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<select aria-label="Grant Mechanism" data-drupal-selector="edit-grant" id="edit-grant" name="grant" class="form-select"><option value="All" selected="selected">Grant Mechanism</option><option value="1">Career Development Awards</option><option value="2">Cooperative Agreements</option><option value="3">Program Project/Center Grants</option><option value="4">Research Project Grants</option><option value="5">Research Related Programs</option><option value="6">Small Business Cooperative Agreements</option><option value="7">Small Business Grants</option></select>
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<select aria-label="Research Focus Area" data-drupal-selector="edit-rfa" id="edit-rfa" name="rfa" class="form-select"><option value="All" selected="selected">Research Focus Area</option><option value="81">Clinical Research in Pain Management</option><option value="40331">Cross-Cutting Research</option><option value="71">Enhanced Outcomes for Infants and Children Exposed to Opioids</option><option value="66">New Strategies to Prevent and Treat Opioid Addiction</option><option value="76">Novel Therapeutic Options for Opioid Use Disorder and Overdose</option><option value="86">Preclinical and Translational Research in Pain Management</option><option value="46831">Training the Next Generation of Researchers in HEAL</option><option value="61">Translation of Research to Practice for the Treatment of Opioid Addiction</option></select>
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<div class="form-item-input">
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<select aria-label="Research Program" data-drupal-selector="edit-research-program" id="edit-research-program" name="research_program" class="form-select"><option value="All">Research Program</option><option value="186">Acute to Chronic Pain Signatures Program</option><option value="136">Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW)</option><option value="42106">Advancing Health Equity in Pain Management </option><option value="161">Back Pain Consortium Research Program</option><option value="106">Behavioral Research to Improve Medication-Based Treatment</option><option value="42126">Collaborative Care for Polysubstance Use in Primary Care Settings (Co-Care)</option><option value="206">Development and Optimization of Non-Addictive Therapies to Treat Pain</option><option value="151">Development of Novel Immunotherapeutics for Opioid Addiction</option><option value="191">Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions</option><option value="216">Discovery and Validation of Novel Targets for Safe and Effective Treatment of Pain</option><option value="176">Early Phase Pain Investigation Clinical Network (EPPIC-Net)</option><option value="96">Enhancing the National Drug Abuse Treatment Clinical Trials Network to Address Opioids</option><option value="146">Focusing Medication Development to Prevent and Treat Opioid Use Disorder and Overdose</option><option value="41416">Harm Reduction Research Network</option><option value="42121">HEAL Data2Action (HD2A)</option><option value="91">HEALing Communities Study</option><option value="141">HEALthy Brain and Child Development (HBCD) Study</option><option value="42146">Improving Delivery of Healthcare Services for Polysubstance Use</option><option value="181">Integrated Approach to Pain and Opioid Use in Hemodialysis Patients</option><option value="44116">Integrated Basic and Clinical Team-Based Research in Pain</option><option value="101">Justice Community Overdose Innovation Network (JCOIN)</option><option value="42116">Leveraging Existing and Real-Time Opioid and Pain Management Data</option><option value="42586">Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain </option><option value="111">Optimizing Care for People with Opioid Use Disorder and Mental Health Conditions</option><option value="126">Optimizing the Duration, Retention, and Discontinuation of Medication Treatment for Opioid Use Disorder</option><option value="44086" selected="selected">Optimizing the Quality, Reach, and Impact of Addiction Services</option><option value="44106">Oral Complications Arising From Pharmacotherapies to Treat Opioid Use Disorders</option><option value="166">Pain Management Effectiveness Research Network (ERN)</option><option value="171">Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM)</option><option value="211">Preclinical Screening Platform for Pain</option><option value="116">Preventing Opioid Use Disorder </option><option value="44091">Prevention and Management of Chronic Pain in Rural Populations</option><option value="131">Prevention of Progression to Moderate or Severe Opioid Use Disorder</option><option value="44111">Rapidly Assessing the Public Health Impact of Emerging Opioid Threats</option><option value="39646">Recovery Research Networks</option><option value="39621">Reducing Opioid-Related Harms to Treat Chronic Pain (IMPOWR and MIRHIQL)</option><option value="42136">Restoring Joint Health and Function to Reduce Pain (RE-JOIN)</option><option value="121">Sleep Dysfunction as a Core Feature of Opioid Use Disorder and Recovery</option><option value="42111">Small Business Programs</option><option value="40256">Stigma in Pain Management and Opioid Use Disorder</option><option value="44096">The Biology of Opioid Exposure During Pregnancy and Effects on Early Neuro-Behavioral Development</option><option value="42151">The Continuum of Care in Hospitalized Patients with Opioid Use Disorder and Infectious Complications of Drug Use (CHOICE)</option><option value="201">Translating Discoveries into Effective Devices to Treat Pain</option><option value="196">Translational Research to Advance Testing of Novel Drugs and Human Cell-Based Screening Platforms to Treat Pain and Opioid Use Disorder</option><option value="44101">Virtual Assessments to Understand Developmental Trajectories of Substance Use Exposure</option></select>
