Name: rs7412
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs7412

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr19:44908822 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: C>T
Variation Type: SNV Single Nucleotide Variation
Frequency: T=0.078122 (20678/264690, TOPMED)
T=0.083116 (15469/186114, ALFA)
T=0.079856 (11185/140064, GnomAD) (+ 19 more)
T=0.061504 (8425/136984, GnomAD_exome)
T=0.04315 (1219/28248, 14KJPN)
T=0.04346 (728/16750, 8.3KJPN)
T=0.07182 (972/13534, ExAC)
T=0.0771 (494/6404, 1000G_30x)
T=0.0751 (376/5008, 1000G)
T=0.1009 (452/4480, Estonian)
T=0.0924 (356/3854, ALSPAC)
T=0.0917 (340/3708, TWINSUK)
T=0.0693 (200/2888, KOREAN)
T=0.0720 (97/1348, HapMap)
T=0.078 (62/792, PRJEB37584)
T=0.082 (49/600, NorthernSweden)
T=0.014 (3/216, Qatari)
C=0.45 (29/64, SGDP_PRJ)
T=0.20 (8/40, GENOME_DK)
T=0.05 (2/38, Ancient Sardinia)
C=0.5 (4/8, Siberian)
T=0.5 (4/8, Siberian)

Clinical Significance: Reported in ClinVar
Gene : Consequence: APOE : Missense Variant
Publications: 439 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20231103111315

Population	Group	Sample Size	Ref Allele	Alt Allele	Ref HMOZ	Alt HMOZ	HTRZ	HWEP
Total	Global	186236	C=0.916901	T=0.083099	0.848955	0.015153	0.135892	32
European	Sub	165692	C=0.917081	T=0.082919	0.849914	0.015752	0.134334	32
African	Sub	6440	C=0.8955	T=0.1045	0.802484	0.011491	0.186025	0
African Others	Sub	212	C=0.882	T=0.118	0.764151	0.0	0.235849	1
African American	Sub	6228	C=0.8960	T=0.1040	0.803789	0.011882	0.184329	0
Asian	Sub	276	C=0.920	T=0.080	0.84058	0.0	0.15942	1
East Asian	Sub	186	C=0.930	T=0.070	0.860215	0.0	0.139785	0
Other Asian	Sub	90	C=0.90	T=0.10	0.8	0.0	0.2	0
Latin American 1	Sub	482	C=0.929	T=0.071	0.858921	0.0	0.141079	1
Latin American 2	Sub	686	C=0.974	T=0.026	0.947522	0.0	0.052478	0
South Asian	Sub	146	C=0.979	T=0.021	0.958904	0.0	0.041096	0
Other	Sub	12514	C=0.92113	T=0.07887	0.853284	0.011028	0.135688	15

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	C=0.921878	T=0.078122
Allele Frequency Aggregator	Total	Global	186114	C=0.916884	T=0.083116
Allele Frequency Aggregator	European	Sub	165588	C=0.917065	T=0.082935
Allele Frequency Aggregator	Other	Sub	12510	C=0.92110	T=0.07890
Allele Frequency Aggregator	African	Sub	6426	C=0.8954	T=0.1046
Allele Frequency Aggregator	Latin American 2	Sub	686	C=0.974	T=0.026
Allele Frequency Aggregator	Latin American 1	Sub	482	C=0.929	T=0.071
Allele Frequency Aggregator	Asian	Sub	276	C=0.920	T=0.080
Allele Frequency Aggregator	South Asian	Sub	146	C=0.979	T=0.021
gnomAD - Genomes	Global	Study-wide	140064	C=0.920144	T=0.079856
gnomAD - Genomes	European	Sub	75828	C=0.92632	T=0.07368
gnomAD - Genomes	African	Sub	42000	C=0.89540	T=0.10460
gnomAD - Genomes	American	Sub	13638	C=0.95967	T=0.04033
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	C=0.9329	T=0.0671
gnomAD - Genomes	East Asian	Sub	3126	C=0.9197	T=0.0803
gnomAD - Genomes	Other	Sub	2150	C=0.9158	T=0.0842
gnomAD - Exomes	Global	Study-wide	136984	C=0.938496	T=0.061504
gnomAD - Exomes	European	Sub	59780	C=0.92847	T=0.07153
gnomAD - Exomes	Asian	Sub	33656	C=0.94750	T=0.05250
gnomAD - Exomes	American	Sub	24704	C=0.96883	T=0.03117
gnomAD - Exomes	Ashkenazi Jewish	Sub	8126	C=0.9203	T=0.0797
gnomAD - Exomes	African	Sub	6624	C=0.8921	T=0.1079
gnomAD - Exomes	Other	Sub	4094	C=0.9392	T=0.0608
14KJPN	JAPANESE	Study-wide	28248	C=0.95685	T=0.04315
8.3KJPN	JAPANESE	Study-wide	16750	C=0.95654	T=0.04346
ExAC	Global	Study-wide	13534	C=0.92818	T=0.07182
ExAC	Asian	Sub	7974	C=0.9545	T=0.0455
ExAC	Europe	Sub	4754	C=0.8944	T=0.1056
ExAC	African	Sub	460	C=0.815	T=0.185
ExAC	American	Sub	204	C=0.961	T=0.039
ExAC	Other	Sub	142	C=0.901	T=0.099
1000Genomes_30x	Global	Study-wide	6404	C=0.9229	T=0.0771
1000Genomes_30x	African	Sub	1786	C=0.8914	T=0.1086
1000Genomes_30x	Europe	Sub	1266	C=0.9336	T=0.0664
1000Genomes_30x	South Asian	Sub	1202	C=0.9592	T=0.0408
1000Genomes_30x	East Asian	Sub	1170	C=0.9034	T=0.0966
1000Genomes_30x	American	Sub	980	C=0.945	T=0.055
1000Genomes	Global	Study-wide	5008	C=0.9249	T=0.0751
1000Genomes	African	Sub	1322	C=0.8971	T=0.1029
1000Genomes	East Asian	Sub	1008	C=0.8998	T=0.1002
1000Genomes	Europe	Sub	1006	C=0.9374	T=0.0626
1000Genomes	South Asian	Sub	978	C=0.956	T=0.044
1000Genomes	American	Sub	694	C=0.952	T=0.048
Genetic variation in the Estonian population	Estonian	Study-wide	4480	C=0.8991	T=0.1009
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.9076	T=0.0924
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.9083	T=0.0917
KOREAN population from KRGDB	KOREAN	Study-wide	2888	C=0.9307	T=0.0693
HapMap	Global	Study-wide	1348	C=0.9280	T=0.0720
HapMap	American	Sub	536	C=0.924	T=0.076
HapMap	African	Sub	392	C=0.923	T=0.077
HapMap	Asian	Sub	250	C=0.924	T=0.076
HapMap	Europe	Sub	170	C=0.959	T=0.041
CNV burdens in cranial meningiomas	Global	Study-wide	792	C=0.922	T=0.078
CNV burdens in cranial meningiomas	CRM	Sub	792	C=0.922	T=0.078
Northern Sweden	ACPOP	Study-wide	600	C=0.918	T=0.082
Qatari	Global	Study-wide	216	C=0.986	T=0.014
SGDP_PRJ	Global	Study-wide	64	C=0.45	T=0.55
The Danish reference pan genome	Danish	Study-wide	40	C=0.80	T=0.20
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	38	C=0.95	T=0.05
Siberian	Global	Study-wide	8	C=0.5	T=0.5

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 19	NC_000019.10:g.44908822C>T
GRCh37.p13 chr 19	NC_000019.9:g.45412079C>T
APOE RefSeqGene	NG_007084.2:g.8041C>T

Gene: APOE, apolipoprotein E (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
APOE transcript variant 2	NM_000041.4:c.526C>T	R [CGC] > C [TGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_000032.1:p.Arg176Cys	R (Arg) > C (Cys)	Missense Variant
APOE transcript variant 3	NM_001302689.2:c.526C>T	R [CGC] > C [TGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289618.1:p.Arg176Cys	R (Arg) > C (Cys)	Missense Variant
APOE transcript variant 1	NM_001302688.2:c.604C>T	R [CGC] > C [TGC]	Coding Sequence Variant
apolipoprotein E isoform a precursor	NP_001289617.1:p.Arg202Cys	R (Arg) > C (Cys)	Missense Variant
APOE transcript variant 5	NM_001302691.2:c.526C>T	R [CGC] > C [TGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289620.1:p.Arg176Cys	R (Arg) > C (Cys)	Missense Variant
APOE transcript variant 4	NM_001302690.2:c.526C>T	R [CGC] > C [TGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289619.1:p.Arg176Cys	R (Arg) > C (Cys)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 32887 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000019428.31	Familial type 3 hyperlipoproteinemia	Pathogenic
RCV000019439.30	Hyperlipoproteinemia due to APOE1	Pathogenic
RCV000019452.32	Familial type 3 hyperlipoproteinemia	Pathogenic
RCV000019454.31	Familial type 3 hyperlipoproteinemia	Pathogenic
RCV000211178.4	atorvastatin response - Efficacy	Drug-Response
RCV000346955.9	not provided	Other,Risk-Factor
RCV000825286.4	not specified	Uncertain-Significance
RCV000845582.3	Warfarin response	Drug-Response
RCV001262472.2	Hypercholesterolemia	Benign
RCV001529800.3	not specified	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	C=	T
GRCh38.p14 chr 19	NC_000019.10:g.44908822=	NC_000019.10:g.44908822C>T
GRCh37.p13 chr 19	NC_000019.9:g.45412079=	NC_000019.9:g.45412079C>T
