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<h1 style="text-align: center">NLM DIR Seminar Schedule</h1>
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<h4>UPCOMING SEMINARS</h4>
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<li>
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<a href="/seminar/5213/detail/">March 11, 2025 <b>Sofya Garushyants</b></a><br>Tmn – bacterial anti-phage defense system
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</li>
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<li>
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<a href="/seminar/5214/detail/">March 18, 2025 <b>MG Hirsch</b></a><br>TBD
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</li>
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<li>
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<a href="/seminar/5215/detail/">March 25, 2025 <b>Yifan Yang</b></a><br>TBD
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</li>
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<li>
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<a href="/seminar/5216/detail/">April 1, 2025 <b>Roman Kogay</b></a><br>TBD
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</li>
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<li>
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<a href="/seminar/5217/detail/">April 8, 2025 <b>Jaya Srivastava</b></a><br>TBD
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<h4>RECENT SEMINARS</h4>
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<!-- change object_list to recent_sem -->
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<a href="/seminar/5212/detail/">March 4, 2025 <b>Sanasar Babajanyan</b></a><br>Evolution of antivirus defense in prokaryotes depending on the environmental virus load
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<!-- change object_list to recent_sem -->
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<li>
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<a href="/seminar/5211/detail/">Feb. 25, 2025 <b>Zhizheng Wang</b></a><br>GeneAgent: Self-verification Language Agent for Gene Set Analysis using Domain Databases
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<!-- change object_list to recent_sem -->
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<li>
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<a href="/seminar/5210/detail/">Feb. 18, 2025 <b>Samuel Lee</b></a><br>Efficient predictions of alternative protein conformations by AlphaFold2-based sequence association
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<!-- change object_list to recent_sem -->
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<li>
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<a href="/seminar/5209/detail/">Feb. 11, 2025 <b>Po-Ting Lai</b></a><br>Enhancing Biomedical Relation Extraction with Directionality
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<!-- change object_list to recent_sem -->
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<li>
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<a href="/seminar/5208/detail/">Feb. 4, 2025 <b>Victor Tobiasson</b></a><br>On the dominance of Asgard contributions to Eukaryogenesis
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</li>
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<h2>Scheduled Seminars on Feb. 9, 2023</h2>
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<div class="tablet:grid-col-4"> Speaker</div>
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<div class="tablet:grid-col-8"><strong>Iris Zhu</strong></div>
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<div class="tablet:grid-col-4"> Time</div>
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<div class="tablet:grid-col-8"><strong>3 p.m.</strong></div>
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<div class="tablet:grid-col-4"> Presentation Title</div>
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<div class="tablet:grid-col-8"><strong> An alternative interpretation of gene regulatory loops and chromatin folding </strong></div>
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<div class="tablet:grid-col-4"> Location</div>
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<div class="tablet:grid-col-8"><strong> Virtual - see link below </strong></div>
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</div>
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<div class="grid-row">
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<p class="padding-left-2">Contact <a href="mailto:NLMDIRSeminarScheduling@mail.nih.gov">NLMDIRSeminarScheduling@mail.nih.gov</a>
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with questions about this seminar.</p>
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<div class="grid-col padding-x-2 padding-bottom-2" id="textalign">
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<h4> Abstract: </h4>
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<p><p>Millions of enhancers have been predicted in the human and mouse genomes based on enhancer-like signatures or massively parallel report assays (MPRAs). The number of experimentally validated in vivo enhancer-promoter pairs is, however, only in the dozens. How exactly tens of thousands of enhancers and active promoters in a cell organize into transcription regulatory loops remains unclear.<br>Using TF enrichment as an indicator of enhancer strength, we identified a portion of H3K27ac peaks as potentially strong enhancers and found a universal pattern of promoter and enhancer distribution that would not show if all the H3K27ac peaks are counted as enhancers: At actively transcribed regions of length of ~200-300kb, the numbers of active promoters and enhancers are inversely related. Super enhancers or enhancer clusters are associated with isolated active promoters, regardless of the gene’s cell-type specificity. As the number of nearby active promoters increases, the number of enhancers decreases. At regions where multiple active genes are closely located, there are few distant enhancers. With Hi-C analysis, we demonstrate that the interactions among the regulatory elements occur predominantly in clusters and multiway among linearly close elements . We propose a simple model of spatial organization of active promoters and enhancers: Gene transcriptions and regulations mainly occur at local active transcription hubs contributed dynamically by multiple elements from linearly close enhancers and/or active promoters. The model can be represented with a flower-shaped structure. Furthermore, local transcription hubs from distant parts of a chromosome can get into contact and form larger hubs, reflected as nodes in hierarchical TAD structures in Hi-C contact maps.</p></p>
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<h4>ARCHIVES</h4>
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<div class="grid-col padding-right-3">
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<ul class="font-sans-3xs sem-list">
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<li><a href="/archive_seminars/2024/"><b>2024</b> Seminars</a></li>
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<li><a href="/archive_seminars/2023/"><b>2023</b> Seminars</a></li>
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<li><a href="/archive_seminars/2022/"><b>2022</b> Seminars</a></li>
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<li><a href="/archive_seminars/2021/"><b>2021</b> Seminars</a></li>
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<li><a href="/archive_seminars/2020/"><b>2020</b> Seminars</a></li>
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||
<li><a href="/archive_seminars/2019/"><b>2019</b> Seminars</a></li>
|
||
<li><a href="/archive_seminars/2018/"><b>2018</b> Seminars</a></li>
|
||
<li><a href="/archive_seminars/2017/"><b>2017</b> Seminars</a></li>
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<li><a href="/archive_seminars/2016/"><b>2016</b> Seminars</a></li>
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<li><a href="/archive_seminars/2015/"><b>2015</b> Seminars</a></li>
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<li><a href="/archive_seminars/2014/"><b>2014</b> Seminars</a></li>
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<li><a href="/archive_seminars/2013/"><b>2013</b> Seminars</a></li>
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<li><a href="/archive_seminars/2012/"><b>2012</b> Seminars</a></li>
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<li><a href="/archive_seminars/2011/"><b>2011</b> Seminars</a></li>
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<li><a href="/archive_seminars/2010/"><b>2010</b> Seminars</a></li>
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<li><a href="/archive_seminars/2009/"><b>2009</b> Seminars</a></li>
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</ul>
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