Name: rs59421388
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs59421388

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr22:42127608 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: C>A / C>T
Variation Type: SNV Single Nucleotide Variation
Frequency: T=0.030005 (7942/264690, TOPMED)
T=0.006727 (1688/250912, GnomAD_exome)
T=0.004656 (714/153350, ALFA) (+ 13 more)
T=0.026825 (3741/139460, GnomAD)
T=0.008375 (1008/120360, ExAC)
T=0.00004 (1/28198, 14KJPN)
T=0.00006 (1/16724, 8.3KJPN)
T=0.03253 (423/13004, GO-ESP)
T=0.0309 (198/6404, 1000G_30x)
T=0.0288 (144/5008, 1000G)
T=0.0067 (22/3284, PRJNA289433)
T=0.001 (1/998, GoNL)
T=0.002 (1/534, MGP)
T=0.022 (8/356, PharmGKB)
T=0.009 (2/216, Qatari)
C=0.44 (7/16, SGDP_PRJ)

Clinical Significance: Reported in ClinVar
Gene : Consequence: CYP2D6 : Missense Variant
Publications: 11 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20231103111315

Population	Group	Sample Size	Ref Allele	Alt Allele	Ref HMOZ	Alt HMOZ	HTRZ	HWEP
Total	Global	153350	C=0.995344	T=0.004656	0.990975	0.000287	0.008738	32
European	Sub	131872	C=0.999507	T=0.000493	0.999029	0.000015	0.000955	32
African	Sub	7048	C=0.9169	T=0.0831	0.839671	0.005959	0.15437	0
African Others	Sub	258	C=0.884	T=0.116	0.767442	0.0	0.232558	2
African American	Sub	6790	C=0.9181	T=0.0819	0.842415	0.006186	0.151399	0
Asian	Sub	3376	C=0.9997	T=0.0003	0.999408	0.0	0.000592	0
East Asian	Sub	2718	C=1.0000	T=0.0000	1.0	0.0	0.0	N/A
Other Asian	Sub	658	C=0.998	T=0.002	0.99696	0.0	0.00304	0
Latin American 1	Sub	792	C=0.977	T=0.023	0.954545	0.0	0.045455	0
Latin American 2	Sub	950	C=0.995	T=0.005	0.989474	0.0	0.010526	0
South Asian	Sub	274	C=1.000	T=0.000	1.0	0.0	0.0	N/A
Other	Sub	9038	C=0.9957	T=0.0043	0.99137	0.0	0.00863	0