APOE RefSeqGene	NG_007084.2:g.8041=	NG_007084.2:g.8041C>T
APOE transcript variant 2	NM_000041.4:c.526=	NM_000041.4:c.526C>T
APOE transcript variant 2	NM_000041.3:c.526=	NM_000041.3:c.526C>T
APOE transcript	NM_000041.2:c.526=	NM_000041.2:c.526C>T
APOE transcript variant 1	NM_001302688.2:c.604=	NM_001302688.2:c.604C>T
APOE transcript variant 1	NM_001302688.1:c.604=	NM_001302688.1:c.604C>T
APOE transcript variant 4	NM_001302690.2:c.526=	NM_001302690.2:c.526C>T
APOE transcript variant 4	NM_001302690.1:c.526=	NM_001302690.1:c.526C>T
APOE transcript variant 5	NM_001302691.2:c.526=	NM_001302691.2:c.526C>T
APOE transcript variant 5	NM_001302691.1:c.526=	NM_001302691.1:c.526C>T
APOE transcript variant 3	NM_001302689.2:c.526=	NM_001302689.2:c.526C>T
APOE transcript variant 3	NM_001302689.1:c.526=	NM_001302689.1:c.526C>T
apolipoprotein E isoform b precursor	NP_000032.1:p.Arg176=	NP_000032.1:p.Arg176Cys
apolipoprotein E isoform a precursor	NP_001289617.1:p.Arg202=	NP_001289617.1:p.Arg202Cys
apolipoprotein E isoform b precursor	NP_001289619.1:p.Arg176=	NP_001289619.1:p.Arg176Cys
apolipoprotein E isoform b precursor	NP_001289620.1:p.Arg176=	NP_001289620.1:p.Arg176Cys
apolipoprotein E isoform b precursor	NP_001289618.1:p.Arg176=	NP_001289618.1:p.Arg176Cys

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

147 SubSNP, 21 Frequency, 10 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	CGAP-GAI	ss9266	Sep 19, 2000 (52)
2	DEBNICK	ss870165	Oct 04, 2000 (86)
3	LEE	ss1542565	Oct 04, 2000 (86)
4	LEE	ss4429119	May 29, 2002 (106)
5	CUORCGL	ss12568612	Aug 26, 2003 (117)
6	SC_SNP	ss15840556	Feb 27, 2004 (120)
7	CGAP-GAI	ss16231140	Feb 27, 2004 (120)
8	ILLUMINA	ss75234864	Dec 07, 2007 (129)
9	RSG_UW	ss107936539	Feb 05, 2009 (130)
10	KRIBB_YJKIM	ss119338070	Dec 01, 2009 (131)
11	ILLUMINA	ss160878071	Dec 01, 2009 (131)
12	COMPLETE_GENOMICS	ss168244006	Jul 04, 2010 (132)
13	ILLUMINA	ss174365507	Jul 04, 2010 (132)
14	PAGE_STUDY	ss181341927	Jul 04, 2010 (132)
15	BUSHMAN	ss203765855	Jul 04, 2010 (132)
16	1000GENOMES	ss228156555	Jul 14, 2010 (132)
17	1000GENOMES	ss237689597	Jul 15, 2010 (132)
18	1000GENOMES	ss243892432	Jul 15, 2010 (132)
19	OMICIA	ss244239675	May 27, 2010 (132)
20	ILLUMINA	ss244309427	Jul 04, 2010 (132)
21	OMIM-CURATED-RECORDS	ss275517959	Dec 03, 2010 (133)
22	GMI	ss283224141	May 04, 2012 (137)
23	ILLUMINA	ss410828265	Sep 17, 2011 (135)
24	PAGE_STUDY	ss469414606	May 04, 2012 (137)
25	ILLUMINA	ss481561588	May 04, 2012 (137)
26	ILLUMINA	ss481591097	May 04, 2012 (137)
27	ILLUMINA	ss482563225	Sep 08, 2015 (146)
28	ILLUMINA	ss485575806	May 04, 2012 (137)
29	1000GENOMES	ss491161753	May 04, 2012 (137)
30	EXOME_CHIP	ss491549550	May 04, 2012 (137)
31	NCBI-CURATED-RECORDS	ss537712917	Jan 04, 2013 (137)
32	SSMP	ss661874597	Apr 25, 2013 (138)
33	NHLBI-ESP	ss713519653	Apr 25, 2013 (138)
34	ILLUMINA	ss783233469	Sep 08, 2015 (146)
35	ILLUMINA	ss783424859	Sep 08, 2015 (146)
36	ILLUMINA	ss832493923	Sep 08, 2015 (146)
37	JMKIDD_LAB	ss974506673	Aug 21, 2014 (142)
38	EVA-GONL	ss994339188	Aug 21, 2014 (142)
39	1000GENOMES	ss1363326191	Aug 21, 2014 (142)
40	EVA_GENOME_DK	ss1578653636	Apr 01, 2015 (144)
41	EVA_UK10K_ALSPAC	ss1638043658	Apr 01, 2015 (144)
42	EVA_UK10K_TWINSUK	ss1681037691	Apr 01, 2015 (144)
43	EVA_EXAC	ss1693665421	Apr 01, 2015 (144)
44	EVA_DECODE	ss1698394132	Apr 01, 2015 (144)
45	EVA_SVP	ss1713664899	Apr 01, 2015 (144)
46	ILLUMINA	ss1752288225	Sep 08, 2015 (146)
47	ILLUMINA	ss1752288226	Sep 08, 2015 (146)
48	ILLUMINA	ss1917938922	Feb 12, 2016 (147)
49	WEILL_CORNELL_DGM	ss1937835823	Feb 12, 2016 (147)
50	ILLUMINA	ss1946537659	Feb 12, 2016 (147)
51	ILLUMINA	ss1959869693	Feb 12, 2016 (147)
52	JJLAB	ss2029695319	Sep 14, 2016 (149)
53	ILLUMINA	ss2094804140	Dec 20, 2016 (150)
54	ILLUMINA	ss2095085224	Dec 20, 2016 (150)
55	USC_VALOUEV	ss2158238083	Dec 20, 2016 (150)
56	HUMAN_LONGEVITY	ss2226012259	Dec 20, 2016 (150)
57	ILLUMINA	ss2633544201	Nov 08, 2017 (151)
58	ILLUMINA	ss2633544202	Nov 08, 2017 (151)
59	ILLUMINA	ss2635083902	Nov 08, 2017 (151)
60	ILLUMINA	ss2710884165	Nov 08, 2017 (151)
61	GNOMAD	ss2744090577	Nov 08, 2017 (151)
62	GNOMAD	ss2750218836	Nov 08, 2017 (151)
63	GNOMAD	ss2963330131	Nov 08, 2017 (151)
64	AFFY	ss2985144683	Nov 08, 2017 (151)
65	AFFY	ss2985775661	Nov 08, 2017 (151)
66	SWEGEN	ss3017540730	Nov 08, 2017 (151)
67	ILLUMINA	ss3021911610	Nov 08, 2017 (151)
68	ILLUMINA	ss3021911611	Nov 08, 2017 (151)
69	ILLUMINA	ss3021911612	Nov 08, 2017 (151)
70	ILLUMINA	ss3021911613	Nov 08, 2017 (151)
71	CSHL	ss3352320694	Nov 08, 2017 (151)
72	ILLUMINA	ss3625742846	Oct 12, 2018 (152)
73	ILLUMINA	ss3625742847	Oct 12, 2018 (152)
74	ILLUMINA	ss3625742848	Oct 12, 2018 (152)
75	ILLUMINA	ss3625742849	Oct 12, 2018 (152)
76	ILLUMINA	ss3633892015	Oct 12, 2018 (152)
77	ILLUMINA	ss3634738107	Oct 12, 2018 (152)
78	ILLUMINA	ss3634738108	Oct 12, 2018 (152)
79	ILLUMINA	ss3635578762	Oct 12, 2018 (152)
80	ILLUMINA	ss3636425137	Oct 12, 2018 (152)
81	ILLUMINA	ss3637330512	Oct 12, 2018 (152)
82	ILLUMINA	ss3638229877	Oct 12, 2018 (152)
83	ILLUMINA	ss3640445415	Oct 12, 2018 (152)
84	ILLUMINA	ss3640445416	Oct 12, 2018 (152)
85	ILLUMINA	ss3641098341	Oct 12, 2018 (152)
86	ILLUMINA	ss3643202423	Oct 12, 2018 (152)
87	ILLUMINA	ss3644726174	Oct 12, 2018 (152)
88	OMUKHERJEE_ADBS	ss3646538370	Oct 12, 2018 (152)
89	ILLUMINA	ss3652337714	Oct 12, 2018 (152)
90	ILLUMINA	ss3652337715	Oct 12, 2018 (152)
91	ILLUMINA	ss3652337716	Oct 12, 2018 (152)
92	ILLUMINA	ss3652337717	Oct 12, 2018 (152)
93	ILLUMINA	ss3652337718	Oct 12, 2018 (152)
94	ILLUMINA	ss3653917429	Oct 12, 2018 (152)
95	EGCUT_WGS	ss3684286600	Jul 13, 2019 (153)
96	EVA_DECODE	ss3702845772	Jul 13, 2019 (153)
97	ACPOP	ss3743072612	Jul 13, 2019 (153)
98	ILLUMINA	ss3744466131	Jul 13, 2019 (153)
99	ILLUMINA	ss3744466132	Jul 13, 2019 (153)
100	ILLUMINA	ss3744466133	Jul 13, 2019 (153)
101	ILLUMINA	ss3744466134	Jul 13, 2019 (153)
102	ILLUMINA	ss3744466135	Jul 13, 2019 (153)
103	ILLUMINA	ss3745038116	Jul 13, 2019 (153)
104	ILLUMINA	ss3745038117	Jul 13, 2019 (153)
105	EVA	ss3756111787	Jul 13, 2019 (153)
106	ILLUMINA	ss3772535200	Jul 13, 2019 (153)
107	ILLUMINA	ss3772535201	Jul 13, 2019 (153)
108	PACBIO	ss3788541393	Jul 13, 2019 (153)
109	PACBIO	ss3793449661	Jul 13, 2019 (153)
110	PACBIO	ss3798336543	Jul 13, 2019 (153)
111	KHV_HUMAN_GENOMES	ss3821359905	Jul 13, 2019 (153)
112	EVA	ss3825301411	Apr 27, 2020 (154)
113	EVA	ss3825938286	Apr 27, 2020 (154)
114	EVA	ss3835481189	Apr 27, 2020 (154)
115	SGDP_PRJ	ss3888305366	Apr 27, 2020 (154)
116	KRGDB	ss3938432692	Apr 27, 2020 (154)
117	FSA-LAB	ss3984156828	Apr 26, 2021 (155)
118	EVA	ss3984742820	Apr 26, 2021 (155)
119	EVA	ss3985856233	Apr 26, 2021 (155)
120	EVA	ss3986802274	Apr 26, 2021 (155)
121	EVA	ss4017826839	Apr 26, 2021 (155)
122	TOPMED	ss5076165870	Apr 26, 2021 (155)
123	TOMMO_GENOMICS	ss5227950598	Apr 26, 2021 (155)
124	EVA	ss5236962740	Apr 26, 2021 (155)
125	EVA	ss5237597849	Apr 26, 2021 (155)
126	EVA	ss5237672910	Oct 13, 2022 (156)
127	1000G_HIGH_COVERAGE	ss5307395588	Oct 13, 2022 (156)
128	TRAN_CS_UWATERLOO	ss5314453657	Oct 13, 2022 (156)
129	EVA	ss5435087071	Oct 13, 2022 (156)
130	HUGCELL_USP	ss5499891501	Oct 13, 2022 (156)
