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Closing in on Nav1.7: A Promising Target for New Pain Treatments
|
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Helping the Body Heal Itself: Injected Stem Cells for Back Pain
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|
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<img loading="lazy" src="/files/styles/callout_carousel/public/women-chronic-pain.jpeg?itok=qLC2mzql" width="900" height="507" alt="women experiencing chronic pain laying on couch" class="img-fluid" />
|
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Protein Engineering for Chronic Pain
|
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</a>
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</p>
|
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</div>
|
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</div>
|
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</div>
|
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<a href="/news/stories/molecule-by-molecule" aria-label="Crafting a Cure for Diabetic Neuropathic Pain, Molecule by Molecule">
|
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|
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<div class="visually-hidden field-label">Image</div>
|
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<a href="/news/stories/molecule-by-molecule">
|
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Crafting a Cure for Diabetic Neuropathic Pain, Molecule by Molecule
|
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|
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</p>
|
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|
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</div>
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</div>
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</div>
|
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<p class='col-12'>
|
||
<h2>Overview </h2>
|
||
|
||
<h3>The Research Need </h3>
|
||
|
||
<p>Overreliance on prescription opioids for chronic pain management has contributed to the opioid overdose crisis. At the same time, millions of Americans do not have adequate relief for pain. New non-addictive therapies for effective pain management as viable alternatives to opioids are urgently needed. </p>
|
||
|
||
<h3>About the Program </h3>
|
||
|
||
<p>This program will facilitate research and development in academic and small business settings to evaluate unexplored targets for clinical testing readiness. Research projects will include collaborative, interdisciplinary team science efforts as well as milestone-driven studies with the goal of filing Investigational New Drug (IND) applications with the U.S. Food and Drug Administration for clinical exploration and potential future commercialization. A team-based research framework allows candidate molecules to be tried, validated in various models, prepped for testing in humans, then moved quickly into clinical testing in the HEAL <a href="https://heal.nih.gov/research/clinical-research/eppic-net">Early Phase Pain Investigation Clinical Network</a> (EPPIC-Net) or other Phase 2 clinical studies. </p>
|
||
|
||
<p>The program also features the Non-addictive Analgesic Therapeutics Development program, which provides resources for a variety of activities necessary for early drug development. This includes access to consultants and contract research organizations with resources and extensive experience in the biotech and pharmaceutical industry. Available services include expertise related to medicinal chemistry, manufacturing and formulation, drug metabolism and pharmacokinetics, good laboratory practice toxicology screening, and Phase 1 clinical testing. </p>
|
||
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</p>
|
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</div>
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</div>
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</div>
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</div>
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</div>
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<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
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</div>
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<div class="js-view-dom-id-48dc2c38d154e2a99d75fa6b627b067c196513712aa5085563fb43e6e3a8ceaa">
|
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|
||
<h2>Open Funding Opportunities</h2>
|
||
|
||
<div class="pattern">
|
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|
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|
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|
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|
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|
||
<div class="col-3 d-none d-lg-block">
|
||
2024
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
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|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-023.html>
|
||
NOFO Link
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Sep 18, 2024
|
||
</div>
|
||
<div class="col-6 d-lg-none">
|
||
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-023.html">NOFO Link</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2024
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-012.html>
|
||
NOFO Link
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 26, 2024
|
||
</div>
|
||
<div class="col-6 d-lg-none">
|
||
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-012.html">NOFO Link</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2023
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-019.html>
|
||
NOFO Link
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Nov 01, 2023
|
||
</div>
|
||
<div class="col-6 d-lg-none">
|
||
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-019.html">NOFO Link</a>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div style="text-align:right;">
|
||
|
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|
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|
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|
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|
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|
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|
||
|
||
|
||
|
||
<a class="btn btn-primary" href=/funding/open?research_program=206>
|
||
View all
|
||
</a>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
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||
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||
|
||
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||
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||
|
||
|
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|
||
|
||
|
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||
|
||
|
||
|
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|
||
|
||
<div class="container">
|
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<div class='basic-content content-align-left pattern'>
|
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<div class='basic-content-grid-container ' style=''>
|
||
<h2 class='basic-content-grid-h2-no-media'>
|
||
Research Examples
|
||
</h2>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<p>Through their awards, the research organizations will develop and optimize non-addictive small molecules and biologic agents for the treatment of chronic pain. </p>
|
||
|
||
<p>Currently funded projects in this program include: </p>
|
||
|
||
<ul>
|
||
<li>Optimizing the properties of an approved multiple sclerosis drug, monomethyl fumarate, to reduce side effects by limiting its availability in pain-related regions in the central nervous system </li>
|
||
<li>Developing a new pain treatment using injected human bone marrow cells that can form and repair skeletal tissues and control nervous and immune system activity </li>
|
||
<li>Optimizing an experimental cancer drug, an MNK inhibitor, for neuropathic pain by restricting entry into the brain </li>
|
||
<li>Synthesizing peripherally active cannabinoid CB1 receptor agonists as pain treatments </li>
|
||
<li>Constructing stem-cell loaded microgels to treat disk-related low back pain </li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--accordion paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
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<div class="container">
|
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|
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|
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<div id="accordion-1845084776" class="col-12 accordion">
|
||
|
||
|
||
|
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<div class="card-header col-12" id="heading-1845084776-0">
|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
||
data-toggle="collapse"
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data-target="#collapse-1845084776-0"
|
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aria-expanded="false"
