Entry - *602254 - SRR1 DOMAIN-CONTAINING PROTEIN; SRRD - OMIM

 
 
* 602254

SRR1 DOMAIN-CONTAINING PROTEIN; SRRD


Alternative titles; symbols

HEPATOCELLULAR CARCINOMA COMPLICATING HEMOCHROMATOSIS
HC/HCC


HGNC Approved Gene Symbol: SRRD

Cytogenetic location: 22q12.1   Genomic coordinates (GRCh38) : 22:26,483,877-26,494,658 (from NCBI)


TEXT

▼ Cloning and Expression

Kedar et al. (1996) used differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) to identify a partial mRNA, termed HC/HCC by them, that was strongly expressed in the liver of a patient with hemochromatosis (HC; 235200) and in tumor tissue from a subject with hepatocellular carcinoma (HCC) complicating HC. The HC/HCC cDNA, encoding a 9.5-kb transcript, consists of 342 amino acid residues. By Northern blot analysis, Kedar et al. (1996) showed that the message of this gene is present at very low levels in normal human liver, and is also expressed in lymphocytes of HC patients and in MOLT-4 human T-lymphoid cells.


▼ Mapping

Hartz (2010) mapped the SRRD gene to chromosome 22q12.1 based on an alignment of the SRRD sequence (GenBank BC066962) with the genomic sequence (GRCh37).

▼ REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 11/5/2010.

  2. Kedar, V., Fletcher, L., Powell, L. Molecular cloning of a novel mRNA highly expressed in haemochromatotic human liver and proliferating cells. Biochem. Biophys. Res. Commun. 226: 461-466, 1996. [PubMed: 8806657, related citations] [Full Text]


Creation Date:
Lori M. Kelman : 1/15/1998
Edit History:
carol : 11/05/2010
carol : 11/4/2010
dholmes : 1/30/1998
dholmes : 1/30/1998

* 602254

SRR1 DOMAIN-CONTAINING PROTEIN; SRRD


Alternative titles; symbols

HEPATOCELLULAR CARCINOMA COMPLICATING HEMOCHROMATOSIS
HC/HCC


HGNC Approved Gene Symbol: SRRD

Cytogenetic location: 22q12.1   Genomic coordinates (GRCh38) : 22:26,483,877-26,494,658 (from NCBI)


TEXT

Cloning and Expression

Kedar et al. (1996) used differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) to identify a partial mRNA, termed HC/HCC by them, that was strongly expressed in the liver of a patient with hemochromatosis (HC; 235200) and in tumor tissue from a subject with hepatocellular carcinoma (HCC) complicating HC. The HC/HCC cDNA, encoding a 9.5-kb transcript, consists of 342 amino acid residues. By Northern blot analysis, Kedar et al. (1996) showed that the message of this gene is present at very low levels in normal human liver, and is also expressed in lymphocytes of HC patients and in MOLT-4 human T-lymphoid cells.


Mapping

Hartz (2010) mapped the SRRD gene to chromosome 22q12.1 based on an alignment of the SRRD sequence (GenBank BC066962) with the genomic sequence (GRCh37).

REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 11/5/2010.

  2. Kedar, V., Fletcher, L., Powell, L. Molecular cloning of a novel mRNA highly expressed in haemochromatotic human liver and proliferating cells. Biochem. Biophys. Res. Commun. 226: 461-466, 1996. [PubMed: 8806657] [Full Text: https://doi.org/10.1006/bbrc.1996.1378]


Creation Date:
Lori M. Kelman : 1/15/1998

Edit History:
carol : 11/05/2010
carol : 11/4/2010
dholmes : 1/30/1998
dholmes : 1/30/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.
Printed: March 12, 2025