dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs4149056
Current Build 156
Released September 21, 2022
- Organism
- Homo sapiens
- Position
-
chr12:21178615 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- T>A / T>C
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
C=0.149533 (45547/304594, ALFA)C=0.111092 (29405/264690, TOPMED)C=0.132876 (33347/250964, GnomAD_exome) (+ 27 more)
- Clinical Significance
- Reported in ClinVar
- Gene : Consequence
- SLCO1B1 : Missense Variant
- Publications
- 256 citations
- Genomic View
- See rs on genome
ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20231103111315
| Population | Group | Sample Size | Ref Allele | Alt Allele | Ref HMOZ | Alt HMOZ | HTRZ | HWEP |
|---|---|---|---|---|---|---|---|---|
| Total | Global | 321016 | T=0.852045 | C=0.147955 | 0.727023 | 0.022933 | 0.250044 | 6 |
| European | Sub | 261980 | T=0.841412 | C=0.158588 | 0.707878 | 0.025055 | 0.267066 | 0 |
| African | Sub | 16376 | T=0.96629 | C=0.03371 | 0.93405 | 0.001466 | 0.064485 | 1 |
| African Others | Sub | 554 | T=0.995 | C=0.005 | 0.98917 | 0.0 | 0.01083 | 0 |
| African American | Sub | 15822 | T=0.96530 | C=0.03470 | 0.93212 | 0.001517 | 0.066363 | 0 |
| Asian | Sub | 3846 | T=0.8801 | C=0.1199 | 0.774831 | 0.014561 | 0.210608 | 0 |
| East Asian | Sub | 2452 | T=0.8785 | C=0.1215 | 0.772431 | 0.015498 | 0.212072 | 0 |
| Other Asian | Sub | 1394 | T=0.8831 | C=0.1169 | 0.779053 | 0.012912 | 0.208034 | 0 |
| Latin American 1 | Sub | 1336 | T=0.8645 | C=0.1355 | 0.752994 | 0.023952 | 0.223054 | 1 |
| Latin American 2 | Sub | 9048 | T=0.8773 | C=0.1227 | 0.76901 | 0.014368 | 0.216622 | 0 |
| South Asian | Sub | 5054 | T=0.9523 | C=0.0477 | 0.908192 | 0.003562 | 0.088247 | 1 |
| Other | Sub | 23376 | T=0.85438 | C=0.14562 | 0.731776 | 0.023015 | 0.245209 | 2 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| Allele Frequency Aggregator | Total | Global | 304594 | T=0.850467 | C=0.149533 |
| Allele Frequency Aggregator | European | Sub | 251826 | T=0.841398 | C=0.158602 |
| Allele Frequency Aggregator | Other | Sub | 21930 | T=0.85417 | C=0.14583 |
| Allele Frequency Aggregator | African | Sub | 11554 | T=0.96400 | C=0.03600 |
| Allele Frequency Aggregator | Latin American 2 | Sub | 9048 | T=0.8773 | C=0.1227 |
| Allele Frequency Aggregator | South Asian | Sub | 5054 | T=0.9523 | C=0.0477 |
| Allele Frequency Aggregator | Asian | Sub | 3846 | T=0.8801 | C=0.1199 |
| Allele Frequency Aggregator | Latin American 1 | Sub | 1336 | T=0.8645 | C=0.1355 |
| TopMed | Global | Study-wide | 264690 | T=0.888908 | C=0.111092 |
| gnomAD - Exomes | Global | Study-wide | 250964 | T=0.867124 | C=0.132876 |
| gnomAD - Exomes | European | Sub | 135084 | T=0.834644 | C=0.165356 |
| gnomAD - Exomes | Asian | Sub | 48934 | T=0.92116 | C=0.07884 |
| gnomAD - Exomes | American | Sub | 34530 | T=0.88789 | C=0.11211 |
| gnomAD - Exomes | African | Sub | 16252 | T=0.97188 | C=0.02812 |
| gnomAD - Exomes | Ashkenazi Jewish | Sub | 10048 | T=0.81977 | C=0.18023 |
| gnomAD - Exomes | Other | Sub | 6116 | T=0.8344 | C=0.1656 |
| gnomAD - Genomes | Global | Study-wide | 140136 | T=0.878939 | C=0.121061 |
| gnomAD - Genomes | European | Sub | 75854 | T=0.83402 | C=0.16598 |
| gnomAD - Genomes | African | Sub | 42040 | T=0.96751 | C=0.03249 |
| gnomAD - Genomes | American | Sub | 13640 | T=0.87045 | C=0.12955 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 3322 | T=0.8257 | C=0.1743 |
| gnomAD - Genomes | East Asian | Sub | 3128 | T=0.8724 | C=0.1276 |
| gnomAD - Genomes | Other | Sub | 2152 | T=0.8773 | C=0.1227 |
| ExAC | Global | Study-wide | 121290 | T=0.870566 | C=0.129434 |
| ExAC | Europe | Sub | 73286 | T=0.83487 | C=0.16513 |
| ExAC | Asian | Sub | 25144 | T=0.92360 | C=0.07640 |
| ExAC | American | Sub | 11552 | T=0.89352 | C=0.10648 |
| ExAC | African | Sub | 10402 | T=0.97164 | C=0.02836 |
| ExAC | Other | Sub | 906 | T=0.833 | C=0.167 |
| 14KJPN | JAPANESE | Study-wide | 28258 | T=0.85576 | C=0.14424 |
| 8.3KJPN | JAPANESE | Study-wide | 16760 | T=0.85758 | C=0.14242 |
| GO Exome Sequencing Project | Global | Study-wide | 13006 | T=0.88505 | C=0.11495 |
| GO Exome Sequencing Project | European American | Sub | 8600 | T=0.8447 | C=0.1553 |
| GO Exome Sequencing Project | African American | Sub | 4406 | T=0.9639 | C=0.0361 |
| 1000Genomes_30x | Global | Study-wide | 6404 | T=0.9171 | C=0.0829 |
| 1000Genomes_30x | African | Sub | 1786 | T=0.9860 | C=0.0140 |
| 1000Genomes_30x | Europe | Sub | 1266 | T=0.8515 | C=0.1485 |
| 1000Genomes_30x | South Asian | Sub | 1202 | T=0.9584 | C=0.0416 |
| 1000Genomes_30x | East Asian | Sub | 1170 | T=0.8812 | C=0.1188 |
| 1000Genomes_30x | American | Sub | 980 | T=0.868 | C=0.132 |
| 1000Genomes | Global | Study-wide | 5008 | T=0.9123 | C=0.0877 |
