1706 lines
72 KiB
Text
1706 lines
72 KiB
Text
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="Through NCATS, NIH is providing science resources and technical expertise to investigators in the areas of pain, addiction, and overdose." />
|
||
<link rel="canonical" href="https://heal.nih.gov/research/preclinical-translational/novel-drugs-screening-platforms" />
|
||
<link rel="image_src" href="/files/heal-logo-social.png" />
|
||
<meta property="og:site_name" content="NIH HEAL Initiative" />
|
||
<meta property="og:type" content="website" />
|
||
<meta property="og:url" content="https://heal.nih.gov/research/preclinical-translational/novel-drugs-screening-platforms" />
|
||
<meta property="og:title" content="Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder | NIH HEAL Initiative" />
|
||
<meta property="og:description" content="NIH is providing resources and expertise to investigators in the areas of pain, addiction, and overdose." />
|
||
<meta property="og:image" content="https://heal.nih.gov/files/heal-logo-social.png" />
|
||
<meta property="og:image:url" content="https://heal.nih.gov/files/heal-logo-social.png" />
|
||
<meta property="og:updated_time" content="Fri, 02/21/2025 - 2:33pm" />
|
||
<meta property="article:published_time" content="Sun, 08/18/2019 - 10:37am" />
|
||
<meta property="article:modified_time" content="Fri, 02/21/2025 - 2:33pm" />
|
||
<meta name="twitter:card" content="summary_large_image" />
|
||
<meta name="twitter:description" content="NIH is providing resources and expertise to investigators in the areas of pain, addiction, and overdose." />
|
||
<meta name="twitter:title" content="Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder | NIH HEAL Initiative" />
|
||
<meta name="twitter:creator" content="@NIH" />
|
||
<meta name="twitter:image" content="https://heal.nih.gov/files/heal-logo-social.png" />
|
||
<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" />
|
||
<meta name="MobileOptimized" content="width" />
|
||
<meta name="HandheldFriendly" content="true" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<link rel="icon" href="/files/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<script>window.a2a_config=window.a2a_config||{};a2a_config.callbacks=[];a2a_config.overlays=[];a2a_config.templates={};</script>
|
||
|
||
<title>Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder | NIH HEAL Initiative</title>
|
||
<link rel="stylesheet" media="all" href="/files/css/css_Xd0pI9rakjfnp2UWa-7weru_1kc-L_azTnBAZQ1TLSs.css?delta=0&language=en&theme=particle&include=eJxFzm0OwyAIBuALoR6poYVNN_wI6trefnHR7A-BB0JeJGoZ0-1wNvahOTU4srIj7QXF4gsvoHwmyUibhPTeBHcWVrfUDDVTTfMcGfhqQ9eXOUJBxadi8XVt_mJ7Kn2XUD3TOGzhEHYjC9S7No5ux8rwCXxW96s2ZurCX0opTZs" />
|
||
<link rel="stylesheet" media="all" href="/files/css/css_Kzcx5y8_UgmvOm2su6202zfZz3qqdNhdBCeZjOratTU.css?delta=1&language=en&theme=particle&include=eJxFzm0OwyAIBuALoR6poYVNN_wI6trefnHR7A-BB0JeJGoZ0-1wNvahOTU4srIj7QXF4gsvoHwmyUibhPTeBHcWVrfUDDVTTfMcGfhqQ9eXOUJBxadi8XVt_mJ7Kn2XUD3TOGzhEHYjC9S7No5ux8rwCXxW96s2ZurCX0opTZs" />
|
||
|
||
<link rel="preconnect" href="https://fonts.gstatic.com/" crossorigin="anonymous">
|
||
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/6.5.1/css/solid.min.css">
|
||
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/6.5.1/css/brands.min.css">
|
||
<link href="https://fonts.googleapis.com/css?family=Montserrat:400,600,700&display=swap" rel="stylesheet">
|
||
<!-- Global site tag (gtag.js) - Google Analytics -->
|
||
<script async src="https://www.googletagmanager.com/gtag/js?id=UA-147034615-1"></script>
|
||
<meta name="msvalidate.01" content="C17405549FB53FD60915A09433C78FF3" />
|
||
<meta http-equiv="X-UA-Compatible" content="IE=EmulateIE8">
|
||
<meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1">
|
||
<script>
|
||
window.dataLayer = window.dataLayer || [];
|
||
function gtag(){dataLayer.push(arguments);}
|
||
gtag('js', new Date());
|
||
|
||
gtag('config', 'UA-147034615-1');
|
||
</script>
|
||
|
||
<!-- Google Tag Manager -->
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':
|
||
new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],
|
||
j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=
|
||
'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);
|
||
})(window,document,'script','dataLayer','GTM-W8TVZ6J');</script>
|
||
<!-- End Google Tag Manager -->
|
||
|
||
<!-- DAP -->
|
||
<script language="javascript" id="_fed_an_ua_tag" src="https://dap.digitalgov.gov/Universal-Federated-Analytics-Min.js?agency=HHS&subagency=NIH&exts=doc,docx,xls,xlsx,xlsm,ppt,pptx,exe,zip,pdf,js,txt,csv,dxf,wmv,jpg,wma,mov,avi,mp3,mp4,csv"></script>
|
||
|
||
<!-- End DAP -->
|
||
</head>
|
||
<body class="fout-fix" data-spy="scroll" data-target="#scrollnav">
|
||
<a href="#main-content" class="visually-hidden focusable">
|
||
Skip to main content
|
||
</a>
|
||
<!-- Google Tag Manager (noscript) -->
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-W8TVZ6J"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
<!-- End Google Tag Manager (noscript) -->
|
||
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
<div class="mobile-overlay" id="overlay" aria-hidden="true"></div>
|
||
|
||
<div id="header-container" class="header-container">
|
||
|
||
<div class="ribbon fluid-container">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-sm-12">
|
||
|
||
<div class="ribbon-links">
|
||
<a href="http://www.hhs.gov/" class="">
|
||
<img src="/assets/hhs-logo.png" alt="U.S. Department of Health & Human Services website"/>
|
||
U.S. Department of Health & Human Services
|
||
</a>
|
||
<img src="/assets/delimiter-arrow.png" alt="" role="presentation"/>
|
||
<a href="https://www.nih.gov/">National Institutes of Health</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="layout-container">
|
||
<header class="container navbar navbar-light navbar">
|
||
<div class="navbar-header-btns">
|
||
<button class="menu-btn" type="button" class="" aria-expanded="false">Menu</button>
|
||
<button class='searchBtnMobile' aria-label="search-toggle"></button>
|
||
|
||
</div>
|
||
<a href="/" class="navbar-logo gtm-header-home" title="Navbar Logo Title"><img src="../../../assets/NIH_HEAL_Color.svg" alt="Navbar Logo Alt"></a>
|
||
<form class="search-menu form-inline d-lg-block" action="https://search.usa.gov/search" accept-charset="UTF-8" method="get">
