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|
||
<div class="center-card-body-content">
|
||
<p class="card-title">
|
||
<a href="/news/stories/eppic-net-effective-pain-treatments">
|
||
The Search for New, More Targeted Pain Treatments
|
||
</a>
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</span>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
<p class='col-12'>
|
||
<h2>Overview</h2>
|
||
|
||
<h3>The Research Need</h3>
|
||
|
||
<p>The Early Phase Pain Investigation Clinical Network (EPPIC-Net) seeks to enhance the treatment of acute and chronic pain and reduce reliance on opioids by accelerating early-phase clinical trials of non-addictive treatments for pain.</p>
|
||
|
||
<h3>About the Program</h3>
|
||
|
||
<p>EPPIC-Net has the capacity to quickly and efficiently conduct many simultaneous multisite studies. The network will conduct studies on a variety of treatments, including drugs and devices, as well as studies to better understand pain.</p>
|
||
|
||
<p>EPPIC-Net will:</p>
|
||
|
||
<ul>
|
||
<li>Test new pain treatments (e.g., small molecules, biologics, devices) with go/no-go criteria in early-stage trials to move toward efficacy trials for regulatory approval.</li>
|
||
<li>Provide proof-of-concept clinical testing of potential biomarkers and new treatments to help identify specific pathways or mechanisms that hold promise for future therapeutic development.</li>
|
||
<li>Validate biomarkers for utility in assessing target engagement or pain outcomes that could be used to accelerate development of new, non-addictive pain therapies.</li>
|
||
<li>Develop and test innovative clinical trial paradigms to evaluate pain therapies.</li>
|
||
<li>Establish well-characterized patient cohorts with specific pain conditions and clearly defined outcome measures for early-stage trials.</li>
|
||
<li>Continuously learn from experience to engineer adaptive, ever-improving early-phase testing of new pain therapies.</li>
|
||
</ul>
|
||
|
||
<p>EPPIC-Net supports clinical trials focused on:</p>
|
||
|
||
<ul>
|
||
<li>Investigational drugs and biologics, investigational devices, natural products, and surgical procedures for the treatment of pain.</li>
|
||
<li>Deeply phenotyped patients with pain conditions of high unmet need.</li>
|
||
<li>Drugs or devices with strong potential to move to industry-funded Phase 3 efficacy trials, should the early-phase study achieve the prespecified endpoints.</li>
|
||
</ul>
|
||
|
||
<p>EPPIC-Net interfaces with the National Institute of Arthritis and Musculoskeletal and Skin Diseases’ <a href="https://www.niams.nih.gov/grants-funding/funded-research/nih-back-pain-consortium-bacpac-research-program">Back Pain Consortium (BACPAC)</a> Research Program to study how people with different types of back pain respond to specific interventions.</p>
|
||
|
||
<p><a href="https://heal.nih.gov/research/clinical-research/back-pain">Learn more about how the Helping to End Addiction Long-term<sup>®</sup> Initiative, or NIH HEAL Initiative<sup>®</sup> is involved in BACPAC</a>.</p>
|
||
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-d90c36f1e577ad2c2fd0218ca1db48c102045b1a2ba89acf4b0b359245503123">
|
||
|
||
|
||
|
||
<h2>Open Funding Opportunities </h2>
|
||
There are no Open Funding Opportunities at this time.
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class='basic-content content-align-left padding-bottom--1'>
|
||
<div class='basic-content-grid-container ' style=''>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<p> </p><h2>Research Examples</h2><p>The awards support a network to advance new treatments for pain by conducting early-phase clinical trials with adults and children. Currently funded trials include:</p><ul><li>In EPPIC-Net’s first Phase 2 clinical trial, researchers will test the novel oral drug CNTX-6970 in patients who experience moderate to <a href="https://reporter.nih.gov/project-details/10352674">severe knee osteoarthritis pain</a>. Preclinical studies of CNTX-6970 have demonstrated potent analgesia in multiple pain models.</li><li>Currently one EPPIC-Net clinical trial is underway to address diabetic neuropathy. Many patients with diabetic peripheral neuropathy find the sensory loss itself uncomfortable; however, some patients report pain due to their diabetic peripheral neuropathy, referred to as painful diabetic peripheral neuropathy. Despite the availability of off-label treatment options, many patients with diabetic peripheral neuropathy still experience significant pain, and thus more effective, non-addictive options are needed.<ul><li>One EPPIC-Net trial will further development of NRD135S.E1, an oral analgesic therapeutic candidate which has been well tolerated and shown clinically relevant benefit in early clinical studies.</li></ul></li></ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--accordion paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class="pattern">
|
||
|
||
|
||
|
||
<div id="accordion-1975402619" class="col-12 accordion">
|
||
|
||
|
||
|
||
<div class="card-header col-12" id="heading-1975402619-0">
|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
||
data-toggle="collapse"
|
||
data-target="#collapse-1975402619-0"
|
||
aria-expanded="false"
|
||
aria-controls="collapse-1975402619-0">
|
||
Funded Institutions and Locations
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-1975402619-0"
|
||
class="collapse "
|
||
aria-labelledby="heading-1975402619-0"
|
||
data-parent="#accordion-1975402619">
|
||
<div class="card-body">
|
||
<h3>Specialized Clinical Centers</h3>
|
||
|
||
<ul>
|
||
<li><strong>Duke University</strong> – North Carolina</li>
|
||
<li><strong>Icahn School of Medicine at Mount Sinai</strong> – New York</li>
|
||
<li><strong>Massachusetts General Hospital</strong> – Massachusetts</li>
|
||
<li><strong>Medical College of Wisconsin </strong>– Wisconsin</li>
|
||
