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Abnormal circulating organic compound concentration

MedGen UID:
1864085
•Concept ID:
C5936827
•
Finding
HPO: HP:0430071

Definition

Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating organic compound concentration

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus.
Pai VB, Sakadjian A, Puthoff TD
Pharmacotherapy 2008 Sep;28(9):1162-82. doi: 10.1592/phco.28.9.1162. PMID: 18752387
Diagnostic and therapeutic uses of inhaled nitric oxide in neonatal Ebstein's anomaly.
Atz AM, Munoz RA, Adatia I, Wessel DL
Am J Cardiol 2003 Apr 1;91(7):906-8. doi: 10.1016/s0002-9149(03)00036-5. PMID: 12667588

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Treatment of low-flow vascular malformations by ultrasound-guided sclerotherapy with polidocanol foam: 24 cases and literature review.
Blaise S, Charavin-Cocuzza M, Riom H, Brix M, Seinturier C, Diamand JM, Gachet G, Carpentier PH
Eur J Vasc Endovasc Surg 2011 Mar;41(3):412-7. Epub 2010 Dec 15 doi: 10.1016/j.ejvs.2010.10.009. PMID: 21111641
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Imaging and epilepsy.
Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380
Diabetes insipidus.
Blevins LS Jr, Wand GS
Crit Care Med 1992 Jan;20(1):69-79. doi: 10.1097/00003246-199201000-00019. PMID: 1729049
Lung serotonin metabolism.
Hart CM, Block ER
Clin Chest Med 1989 Mar;10(1):59-70. PMID: 2650964

Therapy

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910
Anabolic effects of fluoride on bone.
Pak CY, Zerwekh JE, Antich P
Trends Endocrinol Metab 1995 Sep;6(7):229-34. doi: 10.1016/1043-2760(95)00111-t. PMID: 11540313
Concise review: methemoglobinemia.
Mansouri A, Lurie AA
Am J Hematol 1993 Jan;42(1):7-12. doi: 10.1002/ajh.2830420104. PMID: 8416301
Brain edema.
Fishman RA
N Engl J Med 1975 Oct 2;293(14):706-11. doi: 10.1056/NEJM197510022931407. PMID: 1160939

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, Badesch DB, McGoon MD, McLaughlin VV, Roecker EB, Gerber MJ, Dufton C, Wiens BL, Rubin LJ; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group
Circulation 2008 Jun 10;117(23):3010-9. Epub 2008 May 27 doi: 10.1161/CIRCULATIONAHA.107.742510. PMID: 18506008
Effect of food fortification on folic acid intake in the United States.
Quinlivan EP, Gregory JF 3rd
Am J Clin Nutr 2003 Jan;77(1):221-5. doi: 10.1093/ajcn/77.1.221. PMID: 12499345
Lung serotonin metabolism.
Hart CM, Block ER
Clin Chest Med 1989 Mar;10(1):59-70. PMID: 2650964
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474

Clinical prediction guides

Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments.
Garcia-Beltran C, Peyrou M, Navarro-Gascon A, López-Bermejo A, de Zegher F, Villarroya F, Ibáñez L
Front Endocrinol (Lausanne) 2024;15:1325230. Epub 2024 May 16 doi: 10.3389/fendo.2024.1325230. PMID: 38818508Free PMC Article
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Treatment of low-flow vascular malformations by ultrasound-guided sclerotherapy with polidocanol foam: 24 cases and literature review.
Blaise S, Charavin-Cocuzza M, Riom H, Brix M, Seinturier C, Diamand JM, Gachet G, Carpentier PH
Eur J Vasc Endovasc Surg 2011 Mar;41(3):412-7. Epub 2010 Dec 15 doi: 10.1016/j.ejvs.2010.10.009. PMID: 21111641
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Galiè N, Olschewski H, Oudiz RJ, Torres F, Frost A, Ghofrani HA, Badesch DB, McGoon MD, McLaughlin VV, Roecker EB, Gerber MJ, Dufton C, Wiens BL, Rubin LJ; Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy Studies (ARIES) Group
Circulation 2008 Jun 10;117(23):3010-9. Epub 2008 May 27 doi: 10.1161/CIRCULATIONAHA.107.742510. PMID: 18506008

Recent systematic reviews

Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review.
McDonnell M, Sartain S, Westoby C, Katarachia V, Wootton SA, Cummings JRF
Nutrients 2023 Nov 14;15(22) doi: 10.3390/nu15224777. PMID: 38004171Free PMC Article
Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
Obeid R, Derbyshire E, Schön C
Adv Nutr 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. PMID: 36041182Free PMC Article
Alcohol use disorder and circulating cytokines: A systematic review and meta-analysis.
Adams C, Conigrave JH, Lewohl J, Haber P, Morley KC
Brain Behav Immun 2020 Oct;89:501-512. Epub 2020 Aug 14 doi: 10.1016/j.bbi.2020.08.002. PMID: 32805393
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis.
Murri M, Luque-Ramírez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
Hum Reprod Update 2013 May-Jun;19(3):268-88. Epub 2013 Jan 9 doi: 10.1093/humupd/dms059. PMID: 23303572

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