131	1000G_HIGH_COVERAGE	ss5613191139	Oct 13, 2022 (156)
132	SANFORD_IMAGENETICS	ss5624429771	Oct 13, 2022 (156)
133	SANFORD_IMAGENETICS	ss5662475604	Oct 13, 2022 (156)
134	TOMMO_GENOMICS	ss5786644800	Oct 13, 2022 (156)
135	EVA	ss5799404798	Oct 13, 2022 (156)
136	EVA	ss5800009699	Oct 13, 2022 (156)
137	EVA	ss5800073523	Oct 13, 2022 (156)
138	YY_MCH	ss5817637095	Oct 13, 2022 (156)
139	EVA	ss5840606772	Oct 13, 2022 (156)
140	EVA	ss5847497727	Oct 13, 2022 (156)
141	EVA	ss5847846244	Oct 13, 2022 (156)
142	EVA	ss5848495369	Oct 13, 2022 (156)
143	EVA	ss5852304031	Oct 13, 2022 (156)
144	EVA	ss5928256284	Oct 13, 2022 (156)
145	EVA	ss5953885391	Oct 13, 2022 (156)
146	EVA	ss5979547886	Oct 13, 2022 (156)
147	EVA	ss5981313115	Oct 13, 2022 (156)
148	1000Genomes	NC_000019.9 - 45412079	Oct 12, 2018 (152)
149	1000Genomes_30x	NC_000019.10 - 44908822	Oct 13, 2022 (156)
150	The Avon Longitudinal Study of Parents and Children	NC_000019.9 - 45412079	Oct 12, 2018 (152)
151	Genetic variation in the Estonian population	NC_000019.9 - 45412079	Oct 12, 2018 (152)
152	ExAC	NC_000019.9 - 45412079	Oct 12, 2018 (152)
153	The Danish reference pan genome	NC_000019.9 - 45412079	Apr 27, 2020 (154)
154	gnomAD - Genomes	NC_000019.10 - 44908822	Apr 26, 2021 (155)
155	gnomAD - Exomes	NC_000019.9 - 45412079	Jul 13, 2019 (153)
156	HapMap	NC_000019.10 - 44908822	Apr 27, 2020 (154)
157	KOREAN population from KRGDB	NC_000019.9 - 45412079	Apr 27, 2020 (154)
158	Northern Sweden	NC_000019.9 - 45412079	Jul 13, 2019 (153)
159	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000019.9 - 45412079	Apr 26, 2021 (155)
160	CNV burdens in cranial meningiomas	NC_000019.9 - 45412079	Apr 26, 2021 (155)
161	Qatari	NC_000019.9 - 45412079	Apr 27, 2020 (154)
162	SGDP_PRJ	NC_000019.9 - 45412079	Apr 27, 2020 (154)
163	Siberian	NC_000019.9 - 45412079	Apr 27, 2020 (154)
164	8.3KJPN	NC_000019.9 - 45412079	Apr 26, 2021 (155)
165	14KJPN	NC_000019.10 - 44908822	Oct 13, 2022 (156)
166	TopMed	NC_000019.10 - 44908822	Apr 26, 2021 (155)
167	UK 10K study - Twins	NC_000019.9 - 45412079	Oct 12, 2018 (152)
168	ALFA	NC_000019.10 - 44908822	Apr 26, 2021 (155)
169	ClinVar	RCV000019428.31	Oct 13, 2022 (156)
170	ClinVar	RCV000019439.30	Oct 13, 2022 (156)
171	ClinVar	RCV000019452.32	Oct 13, 2022 (156)
172	ClinVar	RCV000019454.31	Oct 13, 2022 (156)
173	ClinVar	RCV000211178.4	Oct 13, 2022 (156)
174	ClinVar	RCV000346955.9	Oct 13, 2022 (156)
175	ClinVar	RCV000825286.4	Oct 13, 2022 (156)
176	ClinVar	RCV000845582.3	Oct 13, 2022 (156)
177	ClinVar	RCV001262472.2	Oct 13, 2022 (156)
178	ClinVar	RCV001529800.3	Oct 13, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs3200542	Jul 03, 2002 (106)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss168244006, ss203765855, ss283224141, ss481561588, ss1698394132, ss1713664899, ss2635083902, ss3643202423	NC_000019.8:50103918:C:T	NC_000019.10:44908821:C:T	(self)
76738726, 42493853, 30024848, 4174091, 4835568, 13406339, 45610086, 16357477, 1082160, 292380, 19877745, 40322346, 10754437, 85919905, 42493853, ss228156555, ss237689597, ss243892432, ss481591097, ss482563225, ss485575806, ss491161753, ss491549550, ss661874597, ss713519653, ss783233469, ss783424859, ss832493923, ss974506673, ss994339188, ss1363326191, ss1578653636, ss1638043658, ss1681037691, ss1693665421, ss1752288225, ss1752288226, ss1917938922, ss1937835823, ss1946537659, ss1959869693, ss2029695319, ss2094804140, ss2095085224, ss2158238083, ss2633544201, ss2633544202, ss2710884165, ss2744090577, ss2750218836, ss2963330131, ss2985144683, ss2985775661, ss3017540730, ss3021911610, ss3021911611, ss3021911612, ss3021911613, ss3352320694, ss3625742846, ss3625742847, ss3625742848, ss3625742849, ss3633892015, ss3634738107, ss3634738108, ss3635578762, ss3636425137, ss3637330512, ss3638229877, ss3640445415, ss3640445416, ss3641098341, ss3644726174, ss3646538370, ss3652337714, ss3652337715, ss3652337716, ss3652337717, ss3652337718, ss3653917429, ss3684286600, ss3743072612, ss3744466131, ss3744466132, ss3744466133, ss3744466134, ss3744466135, ss3745038116, ss3745038117, ss3756111787, ss3772535200, ss3772535201, ss3788541393, ss3793449661, ss3798336543, ss3825301411, ss3825938286, ss3835481189, ss3888305366, ss3938432692, ss3984156828, ss3984742820, ss3985856233, ss3986802274, ss4017826839, ss5227950598, ss5237597849, ss5435087071, ss5624429771, ss5662475604, ss5799404798, ss5800009699, ss5800073523, ss5840606772, ss5847497727, ss5847846244, ss5848495369, ss5953885391, ss5979547886, ss5981313115	NC_000019.9:45412078:C:T	NC_000019.10:44908821:C:T	(self)
RCV000019428.31, RCV000019439.30, RCV000019452.32, RCV000019454.31, RCV000211178.4, RCV000346955.9, RCV000825286.4, RCV000845582.3, RCV001262472.2, RCV001529800.3, 100717074, 541193121, 1701717, 120481904, 291711534, 2262979905, ss244239675, ss275517959, ss537712917, ss2226012259, ss3702845772, ss3821359905, ss5076165870, ss5236962740, ss5237672910, ss5307395588, ss5314453657, ss5499891501, ss5613191139, ss5786644800, ss5817637095, ss5852304031, ss5928256284	NC_000019.10:44908821:C:T	NC_000019.10:44908821:C:T	(self)
ss15840556	NT_011109.15:17680296:C:T	NC_000019.10:44908821:C:T	(self)
ss9266, ss870165, ss1542565, ss4429119, ss12568612, ss16231140, ss75234864, ss107936539, ss119338070, ss160878071, ss174365507, ss181341927, ss244309427, ss410828265, ss469414606	NT_011109.16:17680296:C:T	NC_000019.10:44908821:C:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

439 citations for rs7412

PMID	Title	Author	Year	Journal
2992507	Isolation and characterisation of a variant allele of the gene for human apolipoprotein E.	Gill LL et al.	1985	Biochemical and biophysical research communications
3243553	Genotyping and sequence analysis of apolipoprotein E isoforms.	Emi M et al.	1988	Genomics
6300187	Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.	Rall SC Jr et al.	1983	The Journal of clinical investigation
6323533	A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.	Weisgraber KH et al.	1984	The Journal of clinical investigation
8488843	Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.	van den Maagdenberg AM et al.	1993	American journal of human genetics
8664327	Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 --> Gln) in a hyperlipidemic patient with xanthomatosis.	Moriyama K et al.	1996	Biochimica et biophysica acta
9649566	Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2.	Sullivan PM et al.	1998	The Journal of clinical investigation
15113403	Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.	Dvornyk V et al.	2004	BMC genetics
15157284	Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.	Long JR et al.	2004	BMC genetics
15172743	ApoE genotype accounts for the vast majority of AD risk and AD pathology.	Raber J et al.	2004	Neurobiology of aging
16103896	An association study of 43 SNPs in 16 candidate genes with atorvastatin response.	Thompson JF et al.	2005	The pharmacogenomics journal
16143024	Polymorphisms in the apolipoprotein A5 (APOA5) gene and type III hyperlipidemia.	Evans D et al.	2005	Clinical genetics
16603077	Variation at APOE and STH loci and Alzheimer's disease.	Zuo L et al.	2006	Behavioral and brain functions