| 1000Genomes | African | Sub | 1322 | T=0.9864 | C=0.0136 |
| 1000Genomes | East Asian | Sub | 1008 | T=0.8770 | C=0.1230 |
| 1000Genomes | Europe | Sub | 1006 | T=0.8390 | C=0.1610 |
| 1000Genomes | South Asian | Sub | 978 | T=0.957 | C=0.043 |
| 1000Genomes | American | Sub | 694 | T=0.866 | C=0.134 |
| Genetic variation in the Estonian population | Estonian | Study-wide | 4480 | T=0.7850 | C=0.2150 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | T=0.8563 | C=0.1437 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | T=0.8436 | C=0.1564 |
| MxGDAR/Encodat-PGx | Global | Study-wide | 3254 | T=0.8940 | C=0.1060 |
| MxGDAR/Encodat-PGx | MxGDAR | Sub | 3254 | T=0.8940 | C=0.1060 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2930 | T=0.8563 | C=0.1437 |
| HapMap | Global | Study-wide | 1892 | T=0.9049 | C=0.0951 |
| HapMap | American | Sub | 770 | T=0.905 | C=0.095 |
| HapMap | African | Sub | 692 | T=0.945 | C=0.055 |
| HapMap | Asian | Sub | 254 | T=0.878 | C=0.122 |
| HapMap | Europe | Sub | 176 | T=0.784 | C=0.216 |
| Genome-wide autozygosity in Daghestan | Global | Study-wide | 1134 | T=0.8765 | C=0.1235 |
| Genome-wide autozygosity in Daghestan | Daghestan | Sub | 628 | T=0.876 | C=0.124 |
| Genome-wide autozygosity in Daghestan | Near_East | Sub | 144 | T=0.812 | C=0.188 |
| Genome-wide autozygosity in Daghestan | Central Asia | Sub | 122 | T=0.910 | C=0.090 |
| Genome-wide autozygosity in Daghestan | Europe | Sub | 108 | T=0.898 | C=0.102 |
| Genome-wide autozygosity in Daghestan | South Asian | Sub | 96 | T=0.94 | C=0.06 |
| Genome-wide autozygosity in Daghestan | Caucasus | Sub | 36 | T=0.81 | C=0.19 |
| Genome of the Netherlands Release 5 | Genome of the Netherlands | Study-wide | 998 | T=0.838 | C=0.162 |
| CNV burdens in cranial meningiomas | Global | Study-wide | 790 | T=0.858 | C=0.142 |
| CNV burdens in cranial meningiomas | CRM | Sub | 790 | T=0.858 | C=0.142 |
| Chileans | Chilean | Study-wide | 626 | T=0.867 | C=0.133 |
| A Vietnamese Genetic Variation Database | Global | Study-wide | 614 | T=0.871 | C=0.129 |
| Northern Sweden | ACPOP | Study-wide | 600 | T=0.813 | C=0.187 |
| Medical Genome Project healthy controls from Spanish population | Spanish controls | Study-wide | 534 | T=0.873 | C=0.127 |
| PharmGKB Aggregated | Global | Study-wide | 446 | T=0.883 | C=0.117 |
| PharmGKB Aggregated | PA148417101 | Sub | 356 | T=0.885 | C=0.115 |
| PharmGKB Aggregated | PA142997071 | Sub | 90 | T=0.88 | C=0.12 |
| FINRISK | Finnish from FINRISK project | Study-wide | 304 | T=0.799 | C=0.201 |
| Qatari | Global | Study-wide | 216 | T=0.681 | C=0.319 |
| SGDP_PRJ | Global | Study-wide | 134 | T=0.470 | C=0.530 |
| Ancient Sardinia genome-wide 1240k capture data generation and analysis | Global | Study-wide | 56 | T=0.79 | C=0.21 |
| The Danish reference pan genome | Danish | Study-wide | 40 | T=0.90 | C=0.10 |
| Siberian | Global | Study-wide | 20 | T=0.35 | C=0.65 |
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.21178615T>A |
| GRCh38.p14 chr 12 | NC_000012.12:g.21178615T>C |
| GRCh37.p13 chr 12 | NC_000012.11:g.21331549T>A |
| GRCh37.p13 chr 12 | NC_000012.11:g.21331549T>C |
| SLCO1B1 RefSeqGene (LRG_1022) | NG_011745.1:g.52422T>A |
| SLCO1B1 RefSeqGene (LRG_1022) | NG_011745.1:g.52422T>C |
Gene: SLCO1B1, solute carrier organic anion transporter family member 1B1
(plus strand)
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| SLCO1B1 transcript | NM_006446.5:c.521T>A | V [GTG] > E [GAG] | Coding Sequence Variant |
| solute carrier organic anion transporter family member 1B1 | NP_006437.3:p.Val174Glu | V (Val) > E (Glu) | Missense Variant |
| SLCO1B1 transcript | NM_006446.5:c.521T>C | V [GTG] > A [GCG] | Coding Sequence Variant |
| solute carrier organic anion transporter family member 1B1 | NP_006437.3:p.Val174Ala | V (Val) > A (Ala) | Missense Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Allele: C (allele ID:
40587
)
| ClinVar Accession | Disease Names | Clinical Significance |
|---|---|---|
| RCV000311457.11 | Rotor syndrome | Benign |
| RCV000325818.7 | not provided | Benign,Other |
| RCV000660832.5 | simvastatin acid response - Metabolism/PK | Drug-Response |
| RCV000999565.4 | Gilbert syndrome | Pathogenic |
| RCV001705611.6 | not specified | Benign |
| RCV001787324.2 | rosuvastatin response - Metabolism/PK | Drug-Response |
| RCV001787325.2 | simvastatin response - Toxicity | Drug-Response |
| RCV001787333.2 | hmg coa reductase inhibitors response - Toxicity | Drug-Response |
| RCV001787819.2 | atorvastatin response - Metabolism/PK | Drug-Response |
| RCV001787820.2 | atorvastatin response - Toxicity | Drug-Response |
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | T= | A | C |
|---|---|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.21178615= | NC_000012.12:g.21178615T>A | NC_000012.12:g.21178615T>C |
