2 lines
No EOL
1.4 KiB
Text
2 lines
No EOL
1.4 KiB
Text
"Project #","Project Title","Research Focus Area","Research Program","Administering IC(s)",Institution(s),Investigator(s),Location(s),"Year Awarded",Summary
|
|
1R61NS113316-01,"Discovery and analytical validation of Inflammatory bio-signatures of the human pain experience","Preclinical and Translational Research in Pain Management","Discovery and Validation of Biomarkers, Endpoints, and Signatures for Pain Conditions",NINDS,"THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON","PROSSIN, ALAN RODNEY","Houston, TX",2019,"Postoperative pain is a major contributor to the current opioid epidemic. Novel objective measures capable of personalizing pain care will enhance medical precision in prevention and treatment of postoperative pain. This project seeks to discover and validate a novel biosignature of the human pain experience, based on underlying IL-1 family cytokine activity and associated brain endogenous opioid function, that is readily quantifiable and clinically translatable to prevention and treatment of postoperative pain states. Specific aims will assess whether the novel biosignature will predict 1) experimentally induced pain during an experimental nociceptive pain challenge; 2) postoperative pain states with accuracy >75%, accounting for a wide range of variance in the human pain experience; and 3) postoperative pain states in an expanded clinically enriched sample." |