17048007	Association of warfarin dose with genes involved in its action and metabolism.	Wadelius M et al.	2007	Human genetics
17289397	Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin.	Zuccaro P et al.	2007	Pharmacological research
17356695	Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.	Fredriksson J et al.	2007	PloS one
17357073	Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.	Pare G et al.	2007	American journal of human genetics
17434289	Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.	Yu CE et al.	2007	Genomics
17456829	Evaluation of genetic factors for warfarin dose prediction.	Caldwell MD et al.	2007	Clinical medicine & research
17658295	Association of ApoE genetic variants with obstructive sleep apnea in children.	Kalra M et al.	2008	Sleep medicine
17672902	Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.	Kaushal R et al.	2007	BMC medical genetics
17903299	A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.	Kathiresan S et al.	2007	BMC medical genetics
18034366	Lack of replication of genetic associations with human longevity.	Novelli V et al.	2008	Biogerontology
18216863	Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.	Rhodes B et al.	2008	Genes and immunity
18254975	Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.	Seip RL et al.	2008	Nutrition & metabolism
18275964	Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.	Chamberlain AM et al.	2008	Atherosclerosis
18378515	APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels.	Klos K et al.	2008	Human molecular genetics
18513389	New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.	Penco S et al.	2008	BMC bioinformatics
18596683	Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans.	Schelleman H et al.	2008	Clinical pharmacology and therapeutics
18603647	Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.	Simoni M et al.	2008	Human reproduction update
18823527	A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.	Abraham R et al.	2008	BMC medical genomics
18941475	On Jim Watson's APOE status: genetic information is hard to hide.	Nyholt DR et al.	2009	European journal of human genetics
18974842	Gender differences in genetic risk profiles for cardiovascular disease.	Silander K et al.	2008	PloS one
18976728	Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.	Bertram L et al.	2008	American journal of human genetics
19001172	Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.	Lee JH et al.	2008	Archives of neurology
19014573	Application of two machine learning algorithms to genetic association studies in the presence of covariates.	Nonyane BA et al.	2008	BMC genetics
19058936	A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females.	He LN et al.	2009	Maturitas
19118814	Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.	Beecham GW et al.	2009	American journal of human genetics
19131662	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	Wang X et al.	2009	Stroke
19172988	The complex interaction between APOE promoter and AD: an Italian case-control study.	Bizzarro A et al.	2009	European journal of human genetics
19262956	GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers.	Ramirez-Lorca R et al.	2009	The journal of nutrition, health & aging
19263529	Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.	Zee RY et al.	2009	Clinica chimica acta; international journal of clinical chemistry
19285141	Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.	Liu J et al.	2009	NeuroImage
19299407	Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.	Lanktree MB et al.	2009	Journal of lipid research
19336475	Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.	Drenos F et al.	2009	Human molecular genetics
19377787	Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals.	Souza DR et al.	2009	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
19501493	A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study.	Junyent M et al.	2010	Nutrition, metabolism, and cardiovascular diseases
19541455	Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.	Clark D et al.	2009	European psychiatry
19554612	APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.	Bekris LM et al.	2010	American journal of medical genetics. Part B, Neuropsychiatric genetics
19602472	Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study.	Ren C et al.	2010	Journal of epidemiology and community health
19667110	Identification of genetic variants associated with response to statin therapy.	Mega JL et al.	2009	Arteriosclerosis, thrombosis, and vascular biology
19668339	Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.	Potkin SG et al.	2009	PloS one
19756043	A simple and efficient algorithm for genome-wide homozygosity analysis in disease.	Liu W et al.	2009	Molecular systems biology
19766542	The FAS gene, brain volume, and disease progression in Alzheimer's disease.	Erten-Lyons D et al.	2010	Alzheimer's & dementia
19787382	Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.	Jackson KG et al.	2010	Genes & nutrition
19802338	Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.	Chasman DI et al.	2008	Circulation. Cardiovascular genetics
19818961	Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm.	Golledge J et al.	2010	Atherosclerosis
19884647	Air pollution, obesity, genes and cellular adhesion molecules.	Madrigano J et al.	2010	Occupational and environmental medicine
19913121	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	Talmud PJ et al.	2009	American journal of human genetics
19936222	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	Chasman DI et al.	2009	PLoS genetics
19951432	Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.	Ronald J et al.	2009	Lipids in health and disease
20031551	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	Voora D et al.	2008	Circulation. Cardiovascular genetics
20031563	Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study.	Anand SS et al.	2009	Circulation. Cardiovascular genetics
20031582	Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.	Thompson JF et al.	2009	Circulation. Cardiovascular genetics
20082485	Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.	Báez S et al.	2010	World journal of gastroenterology
20100581	Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.	Shen L et al.	2010	NeuroImage
20167577	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	Reynolds CA et al.	2010	Human molecular genetics
20308031	Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer.	Kato I et al.	2010	Cancer epidemiology
20381870	Progression of geographic atrophy and genotype in age-related macular degeneration.	Klein ML et al.	2010	Ophthalmology
20406466	Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey.	Chang MH et al.	2010	BMC medical genetics
20429872	Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study.	Ariza MJ et al.	2010	BMC medical genetics
20451875	Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.	Saykin AJ et al.	2010	Alzheimer's & dementia
20467002	Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.	Kring SI et al.	2010	Psychosomatic medicine
20498921	APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.	Ken-Dror G et al.	2010	Molecular medicine (Cambridge, Mass.)