| GRCh37.p13 chr 12 | NC_000012.11:g.21331549= | NC_000012.11:g.21331549T>A | NC_000012.11:g.21331549T>C |
| SLCO1B1 RefSeqGene (LRG_1022) | NG_011745.1:g.52422= | NG_011745.1:g.52422T>A | NG_011745.1:g.52422T>C |
| SLCO1B1 transcript | NM_006446.5:c.521= | NM_006446.5:c.521T>A | NM_006446.5:c.521T>C |
| SLCO1B1 transcript | NM_006446.4:c.521= | NM_006446.4:c.521T>A | NM_006446.4:c.521T>C |
| solute carrier organic anion transporter family member 1B1 | NP_006437.3:p.Val174= | NP_006437.3:p.Val174Glu | NP_006437.3:p.Val174Ala |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
159 SubSNP,
30 Frequency,
10 ClinVar
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | RIKENSNPRC | ss5603445 | Dec 16, 2002 (110) |
| 2 | PERLEGEN | ss23994814 | Sep 20, 2004 (123) |
| 3 | PERLEGEN | ss69103281 | May 16, 2007 (127) |
| 4 | PHARMGKB_PAAR-SJCRH | ss69367837 | May 16, 2007 (127) |
| 5 | AFFY | ss74821225 | Aug 16, 2007 (128) |
| 6 | ILLUMINA | ss74860529 | Dec 07, 2007 (129) |
| 7 | AFFY | ss76739628 | Dec 07, 2007 (129) |
| 8 | PHARMGKB_AB_DME | ss84165380 | Dec 15, 2007 (130) |
| 9 | CNG | ss98335524 | Feb 06, 2009 (130) |
| 10 | KRIBB_YJKIM | ss104892522 | Feb 06, 2009 (130) |
| 11 | SNP500CANCER | ss105439952 | Feb 06, 2009 (130) |
| 12 | 1000GENOMES | ss111612583 | Jan 25, 2009 (130) |
| 13 | PMT | ss120239931 | Dec 01, 2009 (131) |
| 14 | ILLUMINA | ss154284256 | Dec 01, 2009 (131) |
| 15 | GMI | ss157207270 | Dec 01, 2009 (131) |
| 16 | ILLUMINA | ss159461161 | Dec 01, 2009 (131) |
| 17 | SEATTLESEQ | ss159725855 | Dec 01, 2009 (131) |
| 18 | ILLUMINA | ss160664636 | Dec 01, 2009 (131) |
| 19 | ILLUMINA | ss173694152 | Jul 04, 2010 (132) |
| 20 | 1000GENOMES | ss235854361 | Jul 15, 2010 (132) |
| 21 | 1000GENOMES | ss242427007 | Jul 15, 2010 (132) |
| 22 | BL | ss254939252 | May 09, 2011 (134) |
| 23 | GMI | ss281304721 | May 04, 2012 (137) |
| 24 | NHLBI-ESP | ss342351447 | May 09, 2011 (134) |
| 25 | ILLUMINA | ss410932299 | Sep 17, 2011 (135) |
| 26 | ILLUMINA | ss480899623 | May 04, 2012 (137) |
| 27 | ILLUMINA | ss480918502 | May 04, 2012 (137) |
| 28 | ILLUMINA | ss481873140 | Sep 08, 2015 (146) |
| 29 | ILLUMINA | ss485244813 | May 04, 2012 (137) |
| 30 | 1000GENOMES | ss491038271 | May 04, 2012 (137) |
| 31 | EXOME_CHIP | ss491465337 | May 04, 2012 (137) |
| 32 | CLINSEQ_SNP | ss491661694 | May 04, 2012 (137) |
| 33 | ILLUMINA | ss537217563 | Sep 08, 2015 (146) |
| 34 | SSMP | ss658575640 | Apr 25, 2013 (138) |
| 35 | ILLUMINA | ss778903365 | Sep 08, 2015 (146) |
| 36 | ILLUMINA | ss780908757 | Sep 08, 2015 (146) |
| 37 | ILLUMINA | ss783068352 | Sep 08, 2015 (146) |
| 38 | ILLUMINA | ss783596229 | Sep 08, 2015 (146) |
| 39 | ILLUMINA | ss784026239 | Sep 08, 2015 (146) |
| 40 | ILLUMINA | ss832326438 | Sep 08, 2015 (146) |
| 41 | ILLUMINA | ss832972664 | Jul 13, 2019 (153) |
| 42 | ILLUMINA | ss834364639 | Sep 08, 2015 (146) |
| 43 | EVA-GONL | ss989317058 | Aug 21, 2014 (142) |
| 44 | JMKIDD_LAB | ss1067532207 | Aug 21, 2014 (142) |
| 45 | JMKIDD_LAB | ss1078305429 | Aug 21, 2014 (142) |
| 46 | 1000GENOMES | ss1344205446 | Aug 21, 2014 (142) |
| 47 | HAMMER_LAB | ss1397628259 | Sep 08, 2015 (146) |
| 48 | DDI | ss1426868011 | Apr 01, 2015 (144) |
| 49 | EVA_GENOME_DK | ss1576155907 | Apr 01, 2015 (144) |
| 50 | EVA_FINRISK | ss1584080712 | Apr 01, 2015 (144) |
| 51 | EVA_DECODE | ss1598989772 | Apr 01, 2015 (144) |
| 52 | EVA_UK10K_ALSPAC | ss1628166987 | Apr 01, 2015 (144) |
| 53 | EVA_UK10K_TWINSUK | ss1671161020 | Apr 01, 2015 (144) |
| 54 | EVA_EXAC | ss1690819669 | Apr 01, 2015 (144) |
| 55 | EVA_MGP | ss1711323290 | Apr 01, 2015 (144) |
| 56 | EVA_SVP | ss1713312654 | Apr 01, 2015 (144) |
| 57 | ILLUMINA | ss1752059980 | Sep 08, 2015 (146) |
| 58 | ILLUMINA | ss1752059981 | Sep 08, 2015 (146) |
| 59 | ILLUMINA | ss1917871588 | Feb 12, 2016 (147) |
| 60 | WEILL_CORNELL_DGM | ss1932681524 | Feb 12, 2016 (147) |
| 61 | ILLUMINA | ss1946333532 | Feb 12, 2016 (147) |
| 62 | ILLUMINA | ss1959419472 | Feb 12, 2016 (147) |
| 63 | JJLAB | ss2027088123 | Sep 14, 2016 (149) |
| 64 | ILLUMINA | ss2094793077 | Dec 20, 2016 (150) |
| 65 | ILLUMINA | ss2095032095 | Dec 20, 2016 (150) |
| 66 | USC_VALOUEV | ss2155413880 | Dec 20, 2016 (150) |
| 67 | HUMAN_LONGEVITY | ss2188375268 | Dec 20, 2016 (150) |
| 68 | SYSTEMSBIOZJU | ss2628023471 | Nov 08, 2017 (151) |
| 69 | ILLUMINA | ss2632934602 | Nov 08, 2017 (151) |
| 70 | ILLUMINA | ss2632934603 | Nov 08, 2017 (151) |
| 71 | ILLUMINA | ss2632934604 | Nov 08, 2017 (151) |
| 72 | ILLUMINA | ss2635034365 | Nov 08, 2017 (151) |
| 73 | GRF | ss2699742158 | Nov 08, 2017 (151) |
| 74 | ILLUMINA | ss2710756091 | Nov 08, 2017 (151) |
| 75 | GNOMAD | ss2739675686 | Nov 08, 2017 (151) |
| 76 | GNOMAD | ss2748826232 | Nov 08, 2017 (151) |