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	C=0.969995	T=0.030005
gnomAD - Exomes	Global	Study-wide	250912	C=0.993273	T=0.006727
gnomAD - Exomes	European	Sub	135126	C=0.999785	T=0.000215
gnomAD - Exomes	Asian	Sub	48894	C=0.99986	T=0.00014
gnomAD - Exomes	American	Sub	34542	C=0.99618	T=0.00382
gnomAD - Exomes	African	Sub	16136	C=0.90816	T=0.09184
gnomAD - Exomes	Ashkenazi Jewish	Sub	10080	C=0.99792	T=0.00208
gnomAD - Exomes	Other	Sub	6134	C=0.9972	T=0.0028
Allele Frequency Aggregator	Total	Global	153350	C=0.995344	T=0.004656
Allele Frequency Aggregator	European	Sub	131872	C=0.999507	T=0.000493
Allele Frequency Aggregator	Other	Sub	9038	C=0.9957	T=0.0043
Allele Frequency Aggregator	African	Sub	7048	C=0.9169	T=0.0831
Allele Frequency Aggregator	Asian	Sub	3376	C=0.9997	T=0.0003
Allele Frequency Aggregator	Latin American 2	Sub	950	C=0.995	T=0.005
Allele Frequency Aggregator	Latin American 1	Sub	792	C=0.977	T=0.023
Allele Frequency Aggregator	South Asian	Sub	274	C=1.000	T=0.000
gnomAD - Genomes	Global	Study-wide	139460	C=0.973175	T=0.026825
gnomAD - Genomes	European	Sub	75756	C=0.99947	T=0.00053
gnomAD - Genomes	African	Sub	41494	C=0.91512	T=0.08488
gnomAD - Genomes	American	Sub	13618	C=0.99075	T=0.00925
gnomAD - Genomes	Ashkenazi Jewish	Sub	3324	C=0.9982	T=0.0018
gnomAD - Genomes	East Asian	Sub	3126	C=1.0000	T=0.0000
gnomAD - Genomes	Other	Sub	2142	C=0.9781	T=0.0219
ExAC	Global	Study-wide	120360	C=0.991625	T=0.008375
ExAC	Europe	Sub	72812	C=0.99974	T=0.00026
ExAC	Asian	Sub	24964	C=0.99988	T=0.00012
ExAC	American	Sub	11472	C=0.99625	T=0.00375
ExAC	African	Sub	10206	C=0.90770	T=0.09230
ExAC	Other	Sub	906	C=0.999	T=0.001
14KJPN	JAPANESE	Study-wide	28198	C=0.99996	T=0.00004
8.3KJPN	JAPANESE	Study-wide	16724	C=0.99994	T=0.00006
GO Exome Sequencing Project	Global	Study-wide	13004	C=0.96747	T=0.03253
GO Exome Sequencing Project	European American	Sub	8600	C=0.9998	T=0.0002
GO Exome Sequencing Project	African American	Sub	4404	C=0.9044	T=0.0956
1000Genomes_30x	Global	Study-wide	6404	C=0.9691	T=0.0309
1000Genomes_30x	African	Sub	1786	C=0.8908	T=0.1092
1000Genomes_30x	Europe	Sub	1266	C=1.0000	T=0.0000
1000Genomes_30x	South Asian	Sub	1202	C=1.0000	T=0.0000
1000Genomes_30x	East Asian	Sub	1170	C=1.0000	T=0.0000
1000Genomes_30x	American	Sub	980	C=0.997	T=0.003
1000Genomes	Global	Study-wide	5008	C=0.9712	T=0.0288
1000Genomes	African	Sub	1322	C=0.8926	T=0.1074
1000Genomes	East Asian	Sub	1008	C=1.0000	T=0.0000
1000Genomes	Europe	Sub	1006	C=1.0000	T=0.0000
1000Genomes	South Asian	Sub	978	C=1.000	T=0.000
1000Genomes	American	Sub	694	C=0.997	T=0.003
MxGDAR/Encodat-PGx	Global	Study-wide	3284	C=0.9933	T=0.0067
MxGDAR/Encodat-PGx	MxGDAR	Sub	3284	C=0.9933	T=0.0067
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	C=0.999	T=0.001
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	C=0.998	T=0.002
PharmGKB Aggregated	Global	Study-wide	356	C=0.978	T=0.022
PharmGKB Aggregated	PA149578422	Sub	356	C=0.978	T=0.022
Qatari	Global	Study-wide	216	C=0.991	T=0.009
SGDP_PRJ	Global	Study-wide	16	C=0.44	T=0.56

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 22	NC_000022.11:g.42127608C>A
GRCh38.p14 chr 22	NC_000022.11:g.42127608C>T
gene/pseudogene RefSeqGene (LRG_303)	NG_008376.4:g.8203G>T
gene/pseudogene RefSeqGene (LRG_303)	NG_008376.4:g.8203G>A
GRCh38.p14 chr 22 novel patch HSCHR22_8_CTG1	NW_015148968.1:g.5349C>A
GRCh38.p14 chr 22 novel patch HSCHR22_8_CTG1	NW_015148968.1:g.5349C>T
GRCh38.p14 chr 22 novel patch HSCHR22_7_CTG1	NW_014040931.1:g.21197C>A
GRCh38.p14 chr 22 novel patch HSCHR22_7_CTG1	NW_014040931.1:g.21197C>T
GRCh38.p14 chr 22 novel patch HSCHR22_5_CTG1	NW_009646208.1:g.13174C>A
GRCh38.p14 chr 22 novel patch HSCHR22_5_CTG1	NW_009646208.1:g.13174C>T
GRCh38.p14 chr 22 alt locus HSCHR22_2_CTG1	NW_004504305.1:g.49935C>A
GRCh38.p14 chr 22 alt locus HSCHR22_2_CTG1	NW_004504305.1:g.49935C>T
GRCh38.p14 chr 22 alt locus HSCHR22_3_CTG1	NT_187682.1:g.49949C>A
GRCh38.p14 chr 22 alt locus HSCHR22_3_CTG1	NT_187682.1:g.49949C>T
GRCh37.p13 chr 22	NC_000022.10:g.42523610C>A
GRCh37.p13 chr 22	NC_000022.10:g.42523610C>T

