html</span><!-- Article --><article><div class="page-info"><div class="page-title"><a name="start" id="start">
|
||
</a><h1 class="with-also">Temozolomide</h1><span class="alsocalled" id="d-pronunciation">pronounced as (te moe zoe' loe mide)
|
||
</span>
|
||
</div><div class="page-actions">
|
||
</div>
|
||
<noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript></div><div id="toc-box"><ul role="navigation" class="group"><li><a href="#why">Why is this medication prescribed?</a>
|
||
</li><li><a href="#how">How should this medicine be used?</a>
|
||
</li><li><a href="#other-uses">Other uses for this medicine</a>
|
||
</li><li><a href="#precautions">What special precautions should I follow?</a>
|
||
</li><li><a href="#special-dietary">What special dietary instructions should I follow?</a>
|
||
</li><li><a href="#if-i-forget">What should I do if I forget a dose?</a>
|
||
</li><li><a href="#side-effects">What side effects can this medication cause?</a>
|
||
</li><li><a href="#storage-conditions">What should I know about storage and disposal of this medication?</a>
|
||
</li><li><a href="#overdose">In case of emergency/overdose</a>
|
||
</li><li><a href="#other-information">What other information should I know?</a>
|
||
</li><li><a href="#brand-name-1">Brand names</a>
|
||
</li></ul></div><section><div id="why" class="section"><div class="section-header"><div class="section-title"><h2>Why is this medication prescribed?</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-1"><p>Temozolomide is used to treat certain types of brain tumors. Temozolomide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.</p></div></div></section><section><div id="how" class="section"><div class="section-header"><div class="section-title"><h2>How should this medicine be used?</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-2"><p>Temozolomide comes as a capsule to take by mouth. It is usually taken once a day in the evening at bedtime. Take temozolomide capsules on an empty stomach with a glass of water. Take temozolomide at around the same time every day. For some types of brain tumors, temozolomide is taken daily for 42–49 days. Then, after a 28-day break, it may be taken once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. For treatment of other types of brain tumors, temozolomide is taken once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. Your doctor will decide how many times you should repeat the treatment cycles. The length of treatment depends on the how well your body responds to it and the type of cancer that you have. Take temozolomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.</p><p>Your full dose may contain more than one type and color of capsules and may be contained in more than one prescription bottle. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.</p><p>Temozolomide capsules come in several different strengths. Your doctor may want you to take a combination of capsules to make up your full dose. Be sure that you know what each type of capsule looks like and how many you are to take of each. Ask your doctor or pharmacist if you have any questions.</p><p>If any of the capsules are broken or leaking, do not touch them with your bare hands and be careful not to breathe in the powder from the capsules. You should wear rubber or latex gloves when you handle broken or opened capsules so that your skin does not come into contact with the powder. If the capsule contents do touch your skin, wash the area well with water right away.</p><p>Swallow the capsules whole; do not empty, chew, or crush them.</p><p>You may vomit after you take the medication. If this happens, let your doctor know right away. Do not take another dose of temozolomide on the same day.</p><p>Your doctor may need to delay your treatment or adjust your dose of temozolomide depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Do not stop taking temozolomide without talking to your doctor.</p><p>Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.</p></div></div></section><section><div id="other-uses" class="section"><div class="section-header"><div class="section-title"><h2>Other uses for this medicine</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-3"><p>This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.</p></div></div></section><section><div id="precautions" class="section"><div class="section-header"><div class="section-title"><h2>What special precautions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-precautions" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-precautions"><h3>Before taking temozolomide,</h3><ul><li>tell your doctor and pharmacist if you are allergic to temozolomide, dacarbazine (DTIC-Dome) any other medications, or any of the ingredients in temozolomide capsules. Ask your pharmacist for a list of the ingredients.</li><li>some medications should not be taken with temozolomide. Make sure you have discussed any medications you are currently taking or plan to take before starting temozolomide with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking temozolomide, please get the advice of your doctor or pharmacist..</li><li>tell your doctor if you have or have ever had kidney or liver disease.</li><li>you should know that temozolomide may interfere with sperm production in men. However, you should not assume that you cannot get someone else pregnant. Tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are taking temozolomide. Use a reliable method of birth control to prevent pregnancy. If you become pregnant while taking temozolomide, call your doctor. Temozolomide may harm the fetus.</li><li>tell your doctor if you are breast-feeding. You should not breastfeed while you are taking temozolomide.</li></ul></div></div></section><section><div id="special-dietary" class="section"><div class="section-header"><div class="section-title"><h2>What special dietary instructions should I follow?</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-5"><p>Unless your doctor tells you otherwise, continue your normal diet.</p></div></div></section><section><div id="if-i-forget" class="section"><div class="section-header"><div class="section-title"><h2>What should I do if I forget a dose?</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-6"><p>Talk to your doctor about what to do if you miss a dose of temozolomide. Do not take a double dose to make up for a missed one.</p></div></div></section><section><div id="side-effects" class="section"><div class="section-header"><div class="section-title"><h2>What side effects can this medication cause?</h2></div><div class="section-button"><button type="submit" aria-controls="section-side-effects" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-side-effects"><h3>Temozolomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
|
||
