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<h1>Studies Closed for Recruitment</h1>
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<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/bpa_pk/" target="_blank">Bisphenol A Controlled Exposure Study</a>
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<div class="clns-description">This is a study on the controlled exposure of BPA and its effects on the body.</div>
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<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">25 - 45&nbsp;</span>
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<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
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<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/black-cohosh/" target="_blank">Black Cohosh Study</a>
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<div class="clns-description">Researchers are investigating whether black cohosh may affect folate and B12 levels, anemia, and metabolomics profiles. They are also investigating whether black cohosh induces genetic changes.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
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<div class="closed">
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<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/vessel/" target="_blank">Blood Vessel Study</a>
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<div class="clns-description">Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases.</div>
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<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
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<strong>Age:&nbsp;</strong><span class="age-group">18 - 65&nbsp;</span>
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<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
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<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/bwps/" target="_blank">Body Weight &amp; Puberty Study</a>
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<div class="clns-description">Girls seem to be going through puberty a lot earlier these days. Doctors think it may be related to body weight. Are you concerned that your daughter is overweight and may start puberty too soon?</div>
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<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">8-14&nbsp;</span>
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<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
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<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/bpa/" target="_blank">BPA Monitoring Study in Cashiers</a>
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<div class="clns-description">A pilot study designed to measure BPA levels before and after occupational exposure to thermal paper used in cash registers.</div>
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<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/calcinosis/" target="_blank">Calcinosis Study</a>
</div>
<div class="clns-description">This study is a clinical trial of intravenous sodium thiosulfate, a drug being tested for efficacy and safety in patients who have moderate to extensive calcinosis associated with juvenile and adult dermatomyositis.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">7+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Multiple Locations&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/carefree/" target="_blank">Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study (CaREFREE)</a>
</div>
<div class="clns-description">Many women develop irregular menstrual cycles which may make it difficult to become pregnant and increase the risk of osteoporosis. Why do exercise and diet have this effect in some women but not others? This study will help us understand how nutrition, exercise, and the environment affect women&#039;s reproductive cycles.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18 - 28&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/consumer/" target="_blank">Chemicals in Consumer Products</a>
</div>
<div class="clns-description">How Does Daily Exposure to Everyday Household and Personal Products Effect You?</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">35-74&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/calcinosis/" target="_blank">Cockroach Allergen Intervention</a>
</div>
<div class="clns-description">Evidence suggests that exposure to cockroach allergen might be the most important risk factor for asthma in inner-city households.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">21+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/covid/" target="_blank">COVID-19 Antibody Detection Study</a>
</div>
<div class="clns-description">This yearlong study will test adult volunteers for antibodies in their blood that indicate exposure to SARS-CoV-2, the virus that causes COVID-19.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/cox2/" target="_blank">Cox-2 Gene and the Immune System</a>
</div>
<div class="clns-description">The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system. It may also play a role in certain immune system diseases. Researchers want to see how COX-2 affects the cells in the immune system.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/dustmite/" target="_blank">Dust Mite Reduction Study</a>
</div>
<div class="clns-description">This study will determine whether use of an in-home test kit results in decreased dust mite allergen levels in homes of children who are sensitive or allergic to dust mites.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">5 - 15&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/e-cigs/" target="_blank">E-Cigs and Smoking Study</a>
</div>
<div class="clns-description">If you are a man or woman, 18-55 years old, living in the Raleigh-Durham-Chapel Hill area, and smoke cigarettes or use an electronic nicotine delivery system (e-cigarette), please join an important study on smokers.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18-55&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/infertility" target="_blank">Environmental Causes of Infertility</a>
</div>
<div class="clns-description">To identify and understand how environmental exposures can alter uterine function in women and may result in infertility and disease.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18 - 35&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/daycare" target="_blank">Exposure to Indoor Allergens in Day Care Facilities</a>
</div>
<div class="clns-description">This study evaluated allergen levels and their predictors in day-care facilities in two North Carolina counties. The purpose was to determine whether further study of day-care facilities on a regional or national basis is warranted and to identify associations that might be important to evaluate in larger studies.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/homes/" target="_blank">Healthy Homes</a>
</div>
<div class="clns-description">The purpose of the study is to learn how to make homes more supportive of healthy eating and physical activity.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">35 - 65&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Other&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/immunity/" target="_blank">Immunity Cells in Blood</a>
</div>