|
||
<input name="utf8" type="hidden" value="✓">
|
||
<input type="hidden" name="affiliate" id="affiliate" value="heal">
|
||
<div class="input-group">
|
||
<input class="search-input form-control" type="search" placeholder="Search" aria-label="Search heal.nih.gov" name="query">
|
||
<div class="input-group-append">
|
||
<button type="submit" class="btn btn gtm-header-search btn-tertiary">Search</button>
|
||
</div>
|
||
</div>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
<nav role="navigation" aria-labelledby="block-particle-mainnavigation-menu" class="container navbar navbar-expand-lg navbar-light primary-navigation">
|
||
|
||
|
||
|
||
<h2 class="visually-hidden" id="block-particle-mainnavigation-menu">Main navigation</h2>
|
||
|
||
|
||
|
||
|
||
<ul class="no-bullets menu-level-0">
|
||
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-0">
|
||
<a href="/about" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/43151">About</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="no-bullets menu-level-1">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/why-heal" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43131">Why HEAL?</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/opioid-crisis" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43136">The Opioid Crisis</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/impact" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/42501">Making a Difference</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/nih-heal-initiative-leadership" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43146">NIH HEAL Initiative Leadership</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/nih-heal-initiative-annual-report-budget" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43141">Annual Report and Budget</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/about/strategic-plan" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/46921">Strategic Planning</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded menu-item--active-trail no-bullets nav-list-item-0">
|
||
<a href="/research" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/16">Research</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-1 no-bullets">
|
||
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/research-to-practice" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/61">Translation of Research to Practice for the Treatment of Opioid Addiction</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="no-bullets menu-level-2">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/brim" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/106">Behavioral Research to Improve Medication-Based Treatment</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/continuum-care-hospitalized-patients-opioid-use-disorder" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42151">The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/enhancing-clinical-trials-network" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/96">Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/harm-reduction-approaches-reduce-overdose-deaths" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/41416">Harm Reduction Research Network</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/healing-communities" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/91">HEALing Communities Study</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/delivery-healthcare-services-polysubstance-use" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42146">Improving Delivery of Healthcare Services for Polysubstance Use</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/jcoin" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/101">Justice Community Opioid Innovation Network</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/native-collective-research-effort-enhance-wellness-overdose-substance-mental-health-pain" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42586">Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/optimizing-addiction-services" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44086">Optimizing the Quality, Reach, and Impact of Addiction Services</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/research-to-practice/research-recovery-network" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/39646">Recovery Research Networks</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/new-strategies" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/66">New Strategies to Prevent and Treat Opioid Addiction</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/care-polysubstance-use-primary-care" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42126">Collaborative Care for Polysubstance use in Primary Care Settings (Co-Care)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/optimizing-care" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/111">Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/duration-retention-discontinuation" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/126">Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/preventing-opioid-use-disorder" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/116">Preventing Opioid Use Disorder</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/prevent-progression" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/131">Prevention of Progression to Moderate or Severe Opioid Use Disorder</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/new-strategies/sleep-dysfunction" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/121">Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/infants-and-children" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/71">Enhanced Outcomes for Infants and Children Exposed to Opioids</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/infants-and-children/act-now" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/136">Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/infants-and-children/opioid-exposure-during-pregnancy" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44096">The Biology of Opioid Exposure During Pregnancy and Effects on Early Neuro-Behavioral Development</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/infants-and-children/healthy-brain" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/141">HEALthy