Alternative titles; symbols
HGNC Approved Gene Symbol: CDY2A
Cytogenetic location: Yq11.222 Genomic coordinates (GRCh38) : Y:18,025,787-18,027,746 (from NCBI)
See CDY1 (400016). Lahn and Page (1997) identified the CDY (chromodomain on Y chromosome) testis-specific gene family. The predicted CDY protein contains a chromodomain and a putative catalytic domain. Lahn and Page (1999) reported that there are at least 2 distinct CDY genes, CDY1 and CDY2. The predicted 541-amino acid CDY2 protein is 98% identical to CDY1. The CDY2 gene does not contain introns. The authors stated that there might be multiple CDY1 and CDY2 genes. They proposed that these Y-linked CDY genes arose by retroposition of an mRNA from the autosomal CDYL (603778) gene, followed by amplification of the retroposed gene.
By analysis of a panel of partial Y chromosomes, Lahn and Page (1997) found that CDY genes mapped to both the 6F and 5L regions on the long arm of the human Y chromosome. Using the same technique, Lahn and Page (1999) mapped the CDY2 gene to Y-chromosome region 5L.
Lahn, B. T., Page, D. C. Functional coherence of the human Y chromosome. Science 278: 675-680, 1997. [PubMed: 9381176] [Full Text: https://doi.org/10.1126/science.278.5338.675]
Lahn, B. T., Page, D. C. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. Nature Genet. 21: 429-433, 1999. Note: Erratum: Nature Genet. 22: 209 only, 1999. [PubMed: 10192397] [Full Text: https://doi.org/10.1038/7771]