nih-gov/heal.nih.gov/events/3rd-HEAL-Investigator-Meeting
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<h1> Third Annual NIH HEAL Initiative Investigator Meeting </h1>
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Mon, 4/11/2022 - 10:00am
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Tue, 4/12/2022 - 4:30pm
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<p><strong>Past event.</strong> This event already took place. Visit <a href="https://heal.nih.gov/news/events">this webpage</a> for upcoming events.</p>
<h2>Overview</h2>
<p>The NIH HEAL Initiative® convened the third annual meeting of more than 400 NIH HEAL Initiative awardees, federal officials, people with lived experience, and other stakeholders to share research findings, explore trends and shared interests, and identify opportunities to advance the goals of the initiative.</p>
<p>This meeting brought together researchers from around the country who are taking on the pain and opioid crises from all angles. These researchers study <a href="https://heal.nih.gov/research">a broad range of topics</a>, such as innovative technology-based therapies for pain management; community-based integrated solutions for prevention, overdose, and medication-based treatment for opioid use disorder; and a variety of new approaches for managing pain.</p>
<h3>Topics Covered</h3>
<ul>
<li>The evolution of the opioid crisis.</li>
<li>Inclusion of communities and people with lived experience in all stages of research.</li>
<li>The intersection of pain and opioid use disorder.</li>
<li>Development of novel and personalized treatment approaches.</li>
<li>The translation of research to practice, including prevention.</li>
<li>Ways to facilitate data sharing and opportunities for new discovery through collaboration.</li>
<li>Addressing the opioid crisis from many angles with federal partners.</li>
</ul>
<h3>Key Takeaways</h3>
<ul>
<li>The pain and opioid use disorder research communities must work together to address shared risk factors and experiences, identify common intervention targets, and integrate treatment.</li>
<li>To enhance study recruitment as well as treatment accessibility and acceptance, community engagement is essential, as is building trust between researchers and the community using targeted approaches.</li>
<li>More efforts are necessary to reduce stigma associated with pain, opioid use disorder, and medications for opioid use disorder at multiple levels, especially among healthcare providers.</li>
<li>HEAL research needs to address changing substance use patterns, including polysubstance use and increased presence of fentanyl in other drugs, as well as changes in populations at risk.</li>
<li>Better data collection and enhanced data sharing are essential to promote new knowledge and inform responses to the pain and opioid crises.</li>
<li>Multi-tiered approaches are necessary to address all aspects of the opioid crisis, including improved pain management, prevention of opioid use disorder and overdose, treatment of opioid use disorder and overdose, recovery support, and disruption of drug supplies.</li>
</ul>
<p><a href="/files/2022-05/HEAL-Investigator-Meeting-Summary-2022.pdf">View the Meeting Summary</a>&nbsp;<span class="link-label label-file label-file-pdf" aria-label="File Type and Size">pdf&nbsp;&nbsp;450.29&nbsp;KB</span>.</p>
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<p><em>Presentation slides are available upon request. Please email <a href="/cdn-cgi/l/email-protection#1c3c54595d5075726a796f68757b7d68736e7179796875727b5c756d6f737069687573726f327f7371"><span class="__cf_email__" data-cfemail="f1b9b4b0bd989f87948285989690859e839c949485989f96b19880829e9d8485989e9f82df929e9c">[email&#160;protected]</span></a>.</em></p>
