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. 2009 Nov;11(6):414-30.
doi: 10.1007/s11940-009-0046-0.

A modern approach to the treatment of mitochondrial disease

Sumit Parikh  1 , Russell Saneto, Marni J Falk, Irina Anselm, Bruce H Cohen, Richard Haas, The Mitochondrial Medicine Society
Affiliations

A modern approach to the treatment of mitochondrial disease

Sumit Parikh et al. Curr Treat Options Neurol. 2009 Nov.

Abstract

The treatment of mitochondrial disease varies considerably. Most experts use a combination of vitamins, optimize patients' nutrition and general health, and prevent worsening of symptoms during times of illness and physiologic stress. We agree with this approach, and we agree that therapies using vitamins and cofactors have value, though there is debate about the choice of these agents and the doses prescribed. Despite the paucity of high-quality scientific evidence, these therapies are relatively harmless, may alleviate select clinical symptoms, and theoretically may offer a means of staving off disease progression. Like many other mitochondrial medicine physicians, we have observed significant (and at times life-altering) clinical responses to such pharmacologic interventions. However, it is not yet proven that these therapies truly alter the course of the disease, and some experts may choose not to use these medications at all. At present, the evidence of their effectiveness does not rise to the level required for universal use. Based on our clinical experience and judgment, however, we agree that a therapeutic trial of coenzyme Q10, along with other antioxidants, should be attempted. Although individual specialists differ as to the exact drug cocktail, a common approach involves combinations of antioxidants that may have a synergistic effect. Because almost all relevant therapies are classified as medical foods or over-the-counter supplements, most physicians also attempt to balance the apparent clinical benefit of mitochondrial cocktails with the cost burden that these supplements pose for the family.

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Conflict of interest statement

Disclosure: Dr. Parikh is a consultant for Solace Pharmaceuticals, a manufacturer of CoQ10 and creatine. Dr. Cohen is a member of the scientific advisory board and on the speaker's bureau for Transgenomic, Inc., a company that performs genetic testing. No other potential conflicts of interest relevant to this article were reported.

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References

    1. Haas RH, Parikh S, Falk MJ, et al. Mitochondrial disease: a practical approach for primary care physicians. Pediatrics. 2007;120:1326–1333. - PubMed
    1. Haas RH, Parikh S, Falk MJ, et al. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008;94:16–37. - PMC - PubMed
    1. Morava E, van den Heuvel L, Hol F, et al. Mitochondrial disease criteria: diagnostic applications in children. Neurology. 2006;67:1823–1826. - PubMed
    1. Wortmann SB, Zweers-van Essen H, Rodenburg RJ. Mitochondrial energy production correlates with the age-related BMI. Pediatr Res. 2009;65:103–108. - PubMed
    1. Morava E, Rodenburg R, van Essen HZ, et al. Dietary intervention and oxidative phosphorylation capacity. J Inherit Metab Dis. 2006;29:589. The Nijmegen group reviews the role of malnutrition leading to oxidative phosphorylation abnormalities and normalization of these findings by renourishment. They present a small cohort of their patients as examples. - PubMed