|
||
</div>
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|
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<div class="form-item-input">
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<div class="form-group js-form-item form-item js-form-type-select form-item-goal js-form-item-goal form-no-label">
|
||
<select aria-label="Heal Initiative Goal" data-drupal-selector="edit-goal" id="edit-goal" name="goal" class="form-select"><option value="All" selected="selected">HEAL Initiative Goal</option><option value="Improve treatments for opioid addiction and overdose">Improve treatments for opioid addiction and overdose</option><option value="Enhance pain management">Enhance pain management</option></select>
|
||
</div>
|
||
|
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<div class="form-item-submit">
|
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|
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<div data-drupal-selector="edit-actions" class="form-actions form-group" id="edit-actions"><input class="btn btn-secondary gtm-database-filter button js-form-submit form-submit" data-drupal-selector="edit-submit-database" type="submit" id="edit-submit-database" value="Apply Filters" />
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<a class="advanced-search reset-button btn btn-secondary" href=/funding/open>
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Reset
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<div class="col-12 display-pattern justify-content-center">
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<a class="file-export" href="/funding/open/export?research_program=44086&_format=csv">Download Results</a>
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<a href="#" class="gtm-copy-query copybutton" aria-label="Copy the URL for your results" data-copy="https://heal.nih.gov/funding/open?research_program=44086">Save this Search</a>
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</form>
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<div class="container-fluid">
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<th id="view-field-foa-number-table-column" class="views-field views-field-field-foa-number" scope="col"><a href="?research_program=44086&combine=&rfa=All&goal=All&grant=All&select_location=All&order=field_foa_number&sort=asc" title="sort by NOFO #">NOFO #</a></th>
|
||
<th id="view-field-foa-title-table-column" class="views-field views-field-field-foa-title" scope="col"><a href="?research_program=44086&combine=&rfa=All&goal=All&grant=All&select_location=All&order=field_foa_title&sort=asc" title="sort by NOFO Title">NOFO Title</a></th>
|
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<th id="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area" scope="col">Research Focus Area</th>
|
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<th id="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da" scope="col"><a href="?research_program=44086&combine=&rfa=All&goal=All&grant=All&select_location=All&order=field_foa_earliest_submission_da&sort=desc" title="sort by Earliest Submission Date">Earliest Submission Date</a></th>
|
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<th id="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date" scope="col"><a href="?research_program=44086&combine=&rfa=All&goal=All&grant=All&select_location=All&order=field_foa_expiration_date&sort=asc" title="sort by Expiration Date">Expiration Date</a></th>
|
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<th id="view-field-foa-posted-date-table-column" aria-sort="descending" class="views-field views-field-field-foa-posted-date is-active" scope="col"><a href="?research_program=44086&combine=&rfa=All&goal=All&grant=All&select_location=All&order=field_foa_posted_date&sort=asc" title="sort by Posted Date">Posted Date<span class="tablesort tablesort--asc">
|
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<span class="visually-hidden">
|
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Sort ascending
|
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</span>
|
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</span>
|
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</a></th>
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</thead>
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<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-078.html" target="_blank">RFA-DA-25-078</a> <br>
|
||
<a class="expand-link" data-toggle="collapse" href="#summary1" role="button" aria-expanded="false" aria-controls="collapseExample">
|
||
Show Summary
|
||
</a>
|
||
</td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/research-to-practice" hreflang="en">Translation of Research to Practice for the Treatment of Opioid Addiction</a> </td>
|
||
|
||
<td headers="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da">Thu, 02/20/2025 </td>
|
||
|
||
<td headers="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date">Fri, 03/21/2025 </td>
|
||
|
||
<td headers="view-field-foa-posted-date-table-column" class="views-field views-field-field-foa-posted-date is-active">Tue, 12/17/2024 </td>
|
||
|
||
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|