Brain and Child Development Study (HBCD)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/infants-and-children/virtual-assessments-developmental-trajectories" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44101">Virtual Assessments to Understand Developmental Trajectories of Substance Use Exposure</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/therapeutic-options" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/76">Novel Therapeutic Options for Opioid Use Disorder and Overdose</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/therapeutic-options/immunotherapies" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/151">Development of Novel Immunotherapeutics for Opioid Addiction</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/therapeutic-options/focusing-development" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/146">Focusing Medication Development to Prevent and Treat Opioid Use Disorders and Overdose</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/therapeutic-options/oral-complications-buprenorphine" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44106">Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/therapeutic-options/rapid-assessment-emerging-opioid-threats" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44111">Rapidly Assessing the Public Health Impact of Emerging Opioid Threats</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/clinical-research" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/81">Clinical Research in Pain Management</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/health-equity-pain-management" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42106">Advancing Health Equity in Pain Management</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/pain-signatures" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/186">Acute to Chronic Pain Signatures Program</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/back-pain" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/161">Back Pain Consortium Research Program</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/biomarkers" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/191">Discovery and Validation of Biomarkers, Endpoints and Signatures for Pain Conditions</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/eppic-net" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/176">Early Phase Pain Investigation Clinical Network (EPPIC-Net)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/hemodialysis" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/181">Integrated Approach to Pain and Opioid Use in Hemodialysis Patients</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/pain-management-research" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/166">Pain Management Effectiveness Research Network</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/prism" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/171">Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/chronic-pain-rural-populations" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44091">Prevention and Management of Chronic Pain in Rural Populations</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/clinical-research/integrative-management-chronic-pain" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/39621">Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded menu-item--active-trail no-bullets nav-list-item-1">
|
||
<a href="/research/preclinical-translational" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/86">Preclinical and Translational Research in Pain Management</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/optimization-non-addictive-therapies" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/206">Development and Optimization of Non-Addictive Therapies to Treat Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/novel-targets" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/216">Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/integrated-research" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/44116">Integrated Basic and Clinical Team-Based Research in Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/screening-platform" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/211">Preclinical Screening Platform for Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/restoring-joint-health-function-reduce-pain" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42136">Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN)</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/discoveries-into-devices" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/201">Translating Discoveries into Effective Devices to Treat Pain</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--active-trail no-bullets nav-list-item-2">
|
||
<a href="/research/preclinical-translational/novel-drugs-screening-platforms" class="menu-link gtm-topnav-third is-active" tabindex="0" data-drupal-link-system-path="node/196" aria-current="page">Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-1">
|
||
<a href="/research/cross-cutting-research" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/40331">Cross-Cutting Research</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-2 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/cross-cutting-research/real-time-opioid-pain-management-data" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42116">Leveraging Existing and Real-Time Opioid and Pain Management Data </a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/cross-cutting-research/small-business-programs" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42111">Small Business Programs </a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/cross-cutting-research/stigma-pain-management-opioid-disorder" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/40256">Stigma in Pain Management and Opioid Use Disorder</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-2">
|
||
<a href="/research/cross-cutting-research/translating-data-action-prevent-overdose" class="menu-link gtm-topnav-third" tabindex="0" data-drupal-link-system-path="node/42121">HEAL Data2Action (HD2A)</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/research/training-next-generation-researchers" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/46831">Training the Next Generation of Researchers in HEAL</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-0">
