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<a href="/topic/sjogrens-syndrome/" class="article_btn">Sjögren's syndrome</a>
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<h1 id="main">Sjögren&#8217;s research explores genetic link to dry mouth, other saliva issues </h1>
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<h2 class="lead_text">One-third of people with Sjögren's don't have the typical blood markers</h2>
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<img src="/images/uploads/main_images/sjogrens-drblakewarner.jpg" alt="Blake Warner, D.D.S., Ph.D., M.P.H., conducts research on salivary disorders, focusing on Sjögren's syndrome. ">
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<p><i class="fa fa-camera"></i> Blake Warner, D.D.S., Ph.D., M.P.H., conducts research on salivary disorders, focusing on Sjögren's syndrome. </p>
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<p class="lead_text">Blake Warner, D.D.S., Ph.D., M.P.H., studies disorders that affect our salivary glands, including Sj&ouml;gren&#39;s syndrome. Sj&ouml;gren&#39;s syndrome is an autoimmune disease, which means that it causes your immune system to attack healthy cells in your body by mistake.</p>
<p>The condition can damage glands that make saliva, or spit. It can also cause dry mouth, loss of taste, swollen glands, and more. &nbsp;</p>
<p>Dr. Warner works at the National Institute of Dental and Craniofacial Research (NIDCR), where he helps oversee research on Sj&ouml;gren&#39;s syndrome. He and his research team at NIDCR want to better understand what causes this disease&nbsp;so they can improve the quality of life of people who have it.</p>
<h3>Why did you decide to study Sj&ouml;gren&#39;s syndrome?</h3>
<p>During my residency, I worked in a clinic with patients with Sj&ouml;gren&#39;s syndrome and other complications. Despite helping patients understand their condition, I felt compelled to find ways to better treat or prevent this condition. By pursuing clinical research, I could play a more active role in improving the lives of people with Sj&ouml;gren&#39;s syndrome.</p>
<h3>What led to your current research on the topic?</h3>
<blockquote>
<p>&quot;Living with Sj&ouml;gren&#39;s syndrome can be easier if you maintain good health habits.&quot;</p>
<p><span>- Blake Warner,&nbsp;D.D.S., Ph.D., M.P.H.</span></p>
</blockquote>
<p><span>Years of development and testing of therapies have led to few successes in the management of the main symptoms of Sj&ouml;gren&#39;s syndrome. These setbacks may be due in part to the variability of Sj&ouml;gren&#39;s syndrome.</span></p>
<p>At NIDCR, we have a more than 35-year history of Sj&ouml;gren&#39;s syndrome research in patients. Studying patients both at baseline and over long periods of follow-up can help us better understand distinct groups of patients with the disease and understand the underlying cause of the disease, with the goal of discovering better treatments.</p>
<h3>Could you talk about the&nbsp;research you&#39;re conducting?</h3>
<p>Our research team strives to discern factors which may be influencing the salivary inflammation seen in Sj&ouml;gren&#39;s syndrome. To do this, there are two main projects that I am very excited about. First, we are working to see if we can turn off specific types of inflammation that damage salivary glands in Sj&ouml;gren&#39;s syndrome patients. Second, we&#39;re working to identify how salivary damage in Sj&ouml;gren&#39;s syndrome may be passed on through genetics.</p>
<p>It&#39;s clear that there can be overlap among Sj&ouml;gren&#39;s syndrome, some autoimmune diseases, and other conditions that cause issues in the salivary glands.</p>
<h3>What do you wish more people knew?</h3>
<p>A diagnosis can take time. It&#39;s not easily diagnosed because it affects people differently. At least one-third of patients don&#39;t have the classic blood markers for Sj&ouml;gren&#39;s syndrome. Don&#39;t be afraid to speak up and inform your medical providers of your symptoms.</p>
<p>Also, living with Sj&ouml;gren&#39;s syndrome can be easier if you maintain good health habits. These include eating a balanced diet, drinking enough water, and having a consistent exercise routine. Manage your symptoms by regularly visiting your primary care providers, dentists, and ophthalmologists [doctors who focus on eye health]. Support groups and foundations focused on Sj&ouml;gren&#39;s syndrome and other autoimmune diseases can provide additional information and social networks to help people cope with symptoms.</p>
<h3>Where do you see research on Sj&ouml;gren&#39;s syndrome going in the future?</h3>
<p>I think we will recognize early symptoms prior to the development of dry eyes and dry mouth. The identification of risk factors may help people better understand the disease course,&nbsp;the development of autoimmunity, and the development of drugs that may prevent damage to target organs such as the salivary glands.</p>
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<div class="mt-1 mb-2"><strong>Image credit:</strong> Courtesy of the National Institute of Dental and Craniofacial Research </div>
<p><i class="fa fa-calendar"></i> June 23, 2020</p>
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<li><a href="https://www.nidcr.nih.gov/health-info/sjogrens-syndrome" target="_blank">National Institute of Dental and Craniofacial Research: Sj&ouml;gren&#39;s Syndrome</a></li>
<li><a href="https://newsinhealth.nih.gov/2012/03/dry-eyes-mouth" target="_blank">NIH News in Health: Dry Eyes and Mouth? You May Have Sj&ouml;gren&#39;s Syndrome</a></li>
<li><a href="https://clinicaltrials.gov/ct2/results?cond=Sjogren%27s+Syndrome&amp;term=&amp;cntry=&amp;state=&amp;city=&amp;dist=" target="_blank">ClinicalTrials.gov: Sj&ouml;gren&#39;s<br />
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<p style="text-align: center;"><span class="ff-40-purple">9x&nbsp;<i aria-hidden="true" class="fa fa-female">&nbsp;</i></span></p>
<p>Women are <strong><span class="ff-purple">nine times more likely </span></strong>to have Sj&ouml;gren&#39;s syndrome than men.</p>
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<div class="explore_link"><a href="https://medlineplus.gov/sjogrenssyndrome.html" class="usa-external_link" target="_blank">Sjogren&#8217;s Syndrome</a><a href="https://medlineplus.gov/arthritis.html" class="usa-external_link" target="_blank">Arthritis</a></div><div class="explore_link"><a href="https://medlineplus.gov/drymouth.html" class="usa-external_link" target="_blank">Dry Mouth</a><a href="https://medlineplus.gov/tears.html" class="usa-external_link" target="_blank">Tears</a> </div>
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