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||
<tr id="summary1" class="summary collapse odd fullSummary">
|
||
<td colspan="6">
|
||
<div class="offset-xl-1 offset-lg-1 offset-md-1 col-10 db-summary">
|
||
<p>The goal of this initiative is to support action-oriented research that accelerates the translation of research to practice to address the overdose crisis. There remains an urgent need for research that advances the design of stigma-free patient-centered systems of care such that people who experience addiction can recover and sustain their recovery over the long-term. This notice of funding opportunity (NOFO) solicits applications that address understudied areas of opportunity, particularly those that focus on fundamental barriers or facilitators to reducing overdose deaths at the individual, provider, organizational, community, or system levels. Projects should be in alignment with the overall goals of the HEAL Initiative, and should focus on replicable, scalable, equitable approaches for accelerating the movement of evidence-based and promising treatments into routine use. This NOFO invites phased applications to support projects for which preliminary or feasibility data is not available at the time of submission. This NOFO is a companion to RFA-DA-25-077, which solicits applications for which pilot data is available.</p>
|
||
</div>
|
||
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|
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</tr> <!-- summary-->
|
||
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||
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||
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<tr class="even">
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||
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<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-25-077.html" target="_blank">RFA-DA-25-077</a> <br>
|
||
<a class="expand-link" data-toggle="collapse" href="#summary2" role="button" aria-expanded="false" aria-controls="collapseExample">
|
||
Show Summary
|
||
</a>
|
||
</td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/research-to-practice" hreflang="en">Translation of Research to Practice for the Treatment of Opioid Addiction</a> </td>
|
||
|
||
<td headers="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da">Thu, 02/20/2025 </td>
|
||
|
||
<td headers="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date">Fri, 03/21/2025 </td>
|
||
|
||
<td headers="view-field-foa-posted-date-table-column" class="views-field views-field-field-foa-posted-date is-active">Tue, 12/17/2024 </td>
|
||
|
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</tr> <!-- closing head of time -->
|
||
|
||
<tr id="summary2" class="summary collapse even fullSummary">
|
||
<td colspan="6">
|
||
<div class="offset-xl-1 offset-lg-1 offset-md-1 col-10 db-summary">
|
||
<p>The goal of this initiative is to support action-oriented research that accelerates the translation of research to practice to address the overdose crisis. There remains an urgent need for research that advances the design of stigma-free patient-centered systems of care such that people who experience addiction can recover and sustain their recovery over the long-term. This notice of funding opportunity (NOFO) solicits applications that address understudied areas of opportunity, particularly those that focus on fundamental barriers or facilitators to reducing overdose deaths at the individual, provider, organizational, community, or system levels. Projects should be in alignment with the overall goals of the Helping to End Addiction Long-term (HEAL) Initiative, and should focus on replicable, scalable, equitable approaches for accelerating the movement of moving evidence-based and promising treatments into routine use. This NOFO invites projects for which preliminary or feasibility data is available. This NOFO is a companion to RFA-DA-25-078, which solicits applications for which pilot data is unavailable.</p>
|
||
</div>
|
||
</td>
|
||
</tr> <!-- summary-->
|
||
|
||
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||
|
||
<tr class="odd">
|
||
|
||
<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/notice-files/NOT-DA-24-011.html" target="_blank">NOT-DA-24-011</a> <br>
|
||
<a class="expand-link" data-toggle="collapse" href="#summary3" role="button" aria-expanded="false" aria-controls="collapseExample">
|
||
Show Summary
|
||
</a>
|
||
</td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">Notice of Special Interest (NOSI): HEAL Initiative: Leveraging Inpatient Medical or Surgical Hospitalizations to Improve Outcomes for People Who Use Drugs </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/training-next-generation-researchers" hreflang="en">Training the Next Generation of Researchers in HEAL</a> </td>
|
||
|
||
<td headers="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da">Wed, 11/15/2023 </td>
|
||
|
||
<td headers="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date">Thu, 11/13/2025 </td>
|
||
|
||
<td headers="view-field-foa-posted-date-table-column" class="views-field views-field-field-foa-posted-date is-active">Tue, 08/01/2023 </td>
|
||
|
||
</tr> <!-- closing head of time -->
|
||
|
||
<tr id="summary3" class="summary collapse odd fullSummary">
|
||
<td colspan="6">
|
||
<div class="offset-xl-1 offset-lg-1 offset-md-1 col-10 db-summary">
|
||