| 77 | GNOMAD | ss2908174641 | Nov 08, 2017 (151) |
| 78 | AFFY | ss2984969936 | Nov 08, 2017 (151) |
| 79 | AFFY | ss2985612469 | Nov 08, 2017 (151) |
| 80 | SWEGEN | ss3009330256 | Nov 08, 2017 (151) |
| 81 | ILLUMINA | ss3021413014 | Nov 08, 2017 (151) |
| 82 | BIOINF_KMB_FNS_UNIBA | ss3027350333 | Nov 08, 2017 (151) |
| 83 | CSIRBIOHTS | ss3029638262 | Nov 08, 2017 (151) |
| 84 | CSHL | ss3349960655 | Nov 08, 2017 (151) |
| 85 | ILLUMINA | ss3625617353 | Oct 12, 2018 (152) |
| 86 | ILLUMINA | ss3626833367 | Oct 12, 2018 (152) |
| 87 | ILLUMINA | ss3626833368 | Oct 12, 2018 (152) |
| 88 | ILLUMINA | ss3630945761 | Oct 12, 2018 (152) |
| 89 | ILLUMINA | ss3633013285 | Oct 12, 2018 (152) |
| 90 | ILLUMINA | ss3633713887 | Oct 12, 2018 (152) |
| 91 | ILLUMINA | ss3634494923 | Oct 12, 2018 (152) |
| 92 | ILLUMINA | ss3634494924 | Oct 12, 2018 (152) |
| 93 | ILLUMINA | ss3635404860 | Oct 12, 2018 (152) |
| 94 | ILLUMINA | ss3636179232 | Oct 12, 2018 (152) |
| 95 | ILLUMINA | ss3637155818 | Oct 12, 2018 (152) |
| 96 | ILLUMINA | ss3637951508 | Oct 12, 2018 (152) |
| 97 | ILLUMINA | ss3640202256 | Oct 12, 2018 (152) |
| 98 | ILLUMINA | ss3640202257 | Oct 12, 2018 (152) |
| 99 | ILLUMINA | ss3642946076 | Oct 12, 2018 (152) |
| 100 | ILLUMINA | ss3644586492 | Oct 12, 2018 (152) |
| 101 | OMUKHERJEE_ADBS | ss3646439197 | Oct 12, 2018 (152) |
| 102 | ILLUMINA | ss3651787138 | Oct 12, 2018 (152) |
| 103 | ILLUMINA | ss3651787139 | Oct 12, 2018 (152) |
| 104 | ILLUMINA | ss3653742482 | Oct 12, 2018 (152) |
| 105 | EGCUT_WGS | ss3676646033 | Jul 13, 2019 (153) |
| 106 | EVA_DECODE | ss3693259763 | Jul 13, 2019 (153) |
| 107 | ILLUMINA | ss3725309283 | Jul 13, 2019 (153) |
| 108 | ACPOP | ss3738837104 | Jul 13, 2019 (153) |
| 109 | ILLUMINA | ss3744392910 | Jul 13, 2019 (153) |
| 110 | ILLUMINA | ss3744795636 | Jul 13, 2019 (153) |
| 111 | ILLUMINA | ss3744795637 | Jul 13, 2019 (153) |
| 112 | EVA | ss3750230606 | Jul 13, 2019 (153) |
| 113 | ILLUMINA | ss3772295160 | Jul 13, 2019 (153) |
| 114 | ILLUMINA | ss3772295161 | Jul 13, 2019 (153) |
| 115 | KHV_HUMAN_GENOMES | ss3815548219 | Jul 13, 2019 (153) |
| 116 | EVA | ss3824711168 | Apr 26, 2020 (154) |
| 117 | EVA | ss3825817689 | Apr 26, 2020 (154) |
| 118 | EVA | ss3833014604 | Apr 26, 2020 (154) |
| 119 | EVA | ss3840075138 | Apr 26, 2020 (154) |
| 120 | EVA | ss3845558985 | Apr 26, 2020 (154) |
| 121 | SGDP_PRJ | ss3877844671 | Apr 26, 2020 (154) |
| 122 | KRGDB | ss3926377291 | Apr 26, 2020 (154) |
| 123 | FSA-LAB | ss3984023422 | Apr 26, 2021 (155) |
| 124 | EVA | ss3984449720 | Apr 26, 2021 (155) |
| 125 | EVA | ss3984663677 | Apr 26, 2021 (155) |
| 126 | EVA | ss3985579645 | Apr 26, 2021 (155) |
| 127 | EVA | ss3986058796 | Apr 26, 2021 (155) |
| 128 | EVA | ss3986562208 | Apr 26, 2021 (155) |
| 129 | EVA | ss4017578099 | Apr 26, 2021 (155) |
| 130 | TOPMED | ss4911206782 | Apr 26, 2021 (155) |
| 131 | TOMMO_GENOMICS | ss5205394692 | Apr 26, 2021 (155) |
| 132 | EVA | ss5236903606 | Apr 26, 2021 (155) |
| 133 | EVA | ss5237219032 | Apr 26, 2021 (155) |
| 134 | EVA | ss5237508214 | Apr 26, 2021 (155) |
| 135 | EVA | ss5237508215 | Apr 26, 2021 (155) |
| 136 | EVA | ss5237659610 | Oct 13, 2022 (156) |
| 137 | 1000G_HIGH_COVERAGE | ss5290064531 | Oct 13, 2022 (156) |
| 138 | TRAN_CS_UWATERLOO | ss5314434916 | Oct 13, 2022 (156) |
| 139 | EVA | ss5315606464 | Oct 13, 2022 (156) |
| 140 | EVA | ss5404381307 | Oct 13, 2022 (156) |
| 141 | HUGCELL_USP | ss5484924592 | Oct 13, 2022 (156) |
| 142 | EVA | ss5510619775 | Oct 13, 2022 (156) |
| 143 | EVA | ss5512473923 | Oct 13, 2022 (156) |
| 144 | 1000G_HIGH_COVERAGE | ss5587120899 | Oct 13, 2022 (156) |
| 145 | EVA | ss5624030208 | Oct 13, 2022 (156) |
| 146 | SANFORD_IMAGENETICS | ss5624296724 | Oct 13, 2022 (156) |
| 147 | SANFORD_IMAGENETICS | ss5652739689 | Oct 13, 2022 (156) |
| 148 | TOMMO_GENOMICS | ss5754290641 | Oct 13, 2022 (156) |
| 149 | EVA | ss5799403798 | Oct 13, 2022 (156) |
| 150 | EVA | ss5799866322 | Oct 13, 2022 (156) |
| 151 | YY_MCH | ss5813078406 | Oct 13, 2022 (156) |
| 152 | EVA | ss5837690650 | Oct 13, 2022 (156) |
| 153 | EVA | ss5847405673 | Oct 13, 2022 (156) |
| 154 | EVA | ss5847662855 | Oct 13, 2022 (156) |
| 155 | EVA | ss5848347707 | Oct 13, 2022 (156) |
| 156 | EVA | ss5850291737 | Oct 13, 2022 (156) |
| 157 | EVA | ss5903573748 | Oct 13, 2022 (156) |
| 158 | EVA | ss5944090257 | Oct 13, 2022 (156) |
| 159 | EVA | ss5979385028 | Oct 13, 2022 (156) |
| 160 | 1000Genomes | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 161 | 1000Genomes_30x | NC_000012.12 - 21178615 | Oct 13, 2022 (156) |
| 162 | The Avon Longitudinal Study of Parents and Children | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 163 | Chileans | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 164 | Genome-wide autozygosity in Daghestan | NC_000012.10 - 21222816 | Apr 26, 2020 (154) |
