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Empty follicle syndrome

MedGen UID:
730227
•Concept ID:
C1328577
•
Disease or Syndrome
SNOMED CT: Empty follicle syndrome (426958002)

Professional guidelines

PubMed

Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data.
Luo Z, Xu S, Hao G
Front Endocrinol (Lausanne) 2024;15:1424837. Epub 2024 Jul 11 doi: 10.3389/fendo.2024.1424837. PMID: 39055059Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramón O, Gomez-Picado O, Exposito A
Reprod Biomed Online 2014 Nov;29(5):634-9. Epub 2014 Aug 12 doi: 10.1016/j.rbmo.2014.07.020. PMID: 25263264

Recent clinical studies

Etiology

Risk factors for poor oocyte yield and oocyte immaturity after GnRH agonist triggering.
Gambini S, Sonigo C, Robin G, Cedrin-Durnerin I, Vinolas C, Sifer C, Boumerdassi Y, Mayeur A, Gallot V, Grynberg M, Peigné M
Hum Reprod 2024 May 2;39(5):963-973. doi: 10.1093/humrep/deae041. PMID: 38452353
Empty follicle syndrome: Frequency and probable causes in Pakistani Population.
Jehan S, Iram Z, Syed S
J Pak Med Assoc 2020 Sep;70(9):1538-1542. doi: 10.5455/JPMA.18623. PMID: 33040104
Gonadotropin-releasing hormone agonist ovulation trigger-beyond OHSS prevention.
Castillo JC, Haahr T, Martínez-Moya M, Humaidan P
Ups J Med Sci 2020 May;125(2):138-143. Epub 2020 Mar 25 doi: 10.1080/03009734.2020.1737599. PMID: 32208810Free PMC Article
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Empty follicle syndrome: evidence for recurrence.
Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE
Hum Reprod 2000 May;15(5):999-1002. doi: 10.1093/humrep/15.5.999. PMID: 10783341

Diagnosis

Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida.
Sun L, Tong K, Liu W, Tian Y, Liu D, Huang G, Li J
Reprod Biomed Online 2023 May;46(5):847-855. Epub 2023 Jan 16 doi: 10.1016/j.rbmo.2023.01.010. PMID: 36931917
A Novel Homozygous Nonsense Mutation in ZP1 Causes Female Infertility due to Empty Follicle Syndrome.
Zou T, Xi Q, Liu Z, Li Z, Hou M, Zhu L, Jin L, Zhang X
Reprod Sci 2022 Dec;29(12):3516-3520. Epub 2022 Jun 30 doi: 10.1007/s43032-022-01024-8. PMID: 35773450
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Poor prognosis in cycles following "genuine" empty follicle syndrome.
Coskun S, Madan S, Bukhari I, Al-Hassan S, Al-Rejjal R, Awartani K
Eur J Obstet Gynecol Reprod Biol 2010 Jun;150(2):157-9. Epub 2010 Mar 1 doi: 10.1016/j.ejogrb.2010.02.013. PMID: 20197208
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817

Therapy

Risk factors for poor oocyte yield and oocyte immaturity after GnRH agonist triggering.
Gambini S, Sonigo C, Robin G, Cedrin-Durnerin I, Vinolas C, Sifer C, Boumerdassi Y, Mayeur A, Gallot V, Grynberg M, Peigné M
Hum Reprod 2024 May 2;39(5):963-973. doi: 10.1093/humrep/deae041. PMID: 38452353
Gonadotropin-releasing hormone agonist ovulation trigger-beyond OHSS prevention.
Castillo JC, Haahr T, Martínez-Moya M, Humaidan P
Ups J Med Sci 2020 May;125(2):138-143. Epub 2020 Mar 25 doi: 10.1080/03009734.2020.1737599. PMID: 32208810Free PMC Article
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.
Stevenson TL, Lashen H
Fertil Steril 2008 Sep;90(3):691-8. Epub 2007 Nov 26 doi: 10.1016/j.fertnstert.2007.07.1312. PMID: 18023430
The empty follicle syndrome.
Ng SP, Jamil MA, Nurshaireen A, Zainul MR
Med J Malaysia 2006 Oct;61(4):499-500. PMID: 17243533

Prognosis

Whole exome sequencing identifies a novel homozygous missense mutation of LHCGR gene in primary infertile women with empty follicle syndrome.
Xu Y, Wang E, Liu T, Wang S, Wu F, Zhao X, Wang A
J Obstet Gynaecol Res 2023 Oct;49(10):2436-2445. Epub 2023 Jul 18 doi: 10.1111/jog.15747. PMID: 37462066
Empty follicle syndrome revisited: definition, incidence, aetiology, early diagnosis and treatment.
Revelli A, Carosso A, Grassi G, Gennarelli G, Canosa S, Benedetto C
Reprod Biomed Online 2017 Aug;35(2):132-138. Epub 2017 May 23 doi: 10.1016/j.rbmo.2017.04.012. PMID: 28596003
Poor prognosis in cycles following "genuine" empty follicle syndrome.
Coskun S, Madan S, Bukhari I, Al-Hassan S, Al-Rejjal R, Awartani K
Eur J Obstet Gynecol Reprod Biol 2010 Jun;150(2):157-9. Epub 2010 Mar 1 doi: 10.1016/j.ejogrb.2010.02.013. PMID: 20197208
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Empty follicle syndrome.
Coulam CB, Bustillo M, Schulman JD
Fertil Steril 1986 Dec;46(6):1153-5. doi: 10.1016/s0015-0282(16)49898-5. PMID: 3781029

Clinical prediction guides

Whole exome sequencing identifies a novel homozygous missense mutation of LHCGR gene in primary infertile women with empty follicle syndrome.
Xu Y, Wang E, Liu T, Wang S, Wu F, Zhao X, Wang A
J Obstet Gynaecol Res 2023 Oct;49(10):2436-2445. Epub 2023 Jul 18 doi: 10.1111/jog.15747. PMID: 37462066
Zona pellucida glycoproteins: Relevance in fertility and development of contraceptive vaccines.
Gupta SK
Am J Reprod Immunol 2023 Feb;89(2):e13535. Epub 2022 Mar 15 doi: 10.1111/aji.13535. PMID: 35249246
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
The empty follicle syndrome.
Kourtis A, Rousso D, Panidis D
J Endocrinol Invest 2004 Feb;27(2):187-91. doi: 10.1007/BF03346267. PMID: 15129817
Empty follicle syndrome.
Coulam CB, Bustillo M, Schulman JD
Fertil Steril 1986 Dec;46(6):1153-5. doi: 10.1016/s0015-0282(16)49898-5. PMID: 3781029

Recent systematic reviews

A systematic review and standardized clinical validity assessment of genes involved in female reproductive failure.
Volozonoka L, Miskova A, Kornejeva L, Kempa I, Bargatina V, Gailite L
Reproduction 2022 Apr 22;163(6):351-363. doi: 10.1530/REP-21-0486. PMID: 35451369Free PMC Article
Prediction, assessment, and management of suboptimal GnRH agonist trigger: a systematic review.
Ganer Herman H, Horowitz E, Mizrachi Y, Farhi J, Raziel A, Weissman A
J Assist Reprod Genet 2022 Feb;39(2):291-303. Epub 2022 Mar 19 doi: 10.1007/s10815-021-02359-y. PMID: 35306603Free PMC Article
Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.
Stevenson TL, Lashen H
Fertil Steril 2008 Sep;90(3):691-8. Epub 2007 Nov 26 doi: 10.1016/j.fertnstert.2007.07.1312. PMID: 18023430

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