Gene: CYP2D6, cytochrome P450 family 2 subfamily D member 6 (minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
CYP2D6 transcript variant 1	NM_000106.6:c.1012G>T	V [GTG] > L [TTG]	Coding Sequence Variant
cytochrome P450 2D6 isoform 1	NP_000097.3:p.Val338Leu	V (Val) > L (Leu)	Missense Variant
CYP2D6 transcript variant 1	NM_000106.6:c.1012G>A	V [GTG] > M [ATG]	Coding Sequence Variant
cytochrome P450 2D6 isoform 1	NP_000097.3:p.Val338Met	V (Val) > M (Met)	Missense Variant
CYP2D6 transcript variant 2	NM_001025161.3:c.859G>T	V [GTG] > L [TTG]	Coding Sequence Variant
cytochrome P450 2D6 isoform 2	NP_001020332.2:p.Val287Leu	V (Val) > L (Leu)	Missense Variant
CYP2D6 transcript variant 2	NM_001025161.3:c.859G>A	V [GTG] > M [ATG]	Coding Sequence Variant
cytochrome P450 2D6 isoform 2	NP_001020332.2:p.Val287Met	V (Val) > M (Met)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 589324 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000734608.5	not provided	Likely-Benign,Other

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	C=	A	T
GRCh38.p14 chr 22	NC_000022.11:g.42127608=	NC_000022.11:g.42127608C>A	NC_000022.11:g.42127608C>T
gene/pseudogene RefSeqGene (LRG_303)	NG_008376.4:g.8203=	NG_008376.4:g.8203G>T	NG_008376.4:g.8203G>A
CYP2D6 transcript variant 1	NM_000106.6:c.1012=	NM_000106.6:c.1012G>T	NM_000106.6:c.1012G>A
CYP2D6 transcript variant 1	NM_000106.5:c.1012=	NM_000106.5:c.1012G>T	NM_000106.5:c.1012G>A
CYP2D6 transcript variant 2	NM_001025161.3:c.859=	NM_001025161.3:c.859G>T	NM_001025161.3:c.859G>A
CYP2D6 transcript variant 2	NM_001025161.2:c.859=	NM_001025161.2:c.859G>T	NM_001025161.2:c.859G>A
GRCh38.p14 chr 22 novel patch HSCHR22_8_CTG1	NW_015148968.1:g.5349=	NW_015148968.1:g.5349C>A	NW_015148968.1:g.5349C>T
GRCh38.p14 chr 22 novel patch HSCHR22_7_CTG1	NW_014040931.1:g.21197=	NW_014040931.1:g.21197C>A	NW_014040931.1:g.21197C>T
GRCh38.p14 chr 22 novel patch HSCHR22_5_CTG1	NW_009646208.1:g.13174=	NW_009646208.1:g.13174C>A	NW_009646208.1:g.13174C>T
GRCh38.p14 chr 22 alt locus HSCHR22_2_CTG1	NW_004504305.1:g.49935=	NW_004504305.1:g.49935C>A	NW_004504305.1:g.49935C>T
GRCh38.p14 chr 22 alt locus HSCHR22_3_CTG1	NT_187682.1:g.49949=	NT_187682.1:g.49949C>A	NT_187682.1:g.49949C>T
GRCh37.p13 chr 22	NC_000022.10:g.42523610=	NC_000022.10:g.42523610C>A	NC_000022.10:g.42523610C>T
cytochrome P450 2D6 isoform 1	NP_000097.3:p.Val338=	NP_000097.3:p.Val338Leu	NP_000097.3:p.Val338Met
cytochrome P450 2D6 isoform 2	NP_001020332.2:p.Val287=	NP_001020332.2:p.Val287Leu	NP_001020332.2:p.Val287Met