<div class="clns-description">The Immunity Cells in Blood Study aims to determine the response of immune cells from the bloodstream. </div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/inflammatory/" target="_blank">Inflammatory Response to Endotoxin</a>
</div>
<div class="clns-description">Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the bodys response can contribute to chronic illnesses or diseases such as asthma and certain types of cancer.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/icas/" target="_blank">Inner-City Asthma Study</a>
</div>
<div class="clns-description">ICAS Study evaluates the effectiveness of two types of interventions to reduce the prevalence and severity of asthma in children.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">5 - 11&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/solis" target="_blank">Investigational Trial: Interstitial Lung Disease</a>
</div>
<div class="clns-description">This study will evaluate a new medication called Hymecromone to see if it can help people with interstitial lung disease or idiopathic pulmonary fibrosis (IPF). Medications that stop or reverse the progression of lung fibrosis are urgently needed. This research will determine if Hymecromone can treat lung fibrosis by lowering hyaluronan levels.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="" target="_blank">inVitD Trial </a>
</div>
<div class="clns-description">Vitamin D supplementation may be a low-cost intervention that improves menstrual cycle function and fertility.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">19-40&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/glucocorticoid/" target="_blank">Metabolic Disease</a>
</div>
<div class="clns-description">NIEHS researchers theorize that changes in the surface proteins of cells called receptors may predispose people to diseases, such as heart disease, arthritis, and diabetes. The volunteers of this study underwent tests to determine how these changes or variants lead to illness.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/myositis/" target="_blank">Myositis in Military Personnel</a>
</div>
<div class="clns-description">This study attempts to determine if environmental and geographic exposures may be related to the development of myositis during military service.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Bethesda, MD&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/nhanes/" target="_blank">National Health &amp; Nutrition Examination Survey (NHANES)</a>
</div>
<div class="clns-description">NHANES allowed researchers to examine the role of diet, obesity, diabetes, and genetics in the development of allergic disease.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">1-74&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/nslah/" target="_blank">National Survey of Lead &amp; Allergens in Housing</a>
</div>
<div class="clns-description">NSLAH measures levels of lead in dust, soil, and paint, and the levels of various indoor allergens in floor and bedding dust.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18-65&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/nhales/" target="_blank">NHALES: Asthma Study</a>
</div>
<div class="clns-description">NHALES stands for Natural History of Asthma with Longitudinal Environmental Sampling. Your participation in the NHALES Study will contribute to research on how the environment affects the human body and asthma. Please consider joining today.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18 - 60&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/plasma/" target="_blank">Plasma Study</a>
</div>
<div class="clns-description">This project will look at how oxidative stress occurs in smokers compared to non-smokers.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18-50&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/polycystic/" target="_blank">Polycystic Ovary Syndrome in Twin Sisters</a>
</div>
<div class="clns-description">The goal of this study is to find out whether polycystic ovary syndrome in twins is caused by genetics, environmental triggers or a combination of both.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Other&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/psoriasis/" target="_blank">Psoriasis Study</a>
</div>
<div class="clns-description">Researchers are studying the differences in immune response between a person with psoriasis, a person with chronic inflammatory disease and a healthy person.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18 - 70&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/twin-sibs/" target="_blank">Rheumatic Disorders in Siblings</a>
</div>
<div class="clns-description">The research team will study the genetic and environmental risk factors in the development of autoimmune diseases in twins and same-sex siblings, in which one has the disease and the other does not.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">All&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Bethesda, MD&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/tgf-beta1/" target="_blank">RSV Infection and Asthma</a>
</div>
<div class="clns-description">NIEHS scientists will explore whether there is a difference in lung cells from healthy and asthmatic participants and how these cells respond to exposure to respiratory syncytial virus (RSV), a very common virus that leads to cold-like symptoms. The study will also evaluate if a protein in lung cells called TGF-Beta increases risk of infection with RSV.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18-60&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/registry/" target="_blank">Sample Collection Registry</a>
</div>
<div class="clns-description">Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies. The samples will be used to determine if new tests are sufficiently valid and precise to be used in research studies and for quality control purposes.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/covid_smoke/" target="_blank">Smoke Exposure COVID-19 Study</a>
</div>
<div class="clns-description">This study will help determine if smoking increases the risk of developing coronavirus disease 2019 (COVID-19), and will evaluate the effect of COVID-19 on the immune system of people who smoke.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">30 - 55&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/ovarian/" target="_blank">The Ovarian Health Study</a>
</div>
<div class="clns-description">Anti-müllerian hormone (AMH) is a hormone produced in the ovaries. Researchers are investigating the possibility of developing lab assays to measure AMH in urine.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Female&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">25-29&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
<div class="closed">
<div class="clns-title">
<a href="" target="_blank">Women&#039;s Health Awareness Vaccine Confidence Study</a>
</div>
<div class="clns-description">If you are a Black, African American, African or Afro-Caribbean woman or man over the age of 18 and living in North Carolina, we want to hear from you.</div>
<div class="clns-criteria">
<strong>Sex:&nbsp;</strong><span class="sex">Both&nbsp;</span>
<br>
<strong>Age:&nbsp;</strong><span class="age-group">18+&nbsp;</span>
<br>
<strong>Location:&nbsp;</strong><span class="location">Durham, NC&nbsp;</span>
</div>
</div>
</div>
</div>
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<p>Last Reviewed: January 31, 2025</p>
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