| 165 | Genetic variation in the Estonian population | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 166 | ExAC | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 167 | FINRISK | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 168 | The Danish reference pan genome | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 169 | gnomAD - Genomes | NC_000012.12 - 21178615 | Apr 26, 2021 (155) |
| 170 | gnomAD - Exomes | NC_000012.11 - 21331549 | Jul 13, 2019 (153) |
| 171 | GO Exome Sequencing Project | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 172 | Genome of the Netherlands Release 5 | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 173 | HapMap | NC_000012.12 - 21178615 | Apr 26, 2020 (154) |
| 174 | KOREAN population from KRGDB | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 175 | Medical Genome Project healthy controls from Spanish population | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 176 | Northern Sweden | NC_000012.11 - 21331549 | Jul 13, 2019 (153) |
| 177 | Ancient Sardinia genome-wide 1240k capture data generation and analysis | NC_000012.11 - 21331549 | Apr 26, 2021 (155) |
| 178 | CNV burdens in cranial meningiomas | NC_000012.11 - 21331549 | Apr 26, 2021 (155) |
| 179 | MxGDAR/Encodat-PGx | NC_000012.11 - 21331549 | Apr 26, 2021 (155) |
| 180 | PharmGKB Aggregated | NC_000012.12 - 21178615 | Apr 26, 2020 (154) |
| 181 | Qatari | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 182 | SGDP_PRJ | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 183 | Siberian | NC_000012.11 - 21331549 | Apr 26, 2020 (154) |
| 184 | 8.3KJPN | NC_000012.11 - 21331549 | Apr 26, 2021 (155) |
| 185 | 14KJPN | NC_000012.12 - 21178615 | Oct 13, 2022 (156) |
| 186 | TopMed | NC_000012.12 - 21178615 | Apr 26, 2021 (155) |
| 187 | UK 10K study - Twins | NC_000012.11 - 21331549 | Oct 12, 2018 (152) |
| 188 | A Vietnamese Genetic Variation Database | NC_000012.11 - 21331549 | Jul 13, 2019 (153) |
| 189 | ALFA | NC_000012.12 - 21178615 | Apr 26, 2021 (155) |
| 190 | ClinVar | RCV000311457.11 | Oct 13, 2022 (156) |
| 191 | ClinVar | RCV000325818.7 | Oct 13, 2022 (156) |
| 192 | ClinVar | RCV000660832.5 | Oct 13, 2022 (156) |
| 193 | ClinVar | RCV000999565.4 | Oct 13, 2022 (156) |
| 194 | ClinVar | RCV001705611.6 | Oct 13, 2022 (156) |
| 195 | ClinVar | RCV001787324.2 | Oct 13, 2022 (156) |
| 196 | ClinVar | RCV001787325.2 | Oct 13, 2022 (156) |
| 197 | ClinVar | RCV001787333.2 | Oct 13, 2022 (156) |
| 198 | ClinVar | RCV001787819.2 | Oct 13, 2022 (156) |
| 199 | ClinVar | RCV001787820.2 | Oct 13, 2022 (156) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
| Associated ID | History Updated (Build) |
|---|---|
| rs52816141 | Sep 21, 2007 (128) |
| rs60037639 | May 25, 2008 (130) |
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| ss5512473923 | NC_000012.11:21331548:T:A | NC_000012.12:21178614:T:A | |
| 99234, ss111612583, ss254939252, ss281304721, ss480899623, ss491661694, ss1397628259, ss1598989772, ss1713312654, ss2635034365, ss3642946076 | NC_000012.10:21222815:T:C | NC_000012.12:21178614:T:C | (self) |
| 56924047, 31607599, 94341, 22384281, 1109611, 77173, 2875614, 8903622, 1168653, 14103403, 33554685, 439050, 12121969, 805572, 213169, 2721, 14723454, 29861651, 7930234, 63363999, 31607599, 7013363, ss235854361, ss242427007, ss342351447, ss480918502, ss481873140, ss485244813, ss491038271, ss491465337, ss537217563, ss658575640, ss778903365, ss780908757, ss783068352, ss783596229, ss784026239, ss832326438, ss832972664, ss834364639, ss989317058, ss1067532207, ss1078305429, ss1344205446, ss1426868011, ss1576155907, ss1584080712, ss1628166987, ss1671161020, ss1690819669, ss1711323290, ss1752059980, ss1752059981, ss1917871588, ss1932681524, ss1946333532, ss1959419472, ss2027088123, ss2094793077, ss2095032095, ss2155413880, ss2628023471, ss2632934602, ss2632934603, ss2632934604, ss2699742158, ss2710756091, ss2739675686, ss2748826232, ss2908174641, ss2984969936, ss2985612469, ss3009330256, ss3021413014, ss3029638262, ss3349960655, ss3625617353, ss3626833367, ss3626833368, ss3630945761, ss3633013285, ss3633713887, ss3634494923, ss3634494924, ss3635404860, ss3636179232, ss3637155818, ss3637951508, ss3640202256, ss3640202257, ss3644586492, ss3646439197, ss3651787138, ss3651787139, ss3653742482, ss3676646033, ss3738837104, ss3744392910, ss3744795636, ss3744795637, ss3750230606, ss3772295160, ss3772295161, ss3824711168, ss3825817689, ss3833014604, ss3840075138, ss3877844671, ss3926377291, ss3984023422, ss3984449720, ss3984663677, ss3985579645, ss3986058796, ss3986562208, ss4017578099, ss5205394692, ss5237508214, ss5237508215, ss5315606464, ss5404381307, ss5510619775, ss5512473923, ss5624030208, ss5624296724, ss5652739689, ss5799403798, ss5799866322, ss5837690650, ss5847405673, ss5847662855, ss5848347707, ss5944090257, ss5979385028 | NC_000012.11:21331548:T:C | NC_000012.12:21178614:T:C | (self) |