</h3><ul><li>nausea</li><li>vomiting</li><li>diarrhea</li><li>constipation</li><li>loss of appetite</li><li>sores in the mouth and throat</li><li>headache</li><li>pale skin</li><li>lack of energy</li><li>loss of balance or coordination</li><li>fainting</li><li>dizziness</li><li>hair loss</li><li>insomnia</li><li>memory problems</li><li>changes in vision</li></ul><h3>Some side effects can be serious. If you experience any of these symptoms, stop taking temozolomide and call your doctor immediately or get emergency medical treatment:
|
||
</h3><ul><li>unusual bleeding or bruising </li><li>red or black, tarry stools</li><li>pink, red, or dark brown urine</li><li>coughing up or vomiting blood or material that looks like coffee grounds</li><li>fever, sore throat, ongoing cough and congestion, or other signs of infection</li><li>unusual tiredness or weakness</li><li>rash</li><li>unable to move one side of the body</li><li>shortness of breath</li><li>seizures</li><li>yellowing of the skin or eyes</li><li>pain in the upper right part of the stomach</li><li>decreased urination</li></ul><p>Temozolomide may increase the risk that you will develop other cancers. Talk to your doctor about the risks of taking temozolomide.</p><p>Temozolomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.</p><p>If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (<a target="_blank" href="https://www.fda.gov/Safety/MedWatch">https://www.fda.gov/Safety/MedWatch</a>) or by phone (1-800-332-1088).</p></div></div></section><section><div id="storage-conditions" class="section"><div class="section-header"><div class="section-title"><h2>What should I know about storage and disposal of this medication?</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-8"><p>Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).</p><p>Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (<a target="_blank" href="https://goo.gl/c4Rm4p">https://goo.gl/c4Rm4p</a>) for more information if you do not have access to a take-back program.</p><p>It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. <a target="_blank" href="https://www.upandaway.org">https://www.upandaway.org</a></p></div></div></section><section><div id="overdose" class="section"><div class="section-header"><div class="section-title"><h2>In case of emergency/overdose</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-9"><p>In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a target="_blank" href="https://www.poisonhelp.org/help">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.</p><h3>Symptoms of overdose may include the following:
|
||
</h3><ul><li>unusual bleeding or bruising </li><li>red or black, tarry stools</li><li>pink, red, or dark brown urine</li><li>coughing up or vomiting blood or material that looks like coffee grounds</li><li>fever, sore throat, ongoing cough and congestion, or other signs of infection</li></ul></div></div></section><section><div id="other-information" class="section"><div class="section-header"><div class="section-title"><h2>What other information should I know?</h2></div><div class="section-button"><button type="submit" aria-controls="section-10" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-10"><p>Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during, and after your treatment to check your body's response to temozolomide and to see if your blood cells are affected by this drug.</p><p>Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.</p><p>It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.</p></div></div></section><section><div id="brand-name-1" class="section"><div class="section-header"><div class="section-title"><h2>Brand names</h2></div><div class="section-button"><button type="submit" aria-controls="section-brandname-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-brandname-1"><ul><li>Temodar<sup>®</sup></li></ul></div></div></section><span>Last Revised - </span><span>07/20/2024</span>
|
||
</p>
|
||
<div id="bdme"><a href="https://medlineplus.gov/druginformation.html">Browse Drugs and Medicines</a></div><div id="citation-how-to"><button><span>Learn how to cite this page</span></button></div></article></div><footer><div class="provider-box"><img src="https://medlineplus.gov/images/ashpTM_CMYK_small.jpg" alt="ASHP Logo" title="ASHP Logo"/><a href="https://medlineplus.gov/ashpdisclaimer.html">American Society of Health-System Pharmacists, Inc. Disclaimer</a><div><p>AHFS<sup>®</sup> Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists<sup>®</sup>, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.</p></div></div>
|
||
|
||
<div id="mplus-footer">
|
||
<div class="footer1">
|
||
<ul class="secondarynav">
|
||
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
|
||
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
|
||
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
|
||
<li><a target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from="><span>Customer Support</span></a></li>
|
||
</ul>
|
||
<ul class="follow-footer">
|
||
<li>
|
||
<a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a>
|
||
</li>
|
||
<li>
|
||
<span class="follow-label">Follow us</span>
|
||
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X">
|
||
</a>
|
||
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook">
|
||
</a>
|
||
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank">
|
||
<img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram">
|
||
</a>
|
||
</li>
|
||
<li>
|
||
<a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
<div class="footer2">
|
||
<ul>
|
||
<li><a href=" https://www.nlm.nih.gov/web_policies.html" target='_blank'>NLM Web Policies</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
|
||
<li><a href="https://medlineplus.gov/accessibility.html">Accessibility</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
|
||
<li><a href="https://medlineplus.gov/plugins.html">Viewers & Players</a></li>
|
||
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
|
||
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
|
||
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
|
||
</ul>
|
||
<div class="address">
|
||
<a href="//www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
|
||
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
|
||
<a href="//www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
|
||
<a href="//www.nih.gov" target="_blank">National Institutes of Health</a>
|
||
</div>
|
||
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
|
||
</div>
|
||
</div>
|
||
|
||
</footer></div><!-- End Wrap --><script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/mplus-frontend-controls.js" type="text/javascript">
|
||
</script><!--[if lte IE 9]>
|
||
<script src="https://medlineplus.gov/jslib/jquery.placeholder.js" type="text/javascript"></script>
|
||
<![endif]--><script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/control.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript">
|
||
</script><script src="https://medlineplus.gov/jslib/drug.js" type="text/javascript">
|
||
</script></body></html> |