|
||
<a href="/data" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/44206">Data</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="no-bullets menu-level-1">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/heal-data-ecosystem" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/38836">About the HEAL Data Ecosystem</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/complying-heal-data-sharing-policy" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/39216">Complying With the HEAL Data Sharing Policy</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/common-data-elements" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/39116">Common Data Elements (CDEs) Program</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/common-data-elements-repository" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/42871">Common Data Elements (CDEs) Repository</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/ecosystem-events-outreach" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/40321">HEAL Data Ecosystem Events and Outreach</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/public-access-data" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/51">HEAL Public Access and Data Sharing</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/data/data-ecosystem-collective-board" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/40951">HEAL Data Ecosystem Collective Board</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-0">
|
||
<a href="/funding" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/221">Funding</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-1 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/funding/awarded" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/881">Funded Projects</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/funding/open" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/871">Open Funding Opportunities</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/funding/closed" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/876">Closed Funding Opportunities</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/funding/research-concepts" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/40206">Research Concepts</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-0">
|
||
<a href="/news" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/226">News & Events</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-1 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/news/news" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/33666">News</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/news/events" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/33671">Events</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/news/events/headliners" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/42551">Headliners Webinar Series</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/news/stories" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/33676">Research Spotlights</a>
|
||
|
||
</li>
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/videos" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/36351">Videos</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
|
||
<li class="menu-item menu-item--expanded no-bullets nav-list-item-0">
|
||
<a href="/resources" class="menu-link gtm-topnav-link" tabindex="0" data-drupal-link-system-path="node/231">Resources</a>
|
||
|
||
<button class="expand-btn" aria-label="expand-button"></button>
|
||
|
||
|
||
<ul class="menu-level-1 no-bullets">
|
||
|
||
|
||
<li class="menu-item no-bullets nav-list-item-1">
|
||
<a href="/resources/engagement" class="menu-link gtm-topnav-drop" tabindex="0" data-drupal-link-system-path="node/43166">Patient and Community Engagement</a>
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</header>
|
||
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
|
||
|
||
|
||
<div class="color-gradient"></div>
|
||
|
||
<main role="main">
|
||
<div class="container">
|
||
<a id="main-content" tabindex="-1"></a>
|
||
<div class="row">
|
||
<div class="col-sm-12 breadcrumb-col col-md-7">
|
||
<div id="block-particle-breadcrumbs">
|
||
|
||
|
||
|
||
|
||
<nav aria-label="breadcrumb" role="navigation">
|
||
<ol class="breadcrumb">
|
||
<li class="breadcrumb-item gtm-breadcrumb"><a href="/" class="gtm-breadcrumb">Home</a></li>
|
||
<li class="breadcrumb-item gtm-breadcrumb"><a href="/research" class="gtm-breadcrumb">Research</a></li>
|
||
<li class="breadcrumb-item gtm-breadcrumb"><a href="/research/preclinical-translational" class="gtm-breadcrumb">Preclinical and Translational Research In Pain Management</a></li>
|
||
<li class="breadcrumb-item active is-active gtm-breadcrumb" aria-current="page">Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-12 col-md-5">
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="layout-content">
|
||
<div>
|
||
<div id="block-particle-content">
|
||
|
||
|
||
|
||
|
||
<h1> Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder </h1>
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--content-and-view paragraph--view-mode--default">
|
||
|
||
<div class="container">
|
||
<div class="pattern">
|
||
<div class='row'>
|
||
<div>
|
||
<div class="col-12 col-xl-6 float-right">
|
||
|
||
<div class="views-element-container form-group"><div class="carousel-view js-view-dom-id-733bf7f3ef614f578c1d642e34d88fe8f10918b9d278219832b067208f759773">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div id="carousel-13324889" class="callout carousel slide" data-ride="carousel">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<button type=button class="btn carousel-pause" >
|
||
|
||
<span class="pause-icon"></span>
|
||
</button>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<button type=button class="btn carousel-play" >
|
||
|
||
<span class="play-icon"></span>
|
||
</button>
|
||
<ol class="carousel-indicators">
|
||
<li data-target="#carousel-13324889" data-slide-to="0" class="active"></li>
|
||
<li data-target="#carousel-13324889" data-slide-to="1" class=""></li>
|
||
<li data-target="#carousel-13324889" data-slide-to="2" class=""></li>
|
||
</ol>
|
||
<div class="carousel-inner">
|
||
<p><strong>Research Spotlights</strong></p>
|