<li><strong>Medical University of South Carolina</strong> – South Carolina</li>
|
||
<li><strong>New York University School of Medicine</strong> – New York</li>
|
||
<li><strong>University of California, San Diego</strong> – California</li>
|
||
<li><strong>University of Florida</strong> – Florida</li>
|
||
<li><strong>University of Pennsylvania</strong> – Pennsylvania</li>
|
||
<li><strong>University of Pittsburgh at Pittsburgh</strong> – Pennsylvania</li>
|
||
<li><strong>University of Rochester</strong> – New York</li>
|
||
<li><strong>University of Washington </strong>– Washington</li>
|
||
</ul>
|
||
|
||
<h3>Clinical Coordinating Center</h3>
|
||
|
||
<ul>
|
||
<li><strong>Massachusetts General Hospital</strong> – Massachusetts</li>
|
||
</ul>
|
||
|
||
<h3>Data Coordinating Center</h3>
|
||
|
||
<ul>
|
||
<li><strong>New York University School of Medicine</strong> – New York</li>
|
||
</ul>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div id="accordion-2037096992" class="col-12 accordion">
|
||
|
||
|
||
|
||
<div class="card-header col-12" id="heading-2037096992-1">
|
||
|
||
<h2 class="mb-0">
|
||
<button class="btn btn-link h2 expand-link"
|
||
data-toggle="collapse"
|
||
data-target="#collapse-2037096992-1"
|
||
aria-expanded="false"
|
||
aria-controls="collapse-2037096992-1">
|
||
Funded Projects
|
||
</button>
|
||
</h2>
|
||
|
||
</div>
|
||
|
||
<div id="collapse-2037096992-1"
|
||
class="collapse "
|
||
aria-labelledby="heading-2037096992-1"
|
||
data-parent="#accordion-2037096992">
|
||
<div class="card-body">
|
||
|
||
<div class="views-element-container form-group"><div class="viewsreference--view-title">
|
||
</div>
|
||
|
||
<div class="js-view-dom-id-e876b2682fccb70099f9c1030776c272fdc4544d73b80239647cf882ce9fee72">
|
||
|
||
|
||
<div class="pattern">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
University of Pittsburgh Hub and Spoke Pain Clinical Trial Network
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=176#project-title-47226>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=176#project-title-47226">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=176#project-title-47216>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=176#project-title-47216">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
California Clinical and Translational Pain Research Consortium
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=176#project-title-47231>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=176#project-title-47231">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
EPPIC-NET DCC - Supplement
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=176#project-title-46941>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=176#project-title-46941">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="row border border-top-0 border-right-0 border-left-0 border-oslo-gray" style="padding: 15px 0;">
|
||
<div class="col-3 d-none d-lg-block">
|
||
2025
|
||
</div>
|
||
<div class="col-lg-6 col-md-12">
|
||
EPPIC-Net Hub at University of Washington
|
||
</div>
|
||
<div class="col-3 d-none d-lg-block">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-tertiary my-2 my-sm-0 float-right" href=/funding/awarded?research_program=176#project-title-47221>
|
||
Summary
|
||
</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
<a href="/funding/awarded?research_program=176#project-title-47221">Summary</a>
|
||
</div>
|
||
|
||
<div class="col-6 d-lg-none">
|
||
Feb 25, 2025
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div style="text-align:right;">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<a class="btn btn-primary" href=/funding/awarded?research_program=176>
|
||
View all
|
||
</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="container">
|
||
<div class='basic-content content-align-left pattern'>
|
||
<div class='basic-content-grid-container ' style=''>
|
||
<h2 class='basic-content-grid-h2-no-media'>
|
||
Participating NIH Institutes, Centers, and Offices
|
||
</h2>
|
||
<div class="basic-content-grid-no-media">
|
||
<div>
|
||
|
||
<ul><li><a href="http://www.nci.nih.gov/">National Cancer Institute (NCI)</a></li><li><a href="http://www.nccam.nih.gov/">National Center for Complementary and Integrative Health (NCCIH)</a></li><li><a href="http://www.niams.nih.gov/">National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)</a></li><li><a href="http://www.niddk.nih.gov/">National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)</a></li><li><a href="https://www.ninds.nih.gov/">National Institute of Neurological Disorders and Stroke (NINDS)</a></li></ul>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="paragraph paragraph--type--gradient-card paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class='pattern'>
|
||
<div class="content-card-grid">
|
||
<div class="row">
|
||
<div class="col-md-4 order-2">
|
||
<div class='card gradient'>
|
||
<div class='card-body'>
|
||
<h3 class='card-title'>
|
||
Contact
|
||
</h3>
|
||
<div class='card-text'>
|
||
<p><a href="https://www.ninds.nih.gov/about-ninds/who-we-are/staff-directory/rebecca-hommer">Rebecca Hommer</a><br>NINDS</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="col-md-8 order-1">
|
||
<p><div class="card gradient"><p><em>EPPIC-Net is <strong>NOT </strong>currently accepting new applications. Announcements regarding updates to the EPPIC-Net application process and any other relevant HEAL funding opportunities will be posted here as they become available.</em></p></div></p>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="paragraph paragraph--type--dynamic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
<div class='container'>
|
||
<div class="dynamic_content">
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--basic-content paragraph--view-mode--default">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
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