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Esophageal squamous cell carcinoma, somatic

MedGen UID:
865318
•Concept ID:
C4016881
•
Finding
Synonym: ESOPHAGEAL SQUAMOUS CELL CARCINOMA, SOMATIC
 
OMIM®: 604242; 605131; 606551

Professional guidelines

PubMed

Data-Driven Molecular Typing: A New Frontier in Esophageal Cancer Management.
Du Y, Gu B, Shi L, She Y, Zhao Q, Gao S
Cancer Med 2025 Mar;14(5):e70730. doi: 10.1002/cam4.70730. PMID: 40018789Free PMC Article
New directions in perioperative management of locally advanced esophagogastric cancer.
Burtness B, Ilson D, Iqbal S
Am Soc Clin Oncol Educ Book 2014:e172-8. doi: 10.14694/EdBook_AM.2014.34.e172. PMID: 24857100
The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.
Yamamoto S, Inoue J, Kawano T, Kozaki K, Omura K, Inazawa J
Mol Cancer Res 2014 Jan;12(1):58-68. Epub 2013 Dec 4 doi: 10.1158/1541-7786.MCR-13-0246-T. PMID: 24307696

Recent clinical studies

Etiology

Exceptional Response to Olaparib: A Case Report of Metastatic Esophageal Squamous Cell Carcinoma in a Patient With Fanconi Anemia, Germline FANCA Mutation, and Somatic BRCA2 Mutations.
Haggstrom LR, Tucker K, Williams R, Nelson A, Walsh R, Brungs D, Aghmesheh M
JCO Precis Oncol 2023 Sep;7:e2300221. doi: 10.1200/PO.23.00221. PMID: 37725782
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence.
Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, Bergstrom EN, Atkins J, He Y, Khandekar A, Smith-Byrne K, Carreira C, Gaborieau V, Latimer C, Thomas E, Abnizova I, Bucciarelli PE, Jones D, Teague JW, Abedi-Ardekani B, Serra S, Scoazec JY, Saffar H, Azmoudeh-Ardalan F, Sotoudeh M, Nikmanesh A, Poustchi H, Niavarani A, Gharavi S, Eden M, Richman P, Campos LS, Fitzgerald RC, Ribeiro LF, Soares-Lima SC, Dzamalala C, Mmbaga BT, Shibata T, Menya D, Goldstein AM, Hu N, Malekzadeh R, Fazel A, McCormack V, McKay J, Perdomo S, Scelo G, Chanudet E, Humphreys L, Alexandrov LB, Brennan P, Stratton MR
Nat Genet 2021 Nov;53(11):1553-1563. Epub 2021 Oct 18 doi: 10.1038/s41588-021-00928-6. PMID: 34663923
Profile of esophageal squamous cell carcinoma mutations in Brazilian patients.
Munari FF, Dos Santos W, Evangelista AF, Carvalho AC, Pastrez PA, Bugatti D, Wohnrath DR, Scapulatempo-Neto C, Guimarães DP, Longatto-Filho A, Reis RM
Sci Rep 2021 Oct 18;11(1):20596. doi: 10.1038/s41598-021-00208-7. PMID: 34663841Free PMC Article
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M
Gastroenterology 2015 Dec;149(7):1700-15. Epub 2015 Sep 12 doi: 10.1053/j.gastro.2015.08.054. PMID: 26376349
Identification of genomic alterations in oesophageal squamous cell cancer.
Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q
Nature 2014 May 1;509(7498):91-5. Epub 2014 Mar 16 doi: 10.1038/nature13176. PMID: 24670651

Diagnosis

The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.
Wang Z, Zhao Y, Wo Y, Peng Y, Hu W, Wu Z, Liu P, Shang Y, Liu C, Chen X, Huang K, Chen Y, Hong H, Li F, Sun Y
Cancer Lett 2024 Jul 1;593:216951. Epub 2024 May 10 doi: 10.1016/j.canlet.2024.216951. PMID: 38734159
Profile of esophageal squamous cell carcinoma mutations in Brazilian patients.
Munari FF, Dos Santos W, Evangelista AF, Carvalho AC, Pastrez PA, Bugatti D, Wohnrath DR, Scapulatempo-Neto C, Guimarães DP, Longatto-Filho A, Reis RM
Sci Rep 2021 Oct 18;11(1):20596. doi: 10.1038/s41598-021-00208-7. PMID: 34663841Free PMC Article
Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.
Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T
World J Gastroenterol 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. PMID: 26900290Free PMC Article
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M
Gastroenterology 2015 Dec;149(7):1700-15. Epub 2015 Sep 12 doi: 10.1053/j.gastro.2015.08.054. PMID: 26376349
Identification of genomic alterations in oesophageal squamous cell cancer.
Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q
Nature 2014 May 1;509(7498):91-5. Epub 2014 Mar 16 doi: 10.1038/nature13176. PMID: 24670651