||
|
||
<div class="carousel-item active">
|
||
<span class="carousel-item-container">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="card overlay-body" id="research-snapshot-new-model-reproduces-overdose-and-recovery-in-the-lab">
|
||
|
||
<a href="/news/stories/new-model-reproduces-overdose-recovery-lab" aria-label="Research Snapshot: New Model Reproduces Overdose and Recovery in the Lab">
|
||
|
||
|
||
|
||
<div>
|
||
<div class="visually-hidden field-label">Image</div>
|
||
<img loading="lazy" src="/files/styles/callout_carousel/public/Neuron%20NCATS%20Snapshot.jpeg?itok=Krqodi4D" width="900" height="507" alt="Neurons with electrical pulses" class="img-fluid" />
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</a>
|
||
|
||
|
||
<div class="card-body">
|
||
<div class="center-card-body">
|
||
<div class="center-card-body-content">
|
||
<p class="card-title">
|
||
<a href="/news/stories/new-model-reproduces-overdose-recovery-lab">
|
||
Research Snapshot: New Model Reproduces Overdose and Recovery in the Lab
|
||
</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</span>
|
||
</div>
|
||
|
||
|
||
<div class="carousel-item ">
|
||
<span class="carousel-item-container">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="card overlay-body" id="a-living-pain-circuit">
|
||
|
||
<a href="/news/stories/living-pain-circuit" aria-label="A Living Pain Circuit ">
|
||
|
||
|
||
|
||
<div>
|
||
<div class="visually-hidden field-label">Image</div>
|
||
<img loading="lazy" src="/files/styles/callout_carousel/public/living-nerve-circuit-spotlight.jpg?itok=CogqvLYl" width="900" height="507" alt="3D image of a “living circuit” in which DRG cells form long extensions toward SCDH cells." class="img-fluid" />
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</a>
|
||
|
||
|
||
<div class="card-body">
|
||
<div class="center-card-body">
|
||
<div class="center-card-body-content">
|
||
<p class="card-title">
|
||
<a href="/news/stories/living-pain-circuit">
|
||
A Living Pain Circuit
|
||
</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</span>
|
||
</div>
|
||
|
||
|
||
<div class="carousel-item ">
|
||
<span class="carousel-item-container">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="card overlay-body" id="human-on-a-chip-models-effects-of-opioid-overdose">
|
||
|
||
<a href="/news/stories/Human-on-a-Chip" aria-label="“Human-on-a-Chip” Models Effects of Opioid Overdose">
|
||
|
||
|
||
|
||
<div>
|
||
<div class="visually-hidden field-label">Image</div>
|
||
<img loading="lazy" src="/files/styles/callout_carousel/public/Tissue%20Chip%20System.jpg?itok=Om5vcdHD" width="900" height="507" alt="Illustration depicting the tissue chip system." class="img-fluid" />
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</a>
|
||
|
||
|
||
<div class="card-body">
|
||
<div class="center-card-body">
|
||
<div class="center-card-body-content">
|
||
<p class="card-title">
|
||
<a href="/news/stories/Human-on-a-Chip">
|
||
“Human-on-a-Chip” Models Effects of Opioid Overdose
|
||
</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</span>
|
||
</div>
|
||
|
||
<a class="carousel-control-prev" href="#carousel-13324889" role="button" data-slide="prev">
|
||
<span class="carousel-control-prev-icon" aria-hidden="true">
|
||
<span class="angle-left-icon"></span>
|
||
</span>
|
||
<span class="sr-only">Previous</span>
|
||
</a>
|
||
<a class="carousel-control-next" href="#carousel-13324889" role="button" data-slide="next">
|
||
<span class="carousel-control-next-icon" aria-hidden="true">
|
||
<span class="angle-right-icon"></span>
|
||
</span>
|
||
</span>
|
||
<span class="sr-only">Next</span>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<p class='col-12'>
|
||
<h2>Overview </h2>
|
||
|
||
<h3>The Research Need </h3>
|
||
|
||
<p>New interventions are needed to treat opioid misuse and addiction as well as to help people manage pain safely and effectively. Scientists need more accurate research models to understand how potential new drugs affect human biology. </p>
|
||
|
||
<h3>About the Program </h3>
|
||
|
||
<p>Through the National Center for Advancing Translational Sciences (NCATS), NIH provides translational science resources and technical expertise to researchers studying pain, addiction, and overdose. This program fosters collaboration between preclinical researchers at NIH-funded institutions and experts at the NCATS Intramural Division of Preclinical Innovation. NIH-funded scientists contribute background knowledge and a starting point for a particular project, and NCATS scientists bring an equivalent wealth of knowledge in translation – along with expertise to transform those starting points into useful tools and platforms for drug development. This research aims to advance knowledge about the underlying biology of pain, addiction, and overdose; develop novel platforms to facilitate therapeutic development; develop new treatments; and determine which ones are most effective. </p>
|
||
|
||
<p>The program uses innovative artificial intelligence algorithms to predict and synthesize novel structures capable of interacting with specific targets; enables small-scale synthesis of predicted molecules; and incorporates in-line, rapid biological testing of those molecules. Through an iterative process, the resulting data are used to improve design, synthesis, and biological characteristics of molecules. </p>
|
||
|
||
<p>The program also creates human tissue-based microphysiological systems, also known as tissue chips or “organs-on-chips.” These tools advance knowledge of how the nervous system responds to painful stimuli – as well as what mechanisms underlie acute and chronic pain, addiction, opioid use disorder, and overdose. </p>
|
||
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-daae2ced25d0d59f3af3e16c263e558e1303df6f8bbfee84a2025f432135c54b">
|
||
|
||
|
||
|
||
<h2>Open Funding Opportunities </h2>
|
||
There are no Open Funding Opportunities at this time.
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class='basic-content content-align-left pattern'>
|
||