20549395	Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies.	Cornelis MC et al.	2010	Current psychiatry reports
20565774	Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.	Cross DS et al.	2010	BMC genetics
20569235	HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.	Jazwinski SM et al.	2010	Aging cell
20663622	A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India.	Singh M et al.	2010	Maturitas
20682755	A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.	Ghebranious N et al.	2011	Clinical medicine & research
20734064	A large-scale candidate gene association study of age at menarche and age at natural menopause.	He C et al.	2010	Human genetics
20832063	Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.	Lu Y et al.	2010	Atherosclerosis
20838585	Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.	Smith EN et al.	2010	PLoS genetics
20885792	Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.	Naj AC et al.	2010	PLoS genetics
21045241	Age-related macular degeneration: genetic and environmental factors of disease.	Chen Y et al.	2010	Molecular interventions
21054877	Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.	Ned RM et al.	2010	BMC medical genetics
21123754	Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.	Kim S et al.	2011	Neurology
21146954	Genes and abdominal aortic aneurysm.	Hinterseher I et al.	2011	Annals of vascular surgery
21215387	IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.	Taylor AE et al.	2011	Biological psychiatry
21228733	Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.	Shahin MH et al.	2011	Pharmacogenetics and genomics
21263195	An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.	Lescai F et al.	2011	Journal of Alzheimer's disease
21285406	Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study.	Benn M et al.	2011	Journal of the National Cancer Institute
21379329	Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.	Wijsman EM et al.	2011	PLoS genetics
21418511	Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.	Deelen J et al.	2011	Aging cell
21441355	Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.	Takeuchi F et al.	2011	Genome research
21450715	High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans.	Cosgun E et al.	2011	Bioinformatics (Oxford, England)
21467728	Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.	Wakai K et al.	2011	Journal of epidemiology
21498624	Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.	McKay GJ et al.	2011	American journal of epidemiology
21547229	Neuroimaging measures as endophenotypes in Alzheimer's disease.	Braskie MN et al.	2011	International journal of Alzheimer's disease
21597005	An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.	Johansen CT et al.	2011	Arteriosclerosis, thrombosis, and vascular biology
21645382	A note on the use of the generalized odds ratio in meta-analysis of association studies involving bi- and tri-allelic polymorphisms.	Pereira TV et al.	2011	BMC research notes
21647738	Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.	Wu Y et al.	2012	Inflammation
21672907	The application of naive Bayes model averaging to predict Alzheimer's disease from genome-wide data.	Wei W et al.	2011	Journal of the American Medical Informatics Association
21689001	Association study between apolipoprotein E gene polymorphism and diabetic nephropathy in a Taiwanese population.	Wen MJ et al.	2011	Genetic testing and molecular biomarkers
21703254	APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.	Napolioni V et al.	2011	Clinica chimica acta; international journal of clinical chemistry
21708280	Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.	Srivastava K et al.	2011	Mutation research
21738485	Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.	Dumitrescu L et al.	2011	PLoS genetics
21738487	Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.	Do CB et al.	2011	PLoS genetics
21767357	Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome.	Povel CM et al.	2011	Lipids in health and disease
21773006	Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.	Curti ML et al.	2011	Journal of obesity
21774831	Association between genetic variants in the Coenzyme Q10 metabolism and Coenzyme Q10 status in humans.	Fischer A et al.	2011	BMC research notes
21784354	The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.	Johnson SC et al.	2011	Alzheimer's & dementia
21792545	ApoE genotypes are associated with age at natural menopause in Chinese females.	Meng FT et al.	2012	Age (Dordrecht, Netherlands)
21799773	Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.	Calero O et al.	2011	PloS one
21803501	Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants.	Bruno D et al.	2012	Psychoneuroendocrinology
21825236	Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.	Cruchaga C et al.	2011	Archives of neurology
21829380	Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability.	Sanna S et al.	2011	PLoS genetics
21845926	Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.	Vasunilashorn S et al.	2011	Biodemography and social biology
21857382	Candidate genes and risk for CP: a population-based study.	Wu YW et al.	2011	Pediatric research
21862702	Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk.	Calandra S et al.	2011	Journal of lipid research
21882290	Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.	McKay GJ et al.	2011	Human mutation
21889590	Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.	Raz N et al.	2012	Biochimica et biophysica acta
21894447	Are centenarians genetically predisposed to lower disease risk?	Ruiz JR et al.	2012	Age (Dordrecht, Netherlands)
21901424	Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.	Swaminathan S et al.	2012	Brain imaging and behavior
21906714	Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study.	Peter I et al.	2011	American journal of ophthalmology
21937998	Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults.	Curocichin G et al.	2011	Journal of human genetics
22005931	Genome-wide association analysis of age-at-onset in Alzheimer's disease.	Kamboh MI et al.	2012	Molecular psychiatry
22024213	A novel gene-environment interaction involved in endometriosis.	McCarty CA et al.	2012	International journal of gynaecology and obstetrics
22042884	Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.	Franceschini N et al.	2011	Circulation. Cardiovascular genetics
22046233	Impact of genetic variation in SORCS1 on memory retention.	Reitz C et al.	2011	PloS one
22074026	Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin.	Cerda A et al.	2011	Lipids in health and disease
22190428	Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.	Hong MG et al.	2012	Human mutation
22209813	Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.	Vounou M et al.	2012	NeuroImage
22234866	Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.	Soerensen M et al.	2013	Age (Dordrecht, Netherlands)
22236693	Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease.	Cheng HC et al.	2012	Journal of negative results in biomedicine
22245009	Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure.	Bender AR et al.	2012	Neuropsychologia
22247473	Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models.	Yu Y et al.	2012	Investigative ophthalmology & visual science
22272811	Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease.	Chen SY et al.	2012	Journal of neuroinflammation
22303384	Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.	Sebastiani P et al.	2011	Frontiers in genetics
22328972	A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.	Lee YC et al.	2011	Journal of data mining in genomics & proteomics
22347417	Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.	Bol SM et al.	2012	PloS one
22348020	Exogenous visual orienting is associated with specific neurotransmitter genetic markers: a population-based genetic association study.	Lundwall RA et al.	2012	PloS one
22359560	Characterization of the poly-T variant in the TOMM40 gene in diverse populations.	Linnertz C et al.	2012	PloS one
22380508	Cognitive reserve, cortical plasticity and resistance to Alzheimer's disease.	Esiri MM et al.	2012	Alzheimer's research & therapy
22499766	The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals.	Murabito JM et al.	2012	The journals of gerontology. Series A, Biological sciences and medical sciences
22530123	Screening and Evaluation of Deleterious SNPs in APOE Gene of Alzheimer's Disease.	Masoodi TA et al.	2012	Neurology research international
22651940	The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts.	Polito L et al.	2013	Alzheimer's & dementia
22666427	Modelling the genetic risk in age-related macular degeneration.	Grassmann F et al.	2012	PloS one
22666496	Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.	Shiffman D et al.	2012	PloS one
22676711	Pharmacogenomics of warfarin in populations of African descent.	Suarez-Kurtz G et al.	2013	British journal of clinical pharmacology
22678500	Genetic factors for choroidal neovascularization associated with high myopia.	Leveziel N et al.	2012	Investigative ophthalmology & visual science
22694956	Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.	Cipriani V et al.	2012	Human molecular genetics
22710912	TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia.	Seripa D et al.	2012	Journal of Alzheimer's disease
22715478	Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.	Barbosa EJ et al.	2012	European journal of endocrinology
22898894	Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection.	Chiba-Falek O et al.	2012	Human genetics
22911757	Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population.	Liu X et al.	2012	PloS one
22911785	An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease.	Borobia AM et al.	2012	PloS one
22922093	Low-density lipoprotein cholesterol and risk of gallstone disease: a Mendelian randomization study and meta-analyses.	Stender S et al.	2013	Journal of hepatology
22933840	Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration.	van de Ven JP et al.	2012	Molecular vision
22992668	Pharmacogenomics knowledge for personalized medicine.	Whirl-Carrillo M et al.	2012	Clinical pharmacology and therapeutics
23050023	Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals.	Takeuchi F et al.	2012	PloS one
23073467	Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients.	Sam WJ et al.	2012	Transplantation
23100282	Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.	Hopewell JC et al.	2013	European heart journal
23112842	The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes).	McIntosh AM et al.	2012	PloS one
23227193	Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.	Swaminathan S et al.	2012	PloS one
23237631	Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial.	Carcas AJ et al.	2012	Trials
23383383	C9ORF72 repeat expansions and other FTD gene mutations in a clinical AD patient series from Mayo Clinic.	Wojtas A et al.	2012	American journal of neurodegenerative disease
23424626	Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.	Spencer KL et al.	2013	PloS one
23430611	Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration.	Mannila MN et al.	2013	Arteriosclerosis, thrombosis, and vascular biology
23497168	Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population.	Rudkowska I et al.	2013	Nutrition & metabolism
23533563	Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.	Bérard AM et al.	2013	PloS one
23687437	Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population.	Chiras D et al.	2013	Molecular vision
23713713	Age-related macular degeneration-clinical review and genetics update.	Ratnapriya R et al.	2013	Clinical genetics
23820649	Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.	Cooper DN et al.	2013	Human genetics
23894628	Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel.	Kim S et al.	2013	PloS one
24014251	Adjustment for smoking does not alter the FOXO3A association with longevity.	Däumer C et al.	2014	Age (Dordrecht, Netherlands)
24059882	Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians.	Boehm J et al.	2014	Renal failure
24069534	Genetics of psoriasis and pharmacogenetics of biological drugs.	Prieto-Pérez R et al.	2013	Autoimmune diseases
24244950	Meta‐analysis of genetic variants associated with human exceptional longevity.	Sebastiani P et al.	2013	Aging
24291031	Association of APOE, GCPII and MMP9 polymorphisms with common diseases and lipid levels in an older adult/elderly cohort.	Mazzotti DR et al.	2014	Gene
24319689	The roles of genetic polymorphisms and human immunodeficiency virus infection in lipid metabolism.	de Almeida ER et al.	2013	BioMed research international
24365473	An association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretation.	Preeprem T et al.	2013	BioData mining
24448547	Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data.	Radmanesh F et al.	2014	European journal of human genetics
24502694	New insights into the distribution of APOE polymorphism in the Iberian Peninsula. The case of Andalusia (Spain).	Reales G et al.	2014	Annals of human biology