| RCV000311457.11, RCV000325818.7, RCV000660832.5, RCV000999565.4, RCV001705611.6, RCV001787324.2, RCV001787325.2, RCV001787333.2, RCV001787819.2, RCV001787820.2, 74646834, 401379866, 771121, 2676, 88127745, 126752439, 3105356627, ss2188375268, ss3027350333, ss3693259763, ss3725309283, ss3815548219, ss3845558985, ss4911206782, ss5236903606, ss5237219032, ss5237659610, ss5290064531, ss5314434916, ss5484924592, ss5587120899, ss5754290641, ss5813078406, ss5850291737, ss5903573748 | NC_000012.12:21178614:T:C | NC_000012.12:21178614:T:C | (self) |
| ss5603445, ss23994814, ss69103281, ss69367837, ss74821225, ss74860529, ss76739628, ss84165380, ss98335524, ss104892522, ss105439952, ss120239931, ss154284256, ss157207270, ss159461161, ss159725855, ss160664636, ss173694152, ss410932299 | NT_009714.17:14091672:T:C | NC_000012.12:21178614:T:C | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
256
citations for rs4149056
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 12811365 | Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. | Nishizato Y et al. | 2003 | Clinical pharmacology and therapeutics |
| 15116054 | Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics. | Mwinyi J et al. | 2004 | Clinical pharmacology and therapeutics |
| 15226675 | High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). | Niemi M et al. | 2004 | Pharmacogenetics |
| 16103896 | An association study of 43 SNPs in 16 candidate genes with atorvastatin response. | Thompson JF et al. | 2005 | The pharmacogenomics journal |
| 16678544 | Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin. | Igel M et al. | 2006 | Clinical pharmacology and therapeutics |
| 16722833 | Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes. | Hedman M et al. | 2006 | British journal of clinical pharmacology |
| 17015053 | SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. | Niemi M et al. | 2006 | Clinical pharmacology and therapeutics |
| 17108811 | SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. | Pasanen MK et al. | 2006 | Pharmacogenetics and genomics |
| 17439540 | SLCO1B1 521T-->C functional genetic polymorphism and lipid-lowering efficacy of multiple-dose pravastatin in Chinese coronary heart disease patients. | Zhang W et al. | 2007 | British journal of clinical pharmacology |
| 17473846 | Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. | Pasanen MK et al. | 2007 | Clinical pharmacology and therapeutics |
| 17622941 | Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants. | Ho RH et al. | 2007 | Pharmacogenetics and genomics |
| 18547414 | Genotyping panel for assessing response to cancer chemotherapy. | Dai Z et al. | 2008 | BMC medical genomics |
| 18650507 | SLCO1B1 variants and statin-induced myopathy--a genomewide study. | Link E et al. | 2008 | The New England journal of medicine |
| 18794729 | Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate. | Pasanen MK et al. | 2008 | Pharmacogenetics and genomics |
| 19414484 | Genome-wide association meta-analysis for total serum bilirubin levels. | Johnson AD et al. | 2009 | Human molecular genetics |
| 19419973 | Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. | Sanna S et al. | 2009 | Human molecular genetics |
| 19474294 | Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. | Hindorff LA et al. | 2009 | Proceedings of the National Academy of Sciences of the United States of America |
| 19642078 | Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients. | Toms TE et al. | 2010 | Musculoskeletal care |
| 19694740 | No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin. | Keskitalo JE et al. | 2009 | British journal of clinical pharmacology |
| 19762696 | Pharmacogenetics and stroke. | Meschia JF et al. | 2009 | Stroke |
| 19833260 | The SLCO1B1*5 genetic variant is associated with statin-induced side effects. | Voora D et al. | 2009 | Journal of the American College of Cardiology |
| 19901119 | Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. | Treviño LR et al. | 2009 | Journal of clinical oncology |
| 19952871 | PharmGKB very important pharmacogene: SLCO1B1. | Oshiro C et al. | 2010 | Pharmacogenetics and genomics |
| 20078617 | The impact of SLCO1B1 polymorphisms on the plasma concentration of lopinavir and ritonavir in HIV-infected men. | Kohlrausch FB et al. | 2010 | British journal of clinical pharmacology |
| 20139798 | ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir. | Lubomirov R et al. | 2010 | Pharmacogenetics and genomics |
| 20175863 | The genetics of ischaemic stroke. | Matarin M et al. | 2010 | Journal of internal medicine |