<div class='basic-content-grid-container ' style=''>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<p> </p><h2 id="h3-research-examples">Research Examples</h2><p>Research examples supported by this program include: </p><ul><li>Performing preclinical testing of candidate therapeutics for treating pain and opioid use disorder </li><li>Developing high-throughput screening methods to identify pharmacological probes </li><li>Elucidating promising chemical structures for therapeutic candidates </li><li>Developing an iterative learning and automated, modular platform to discover non-addictive pain medications </li><li>Developing a closed-loop system integrating chemical, biological, and computational approaches for next-generation pain medications </li><li>Developing and characterizing induced pluripotent stem cell-derived cell types relevant to nociception, addiction, and overdose </li><li>Developing multicellular constructs that mimic the structure and function of tissues involved in pain, addiction, or overdose using relevant human primary or induced pluripotent stem cell-derived cells </li><li>Determining cellular contributors to individual human susceptibility to different pain conditions </li><li>Profiling epigenetic and cellular changes underlying human pain pathways</li></ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--accordion paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class="pattern">
|
||
|
||
|
||
|
||
<div id="accordion-1916499956" class="col-12 accordion">
|
||
|
||
|
||
|
||
<div class="card-header col-12" id="heading-1916499956-0">
|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
||
data-toggle="collapse"
|
||
data-target="#collapse-1916499956-0"
|
||
aria-expanded="false"
|
||
aria-controls="collapse-1916499956-0">
|
||
Funded Institutions and Locations for Tissue Chips to Model Nociception, Addiction, and Overdose
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-1916499956-0"
|
||
class="collapse "
|
||
aria-labelledby="heading-1916499956-0"
|
||
data-parent="#accordion-1916499956">
|
||
<div class="card-body">
|
||
<ul>
|
||
<li><strong>Tulane University</strong> – Louisiana</li>
|
||
<li><strong>University of California, Los Angeles </strong>– California</li>
|
||
<li><strong>University of Central Florida </strong>– Florida</li>
|
||
<li><strong>University of Pittsburgh </strong>– Pennsylvania</li>
|
||
<li><strong>University of Texas, Dallas </strong>– Texas</li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div id="accordion-5833611" class="col-12 accordion">
|
||
|
||
|
||
|
||
<div class="card-header col-12" id="heading-5833611-1">
|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
||
data-toggle="collapse"
|
||
data-target="#collapse-5833611-1"
|
||
aria-expanded="false"
|
||
aria-controls="collapse-5833611-1">
|
||
Funded Projects
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-5833611-1"
|
||
class="collapse "
|
||
aria-labelledby="heading-5833611-1"
|
||
data-parent="#accordion-5833611">
|
||
<div class="card-body">
|
||
|
||
<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-67c4b693e157a5b30f544e3b1a44f7413c8ecbb2515459e61a848faabd94f11d">
|
||
|
||
|
||
<div class="pattern">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2020
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Human Microphysiological Model of Afferent Nociceptive Signaling
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=196#project-title-35196>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=196#project-title-35196">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 19, 2020
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2020
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Multi-organ human-on-a-chip system to address overdose and acute and chronic efficacy and off-target toxicity
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=196#project-title-34631>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=196#project-title-34631">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 19, 2020
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2020
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
hiPSC-based DRG Tissue Mimics on Multi-well Microelectrode Arrays as a Tissue Chip Model of Acute and Chronic Nociception
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=196#project-title-33896>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=196#project-title-33896">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 19, 2020
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2020
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=196#project-title-35036>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=196#project-title-35036">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 19, 2020
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2020
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
Joint Pain on a Chip: Mechanistic Analysis, Therapeutic Targets, and an Empirical Strategy for Personalized Pain Management
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=196#project-title-34476>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=196#project-title-34476">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Mar 19, 2020
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div style="text-align:right;">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-primary" href=/funding/awarded?research_program=196>
|
||
View all
|
||
</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class='basic-content content-align-left pattern'>
|
||
<div class='basic-content-grid-container ' style=''>
|
||
<h2 class='basic-content-grid-h2-no-media'>
|
||
Participating NIH Institutes, Centers, and Offices
|
||
</h2>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<ul><li><a href="http://www.nichd.nih.gov/">Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)</a> </li><li><a href="https://ncats.nih.gov/">National Center for Advancing Translational Sciences (NCATS)</a> </li><li><a href="https://www.nhlbi.nih.gov/">National Heart, Lung, and Blood Institute (NHLBI)</a> </li><li><a href="https://www.niams.nih.gov/">National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS)</a> </li><li><a href="https://www.nibib.nih.gov/">National Institute of Biomedical Imaging and Bioengineering (NIBIB)</a> </li><li><a href="http://www.nidcr.nih.gov/">National Institute of Dental and Craniofacial Research (NIDCR)</a> </li><li><a href="https://www.ninds.nih.gov/">National Institute of Neurological Disorders and Stroke (NINDS)</a> </li><li><a href="http://www.nida.nih.gov/">National Institute on Drug Abuse (NIDA)</a></li></ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class='pattern'>
