{"id":12380,"date":"2023-11-01T13:28:14","date_gmt":"2023-11-01T17:28:14","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=12380"},"modified":"2023-11-01T13:41:21","modified_gmt":"2023-11-01T17:41:21","slug":"ncbi-resources-genotype-based-medication-optimization","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/11\/01\/ncbi-resources-genotype-based-medication-optimization\/","title":{"rendered":"Using NCBI Resources for Genotype-Based Medication Optimization"},"content":{"rendered":"

NCBI offers a variety of clinical genetic resources to help you research, diagnose, and treat diseases and conditions. You can quickly and easily access our data and tools through the <\/span>Medical Genetics and Human Variation page<\/span><\/a> of the NCBI website.\u00a0<\/span>\u00a0<\/span><\/p>\n

How and why should you use our resources? Consider the example below.<\/h5>\n

Your patient is a 58-year-old woman who has been diagnosed with Acute Coronary Syndrome, scheduled for an angioplasty, and she will need to take clopidogrel for at least three months. She mentions that her father died of a stroke while taking the drug and is concerned. You look into pharmacogenetic influences on clopidogrel response and use the results of your patient\u2019s genetic test to determine if a change in the prescription is needed.\u00a0<\/span>\u00a0<\/span><\/p>\n

Use the following relevant NCBI resources to gather information useful for optimizing your patient\u2019s medication.\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\"book<\/td>\nLook up Clopidogrel Response in <\/span><\/span>MedGen<\/span><\/span><\/span><\/a> to learn more about the phenotype<\/span> and read about it<\/span> from <\/span>authoritative <\/span> pharmacogenetics<\/span>.<\/span> Find <\/span>therapeutic <\/span>recommendations based on <\/span>genotype from<\/span> the <\/span><\/span>Medical Genetics Summaries<\/span><\/span><\/a>.<\/span><\/span> Y<\/span>ou can also <\/span>read <\/span>a summary<\/span> of <\/span>the latest <\/span>published research<\/span>.<\/span><\/span><\/span><\/td>\n<\/tr>\n
\"test<\/span><\/td>\nFind a <\/span>clinical <\/span>test in the <\/span><\/span>NIH Genetic Testing Registry<\/span><\/span><\/span><\/a>.<\/span><\/span>\u00a0<\/span><\/span><\/td>\n<\/tr>\n
\"clipboard<\/span><\/td>\nSearch <\/span><\/span>ClinVar<\/span><\/span><\/a> with information from test results to learn about the patient\u2019s variant.<\/span><\/span><\/span><\/td>\n<\/tr>\n
\"Base<\/span><\/td>\nGo to the <\/span><\/span>dbSNP<\/span><\/span><\/a> record to find relevant population frequency data for the variant<\/span>.<\/span><\/span>\u00a0<\/span><\/span><\/td>\n<\/tr>\n
\"Drawing<\/span><\/td>\nLearn more about the variant and its impact on drug response in the NCBI Bookshelf\u2019s <\/span><\/span>Medical Genetics Summaries<\/span><\/span><\/a>.<\/span><\/span>\u00a0<\/span> <\/span><\/td>\n<\/tr>\n
\"drawing<\/span><\/td>\nFor follow-up, search <\/span><\/span>dbGaP<\/span><\/span><\/a> to find clinical studies examining the impact of genetics on clopidogrel response.<\/span><\/span>\u00a0<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Want to view the full case study? Check out our <\/span>video<\/span><\/a> or <\/span>handout<\/span><\/a>.<\/span>\u00a0<\/span><\/p>\n

Stay up to date<\/h5>\n

Follow us on social\u202f<\/span>@NCBI<\/span><\/a>\u202fand\u202f<\/span>join our mailing list<\/span><\/a>\u202fto keep up to date with\u202four clinical genetic resources\u202fand other NCBI news.\u202f\u202f<\/span>\u00a0<\/span><\/p>\n

Questions?<\/h5>\n

Please\u202f<\/span>reach out to us<\/span><\/a>\u202fif you have questions or would like to provide feedback.<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

NCBI offers a variety of clinical genetic resources to help you research, diagnose, and treat diseases and conditions. You can quickly and easily access our data and tools through the Medical Genetics and Human Variation page of the NCBI website.\u00a0\u00a0 How and why should you use our resources? Consider the example below. Your patient is … Continue reading Using NCBI Resources for Genotype-Based Medication Optimization<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":12398,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Using NCBI Resources for Genotype-Based Medication Optimization","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[108204782,14750092,36977864,31926433,651059074,5531713,10192294],"table_tags":[],"class_list":["post-12380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-clinvar","tag-dbgap","tag-genetic-testing-registry","tag-medgen","tag-medical-genetic-summaries","tag-medical-genetics","tag-dbsnp"],"jetpack_publicize_connections":[],"yoast_head":"\nUsing NCBI Resources for Genotype-Based Medication Optimization - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2023\/11\/01\/ncbi-resources-genotype-based-medication-optimization\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Using NCBI Resources for Genotype-Based Medication Optimization - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"NCBI offers a variety of clinical genetic resources to help you research, diagnose, and treat diseases and conditions. 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