<p><strong>Day 1 (Monday, April 11, 2022)</strong></p>
<p><strong>10:00 10:30 a.m. </strong><br />
<em>Welcome and Introduction </em><br />
Dr. Rebecca Baker, Director, Helping to End Addiction Long-term® Initiative, or NIH HEAL Initiative®<br />
Dr. Lawrence Tabak, Acting Director, National Institutes of Health (NIH)<br />
<br />
<em>Keynote Address: What Are We Doing, and What Can We Do Better, to End the Overdose Epidemic?</em><br />
Admiral Rachel L. Levine, M.D., Assistant Secretary for Health, U.S. Department of Health and Human Services</p>
<p><strong>10:30 10:45 a.m.</strong><br />
<em>Helping to End Addiction Long-term Initiative: Progress and Priorities</em><br />
Dr. Rebecca Baker, Director, NIH HEAL Initiative</p>
<p><strong>10:45 11:25 a.m.</strong><br />
<em>Dialogue: NINDS and NICHD Directors in Conversation With the HEAL Community Partner Committee</em><br />
NIH Facilitator: Dr. Rebecca Baker, Director, NIH HEAL Initiative<br />
<br />
NIH Discussants: Dr. Walter Koroshetz, Director, National Institute of Neurological Disorders and Stroke (NINDS)<br />
Dr. Diana Bianchi, <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development (NICHD)<br />
<br />
HEAL Community Partner Committee (HCPC) Discussants:<br />
Kevin Charles, Family and Medical Counseling, Inc.<br />
Jessica Hulsey Nickel, Addiction Policy Forum<br />
Bianca Prieto, Georgia Council on Substance Abuse<br />
Philip Rutherford, Faces &amp; Voices of Recovery<br />
Stephanie Smith, Former HEAL Knee Osteoarthritis Study Participant<br />
Christin Veasley, Chronic Pain Research Alliance</p>
<p><strong>11:35 a.m. 12:30 p.m.</strong></p>
<p><em>Plenary: At the Intersection of Pain and Opioid Use Disorder—Bringing the Research Communities Together</em><br />
NIH Facilitators: Dr. Walter Koroshetz, Director, NINDS; and Dr. Nora Volkow, Director, National Institute on Drug Abuse (NIDA)<br />
HEAL Investigator Facilitator:<br />
<em>Assessing and Addressing the Clinical Needs of Patients with Chronic Pain and Opioid Use Disorder</em><br />
Dr. Declan Barry, Yale School of Medicine</p>
<p>Presentations:<br />
<em>Integrated Approach to Pain and Opioid Use in Hemodialysis Patients</em><br />
Dr. Manisha Jhamb, University of Pittsburgh<br />
<a href="/files/2022-08/plen-at-the-intersection-of-pain-and-opioid-use-disorder-katie-witkiewitz.pdf"><em>Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR)</em></a><br />
Dr. Katie Witkiewitz, University of New Mexico</p>
<p><strong>12:30 1:10 p.m.</strong><br />
<em>Fireside Chat: Addressing the Overdose Epidemic From Many Angles</em><br />
Dr. Rahul Gupta, Director, White House Office of National Drug Control Policy and Dr. Lawrence Tabak, Acting Director, NIH</p>
<p><strong>2:00 3:00 p.m.</strong><br />
Discussion Groups</p>
<p><em>1. Lessons From HEAL Stigma </em>Research<br />
NIH Facilitator: Dr. Wendy Weber, National Center for Complementary and Integrative Health<br />
(NCCIH)<br />
HEAL Investigator<em>&nbsp;</em>Facilitator: Dr. Gavin Bart, University of Minnesota<br />
HCPC Discussant: Stephanie Smith</p>
<p>Presentations:<br />
<em>Behavioral Economics-Based Stigma Reduction Intervention for Low Income, African American Individuals With Opioid Use Disorder</em><br />
Dr. Karen Derefinko, University of Tennessee<br />
<em>Examining the Effect of&nbsp;Intersectional Stigma on the&nbsp;Treatment of Negative Affect in&nbsp;Chronic Low Back Pain</em><br />
Rising Star: Dr. Samantha Meints, Brigham and Womens Hospital</p>
<p><em>2. Expanding Patient and Community Engagement in HEAL Studies</em><br />
NIH Facilitator: Dr. Linda Porter, NINDS<br />