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

49 SubSNP, 16 Frequency, 1 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	PHARMGKB_AB_DME	ss84158047	Dec 15, 2007 (129)
2	AFFY_DM3_1	ss105434365	Feb 05, 2009 (130)
3	SNP500CANCER	ss105439397	Feb 05, 2009 (130)
4	EGP_SNPS	ss159831315	Dec 01, 2009 (131)
5	1000GENOMES	ss341198140	May 09, 2011 (134)
6	NHLBI-ESP	ss342544605	May 09, 2011 (134)
7	1000GENOMES	ss491194341	May 04, 2012 (137)
8	EXOME_CHIP	ss491572603	May 04, 2012 (137)
9	CLINSEQ_SNP	ss491825720	May 04, 2012 (137)
10	ILLUMINA	ss533920158	Sep 08, 2015 (146)
11	EVA-GONL	ss995393785	Aug 21, 2014 (142)
12	1000GENOMES	ss1367336043	Aug 21, 2014 (142)
13	EVA_EXAC	ss1694379058	Apr 01, 2015 (144)
14	EVA_MGP	ss1711571569	Apr 01, 2015 (144)
15	WEILL_CORNELL_DGM	ss1938961266	Feb 12, 2016 (147)
16	ILLUMINA	ss1946595203	Feb 12, 2016 (147)
17	ILLUMINA	ss1959984035	Feb 12, 2016 (147)
18	JJLAB	ss2030253483	Sep 14, 2016 (149)
19	ILLUMINA	ss2710959469	Nov 08, 2017 (151)
20	GNOMAD	ss2745191400	Nov 08, 2017 (151)
21	GNOMAD	ss2750571566	Nov 08, 2017 (151)
22	GNOMAD	ss2974893418	Nov 08, 2017 (151)
23	AFFY	ss2985240494	Nov 08, 2017 (151)
24	AFFY	ss2985857653	Nov 08, 2017 (151)
25	SWEGEN	ss3019375479	Nov 08, 2017 (151)
26	ILLUMINA	ss3022190888	Nov 08, 2017 (151)
27	CSIRBIOHTS	ss3029638766	Nov 08, 2017 (151)
28	ILLUMINA	ss3625804273	Oct 12, 2018 (152)
29	ILLUMINA	ss3628544563	Oct 12, 2018 (152)
30	ILLUMINA	ss3644802019	Oct 12, 2018 (152)
31	ILLUMINA	ss3652655240	Oct 12, 2018 (152)
32	ILLUMINA	ss3654008747	Oct 12, 2018 (152)
33	ILLUMINA	ss3744207433	Jul 13, 2019 (153)
34	EVA	ss3825454782	Apr 27, 2020 (154)
35	SGDP_PRJ	ss3890637636	Apr 27, 2020 (154)
36	EVA	ss3984450681	Apr 26, 2021 (155)
37	EVA	ss3986866434	Apr 26, 2021 (155)
38	TOPMED	ss5110780025	Apr 26, 2021 (155)
39	TOMMO_GENOMICS	ss5232837038	Apr 26, 2021 (155)
40	1000G_HIGH_COVERAGE	ss5311255571	Oct 16, 2022 (156)
41	EVA	ss5441587466	Oct 16, 2022 (156)
42	EVA	ss5512473996	Oct 16, 2022 (156)
43	1000G_HIGH_COVERAGE	ss5618884685	Oct 16, 2022 (156)
44	SANFORD_IMAGENETICS	ss5664576667	Oct 16, 2022 (156)
45	TOMMO_GENOMICS	ss5794028995	Oct 16, 2022 (156)
46	EVA	ss5847946426	Oct 16, 2022 (156)
47	EVA	ss5936464384	Oct 16, 2022 (156)
48	EVA	ss5959434888	Oct 16, 2022 (156)
49	EVA	ss5979638952	Oct 16, 2022 (156)
50	1000Genomes	NC_000022.10 - 42523610	Oct 12, 2018 (152)
51	1000Genomes_30x	NC_000022.11 - 42127608	Oct 16, 2022 (156)
52	ExAC	NC_000022.10 - 42523610	Oct 12, 2018 (152)
53	gnomAD - Genomes	NC_000022.11 - 42127608	Apr 26, 2021 (155)
54	gnomAD - Exomes	NC_000022.10 - 42523610	Jul 13, 2019 (153)
55	GO Exome Sequencing Project	NC_000022.10 - 42523610	Oct 12, 2018 (152)
56	Genome of the Netherlands Release 5	NC_000022.10 - 42523610	Apr 27, 2020 (154)
57	Medical Genome Project healthy controls from Spanish population	NC_000022.10 - 42523610	Apr 27, 2020 (154)
58	MxGDAR/Encodat-PGx	NC_000022.10 - 42523610	Apr 26, 2021 (155)
59	PharmGKB Aggregated	NC_000022.11 - 42127608	Apr 27, 2020 (154)