|
||
aria-controls="collapse-1845084776-0">
|
||
Funded Institutions and Locations
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-1845084776-0"
|
||
class="collapse "
|
||
aria-labelledby="heading-1845084776-0"
|
||
data-parent="#accordion-1845084776">
|
||
<div class="card-body">
|
||
<ul>
|
||
<li><strong>4e Therapeutics Inc</strong>. — Texas </li>
|
||
<li><strong>Cedars-Sinai Medical Center</strong> — California </li>
|
||
<li><strong>Centrexion Therapeutics</strong> — Massachusetts </li>
|
||
<li><strong>Cleveland Clinic Lerner College of Medicine</strong> — Ohio </li>
|
||
<li><strong>Hillhurst Biopharmaceuticals, Inc</strong>. — California </li>
|
||
<li><strong>Holobiome, Inc</strong>. — Massachusetts </li>
|
||
<li><strong>Johns Hopkins University</strong> — Maryland </li>
|
||
<li><strong>Knopp Biosciences, LLC</strong> — Pennsylvania </li>
|
||
<li><strong>Marine Biological Laboratory, Woods Hole </strong>— Massachusetts </li>
|
||
<li><strong>Massachusetts General Hospital</strong> — Massachusetts </li>
|
||
<li><strong>St. Louis College of Pharmacy</strong> — Missouri </li>
|
||
<li><strong>Texas A&M Health Science Center</strong> — Texas </li>
|
||
<li><strong>University of Arizona </strong>— Arizona </li>
|
||
<li><strong>University of California, Davis</strong> — California </li>
|
||
<li><strong>University of Miami School of Medicine </strong>— Florida </li>
|
||
<li><strong>University of New Mexico Health Sciences Center</strong> — New Mexico </li>
|
||
<li><strong>University of Texas MD Anderson Cancer Center</strong> — Texas </li>
|
||
<li><strong>University of Texas Medical Branch</strong> — Texas </li>
|
||
<li><strong>Vanderbilt University</strong> — Tennessee </li>
|
||
<li><strong>Virginia Commonwealth University</strong> — Virginia </li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div id="accordion-364761969" class="col-12 accordion">
|
||
|
||
|
||
|
||
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|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
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data-toggle="collapse"
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data-target="#collapse-364761969-1"
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aria-controls="collapse-364761969-1">
|
||
Funded Projects
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-364761969-1"
|
||
class="collapse "
|
||
aria-labelledby="heading-364761969-1"
|
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data-parent="#accordion-364761969">
|
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<div class="card-body">
|
||
|
||
<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-8613fd321a3d313a7c298f7f4fb2f4e068a8ff35da0c8493e8b7940c16666156">
|
||
|
||
|
||
<div class="pattern">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Development of CNS-Active 5-HT3R Antagonists for the Treatment of Neuropathic Pain
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
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<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=206#project-title-47276>
|
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Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
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<a href="/funding/awarded?research_program=206#project-title-47276">Summary</a>
|
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</div>
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<div class="col-6 d-lg-none">
|
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Feb 25, 2025
|
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</div>
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</div>
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<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Developing equilibrative nucleoside transporter inhibitors as non-opioid pain therapeutics
|
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</div>
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<div class="col-3 d-none d-lg-block">
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<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=206#project-title-47291>
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Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
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<a href="/funding/awarded?research_program=206#project-title-47291">Summary</a>
|
||
</div>
|
||
|
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<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
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</div>
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</div>
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<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
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<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome
|
||
</div>
|
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<div class="col-3 d-none d-lg-block">
|
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|
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<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=206#project-title-47266>
|
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Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=206#project-title-47266">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
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</div>
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<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
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<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Developing small molecules to engage an analgesic GPCR in pain unpleasantness neural circuits
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
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|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=206#project-title-47306>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=206#project-title-47306">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
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</div>
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|
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|
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<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
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<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Topical Neurokinin-1 Receptor Antagonist as an Effective Non-addictive Analgesic for Ocular Pain
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
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|
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|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=206#project-title-47281>
|
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Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=206#project-title-47281">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
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</div>
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<p><a href="/cdn-cgi/l/email-protection#c3b3a6afafa6baaeacb6adb7a6b1ae83adaaabeda4acb5">Mary Ann Pelleymounter, Ph.D. </a><br>NINDS</p><p> </p>
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<ul><li><a href="https://heal.nih.gov/news/events/SEAD">Applicant Webinar: HEAL Initiative Studies to Enable Analgesic Discovery</a> - April 30, 2024, 2:00 p.m. ET<br> </li><li><a href="https://www.ninds.nih.gov/news-events/events/open-stage-webinar-drug-discovery-development-ninds-funding-and-training-opportunities-featuring">OPEN Stage Webinar: Drug Discovery & Development at NINDS - Funding and Training Opportunities Featuring First-hand Experiences from Awardees</a> - November 18, 2022, 3:30 p.m. ET<br> </li><li><a href="https://www.youtube.com/watch?v=sZtSowWilcM">Webinar: Focus on “Non-Addictive Analgesic Therapeutics Development (Small Molecules and Biologics) to Treat Pain”</a> - April 28, 2022, 3:30 p.m. ET <br> </li><li><a href="https://www.youtube.com/watch?v=LXdYBNa8bOM&t=1s">Webinar: OPEN Stage: Drug Discovery & Development at NINDS - Funding and Training Opportunities Featuring First-hand Experiences from Awardees</a> - July 26, 2022, 12:30 p.m. ET </li></ul>
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<li><a href="https://heal.nih.gov/research/preclinical-translational/novel-targets">Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain</a> </li>
|
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|
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<li><a href="https://heal.nih.gov/research/preclinical-translational/restoring-joint-health-function-reduce-pain">Restoring Joint Health and Function to Reduce Pain Consortium (Re-JOIN)</a></li>
|
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<li><a href="https://heal.nih.gov/research/preclinical-translational/discoveries-into-devices">Translating Discoveries into Effective Devices to Treat Pain</a></li>
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