24508314	Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.	Lyall DM et al.	2014	Neurobiology of aging
24675670	Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels.	Ristau T et al.	2014	PloS one
24709297	Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients.	Novotny D et al.	2014	Clinical biochemistry
24733985	Comparison of BMI, AHI, and apolipoprotein E ε4 (APOE-ε4) alleles among sleep apnea patients with different skeletal classifications.	Roedig JJ et al.	2014	Journal of clinical sleep medicine
24746514	Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.	Sun L et al.	2014	Experimental gerontology
24815086	The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemic patients.	Novotny D et al.	2014	Clinica chimica acta; international journal of clinical chemistry
24842701	PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals.	MacLeod CA et al.	2014	PloS one
24867440	APOE moderates the association between lifestyle activities and cognitive performance: evidence of genetic plasticity in aging.	Runge SK et al.	2014	Journal of the International Neuropsychological Society
24899730	Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.	Wagshal D et al.	2015	Journal of neurology, neurosurgery, and psychiatry
24924924	Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.	Lu F et al.	2014	PloS one
24979464	Association of apolipoprotein E polymorphism with type 2 diabetes mellitus in a Saudi population.	Alharbi KK et al.	2014	DNA and cell biology
24987407	eMERGEing progress in genomics-the first seven years.	Crawford DC et al.	2014	Frontiers in genetics
25114068	Genetic determinants of disease progression in Alzheimer's disease.	Wang X et al.	2015	Journal of Alzheimer's disease
25137520	Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions.	Napier MD et al.	2016	Archives of environmental & occupational health
25176936	Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia.	De Castro-Orós I et al.	2014	Circulation. Cardiovascular genetics
25224634	Genetic variation in key genes associated with statin therapy in the Azores Islands (Portugal) healthy population.	Melo MS et al.	2015	Annals of human biology
25239657	Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene.	van Blitterswijk M et al.	2014	Molecular neurodegeneration
25268647	The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.	Tejedor MT et al.	2014	PloS one
25333069	Disease variants in genomes of 44 centenarians.	Freudenberg-Hua Y et al.	2014	Molecular genetics & genomic medicine
25361584	Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population.	Frikke-Schmidt R et al.	2015	International journal of epidemiology
25430627	A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake.	Goni L et al.	2015	Genes & nutrition
25545672	Apolipoprotein E gene polymorphisms in relation to chronic periodontitis, periodontopathic bacteria, and lipid levels.	Borilova Linhartova P et al.	2015	Archives of oral biology
25558172	Pharmacogenetic associations with long-term response to anti-vascular endothelial growth factor treatment in neovascular AMD patients.	Park UC et al.	2014	Molecular vision
25601895	Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.	Cahua-Pablo G et al.	2016	Clinical and applied thrombosis/hemostasis
25649863	Identifying genetic interactions associated with late-onset Alzheimer's disease.	Floudas CS et al.	2014	BioData mining
25682026	Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia?	Futema M et al.	2015	Atherosclerosis
25731628	Clinical relevance of apolipoprotein E genotyping based on a family history of Alzheimer's disease.	Luckhoff HK et al.	2015	Current Alzheimer research
25869804	GWAS for executive function and processing speed suggests involvement of the CADM2 gene.	Ibrahim-Verbaas CA et al.	2016	Molecular psychiatry
26043189	Genetic determinants of quantitative traits associated with cardiovascular disease risk.	Smolková B et al.	2015	Mutation research
26175754	DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women.	Chagnon YC et al.	2015	Frontiers in genetics
26301579	Association between the Lipid Levels and Single Nucleotide Polymorphisms of ABCA1, APOE and HMGCR Genes in Subjects with Spontaneous Preterm Delivery.	Li L et al.	2015	PloS one
26343804	Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults.	Sapkota S et al.	2016	International journal of geriatric psychiatry
26362601	Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.	DeCarlo CA et al.	2016	The journals of gerontology. Series B, Psychological sciences and social sciences
26365620	Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.	Son KY et al.	2015	Lipids in health and disease
26404360	Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults.	Yuan L et al.	2015	Nutrients
26405973	Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population.	Zhang X et al.	2015	Bio-medical materials and engineering
26497592	The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.	Pleva L et al.	2015	BMC cardiovascular disorders
26619808	APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.	Vélez JI et al.	2016	Molecular psychiatry
26621708	Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.	Schwarz F et al.	2016	Proceedings of the National Academy of Sciences of the United States of America
26627480	Genetic predisposition to acute kidney injury--a systematic review.	Vilander LM et al.	2015	BMC nephrology
26661731	ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy.	Montañola A et al.	2016	Neuromolecular medicine
26669675	Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.	Schrewe L et al.	2015	Journal of neuroinflammation
26677855	Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.	Fortney K et al.	2015	PLoS genetics
26680604	Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.	Jiao B et al.	2015	PloS one
26690118	An Updated Review on the Genetics of Primary Open Angle Glaucoma.	Abu-Amero K et al.	2015	International journal of molecular sciences
26726928	Common variants of APOE are associated with anti-epileptic drugs resistance in Han Chinese patients.	Gong JE et al.	2017	The International journal of neuroscience
26739746	A multi-factorial analysis of response to warfarin in a UK prospective cohort.	Bourgeois S et al.	2016	Genome medicine
26741362	Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico.	Gonzalez-Aldaco K et al.	2016	PloS one
26754117	A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism.	Zhong L et al.	2016	Molecular neurodegeneration
26756273	Genetics of psychosis of Alzheimer disease.	Shah C et al.	2017	American journal of medical genetics. Part B, Neuropsychiatric genetics
26788404	Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.	Lange J et al.	2015	Parkinson's disease
26930295	Genetic landscape of APOE in human longevity revealed by high-throughput sequencing.	Ryu S et al.	2016	Mechanisms of ageing and development
26937653	Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease.	Yin Y et al.	2016	PloS one
26958812	ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.	Gao Y et al.	2016	Oncotarget
26971241	Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans.	Larifla L et al.	2016	The Canadian journal of cardiology
26977927	A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population.	Tong HY et al.	2016	PloS one
26985771	Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease.	Bai F et al.	2016	Oncotarget
27003218	Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.	Nho K et al.	2016	Journal of Alzheimer's disease
27015805	Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.	Pilling LC et al.	2016	Aging
27067897	Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients.	Chan DP et al.	2016	BMJ open
27073747	The presenilin 1 p.Gly206Ala mutation is a frequent cause of early-onset Alzheimer's disease in Hispanics in Florida.	Ravenscroft TA et al.	2016	American journal of neurodegenerative disease
27112212	Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.	Shahid SU et al.	2016	Lipids in health and disease
27177774	Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population.	Wu S et al.	2016	Lipids in health and disease
27189021	Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.	Cook JP et al.	2016	European journal of human genetics
27193889	The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms.	Limon-Sztencel A et al.	2016	Alzheimer's research & therapy
27227539	The Contribution of GWAS Loci in Familial Dyslipidemias.	Ripatti P et al.	2016	PLoS genetics
27239546	Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging.	Gupta VB et al.	2016	Alzheimer's & dementia (Amsterdam, Netherlands)
27239555	Oxidative stress, innate immunity, and age-related macular degeneration.	Shaw PX et al.	2016	AIMS molecular science
27240396	Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause.	Rył A et al.	2016	International journal of environmental research and public health
27244899	FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.	Zhang QY et al.	2016	Oncotarget
27249957	CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking.	Weng PH et al.	2016	Scientific reports
27276684	MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses.	Tang SS et al.	2016	Oncotarget
27289440	ABCA7 p.G215S as potential protective factor for Alzheimer's disease.	Sassi C et al.	2016	Neurobiology of aging
27301361	Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases.	Tšuiko O et al.	2016	Human reproduction (Oxford, England)
27358062	A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers.	Ayers KL et al.	2016	BMC genomics
27439317	Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians - a cross-sectional study.	Bustami J et al.	2016	BMC geriatrics
27453991	A novel approach for multi-SNP GWAS and its application in Alzheimer's disease.	Bodily PM et al.	2016	BMC bioinformatics
27482534	An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults.	Harrison TM et al.	2016	eNeuro
27494614	Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.	Dinov ID et al.	2016	PloS one
27540764	Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.	Noordam R et al.	2016	Aging
27583919	The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population.	Zheng J et al.	2016	Medicine
27584680	Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study.	Ding N et al.	2016	PloS one
27589735	A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.	Ponasenko AV et al.	2016	International journal of molecular sciences
27662287	Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.	Darst BF et al.	2017	Journal of Alzheimer's disease
27677442	Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.	Weber KS et al.	2016	Cardiovascular diabetology
27716211	A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.	Beaney KE et al.	2016	Cardiovascular diabetology
27724906	Association of apolipoprotein E polymorphism with plasma lipid disorders, independent of obesity-related traits in Vietnamese children.	Hanh NT et al.	2016	Lipids in health and disease
27775101	Incorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.	Graham HT et al.	2016	Frontiers in genetics
27783031	Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B(12) and Hcy Status with Cognitive Functions in Chinese Adults.	Cai C et al.	2016	Nutrients
27798356	Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population.	Yvert T et al.	2016	Physiological reports
27805002	Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease.	Chen YC et al.	2016	Scientific reports
27814994	The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.	Gan-Or Z et al.	2017	Neurobiology of aging
27943270	A genetic risk score is significantly associated with statin therapy response in the elderly population.	Ciuculete DM et al.	2017	Clinical genetics
27979356	Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.	Irwin DJ et al.	2017	The Lancet. Neurology
28034305	SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan.	Chou CT et al.	2016	Alzheimer's research & therapy
28050343	Brain insulin resistance deteriorates cognition by altering the topological features of brain networks.	Su F et al.	2017	NeuroImage. Clinical
28079798	Clinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement.	Liu R et al.	2017	Medicine
28086795	Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study.	Fawzy MS et al.	2017	BMC cardiovascular disorders
28099408	Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202.	Verma A et al.	2017	Pharmacogenetics and genomics
28123423	Apolipoprotein E polymorphisms increase the risk of post-stroke depression.	Li XB et al.	2016	Neural regeneration research
28167353	Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.	Shahid SU et al.	2017	Atherosclerosis
28189700	CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.	Fardo DW et al.	2017	Experimental gerontology
28253266	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.	Wu X et al.	2017	PloS one
28371326	Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study.	Zhu Y et al.	2017	Journal of cellular and molecular medicine