| 20389299 | Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. | Xu CF et al. | 2010 | British journal of cancer |
| 20435227 | Clinical assessment incorporating a personal genome. | Ashley EA et al. | 2010 | Lancet (London, England) |
| 20521218 | Progress toward genetic tailoring of heart failure therapy. | Lillvis JH et al. | 2010 | Current opinion in molecular therapeutics |
| 20639394 | Genome-wide association of serum bilirubin levels in Korean population. | Kang TW et al. | 2010 | Human molecular genetics |
| 20837016 | Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. | Buch S et al. | 2010 | Gastroenterology |
| 20921971 | Mapping genes that predict treatment outcome in admixed populations. | Baye TM et al. | 2010 | The pharmacogenomics journal |
| 20973885 | Organic anion transporter 1B1 (SLCO1B1) polymorphism and gallstone formation: High incidence of Exon4 CA genotype in female patients in North India. | Srivastava A et al. | 2011 | Hepatology research |
| 21072184 | Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. | Ni W et al. | 2010 | PloS one |
| 21080475 | Genetic influences on serum bilirubin in American Indians: The Strong Heart Family Study. | Melton PE et al. | 2011 | American journal of human biology |
| 21104722 | ||||
| 21107304 | Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. | Jacobson PA et al. | 2011 | Transplantation |
| 21178985 | Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study. | Donnelly LA et al. | 2011 | Clinical pharmacology and therapeutics |
| 21243006 | Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. | Brunham LR et al. | 2012 | The pharmacogenomics journal |
| 21245207 | Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. | Niemi M et al. | 2011 | Pharmacological reviews |
| 21288825 | Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study. | Lubomirov R et al. | 2011 | The Journal of infectious diseases |
| 21360500 | Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. | Mammen AL et al. | 2011 | Arthritis and rheumatism |
| 21368754 | Functional characterization of liver enhancers that regulate drug-associated transporters. | Kim MJ et al. | 2011 | Clinical pharmacology and therapeutics |
| 21386754 | Cerivastatin, genetic variants, and the risk of rhabdomyolysis. | Marciante KD et al. | 2011 | Pharmacogenetics and genomics |
| 21573225 | Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. | Tayo BO et al. | 2011 | PloS one |
| 21629240 | Genetic susceptibility to ischemic stroke. | Meschia JF et al. | 2011 | Nature reviews. Neurology |
| 21630030 | Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method. | Aklillu E et al. | 2011 | European journal of clinical pharmacology |
| 21826682 | Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS. | Isackson PJ et al. | 2011 | Muscle & nerve |
| 21851379 | The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin. | Martin NG et al. | 2012 | British journal of clinical pharmacology |
| 21928084 | SLCO1B1 haplotypes are not associated with atorvastatin-induced myalgia in Brazilian patients with familial hypercholesterolemia. | Santos PC et al. | 2012 | European journal of clinical pharmacology |
| 21950641 | Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin. | Shin J et al. | 2011 | Pharmacotherapy |
| 22003003 | Personalized vascular medicine: individualizing drug therapy. | Degoma EM et al. | 2011 | Vascular medicine (London, England) |
| 22016628 | Pharmacogenetics of OATP transporters reveals that SLCO1B1 c.388A>G variant is determinant of increased atorvastatin response. | Rodrigues AC et al. | 2011 | International journal of molecular sciences |
| 22085899 | UGT1A1 is a major locus influencing bilirubin levels in African Americans. | Chen G et al. | 2012 | European journal of human genetics |
| 22136368 | Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians. | Sortica Vde A et al. | 2012 | Basic & clinical pharmacology & toxicology |
| 22162992 | Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients. | Yimer G et al. | 2011 | PloS one |
| 22163054 | Stroke Genetics Update: 2011. | Cole JW et al. | 2011 | Current cardiovascular risk reports |
| 22189199 | Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. | Akao H et al. | 2012 | Atherosclerosis |
| 22235271 | Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy. | Glass TR et al. | 2012 | PloS one |
| 22258528 | Discovery of variants unmasked by hemizygous deletions. | Hochstenbach R et al. | 2012 | European journal of human genetics |
| 22275900 | Pharmacogenomics: what is next? | di Iulio J et al. | 2011 | Frontiers in pharmacology |
| 22280100 | Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions. | Clarke JD et al. | 2012 | Expert opinion on drug metabolism & toxicology |