HEAL Investigator Facilitator: Dr. Megan Irby, Wake Forest School of Medicine</p>
<p>HCPC Discussant: Christin Veasley, Chronic Pain Research Alliance</p>
<p>Presentations:<br />
<a href="/files/2022-08/dg-expanding-patient-and-community-engagement-in-heal-studies-afton-hassett.pdf"><em>Developing a Community-Engaged Research Unit</em></a><br />
Dr. Afton Hassett, University of Michigan<br />
<a href="/files/2022-08/dg-expanding-patient-and-community-engagement-in-heal-studies-cynthia-rogers.pdf"><em>HEALthy Brain and Child Development Study</em></a><br />
Dr. Cynthia Rogers, Washington University, St. Louis, Missouri</p>
<p><em>3. Addressing the Unique Needs of Pediatric Populations</em><br />
NIH Facilitator: Dr. Janani Prabhakar, NIDA<br />
HEAL Investigator Facilitator: Dr. Alice Graham, Oregon Health and Science University</p>
<p>Presentations:<br />
<em>Pediatric Pain and Opioid Prescribing: Disparities, Trends, &amp; Health Literacy</em><br />
Dr. Deena Chisolm, Nationwide Childrens Hospital, Columbus, Ohio<br />
<em>Data Collection With Pregnant People, Infants, and Young Children</em><br />
Rising Star: Dr. Kathryn Humphreys, Vanderbilt University</p>
<p><em>4. Advances in Digital Therapeutics and Other Technologies</em><br />
NIH Facilitator: Dr. Will Aklin, NIDA<br />
HEAL Investigator Facilitator: Dr. Suzette Glasner, University of California, Los Angeles</p>
<p>Presentations:<br />
<em>Treating Sickle Cell Pain by Means of Transcranial Focused Ultrasound Neuromodulation</em><br />
Dr. Bin He, Carnegie-Mellon University<br />
<em>A Prescription Digital Therapeutic to Promote Adherence to Buprenorphine Pharmacotherapy for Patients With Opioid Use Disorder</em><br />
Dr. Hilary Luderer, Pear Therapeutics, Inc.</p>
<p><em>5. Improving Access to Medications for Opioid Use Disorder</em><br />
NIH Facilitator: Dr. Kristen Huntley, NIDA<br />
HEAL Investigator Facilitator: Dr. Edward Nunes, Columbia University</p>
<p>HCPC Discussants: Jessica Hulsey Nickel, Addiction Policy Forum, and Philip Rutherford, Faces &amp; Voices of Recovery</p>
<p>Presentations:<br />
<em>ED-Initiated Buprenorphine for Opioid Use Disorder</em><br />
Dr. Gail DOnofrio, Yale School of Medicine<br />
<a href="/files/2022-08/dg-improving-access-to-medications-for-opioid-use-disorder-benjaminlinas.pdf"><em>What Models Can Tell Us About Ending the Opioid Crisis</em></a><br />
Dr. Benjamin Linas, Boston Medical Center<br />
<a href="https://www.youtube.com/watch?v=nlg4FDb8O2c">Watch Dr. Linas' presentation</a></p>
<p><strong>3:00 4:00 p.m. (CLOSED TO PUBLIC)</strong><br />
Poster Session and Networking</p>
<p><strong>4:00 5:00 p.m.</strong><br />
<em>Scientific Symposium: Advancing Research to Practice</em><br />
NIH Facilitator: Dr. Helene Langevin, Director, National Center for Complementary and Integrative Health<br />
HEAL Investigator Facilitator: Dr. Donald Penzien, Wake Forest School of Medicine</p>
<p>Presentations:<br />
<em>Recidivism and mortality after in-jail buprenorphine treatment for opioid use disorder</em><br />
Dr. Elizabeth Evans, University of Massachusetts Amherst<br />
<a href="/files/2022-08/ss-advancing-research-to-practice-craig-lefebvre.pdf"><em>HCS Community Health Campaigns Shifting from Engagement to Action</em></a><br />
Dr. Craig Lefebvre, RTI International<br />
<em>NOHARM: Non-pharmacological Options in post-operative Hospital-based And Rehabilitation pain Management pragmatic trial</em><br />
Dr. Andrea Cheville, Mayo Clinic Rochester<br />
<em>JCOIN PIERS: Providing Interventions for Enhancing Recovery during Supervision</em><br />
Rising Star: Dr. Lauren Brinkley-Rubinstein, University of North Carolina at Chapel Hill</p>
