1481 lines
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<h2><strong>Key Points</strong></h2>
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<li><span><span><span><span>Health care providers hope to use polygenic risk scores to help determine if you are at risk for a health condition that can be difficult to predict.</span></span></span></span></li>
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<li><span><span><span><span>Currently, most polygenic risk scores are more accurate for people of European ancestry than for people from other backgrounds.</span></span></span></span></li>
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<li><span><span><span>Researchers applied <em>All of Us</em> data to adjust polygenic risk scores for 10 common conditions so that the scores are more accurate for individuals from many ancestries.</span></span></span></li>
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<p><span><span><span>Researchers are developing a tool that could use a person’s DNA to determine their genetic risk for complex health conditions.</span></span></span></p>
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<p><span><span><span>This tool is called the </span><a href="https://www.genome.gov/Health/Genomics-and-Medicine/Polygenic-risk-scores"><span><span>polygenic risk score</span></span></a><span>. <em>Poly-</em> means “many,” and <em>-genic</em> means “involving genes.” <strong>Polygenic risk scores are measures of how likely you are to get particular conditions—your risk—based on changes in multiple genes in your DNA.</strong></span></span></span></p>
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<p><span><span><span>So far, these scores are better at estimating risk for people of European ancestry than for people from other backgrounds. <strong>But researchers were able to use the diverse genetic data in <em>All of Us </em>to adjust the scores for 10 health conditions so that they are accurate for people of different ancestries.</strong> This study was published in </span><a href="https://www.nature.com/articles/s41591-024-02796-z"><em><span><span>Nature Medicine</span></span></em></a><span>.</span></span></span></p>
|
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<h2><span><span><span>Importance of Polygenic Risk Scores</span></span></span></h2>
|
||
<p><span><span><span>The </span><a href="https://medlineplus.gov/genetics/understanding/mutationsanddisorders/mutationscausedisease/"><span><span>genetic cause</span></span></a><span> of some conditions is fairly straightforward: They are closely linked to changes (or variants) in a particular gene. For example, <em>CFTR </em>gene variants are the main cause of </span><a href="https://medlineplus.gov/cysticfibrosis.html"><span><span>cystic fibrosis</span></span></a><span>. Health care providers can often use genetic tests to learn whether someone has these kinds of conditions.</span></span></span></p>
|
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<p><span><span><span>But common and complex conditions, such as </span><a href="https://medlineplus.gov/diabetestype2.html"><span><span>type 2 diabetes</span></span></a><span>, are shaped by a combination of factors. These include social and environmental factors as well as changes that affect hundreds or thousands of genes. These complex conditions are much harder to predict. Polygenic risk scores can uncover the genetic piece of a person’s risk for these kinds of conditions.</span></span></span></p>
|
||
<p><span><span><span>Finding out early about your risk for a health condition lets you take action to manage or prevent it before it becomes a serious problem.</span></span></span></p>
|
||
<h2><span><span><span><span><span><span><span>Adjusting Risk Scores</span></span></span></span></span></span></span></h2>
|
||
<p><span><span><span>To calculate polygenic risk scores, researchers compare the DNA of many people—some with the condition, and some without it. At first, most DNA data used for these calculations was from people of European ancestry, so the scores were most useful for people with that background.</span></span></span></p>
|
||
<p><span><span><span>But researchers want to make sure that scores will be accurate for people of any genetic ancestry. In this study, they started with the risk scores for 10 complex conditions:</span></span></span></p>
|
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<ul>
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<li><span><span><span>Asthma</span></span></span></li>
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<p><span><span><span><span>Looking at <strong>DNA and health information shared by more than 13,000 <em>All of Us</em> participants, </strong>the researchers adjusted the polygenic risk scores so that they </span></span><span>accurately estimate risk<span> in people from many ancestry groups.</span></span></span></span></p>
|
||
<h2><span><span><span><span><span><span><span>Bringing Polygenic Risk Scores to Health Care</span></span></span></span></span></span></span></h2>
|
||
<p><span><span><span>The researchers in this study also developed and tested a process to share polygenic risk scores with patients. While these scores are not yet used in doctors’ offices, <strong>this work helps move health care closer to using accurate polygenic risk scores in the future.</strong></span></span></span></p>
|
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<p><span><span><span>As <em>All of Us</em> and other datasets continue to grow, researchers will be able to adjust polygenic risk scores for more health conditions. With more diverse genetic data, these scores will become more accurate for any patient, no matter their ancestry. <strong>Polygenic risk scores that work for individuals from diverse backgrounds can help reduce health differences across populations. Such scores mean everyone has access to accurate information about their health.</strong></span></span></span></p>
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