| 22533838 | Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene. | Trdan Lušin T et al. | 2012 | Journal of translational medicine |
| 22552919 | Bioinformatics and variability in drug response: a protein structural perspective. | Lahti JL et al. | 2012 | Journal of the Royal Society, Interface |
| 22562052 | SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury. | Li LM et al. | 2012 | Molecular medicine reports |
| 22580719 | UGT1A1, SLCO1B1, and SLCO1B3 polymorphisms vs. neonatal hyperbilirubinemia: is there an association? | Alencastro de Azevedo L et al. | 2012 | Pediatric research |
| 22616673 | Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes. | Dai H et al. | 2012 | BioData mining |
| 22617227 | The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. | Wilke RA et al. | 2012 | Clinical pharmacology and therapeutics |
| 22668755 | Intronic variants in SLCO1B1 related to statin-induced myopathy are associated with the low-density lipoprotein cholesterol response to statins in Chinese patients with hyperlipidaemia. | Hu M et al. | 2012 | Pharmacogenetics and genomics |
| 22688219 | Transgenic mouse model reveals an unsuspected role of the acetylcholine receptor in statin-induced neuromuscular adverse drug reactions. | Grajales-Reyes GE et al. | 2013 | The pharmacogenomics journal |
| 22711709 | Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel. | de Graan AJ et al. | 2012 | Clinical cancer research |
| 22741812 | MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population. | Santos PC et al. | 2012 | Lipids in health and disease |
| 22808112 | Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania. | Mugusi S et al. | 2012 | PloS one |
| 22938532 | Sequencing and analysis of a South Asian-Indian personal genome. | Gupta R et al. | 2012 | BMC genomics |
| 22990751 | OATP1B1 polymorphism as a determinant of erythromycin disposition. | Lancaster CS et al. | 2012 | Clinical pharmacology and therapeutics |
| 22992668 | Pharmacogenomics knowledge for personalized medicine. | Whirl-Carrillo M et al. | 2012 | Clinical pharmacology and therapeutics |
| 23100282 | Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study. | Hopewell JC et al. | 2013 | European heart journal |
| 23133420 | Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin. | Suarez-Kurtz G et al. | 2012 | Frontiers in pharmacology |
| 23183505 | Possible gene-gender interaction between the SLCO1B1 polymorphism and statin treatment efficacy. | Hubacek JA et al. | 2012 | Neuro endocrinology letters |
| 23233662 | Genome-wide study of methotrexate clearance replicates SLCO1B1. | Ramsey LB et al. | 2013 | Blood |
| 23294634 | Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction. | Dai H et al. | 2013 | BioData mining |
| 23300409 | Chapter 7: Pharmacogenomics. | Karczewski KJ et al. | 2012 | PLoS computational biology |
| 23335936 | Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia. | Stocco G et al. | 2012 | Frontiers in genetics |
| 23361102 | Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects. | Ulvestad M et al. | 2013 | Clinical pharmacology and therapeutics |
| 23471819 | Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method. | Yoshida K et al. | 2013 | The AAPS journal |
| 23480028 | Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings. | Ziesenitz VC et al. | 2013 | Basic & clinical pharmacology & toxicology |
| 23503447 | Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. | Zhang X et al. | 2013 | Therapeutic drug monitoring |
| 23652803 | Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia. | Radtke S et al. | 2013 | Blood |
| 23708174 | Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy. | Danik JS et al. | 2013 | American heart journal |
| 23778707 | International Transporter Consortium commentary on clinically important transporter polymorphisms. | Giacomini KM et al. | 2013 | Clinical pharmacology and therapeutics |
| 23829278 | Genetic polymorphisms predicting methotrexate blood levels and toxicity in adult non-Hodgkin lymphoma. | Avivi I et al. | 2014 | Leukemia & lymphoma |
| 23861838 | Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations. | Ngaimisi E et al. | 2013 | PloS one |
| 23876492 | Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care. | DeGorter MK et al. | 2013 | Circulation. Cardiovascular genetics |
| 23911231 | Statin pharmacogenomics: pursuing biomarkers for predicting clinical outcomes. | Kitzmiller JP et al. | 2013 | Discovery medicine |
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| 36055153 | SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico. | Perea-Jacobo R et al. | 2022 | Tuberculosis (Edinburgh, Scotland) |
Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
Genome context:
Select flank length:
Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.