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<time class="article-date es-date">8 October 2024</time>
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<h1 class="page-title">Lo que All of Us muestra sobre el colesterol y el riesgo de desarrollar cáncer de seno</h1>
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<img src="/sites/default/files/24-0461%20AoU%20Research%20Highlight%20Graphics%20October%202024.dev13_highlightSP_1980x855px%20copy%203.png" width="1980" height="855" alt="Una ilustración muestra a una profesional de la salud hablando con una paciente sobre el colesterol malo (o LDL) y el bueno (o HDL). Le muestra una pantalla que contiene un dibujo de componentes de la sangre bajo el microscopio, junto a un tubo de recolección de sangre, bajo la etiqueta “Colesterol en la sangre”. Un texto dice “Medir el colesterol para entender el riesgo de desarrollar cáncer de seno puede ser complicado”. El logo del Programa Científico All of Us está en la esquina inferior derecha. " loading="lazy" typeof="foaf:Image" class="img-fluid" />
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<h2>Puntos clave</h2>
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<li><span><span><span><span lang="es-419"><span>Los investigadores analizaron la información de <em>All of Us</em> para entender mejor el vínculo entre el colesterol y el riesgo de desarrollar cáncer de seno.</span></span></span></span></span></li>
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<li><span><span><span><span lang="es-419"><span>Los altos niveles del colesterol LDL (llamado colesterol “malo”) y el alto colesterol total se relacionaron con un riesgo más alto de desarrollar cáncer de seno.</span></span></span></span></span></li>
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<li><span lang="es-419"><span><span><span>La relación entre los bajos niveles del colesterol HDL (o colesterol “bueno”) y el riesgo de desarrollar cáncer de seno dependió de la edad.</span></span></span></span></li>
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<h2>En pocas palabras</h2>
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<p>Un alto <a href="https://www.nhlbi.nih.gov/es/salud/colesterol-en-sangre">colesterol</a> puede incrementar el riesgo de una persona de tener un ataque cardíaco o un derrame cerebral. Pero, ¿afecta esto el riesgo de una persona de desarrollar otros problemas de salud, como el <a href="https://www.cancer.gov/espanol/tipos/seno">cáncer de seno</a> (cáncer de mama)? Los estudios previos no han proporcionado claridad sobre esto. Los investigadores científicos acudieron a la información de All of Us para aclarar esta confusión.</p>
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<p>La información de All of Us permitió a los investigadores científicos estudiar las mediciones individuales de colesterol y otros factores. Esto les ayudó a obtener una perspectiva más completa del vínculo entre los niveles de colesterol y el riesgo de desarrollar cáncer de seno. <strong>Aprendieron que tener un nivel demasiado alto de un tipo de colesterol está relacionado con un riesgo más elevado de desarrollar cáncer de seno</strong>. La edad juega un papel en la forma en que otro tipo de colesterol afecta el riesgo de desarrollar cáncer de seno. Estos resultados fueron publicados en la revista <em><a href="https://doi.org/10.1177%2F11769351221144132">Cancer Informatics</a></em> (en inglés).</p>
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<h2>Lo bueno y lo malo</h2>
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<p>El colesterol es una sustancia similar a la grasa, presente en su sangre. Hay dos tipos:</p>
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<p>● <strong>Lipoproteína de baja densidad (LDL, por sus siglas en inglés)</strong>: la LDL es conocida como el colesterol “malo” porque una cantidad demasiado alta no es buena para el corazón.</p>
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<p>● <strong>Lipoproteína de alta densidad (HDL, por sus siglas en inglés)</strong>: la HDL es conocida como el colesterol “bueno” porque los niveles altos son buenos para el corazón.</p>
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<p>Tanto la LDL como la HDL son a menudo medidas de manera conjunta, como niveles totales de colesterol. Pero pueden ser medidas y estudiadas por separado. Además, los investigadores a menudo estudian los niveles de triglicéridos junto al colesterol. Los altos niveles de estas grasas en nuestra sangre pueden ser perjudiciales para el corazón.</p>
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<p>La LDL, la HDL, el colesterol total y los triglicéridos podrían tener sus propios efectos en el riesgo de desarrollar cáncer de seno. Otros factores, como la edad, podrían también jugar un papel.</p>
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<h2>Los vínculos con el riesgo de desarrollar el cáncer de seno</h2>
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<p>En este estudio, los investigadores analizaron la información de All of Us, para considerar todos estos factores. Estudiaron información de los registros electrónicos de salud y las medidas físicas compartidas por más de 6,300 participantes mujeres con cáncer de seno.</p>
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<p>● En general, <strong>los niveles altos del colesterol malo (LDL) y los niveles totales altos de colesterol se relacionaron con un alto riesgo de desarrollar cáncer de seno</strong>.</p>
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<p>● El efecto de los niveles del colesterol bueno (HDL) en el riesgo de desarrollar cáncer de seno, dependió de la edad.<strong> Los participantes de 56 años de edad o más, con bajos niveles de colesterol bueno tuvieron un riesgo más alto de desarrollar cáncer de seno</strong>. Pero en las personas menores de 56 años, los niveles del colesterol bueno no afectaron el riesgo de desarrollar cáncer de seno.</p>
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<p>● Los niveles de triglicéridos no se vincularon al riesgo de desarrollar cáncer de seno.</p>
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<h2>Aclarando la confusión</h2>
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<p>Los investigadores observaron estas relaciones en participantes que no habían tomado <a href="https://medlineplus.gov/spanish/statins.html">estatinas</a>, un tipo de medicamento para el colesterol. Las estatinas ayudan a reducir el colesterol malo.</p>
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<p>Sin embargo, las relaciones no estaban tan claras entre los participantes que habían tomado estatinas. Eso podría ayudar a explicar por qué los estudios anteriores han tenido resultados contradictorios. El gran número de participantes de All of Us que compartieron su información de registros electrónicos de salud hizo posible que los investigadores pudieran separar a los dos grupos para descubrir los efectos del medicamento.</p>
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<p>Esta investigación ayuda a clarificar algo de la confusión sobre los niveles de colesterol y el riesgo de desarrollar cáncer de seno, aunque presenta ciertos límites. El estudio sólo incluyó a mujeres, ya que había muy pocas personas de otros géneros con cáncer de seno. No sabemos si los resultados de este estudio se aplican a las personas de todos los géneros.</p>
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<p>Este estudio no pudo analizar todos los factores que podrían influir en los niveles de colesterol o en el desarrollo del cáncer de seno. Comenzó por analizar la edad y el uso de estatinas. Pero ¿qué pasa si otros medicamentos, el trabajo o el entorno de una persona, también juegan un papel? Ahora que sabemos un poco más, los estudios futuros podrían analizar otros factores.</p>
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<p><strong>Este trabajo y futuros estudios son posibles gracias al tamaño y a la diversidad del conjunto de datos de All of Us. Con el tiempo, esta investigación podría ayudar a los proveedores de cuidado de salud a identificar mejor a las personas que tienen más probabilidad de desarrollar cáncer de seno</strong>. Entonces podrían tomar medidas para prevenir el cáncer de seno, realizarse pruebas de detección más tempranamente y obtener tratamiento más pronto.</p>
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