<p><strong>5:00 5:45 p.m.</strong><br />
NIDA Director, Dr. Nora Volkow in Conversation With Maia Szalavitz, Journalist and Author of <em>Undoing Drugs: The Untold Story of Harm Reduction and the Future of Addiction</em>, and the <em>New York Times</em> Bestseller, <em>Unbroken Brain</em>.</p>
<p><strong>5:45 p.m.</strong><br />
Adjourn</p>
<h3>Day 2 (Tuesday, April 12, 2022)</h3>
<p><strong>10:00 10:10 a.m. </strong><br />
<em>Welcome</em><br />
Dr. Rebecca Baker, Director, NIH HEAL Initiative®<br />
<br />
<em>The Opioid Crisis: Scientific Challenges and Opportunities</em><br />
Dr. Nora Volkow, Director, NIDA</p>
<p><strong>10:10 11:10 a.m.</strong><br />
<em>Scientific Symposium: Advancing the Pain and Addiction Therapeutic Research Pipeline</em><br />
NIH Facilitator: Dr. Joni Rutter, Director, National Center for Advancing Translational Sciences<br />
HEAL Investigator Facilitator: Dr. Sandra Comer, Columbia University</p>
<p>Presentations:<br />
<em>REINVENT MEDICINE FOR A HEALTHIER WORLD: Weekly Oral Levomethadone</em><br />
Dr. Richard Scranton, Lyndra Therapeutics<br />
<em>FKBP51 as a promising therapeutic target for the prevention of chronic posttraumatic pain</em><br />
Dr. Sarah Linnstaedt, University of North Carolina at Chapel Hill<br />
<em>Multi-organ-on-chip Device for Modeling Opioid Reinforcement and Withdrawal, and the Negative Affective Component of Pain: a Therapeutic Screening Tool</em><br />
Dr. Stephanie Seidlits, University of California, Los Angeles<br />
Rising Star: Dr. Amol Patwardhan, University of Arizona</p>
<p><strong>11:10 a.m. 12:10 p.m.</strong><br />
<em>Plenary: Better Together—Collective HEALing Through Data Sharing</em><br />
NIH Facilitator: Dr. Jessica Mazerik, NIH HEAL Initiative<br />
RENCI Facilitator: Dr. Kira Bradford, Renaissance Computing Institute (RENCI), University of North Carolina at Chapel Hill</p>
<p>Presentations:<br />
<em>The case for collaborative, large scale studies and aggressive data sharing policies:&nbsp; The ABCD Study Data Sharing Model</em><br />
Dr. Terry Jernigan, University of California San Diego<br />
<a href="/files/2022-08/plen-better-together-collective-healing-through-data-sharing-ty-ridenour.pdf"><em>Data Harmonization of HEAL Prevention Outcomes Studies</em></a><br />
Dr. Ty Ridenour, RTI International, University of North Carolina at Chapel Hill<br />
<em>HEAL Pain Common Data Elements (CDE) Program</em><br />
Dr. Laura Wandner, NINDS<br />
<a href="/files/2022-08/plen_better-together-collective-healing-through-data-sharing-robert-grossman-phil-schumm.pdf"><em>HEAL Data Platform</em></a><br />
Dr. Robert Grossman and Dr. Phil Schumm, University of Chicago<br />
<em>HEAL Study-level Core Metadata</em><br />
Dr. Andrea Tentner, University of Chicago</p>
<p><strong>1:10 2:10 p.m.&nbsp;</strong><br />
Discussion Groups</p>
<p><em>1. Building the Translational Research Pipeline: Pain Pathways and Biology</em><br />
NIH Facilitator: Dr. Michael Oshinsky, NINDS<br />
HEAL Investigator Facilitator: Dr. Miriam Goodman, Stanford University</p>
<p>Presentations:<br />
<em>Building the Translational Research Pipeline: Implantable Devices for Pain</em><br />
Dr. Kip Ludwig, University of Wisconsin-Madison<br />
<em>Discovery and Validation of a Novel Target for Safe and Effective Treatment of Pain</em><br />
Dr. Fan Wang, Massachusetts Institute of Technology</p>
<p><em>2. Better Together: Collaborations in AI and HEAL Data</em><br />
NIH Facilitator: Dr. Jessica Mazerik,<br />
NIH HEAL Initiative HEAL Data Stewards Facilitators: Dr. Kira Bradford and Chelsea Noyes, RENCI/RTI</p>
<p>Presenters:<br />
Dr. Chris Bizon, RENCI<br />
Dr. Matthew Might, Harvard Medical School</p>