Therapy

The single cell immunogenomic landscape after neoadjuvant immunotherapy combined chemotherapy in esophageal squamous cell carcinoma.
Wang Z, Zhao Y, Wo Y, Peng Y, Hu W, Wu Z, Liu P, Shang Y, Liu C, Chen X, Huang K, Chen Y, Hong H, Li F, Sun Y
Cancer Lett 2024 Jul 1;593:216951. Epub 2024 May 10 doi: 10.1016/j.canlet.2024.216951. PMID: 38734159
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D, Decock J
Front Immunol 2018;9:947. Epub 2018 May 1 doi: 10.3389/fimmu.2018.00947. PMID: 29770138Free PMC Article
New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints.
Wang VE, Grandis JR, Ko AH
Clin Cancer Res 2016 Sep 1;22(17):4283-90. Epub 2016 Jul 1 doi: 10.1158/1078-0432.CCR-16-0292. PMID: 27370606
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M
Gastroenterology 2015 Dec;149(7):1700-15. Epub 2015 Sep 12 doi: 10.1053/j.gastro.2015.08.054. PMID: 26376349
Identification of genomic alterations in oesophageal squamous cell cancer.
Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q
Nature 2014 May 1;509(7498):91-5. Epub 2014 Mar 16 doi: 10.1038/nature13176. PMID: 24670651

Prognosis

Early development of esophageal squamous cell cancer: Stem cells, cellular origins and early clone evolution.
Liao G, Tang J, Bai J
Cancer Lett 2023 Feb 28;555:216047. Epub 2022 Dec 30 doi: 10.1016/j.canlet.2022.216047. PMID: 36587837
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence.
Moody S, Senkin S, Islam SMA, Wang J, Nasrollahzadeh D, Cortez Cardoso Penha R, Fitzgerald S, Bergstrom EN, Atkins J, He Y, Khandekar A, Smith-Byrne K, Carreira C, Gaborieau V, Latimer C, Thomas E, Abnizova I, Bucciarelli PE, Jones D, Teague JW, Abedi-Ardekani B, Serra S, Scoazec JY, Saffar H, Azmoudeh-Ardalan F, Sotoudeh M, Nikmanesh A, Poustchi H, Niavarani A, Gharavi S, Eden M, Richman P, Campos LS, Fitzgerald RC, Ribeiro LF, Soares-Lima SC, Dzamalala C, Mmbaga BT, Shibata T, Menya D, Goldstein AM, Hu N, Malekzadeh R, Fazel A, McCormack V, McKay J, Perdomo S, Scelo G, Chanudet E, Humphreys L, Alexandrov LB, Brennan P, Stratton MR
Nat Genet 2021 Nov;53(11):1553-1563. Epub 2021 Oct 18 doi: 10.1038/s41588-021-00928-6. PMID: 34663923
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis.
Zhang X, Peng L, Luo Y, Zhang S, Pu Y, Chen Y, Guo W, Yao J, Shao M, Fan W, Cui Q, Xi Y, Sun Y, Niu X, Zhao X, Chen L, Wang Y, Liu Y, Yang X, Wang C, Zhong C, Tan W, Wang J, Wu C, Lin D
Nat Commun 2021 Sep 6;12(1):5291. doi: 10.1038/s41467-021-25539-x. PMID: 34489433Free PMC Article
Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.
Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T
World J Gastroenterol 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. PMID: 26900290Free PMC Article
Genetic landscape of esophageal squamous cell carcinoma.
Gao YB, Chen ZL, Li JG, Hu XD, Shi XJ, Sun ZM, Zhang F, Zhao ZR, Li ZT, Liu ZY, Zhao YD, Sun J, Zhou CC, Yao R, Wang SY, Wang P, Sun N, Zhang BH, Dong JS, Yu Y, Luo M, Feng XL, Shi SS, Zhou F, Tan FW, Qiu B, Li N, Shao K, Zhang LJ, Zhang LJ, Xue Q, Gao SG, He J
Nat Genet 2014 Oct;46(10):1097-102. Epub 2014 Aug 24 doi: 10.1038/ng.3076. PMID: 25151357

Clinical prediction guides

A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa.
Van Loon K, Mmbaga EJ, Mushi BP, Selekwa M, Mwanga A, Akoko LO, Mwaiselage J, Mosha I, Ng DL, Wu W, Silverstein J, Mulima G, Kaimila B, Gopal S, Snell JM, Benz SC, Vaske C, Sanborn Z, Sedgewick AJ, Radenbaugh A, Newton Y, Collisson EA
Cancer Epidemiol Biomarkers Prev 2023 Oct 2;32(10):1411-1420. doi: 10.1158/1055-9965.EPI-22-0775. PMID: 37505926Free PMC Article
Profile of esophageal squamous cell carcinoma mutations in Brazilian patients.
Munari FF, Dos Santos W, Evangelista AF, Carvalho AC, Pastrez PA, Bugatti D, Wohnrath DR, Scapulatempo-Neto C, Guimarães DP, Longatto-Filho A, Reis RM
Sci Rep 2021 Oct 18;11(1):20596. doi: 10.1038/s41598-021-00208-7. PMID: 34663841Free PMC Article
NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives.
Thomas R, Al-Khadairi G, Roelands J, Hendrickx W, Dermime S, Bedognetti D, Decock J
Front Immunol 2018;9:947. Epub 2018 May 1 doi: 10.3389/fimmu.2018.00947. PMID: 29770138Free PMC Article
Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.
Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T
World J Gastroenterol 2016 Feb 21;22(7):2284-93. doi: 10.3748/wjg.v22.i7.2284. PMID: 26900290Free PMC Article
Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma.
Ohashi S, Miyamoto S, Kikuchi O, Goto T, Amanuma Y, Muto M
Gastroenterology 2015 Dec;149(7):1700-15. Epub 2015 Sep 12 doi: 10.1053/j.gastro.2015.08.054. PMID: 26376349

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