HGNC Approved Gene Symbol: DAZ3
Cytogenetic location: Yq11.23 Genomic coordinates (GRCh38) : Y:24,763,069-24,813,393 (from NCBI)
The 'deleted in azoospermia' genes (see DAZ1; 400003) encode putative RNA-binding proteins.
By fluorescence in situ hybridization and characterization of BAC clones, Saxena et al. (2000) identified 4 DAZ genes in 2 clusters, each comprising an inverted pair, in the AZF region (415000) of the Y chromosome. Each of the 4 genes contains at least 7 tandem copies of a 2.4-kb repeat unit that encodes 24 amino acids, which had previously been identified by Saxena et al. (1996). DAZ1 is paired with DAZ2 (400026), and DAZ3 is paired with DAZ4 (400048). Saxena et al. (2000) found that at least 3 of the genes, DAZ1, DAZ2, and DAZ3, are functional. The DAZ3 cDNA encodes a predicted 487-amino acid protein with a molecular mass of 55 kD. The DAZ3 gene spans approximately 50 kb.
Saxena, R., Brown, L. G., Hawkins, T., Alagappan, R. K., Skaletsky, H., Reeve, M. P., Reijo, R., Rozen, S., Dinulos, M. B., Disteche, C. M., Page, D. C. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nature Genet. 14: 292-299, 1996. [PubMed: 8896558] [Full Text: https://doi.org/10.1038/ng1196-292]
Saxena, R., de Vries, J. W. A., Repping, S., Alagappan, R. K., Skaletsky, H., Brown, L. G., Ma, P., Chen, E., Hoovers, J. M. N., Page, D. C. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics 67: 256-267, 2000. [PubMed: 10936047] [Full Text: https://doi.org/10.1006/geno.2000.6260]