28388928	SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature.	Bokharaeian B et al.	2017	Journal of biomedical semantics
28399184	Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.	Huertas I et al.	2017	PloS one
28449691	The impact of rare and low-frequency genetic variants in common disease.	Bomba L et al.	2017	Genome biology
28464262	A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans.	Reales G et al.	2017	American journal of physical anthropology
28480219	Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort.	Norda S et al.	2017	BioMed research international
28512139	A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms.	Mack S et al.	2017	Journal of lipid research
28558900	Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.	Shankarappa BM et al.	2017	Asian journal of psychiatry
28577571	Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.	Paththinige CS et al.	2017	Lipids in health and disease
28605058	Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia.	Ward KM et al.	2017	Pharmacotherapy
28645497	An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players.	Abrahams S et al.	2018	Journal of science and medicine in sport
28672022	APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.	Yu L et al.	2017	PloS one
28686695	Coronary artery disease-associated genetic variants and biomarkers of inflammation.	Christiansen MK et al.	2017	PloS one
28705542	Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease.	Ansari WM et al.	2019	Cytokine
28720344	APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome.	Franco LP et al.	2018	Clinical nutrition (Edinburgh, Scotland)
28727855	Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.	Larifla L et al.	2017	PloS one
28800603	Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.	Arpawong TE et al.	2017	PloS one
28812116	SLCO1B1 521T > C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case-control study.	Liu JE et al.	2017	European journal of clinical pharmacology
28824412	ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population.	Zhen J et al.	2017	Frontiers in aging neuroscience
28840058	P2X(7) Receptor and APOE Polymorphisms and Survival from Heart Failure: A Prospective Study in Frail Patients in a Geriatric Unit.	Pasqualetti G et al.	2017	Aging and disease
29059476	Influence of Apolipoprotein E polymorphism on susceptibility of Wilson disease.	Roy S et al.	2018	Annals of human genetics
29074556	Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.	Zhao LL et al.	2017	Bioscience reports
29125573	Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms.	Ojeda-Granados C et al.	2017	Journal of personalized medicine
29193749	Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.	Borobia AM et al.	2018	Clinical and translational science
29201112	Association of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population.	Rafiee S et al.	2017	Iranian journal of pharmaceutical research
29213291	Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population.	Suvatha A et al.	2017	Cellular & molecular biology letters
29340220	Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study.	Kukava NG et al.	2017	Acta naturae
29374275	Usefulness of the genetic risk score to identify phenocopies in families with familial hypercholesterolemia?	Ghaleb Y et al.	2018	European journal of human genetics
29395286	An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk.	Rao S et al.	2018	Neurobiology of aging
29532745	Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.	Graetz C et al.	2019	Multiple sclerosis (Houndmills, Basingstoke, England)
29534716	Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals.	Nordestgaard LT et al.	2018	BMC medicine
29558945	Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population.	Gu M et al.	2018	Virology journal
29712557	Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors.	Shatwan IM et al.	2018	Lipids in health and disease
29764032	[Genes polymorphism of BIN1 and ApoE in patients with amnestic mild cognitive impairment from Enshi Tujia area].	Chen J et al.	2018	Zhonghua yi xue za zhi
29776682	The impact of Apolipoprotein E alleles on cognitive performance in patients with Parkinson's disease.	Pierzchlińska A et al.	2018	Neurologia i neurochirurgia polska
29851526	The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration.	Liutkeviciene R et al.	2018	Ophthalmic genetics
29892926	The relationship between genetic polymorphisms in apolipoprotein E (ApoE) gene and osteonecrosis of the femoral head induced by steroid in Chinese Han population.	Yuan L et al.	2018	Genes & genomics
29932521	Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia.	Pawlikowska L et al.	2018	Molecular genetics & genomic medicine
29942042	A decade in psychiatric GWAS research.	Horwitz T et al.	2019	Molecular psychiatry
29972410	Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants.	Pereira A et al.	2018	Arquivos brasileiros de cardiologia
29976289	Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease.	Saeed A et al.	2018	Journal of the American College of Cardiology
29996665	The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.	Reuter-Rice K et al.	2018	Biological research for nursing
30088610	An association study of FOXO3 variant and longevity.	Silva-Sena GG et al.	2018	Genetics and molecular biology
30112393	Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population.	Zhou L et al.	2018	BioMed research international
30182779	Genetic susceptibility to cerebrovascular disease: A systematic review.	Griessenauer CJ et al.	2018	Journal of cerebral blood flow and metabolism
30202567	Genetic findings in sport-related concussions: potential for individualized medicine?	McDevitt J et al.	2017	Concussion (London, England)
30235358	Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study.	Almigbal TH et al.	2018	Acta biochimica Polonica
30338758	First Bosnian Study of the Relationship between APOE rs7412 and rs429358 Variants and Pregnancy Loss.	Adler G et al.	2018	Folia biologica
30462377	Independent associations of TOMM40 and APOE variants with body mass index.	Kulminski AM et al.	2019	Aging cell
30478798	Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV.	Womersley JS et al.	2019	Journal of neurovirology
30571812	Additional value of a combined genetic risk score to standard cardiovascular stratification.	Pereira A et al.	2018	Genetics and molecular biology
30576806	APOE hypermethylation is significantly associated with coronary heart disease in males.	Ji H et al.	2019	Gene
30584432	Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.	Daneshpour MS et al.	2018	International journal of endocrinology and metabolism
30660866	Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.	Schmid B et al.	2019	Stem cell research
30679475	The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.	Karjalainen JP et al.	2019	Scientific reports
30740535	Coronary artery disease, genetic risk and the metabolome in young individuals.	Battram T et al.	2018	Wellcome open research
30788380	Association study between DNA methylation and genetic variation of APOE gene with the risk of coronary artery disease.	Ghaznavi H et al.	2018	Molecular biology research communications
30819100	10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors.	Tindale LC et al.	2019	BMC geriatrics
30909076	BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.	Doherty C et al.	2019	Epilepsy & behavior
31054363	Association of ApoE haplotype with clinical evidence of pituitary adenoma.	Sidaraite A et al.	2019	Gene
31126849	Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population.	Diptiranjan S et al.	2019	Journal of clinical neuroscience
31127079	Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.	Chaudhury S et al.	2019	Translational psychiatry
31134487	Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.	Pal P et al.	2019	Neuromolecular medicine
31166609	Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study.	Gomez-Delgado F et al.	2019	European journal of clinical investigation
31192002	Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population.	Ma YN et al.	2019	Journal of ophthalmology
31249592	The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2(nd) Trimester Lipid Levels and Preterm Birth.	Kovac U et al.	2019	Frontiers in genetics
31381519	APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke.	Werden E et al.	2019	Journal of Alzheimer's disease
31413261	A meta-analysis of genome-wide association studies identifies multiple longevity genes.	Deelen J et al.	2019	Nature communications
31469155	The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease.	Santos LRD et al.	2020	Genetics and molecular biology
31480637	Impact of the Apolipoprotein E (epsilon) Genotype on Cardiometabolic Risk Markers and Responsiveness to Acute and Chronic Dietary Fat Manipulation.	Rathnayake KM et al.	2019	Nutrients
31481563	Cohort profile: role of lipoproteins in cardiovascular disease-the LipidCardio study.	König M et al.	2019	BMJ open
31523375	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.	Camargos EF et al.	2019	International journal of molecular epidemiology and genetics
31559922	APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population.	Wang C et al.	2019	Pharmacogenomics
31585025	The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus.	Gavra P et al.	2019	International journal of clinical practice
31654486	The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population.	Fernández-Vega B et al.	2020	Acta ophthalmologica
31854268	Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients.	Li W et al.	2020	Pharmacogenomics
31861518	Genetic Associations with Aging Muscle: A Systematic Review.	Pratt J et al.	2019	Cells
32211503	Genetic and regulatory architecture of Alzheimer's disease in the APOE region.	Kulminski AM et al.	2020	Alzheimer's & dementia (Amsterdam, Netherlands)
32326111	Role of Genetic Variations in the Hepatic Handling of Drugs.	Marin JJG et al.	2020	International journal of molecular sciences
32352830	Combined genetic influences on episodic memory decline in older adults without dementia.	Laukka EJ et al.	2020	Neuropsychology
32358224	Is APOE ε4 associated with cognitive performance in early MS?	Engel S et al.	2020	Neurology(R) neuroimmunology & neuroinflammation
32622117	Trace elements and APOE polymorphisms in pregnant women and their new-borns.	Trdin A et al.	2020	Environment international
32651314	Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers.	Fan KH et al.	2020	Journal of Alzheimer's disease
32676622	Genetic associations for two biological age measures point to distinct aging phenotypes.	Kuo CL et al.	2020	medRxiv
32713352	Does polymorphisms in PPAR and APOE genes modify associations between fatty acid desaturase (FADS), n-3 long-chain PUFA and cardiometabolic markers in 8-11-year-old Danish children?	Damsgaard CT et al.	2021	The British journal of nutrition
32795354	Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response.	Yuan B et al.	2020	BMC psychiatry
32808727	APOE and dementia - resequencing and genotyping in 105,597 individuals.	Rasmussen KL et al.	2020	Alzheimer's & dementia
32867607	Are KIF6 and APOE polymorphisms associated with power and endurance athletes?	Wojciechowicz B et al.	2021	European journal of sport science
32891149	The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population.	Wu H et al.	2020	Lipids in health and disease
32914893	Association of PICALM with Cognitive Impairment in Parkinson's Disease.	Periñán MT et al.	2021	Movement disorders
32924542	Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E.	Brewin JN et al.	2020	Circulation. Genomic and precision medicine
32985495	Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.	Li W et al.	2020	Medical science monitor
32996248	A Combination of Single Nucleotide Polymorphisms is Associated with the Interindividual Variability of Cholesterol Bioavailability in Healthy Adult Males.	Desmarchelier C et al.	2020	Molecular nutrition & food research
33057949	Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).	Alavez-Rubio JS et al.	2021	Molecular neurobiology
33059023	Association of Apolipoprotein E gene polymorphism with the risk of T2DM and obesity among Egyptian subjects.	Galal AA et al.	2021	Gene
33163038	Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study.	Boulenouar H et al.	2020	African health sciences
33285739	The association study of Apolipoprotein E polymorphisms and chronic obstructive pulmonary disease in the Chinese population: A case-control study.	Zhang Y et al.	2020	Medicine
33287609	"Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients".	Occhiutto ML et al.	2021	Ophthalmic genetics
33296721	Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications.	Williams PT et al.	2021	International journal of cardiology
33437219	Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.	Al-Eitan LN et al.	2021	International journal of medical sciences
33467888	Evaluation of APOE polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian population.	Viturino MG et al.	2021	Experimental biology and medicine (Maywood, N.J.)
