Factor VII Padua

MedGen UID:: 67097
•Concept ID:: C0214776
•: Amino Acid, Peptide, or Protein

Recent clinical studies

Etiology

Thrombotic Events in Homozygotes with a Proven or Highly Probable Arg304Gln Factor VII Mutation (FVII Padua)1): Only Limited Replacement Therapy is Needed in Case of Surgery.

Girolami A, Cosi E, Ferrari S, Girolami B, Randi ML
Cardiovasc Hematol Disord Drug Targets 2019;19(3):233-238. doi: 10.2174/1871529X19666190308114842. PMID: 30854979

Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes.

Girolami A, Bertozzi I, de Marinis GB, Bonamigo E, Fabris F
Hematology 2011 Sep;16(5):308-12. doi: 10.1179/102453311X13085644680069. PMID: 21902896

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Diagnosis

Factor VII Padua in Iran: clinical and laboratory findings of three unrelated patients.

Shams M, Hassani S, Dorgalaleh A, Zamani F, Ahmadi A
Blood Coagul Fibrinolysis 2023 Apr 1;34(3):156-160. Epub 2023 Jan 27 doi: 10.1097/MBC.0000000000001195. PMID: 36719811

Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes.

Girolami A, Bertozzi I, de Marinis GB, Bonamigo E, Fabris F
Hematology 2011 Sep;16(5):308-12. doi: 10.1179/102453311X13085644680069. PMID: 21902896

Worldwide diffusion of FVII Arg304Gln coagulation defect (FVII Padua).

Girolami A, Berti de Marinis G, Bonamigo E, Allemand E
Eur J Haematol 2011 Feb;86(2):135-9. Epub 2010 Dec 29 doi: 10.1111/j.1600-0609.2010.01544.x. PMID: 20958793

Ox brain versus rabbit brain thromboplastin assays are the best tool for a preliminary diagnosis of the Arg304Gln factor VII defect (FVII Padua).

Girolami A, Berti de Marinis G, Bonamigo E, Sartori R, Vettore S
Acta Haematol 2010;124(4):229-34. Epub 2010 Nov 20 doi: 10.1159/000321534. PMID: 21099211

First report of combined factor VII Padua defect and von Willebrand's disease due to casual association of the two defects.

Girolami A, Pontara E, Dannhauser D, Bertomoro A, Ferasin S, Piccolo M, Casonato A
Blood Coagul Fibrinolysis 1993 Feb;4(1):177-81. PMID: 8457648

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Therapy

First report of combined factor VII Padua defect and von Willebrand's disease due to casual association of the two defects.

Girolami A, Pontara E, Dannhauser D, Bertomoro A, Ferasin S, Piccolo M, Casonato A
Blood Coagul Fibrinolysis 1993 Feb;4(1):177-81. PMID: 8457648

Factor VII survival studies in factor VII Padua abnormality.

Girolami A, Toffanin F, Gazzetta R
Acta Haematol 1980;63(6):333-5. doi: 10.1159/000207432. PMID: 6774569

Factor VII Padua 2: another factor VII abnormality with defective ox brain thromboplastin activation and a complex hereditary pattern.

Girolami A, Cattarozzi G, Dal Bo Zanon R, Toffanin F
Blood 1979 Jul;54(1):46-53. PMID: 444674

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Prognosis

Thrombotic Events in Homozygotes with a Proven or Highly Probable Arg304Gln Factor VII Mutation (FVII Padua)1): Only Limited Replacement Therapy is Needed in Case of Surgery.

Girolami A, Cosi E, Ferrari S, Girolami B, Randi ML
Cardiovasc Hematol Disord Drug Targets 2019;19(3):233-238. doi: 10.2174/1871529X19666190308114842. PMID: 30854979

See all (1)