|
||
<div class="content-card-grid">
|
||
<div class="row">
|
||
<div class="col-md-4 order-1">
|
||
<div class='card gradient'>
|
||
<div class='card-body'>
|
||
<h3 class='card-title'>
|
||
Contact
|
||
</h3>
|
||
<div class='card-text'>
|
||
<p><a href="/cdn-cgi/l/email-protection#2c5f58495a4942025c45585849424b495e6c424544024b435a">Steven T. Pittenger Ph.D.</a> <br />
|
||
NCATS </p>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="col-md-8 order-2">
|
||
<h3>Resources</h3>
|
||
<p><h3>Collaboration Opportunities</h3>
|
||
|
||
<ul>
|
||
<li><a href="/files/2023-08/nih-heal-initiative-expertise-and-resources.pdf">NIH HEAL Initiative Expertise and Resources</a></li>
|
||
</ul>
|
||
|
||
<h3>ASPIRE Design Challenges</h3>
|
||
|
||
<ul>
|
||
<li><a href="https://grants.nih.gov/grants/guide/notice-files/NOT-TR-18-031.html">Announcement of the NCATS ASPIRE Design Challenges to Develop Innovative and Catalytic Approaches Towards Solving the Opioid Crisis NIH Guide Notice (NOT-TR-18-031)</a></li>
|
||
<li><a href="https://ncats.nih.gov/aspire/challenges/challenge1">Challenge 1: Integrated Chemistry Database for Translational Innovation in Pain, Opioid Use Disorder and Overdose</a></li>
|
||
<li><a href="https://ncats.nih.gov/aspire/challenges/challenge2">Challenge 2: Electronic Synthetic Chemistry Portal for Translational Innovation in Pain, Opioid Use Disorder and Overdose</a></li>
|
||
<li><a href="https://ncats.nih.gov/aspire/challenges/challenge3">Challenge 3: Predictive Algorithms for Translational Innovation in Pain, Opioid Use Disorder and Overdose</a></li>
|
||
<li><a href="https://ncats.nih.gov/aspire/challenges/challenge4">Challenge 4: Biological Assays for Translational Innovation in Pain, Opioid Use Disorder and Overdose</a></li>
|
||
<li><a href="https://ncats.nih.gov/aspire/challenges/challenge5">Challenge 5: Integrated Solution for Translational Innovation in Pain, Opioid Use Disorder and Overdose</a></li>
|
||
</ul>
|
||
</p>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class='basic-content content-align-left pattern'>
|
||
<div class='basic-content-grid-container ' style=''>
|
||
<h2 class='basic-content-grid-h2-no-media'>
|
||
View Other Research Programs in This Focus Area
|
||
</h2>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<ul>
|
||
<li><a href="https://heal.nih.gov/research/preclinical-translational/optimization-non-addictive-therapies">Development and Optimization of Non-Addictive Therapies to Treat Pain</a></li>
|
||
<li><a href="https://heal.nih.gov/research/preclinical-translational/novel-targets">Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain</a> </li>
|
||
<li><a href="https://heal.nih.gov/research/preclinical-translational/screening-platform">Preclinical Screening Platform for Pain (PSPP)</a></li>
|
||
<li><a href="https://heal.nih.gov/research/preclinical-translational/restoring-joint-health-function-reduce-pain">Restoring Joint Health and Function to Reduce Pain Consortium (Re-JOIN)</a></li>
|
||
<li><a href="https://heal.nih.gov/research/preclinical-translational/discoveries-into-devices">Translating Discoveries into Effective Devices to Treat Pain</a></li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</main>
|
||
<div class="container">
|
||
<p class="last-updated">Page last updated
|
||
February 21, 2025</p>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<footer class="fluid-container p-3 footer" role="contentinfo">
|
||
<div class="container">
|
||
<div class="row">
|
||
<div class="col-12 col-md-3">
|
||
<div class="footer-logo"><a href="/"><img alt="NIH HEAL Initiative" src="/assets/HEAL_Initaitive_White.svg" /></a></div>
|
||
|
||
<h2>Contact Us</h2>
|
||
|
||
<p>Please send email to <a href="/cdn-cgi/l/email-protection#e1a9a4a0ad9094849295888e8fa18e85cf8f8889cf868e97"><span class="__cf_email__" data-cfemail="561e13171a27233325223f393816393278383f3e78313920">[email protected]</span></a></p>
|
||
</div>
|
||
|
||
<div class="col-6 col-md-3">
|
||
<h2><a class="gtm-footer-link" href="/about">About</a></h2>
|
||
|
||
<ul class="list-unstyled">
|
||
<li><a class="gtm-footer-link" href="/about/research-plan">Research Plan</a></li>
|
||
<li><a class="gtm-footer-link" href="/about/nih-heal-initiative-leadership">Leadership</a></li>
|
||
</ul>
|
||
|
||
<h2><a class="gtm-footer-link" href="/funding">Funding</a></h2>
|
||
|
||
<ul class="list-unstyled">
|
||
<li><a class="gtm-footer-link" href="/funding/awarded">Funded Projects</a></li>
|
||
<li><a class="gtm-footer-link" href="/funding/open">Open Opportunities</a></li>
|
||
<li><a class="gtm-footer-link" href="/funding/closed">Closed Opportunities</a></li>
|
||
</ul>
|
||
|
||
<h2><a class="gtm-footer-link" href="/data">Data</a></h2>
|
||
|
||
<h2><a class="gtm-footer-link" href="/news">News</a></h2>
|
||
|
||
<h2><a class="gtm-footer-link" href="/resources">Resources</a></h2>
|
||
</div>
|
||
|
||
<div class="col-6 col-md-3">
|
||
<h2><a class="gtm-footer-link" href="/research">Research</a></h2>
|
||
|
||
<ul class="list-unstyled research-list">
|
||
<li><a class="gtm-footer-link" href="/research/research-to-practice">Translation of Research to Practice for the Treatment of Opioid Addiction</a></li>
|
||
<li><a class="gtm-footer-link" href="/research/new-strategies">New Strategies to Prevent and Treat Opioid Addiction</a></li>
|
||
<li><a class="gtm-footer-link" href="/research/infants-and-children">Enhanced Outcomes for Infants and Children Exposed to Opioids</a></li>
|
||
<li><a class="gtm-footer-link" href="/research/medication-options">Novel Therapeutic Options for Opioid Use Disorder and Overdose</a></li>
|
||
<li><a class="gtm-footer-link" href="/research/clinical-research">Clinical Research in Pain Management</a></li>
|
||
<li><a class="gtm-footer-link" href="/research/preclinical-translational">Preclinical and Translational Research in Pain Management</a></li>
|
||
<li><a href="/research/cross-cutting-research">Cross-Cutting Research</a></li>
|
||
<li><a href="/research/training-next-generation-researchers">Training the Next Generation of Researchers in HEAL</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="col-12 col-md-3">
|
||
<h2>Stay Connected</h2>
|
||
|
||
<p><a href="https://public.govdelivery.com/accounts/USNIHNIDA/signup/43013" target="_blank" class="signup">Sign up for news and updates.</a></p>