60	Qatari	NC_000022.10 - 42523610	Apr 27, 2020 (154)
61	SGDP_PRJ	NC_000022.10 - 42523610	Apr 27, 2020 (154)
62	8.3KJPN	NC_000022.10 - 42523610	Apr 26, 2021 (155)
63	14KJPN	NC_000022.11 - 42127608	Oct 16, 2022 (156)
64	TopMed	NC_000022.11 - 42127608	Apr 26, 2021 (155)
65	ALFA	NC_000022.11 - 42127608	Apr 26, 2021 (155)
66	ClinVar	RCV000734608.5	Oct 16, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss5936464384	NC_000022.10:42523609:C:A	NC_000022.11:42127607:C:A
ss491825720	NC_000022.9:40853553:C:T	NC_000022.11:42127607:C:T	(self)
80894458, 5962343, 14524119, 1911612, 19935849, 687329, 3682, 21003188, 42654616, 90806345, ss341198140, ss342544605, ss491194341, ss491572603, ss533920158, ss995393785, ss1367336043, ss1694379058, ss1711571569, ss1938961266, ss1946595203, ss1959984035, ss2030253483, ss2710959469, ss2745191400, ss2750571566, ss2974893418, ss2985240494, ss2985857653, ss3019375479, ss3022190888, ss3029638766, ss3625804273, ss3628544563, ss3644802019, ss3652655240, ss3654008747, ss3744207433, ss3825454782, ss3890637636, ss3984450681, ss3986866434, ss5232837038, ss5441587466, ss5512473996, ss5664576667, ss5847946426, ss5936464384, ss5959434888, ss5979638952	NC_000022.10:42523609:C:T	NC_000022.11:42127607:C:T	(self)
RCV000734608.5, 106410620, 571269436, 7679, 127866099, 385888972, 10515378487, ss5110780025, ss5311255571, ss5618884685, ss5794028995	NC_000022.11:42127607:C:T	NC_000022.11:42127607:C:T	(self)
ss84158047, ss105434365, ss105439397, ss159831315	NT_011520.12:21914178:C:T	NC_000022.11:42127607:C:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

11 citations for rs59421388

PMID	Title	Author	Year	Journal
22482072	Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.	Cacabelos R et al.	2012	International journal of Alzheimer's disease
23133420	Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.	Suarez-Kurtz G et al.	2012	Frontiers in pharmacology
25266489	Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China.	Zhang J et al.	2014	BMC genetics
26091847	Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China.	Wang L et al.	2015	BMC genetics
27233804	Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China.	Jin T et al.	2016	BMC genetics
27467145	Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.	Silvino AC et al.	2016	PloS one
30093869	Biological Predictors of Clozapine Response: A Systematic Review.	Samanaite R et al.	2018	Frontiers in psychiatry
33519226	Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.	Fernandes MR et al.	2021	Pharmacogenomics and personalized medicine
33875422	Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment.	Pernaute-Lau L et al.	2021	Antimicrobial agents and chemotherapy
34621706	Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.	Kim B et al.	2021	Translational and clinical pharmacology
34958284	Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes.	Muyambo S et al.	2022	Omics

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
Top▲ Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs59421388