<p>This notice of special interest (NOSI) is part of the NIH's Helping to End Addiction Long-term (HEAL) initiative to speed the development and implementation of scientific solutions to the national opioid public health crisis by bolstering research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information and periodic updates about the HEAL Initiative are available at: <a href="https://heal.nih.gov/">https://heal.nih.gov/</a>.</p><p>In the United States, a relatively small number of high-need patients account for a disproportionately high level of healthcare utilization, including hospital admissions and costs. Having a substance use disorder (SUD) increases the risk of an individual falling into this high-risk, high-need population. Furthermore, the co-occurrence of general medical conditions and SUD, including opioid use disorder (OUD) complicates the treatment and can worsen the outcomes of both. Screening for SUD and OUD is not routine for most medical or surgical admissions. Even when identified, individuals can experience worse outcomes for their medical or surgical conditions because of stigma or because their SUD may complicate their hospitalization in other ways (e.g., poor venous access in people who inject drugs). At the same time, individuals being treated in medical or surgical wards may not receive evidence-based treatment or linkage to outpatient OUD/SUD treatment upon discharge.</p><p>There are existing models for initiation of treatment for OUD during general inpatient hospital medical stays, some of which involve linkage to care post-discharge (e.g., addiction consult services, consultation liaison psychiatry referrals, care coordinators, patient navigators, bridge clinics). Some of these have been studied formally for short time periods and/or at limited scale. Others may have both emergency department (ED) and inpatient treatment initiation and linkage, but far more evaluation has been done on the ED initiation and linkage than the inpatient components. These models have not been scaled up and used widely to date, indicating possible limitations with the models, additional barriers to implementation, or limited experience with the models in varied health systems.</p><p>In addition, there is literature to support the idea the hospital may be an appropriate place to screen for and assess SUDs including OUD, that OUD may complicate or extend the hospital stay and increase costs, and that initiation of treatment during hospitalization and linkage to continued outpatient care can be beneficial in reducing hospital re-admissions.</p>
|
||
</div>
|
||
</td>
|
||
</tr> <!-- summary-->
|
||
|
||
|
||
|
||
<tr class="even">
|
||
|
||
<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/notice-files/not-da-23-007.html" target="_blank">NOT-DA-23-007</a> </td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">Notice of Special Interest (NOSI): HEAL Initiative: Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/research-to-practice" hreflang="en">Translation of Research to Practice for the Treatment of Opioid Addiction</a>, <a href="/research/new-strategies" hreflang="en">New Strategies to Prevent and Treat Opioid Addiction</a> </td>
|
||
|
||
<td headers="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da">Wed, 10/12/2022 </td>
|
||
|
||
<td headers="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date">Sun, 07/13/2025 </td>
|
||
|
||
<td headers="view-field-foa-posted-date-table-column" class="views-field views-field-field-foa-posted-date is-active">Wed, 08/03/2022 </td>
|
||
|
||
</tr> <!-- closing head of time -->
|
||
|
||
<tr id="summary4" class="summary collapse even noSummary">
|
||
<td colspan="6">
|
||
<div class="offset-xl-1 offset-lg-1 offset-md-1 col-10 db-summary">
|
||
no summary
|
||
</div>
|
||
</td>
|
||
</tr> <!-- summary-->
|
||
|
||
|
||
|
||
<tr class="odd">
|
||
|
||
<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/notice-files/not-da-23-008.html" target="_blank">NOT-DA-23-008</a> </td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">Notice of Special Interest (NOSI) HEAL Initiative: Workforce Interventions to Improve Addiction Care Quality and Patient Outcomes </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/research-to-practice" hreflang="en">Translation of Research to Practice for the Treatment of Opioid Addiction</a> </td>
|
||
|
||
<td headers="view-field-foa-earliest-submission-da-table-column" class="views-field views-field-field-foa-earliest-submission-da">Wed, 10/05/2022 </td>
|
||
|
||
<td headers="view-field-foa-expiration-date-table-column" class="views-field views-field-field-foa-expiration-date">Mon, 09/08/2025 </td>
|
||
|
||
<td headers="view-field-foa-posted-date-table-column" class="views-field views-field-field-foa-posted-date is-active">Wed, 08/03/2022 </td>
|
||
|
||
</tr> <!-- closing head of time -->
|
||
|
||
<tr id="summary5" class="summary collapse odd noSummary">
|
||
<td colspan="6">
|
||
<div class="offset-xl-1 offset-lg-1 offset-md-1 col-10 db-summary">
|
||
no summary
|
||
</div>
|
||
</td>
|
||
</tr> <!-- summary-->
|
||
|
||
|
||
|
||
<tr class="even">
|
||
|
||
<td headers="view-field-foa-number-table-column" class="views-field views-field-field-foa-number"><a href="https://grants.nih.gov/grants/guide/pa-files/PAS-22-206.html" target="_blank">PAS-22-206</a> </td>
|
||
|
||
<td headers="view-field-foa-title-table-column" class="views-field views-field-field-foa-title">HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required) </td>
|
||
|
||
<td headers="view-field-research-focus-area-table-column" class="views-field views-field-field-research-focus-area"><a href="/research/training-next-generation-researchers" hreflang="en">Training the Next Generation of Researchers in HEAL</a> </td>
|
||
|
||
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