|
||
|
||
<div class="footer-social-media">
|
||
<h2>Follow NIH</h2>
|
||
<a aria-label="Follow us on X" class="gtm-social-twitter" href="https://twitter.com/nih" target="_blank">
|
||
<span aria-label="Twitter Icon" class="x-icon"> </span>
|
||
</a>
|
||
<a aria-label="Follow us on Instagram" class="gtm-social-instagram" href="https://www.instagram.com/nihgov" target="_blank">
|
||
<span aria-label="Instagram Icon" class="ig-icon"> </span>
|
||
</a>
|
||
<a aria-label="Follow us on Facebook" class="gtm-social-facebook" href="https://www.facebook.com/nih.gov/" target="_blank">
|
||
<span aria-label="Facebook Icon" class="fb-icon"> </span>
|
||
</a>
|
||
<a aria-label="Visit the HEAL YouTube" class="gtm-social-youtube" href="https://www.youtube.com/playlist?list=PLd_5BzGlfpgpkK12ToGD9VtxF8ClhEusZ" target="_blank">
|
||
<span aria-label="YouTube Icon" class="yt-icon"> </span>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
<hr class="col-12" />
|
||
<div class="col-md-12 gov-links">
|
||
<ul class="list-inline">
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://www.nih.gov/">NIH Home</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://salud.nih.gov/">En Español</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://www.nih.gov/web-policies-notices">Web Policies and Notices</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office">Freedom of Information Act</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://www.edi.nih.gov/no-fear-act">No Fear Act</a></li>
|
||
<li class="list-inline-item"><a class="gtm-footer-link" href="https://oig.hhs.gov/">Office of Inspector General</a></li>
|
||
</ul>
|
||
|
||
<p><a class="gtm-footer-link" href="https://www.hhs.gov/">U.S. Department of Health and Human Services</a></p>
|
||
</div>
|
||
|
||
<div class="col-md-9 mx-auto gov-links">
|
||
<p>Helping to End Addiction Long-term<sup>®</sup> and NIH HEAL Initiative<sup>®</sup> are registered service marks of the Department of Health and Human Services.</p>
|
||
</div>
|
||
</div>
|
||
</footer>
|
||
|
||
|
||
<script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/196","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxVylkOwyAMBNALsRwpMrFbaM0iG5rk9hVRoqo_1swbA2KvUA4PV3APqaUbrFvhCrhwKu-FIRCT-FvtVHup7ZEyGdr7VI8yGrC7qmkg8BRoUe_lJ26UNgInjYTzsaeVya9VyOihnbIPoGQ-iTb153Xwgv0PcsXB9AV04E3G","theme":"particle","theme_token":null},"ajaxTrustedUrl":[],"data":{"extlink":{"extTarget":true,"extTargetAppendNewWindowLabel":"(opens in a new window)","extTargetNoOverride":false,"extNofollow":false,"extTitleNoOverride":false,"extNoreferrer":false,"extFollowNoOverride":false,"extClass":"ext","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"(\\.gov.*?)","extInclude":"","extCssExclude":".footer-social-media, .social-share-button, .twitter-share-button","extCssInclude":"","extCssExplicit":"","extAlert":false,"extAlertText":"This link will take you to an external web site. We are not responsible for their content.","extHideIcons":false,"mailtoClass":"0","telClass":"","mailtoLabel":"(link sends email)","telLabel":"(link is a phone number)","extUseFontAwesome":false,"extIconPlacement":"append","extPreventOrphan":false,"extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","extAdditionalLinkClasses":"","extAdditionalMailtoClasses":"","extAdditionalTelClasses":"","extFaTelClasses":"fa fa-phone","whitelistedDomains":null,"extExcludeNoreferrer":""}},"views":{"ajax_path":"\/views\/ajax","ajaxViews":{"views_dom_id:67c4b693e157a5b30f544e3b1a44f7413c8ecbb2515459e61a848faabd94f11d":{"view_name":"database","view_display_id":"block_10","view_args":"196","view_path":"\/node\/196","view_base_path":"database\/export","view_dom_id":"67c4b693e157a5b30f544e3b1a44f7413c8ecbb2515459e61a848faabd94f11d","pager_element":0,"viewsreference":{"compressed":"eJxdj9EKwjAMRf8lz3tQEcH9ikiJNKuBtCttNhlj_76W6QYG8nCSewKZwaIitDNgcoOnoNCGQaQBYc879F2XaaeIjtIPlFVog6UBCvgSsqaklYPL0D6eVUjlsinNOhmdYhHqEF3C-Ib_ANuyvlzPt2PTMYk1AX01NxiZPkcg0ciZ-_CVS92rvkVZyRtLUj89LStxD1W8"}},"views_dom_id:daae2ced25d0d59f3af3e16c263e558e1303df6f8bbfee84a2025f432135c54b":{"view_name":"database","view_display_id":"block_16","view_args":"196","view_path":"\/node\/196","view_base_path":"database\/export","view_dom_id":"daae2ced25d0d59f3af3e16c263e558e1303df6f8bbfee84a2025f432135c54b","pager_element":0,"viewsreference":{"compressed":"eJxdjjEKwzAMRe-iuYPjlg65SilCRWoicFxji5QQevfaeAhk0PD_ex-0A5MRjI_nBSTSKwhjETONU-ltoizRsJ7ahrYlgbGVNGVKM5wF5YoH59z9QG-VwBhpadMeVpXvIWRZtegn9rX3_nobKu2qmizIEtqb7vcHubU9lg"}}}},"user":{"uid":0,"permissionsHash":"af5eece730f2d5aa6b0d43e1d564e85bd63161885787ef00214b14f2707a18ff"}}</script>
|
||
<script src="/themes/contrib/particle/apps/drupal/../../dist/app-drupal/assets/drupal-jquery.js?ss1xuy"></script>
|
||
<script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script>
|
||
<script src="/core/misc/drupalSettingsLoader.js?v=10.4.1"></script>
|
||
<script src="/core/misc/drupal.js?v=10.4.1"></script>
|
||
<script src="/core/misc/drupal.init.js?v=10.4.1"></script>
|
||
<script src="/core/assets/vendor/tabbable/index.umd.min.js?v=6.2.0"></script>
|
||
<script src="https://static.addtoany.com/menu/page.js" defer></script>
|
||
<script src="/modules/contrib/addtoany/js/addtoany.js?v=10.4.1"></script>
|
||
<script src="/modules/contrib/extlink/js/extlink.js?v=10.4.1"></script>
|
||
<script src="/themes/contrib/particle/apps/drupal/../../dist/app-drupal/assets/app.js?ss1xuy"></script>
|
||
<script src="/themes/contrib/particle/apps/drupal/menus.js?ss1xuy"></script>
|
||
<script src="/themes/contrib/particle/apps/drupal/funding.js?ss1xuy"></script>
|
||
<script src="/core/misc/jquery.form.js?v=4.3.0"></script>
|
||
<script src="/core/misc/progress.js?v=10.4.1"></script>
|
||
<script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.3.0"></script>
|
||
<script src="/core/misc/debounce.js?v=10.4.1"></script>
|
||
<script src="/core/misc/announce.js?v=10.4.1"></script>
|
||
<script src="/core/misc/message.js?v=10.4.1"></script>
|
||
<script src="/core/misc/ajax.js?v=10.4.1"></script>
|
||
<script src="/themes/contrib/stable/js/ajax.js?v=10.4.1"></script>
|
||
<script src="/core/modules/views/js/base.js?v=10.4.1"></script>
|
||
<script src="/core/modules/views/js/ajax_view.js?v=10.4.1"></script>
|
||
|
||
</body>
|
||
</html>
|