33519226	Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.	Fernandes MR et al.	2021	Pharmacogenomics and personalized medicine
33659002	The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review.	Mewamba EM et al.	2021	Frontiers in immunology
33663605	Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.	Wang H et al.	2021	Alzheimer's research & therapy
33730676	COVID-19 enters the expanding network of apolipoprotein E4-related pathologies.	Gkouskou K et al.	2021	Redox biology
33763108	Whole Genome Interpretation for a Family of Five.	Corpas M et al.	2021	Frontiers in genetics
33815092	Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review.	Vogrinc D et al.	2021	Frontiers in aging neuroscience
33864613	Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population.	Seo JY et al.	2021	Genes & genomics
33926499	Protective genes and pathways in Alzheimer's disease: moving towards precision interventions.	Seto M et al.	2021	Molecular neurodegeneration
33941312	Whole-genome sequencing analysis of semi-supercentenarians.	Garagnani P et al.	2021	eLife
33970751	Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles.	Curtis D et al.	2021	Journal of neurogenetics
34034613	Behavioural effects of the ACE insertion/deletion polymorphism in Alzheimer's disease depend upon stratification according to APOE-ϵ4 carrier status.	Oliveira FF et al.	2021	Cognitive neuropsychiatry
34038024	Genetic associations for two biological age measures point to distinct aging phenotypes.	Kuo CL et al.	2021	Aging cell
34137427	Genetic information improves the prediction of major adverse cardiovascular events in the GENEMACOR population.	Mendonça MI et al.	2021	Genetics and molecular biology
34241534	Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.	Lu Y et al.	2021	Circulation. Genomic and precision medicine
34276231	Epicardial Adipose Tissue: The Genetics Behind an Emerging Cardiovascular Risk Marker.	Sousa JA et al.	2021	Clinical Medicine Insights. Cardiology
34310032	Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.	Kulminski AM et al.	2021	Alzheimer's & dementia
34313350	APOE gene ɛ4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population.	Liu Q et al.	2021	Journal of clinical laboratory analysis
34328600	The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics.	Dlouha L et al.	2021	Molecular biology reports
34339344	Associations between Apolipoprotein E Gene Polymorphism, Diet and Dyslipidemia in a Yao Minority Area, China.	Cai J et al.	2022	Journal of the American Nutrition Association
34426508	Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.	Bowker N et al.	2021	Diabetes
34427645	Lifestyle Factors and Genetic Variants on 2 Biological Age Measures: Evidence From 94 443 Taiwan Biobank Participants.	Lin WY et al.	2022	The journals of gerontology. Series A, Biological sciences and medical sciences
34587962	Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation.	Deng X et al.	2021	Lipids in health and disease
34616421	Single Nucleotide Polymorphisms in Apolipoprotein B, Apolipoprotein E, and Methylenetetrahydrofolate Reductase Are Associated With Serum Lipid Levels in Northern Chilean Subjects. A Pilot Study.	Gálvez AS et al.	2021	Frontiers in genetics
34686405	Examining the effects of the CLU and APOE polymorphisms' combination on coronary artery disease complexed with type 2 diabetes mellitus.	Ozuynuk AS et al.	2022	Journal of diabetes and its complications
34782536	Distribution of APOE gene polymorphism in the Chinese Uyghur children & its association with urolithiasis.	Huang Y et al.	2021	The Indian journal of medical research
34805411	Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects' Periodontal, Glycemic, and Lipid Profiles.	Nicchio IG et al.	2021	Journal of diabetes research
34814699	Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.	Katz DH et al.	2022	Circulation
34817242	Does personalised nutrition advice based on apolipoprotein E and methylenetetrahydrofolate reductase genotype affect dietary behaviour?	King A et al.	2022	Nutrition and health
34905955	Pharmacogenetic loci for rosuvastatin are associated with intima-media thickness change and coronary artery disease risk.	Kononov S et al.	2022	Pharmacogenomics
34958020	Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.	Dong L et al.	2022	Journal of Alzheimer's disease
34958284	Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes.	Muyambo S et al.	2022	Omics
35088019	The role of the KIBRA and APOE genes in developing spatial abilities in humans.	Kazantseva AV et al.	2021	Vavilovskii zhurnal genetiki i selektsii
35124268	Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.	Li J et al.	2022	Clinical gastroenterology and hepatology
35124466	Association of fish oil supplementation with risk of incident dementia: A prospective study of 215,083 older adults.	Liu X et al.	2022	Clinical nutrition (Edinburgh, Scotland)
35135450	Association of Alzheimer's Disease with Genetic Variants of Apolipoprotein E, Clusterin, TNF-α, and IL-6 Among Elderly Saudis.	Abdi S et al.	2022	Current pharmaceutical biotechnology
35193914	Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review.	Keathley J et al.	2022	BMJ open
35241926	Ferroptosis-Related APOE, BCL3 and ALOX5AP Gene Polymorphisms are Associated with the Risk of Thyroid Cancer.	Xiao Z et al.	2022	Pharmacogenomics and personalized medicine
35301180	A genome-wide association study of outcome from traumatic brain injury.	Kals M et al.	2022	EBioMedicine
35332187	Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke.	Pitchika A et al.	2022	Scientific reports
35347084	VEGF-A-related genetic variants protect against Alzheimer's disease.	Petrelis AM et al.	2022	Aging
35351068	Combined homocysteine and apoE rs429358 and rs7412 polymorphism in association with serum lipid levels and cognition in Chinese community-dwelling older adults.	Wang C et al.	2022	BMC psychiatry
35351696	Empowering consumers to PREVENT diet-related diseases through OMICS sciences (PREVENTOMICS): protocol for a parallel double-blinded randomised intervention trial to investigate biomarker-based nutrition plans for weight loss.	Aldubayan MA et al.	2022	BMJ open
35384166	Polygenic risk of Alzheimer's disease in the Faroe Islands.	Johansen M et al.	2022	European journal of neurology
35387194	Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review.	Pérez-Beltrán YE et al.	2022	Frontiers in nutrition
35647761	Apolipoprotein E*Ɛ2 carriers exhibit high aspirin-treated platelet reactivity and low cardiovascular risk during long-term aspirin treatment.	Li XL et al.	2022	Age and ageing
35710974	Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID-19?	Ceylan MR et al.	2022	Journal of medical virology
35719839	Association of DNA methylation and genetic variations of the APOE gene with the risk of diabetic dyslipidemia.	Ereqat S et al.	2022	Biomedical reports
35723376	Associations of APOE Gene Variants rs429358 and rs7412 with Parameters of the Blood Lipid Profile and the Risk of Myocardial Infarction and Death in a White Population of Western Siberia.	Semaev S et al.	2022	Current issues in molecular biology
35809216	Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.	Nazarian A et al.	2023	GeroScience
35892323	The Role of ApoE Serum Levels and ApoE Gene Polymorphisms in Patients with Laryngeal Squamous Cell Carcinoma.	Liutkeviciene R et al.	2022	Biomolecules
35990035	Apolipoprotein-E Gene Polymorphism and Lipid Composition among IUGR and AGA Neonates.	Elangovan B et al.	2022	Journal of pediatric genetics
36011277	Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study.	Yeh KH et al.	2022	Genes

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dbSNP Short Genetic Variations

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Reference SNP (rs) Report

rs7412