<p><em>3. Making Treatments More Specific and Effective Through Phenotyping and Biomarkers</em><br />
NIH Facilitator: Aron Marquitz, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)<br />
HEAL Investigator Facilitator: Dr. William Marras, The Ohio State University</p>
<p>HCPC Discussant: Christin Veasley, Chronic Pain Research Alliance</p>
<p>Presentations:<br />
<em>Discovery and Analytical Validation of Inflammatory Biosignatures of the Human Pain Experience</em><br />
Dr. Alan Prossin, University of Texas Health Science Center at Houston<br />
<em>Discovery and Validation of Prognostic and Robust Biosignatures to Predict Recovery or Persistence in Pediatric Pain</em><br />
Dr. Laura Simons, Stanford University</p>
<p><em>4. Helping Individuals With Polysubstance Use and Fentanyl Use: Challenges and Promising Approaches</em><br />
NIH Facilitator: Dr. Geetha Subramaniam, NIDA<br />
HEAL Investigator Facilitator: Dr. David Fiellin, Yale University</p>
<p>HCPC Discussant: Kayla Zawislak, Addiction Policy Forum</p>
<p>Presentations:<br />
<em>Steps Toward Identifying and Addressing Unhealthy Polysubstance Use in Medical Settings</em><br />
Dr. Jennifer McNeely, NYU Langone Health<br />
<em>Helping Individuals With Polysubstance Use and Fentanyl Use: Perspectives From the Emergency Department</em><br />
Rising Star: Dr. Kathryn Hawk, Yale School of Medicine</p>
<p><em>5. Disparities and Social Determinants of Health</em><br />
NIH Facilitator: Dr. Aria Crump, NIDA, and Dr. Cheryse Sankar, NINDS<br />
PI Facilitator: Dr. Daniel Dickerson, RAND</p>
<p>HCPC Discussants: Stephanie Smith and Philip Rutherford, Faces &amp; Voices of Recovery</p>
<p>Presentations:<br />
<em>Disparities and SDOH Among Youth Experiencing Homelessness at Risk for Opioid Use Disorder</em><br />
Dr. Natasha Slesnick, The Ohio State University<br />
<em>Prospective Observational Study of Postsurgical Pain in Women Undergoing Mastectomy: Postsurgical Pain After Mastectomy (PPAM Study)</em><br />
Rising Star: Dr. Uchenna Umeh, New York University School of Medicine</p>
<p><strong>2:10 3:10 p.m. (CLOSED TO PUBLIC)</strong><br />
Poster Session and Networking</p>
<p><strong>3:10 4:00 p.m. </strong><br />
<em>Federal Panel: How Can Science Inform the Federal Response to the Opioid Crisis?</em><br />
NIH Facilitator: Dr. Lawrence Tabak, Acting Director, NIH</p>
<p>Speakers:<br />
Dr. Robert Califf, Commissioner, U.S. Food and Drug Administration<br />
Dr. Debra Houry, Acting Principal Deputy Director, Centers for Disease Control and Prevention<br />
Dr. Miriam Delphin-Rittmon, Assistant Secretary for Mental Health and Substance Use, Substance Abuse and Mental Health Services Administration</p>
<p><strong>4:00 4:30 p.m.</strong><br />
<em>Observations and Future Directions for HEAL</em><br />
Dr. Rebecca Baker, Director, NIH HEAL Initiative and Dr. Lawrence Tabak, Acting Director, NIH</p>
<p><strong>4:30 p.m.</strong><br />
Adjourn</p>
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<p><strong>Monday, April 11</strong></p>
<p>Morning Session (10:00 a.m. 1:10 p.m.): <a href="https://videocast.nih.gov/watch=45134">https://videocast.nih.gov/watch=45134</a></p>
<p>Afternoon Session (4:00 5:45 p.m.): <a href="https://videocast.nih.gov/watch=45136">https://videocast.nih.gov/watch=45136</a></p>
<p>&nbsp;</p>
<p><strong>Tuesday, April 12</strong></p>
<p>Morning Session (10:00 a.m. 12:10 p.m.): <a href="https://videocast.nih.gov/watch=45138">https://videocast.nih.gov/watch=45138</a></p>
<p>Afternoon Session (3:10 4:30 p.m.): <a href="https://videocast.nih.gov/watch=45140">https://videocast.nih.gov/watch=45140</a></p>
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