RecName: Full=High affinity nerve growth factor receptor; AltName: Ful - Protein

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Protein 3D Structure

TRK-A IN COMPLEX WITH LIGAND 1

PDB: 6PL4

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.06 Å

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Articles about the NTRK1 gene

Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland. [Acta Oncol. 2024]
Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland.
Zhang W, Schmitz AA, Kallionpää RE, Perälä M, Pitkänen N, Tukiainen M, Alanne E, Jöhrens K, Schulze-Rath R, Farahmand B, et al. Acta Oncol. 2024 Jul 5; 63:542-551. Epub 2024 Jul 5.
Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells. [Int J Mol Sci. 2024]
Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells.
Cappabianca L, Ruggieri M, Sebastiano M, Sbaffone M, Martelli I, Ruggeri P, Di Padova M, Farina AR, Mackay AR. Int J Mol Sci. 2024 May 17; 25(10). Epub 2024 May 17.
A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. [Eur J Cancer. 2024]
A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas.
Lippai Z, Péterfia B, Papp G, Dezső K, Bedics G, Pápai Z, Lamers MH, Kuin RC, Szuhai K, Sápi Z. Eur J Cancer. 2024 May; 202:114005. Epub 2024 Mar 14.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the NTRK1 gene (NG_007493.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the NTRK1 gene.

More about the NTRK1 gene

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon n...
Also Known As: MTC, TRK, TRK1, TRKA, T...

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P04629 [Domain Mapping of Disease Mut...]
P04629
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

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RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotro...
RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotrophic tyrosine kinase receptor type 1; AltName: Full=TRK1-transforming tyrosine kinase protein; AltName: Full=Tropomyosin-related kinase A; AltName: Full=Tyrosine kinase receptor; AltName: Full=Tyrosine kinase receptor A; Short=Trk-A; AltName: Full=gp140trk; AltName: Full=p140-TrkA; Flags: Precursor
gi|94730402|sp|P04629.4|NTRK1_HUMAN

Protein
NTRK1 Congenital Insensitivity to Pain with Anhidrosis - GeneReviews®
NTRK1 Congenital Insensitivity to Pain with Anhidrosis - GeneReviews®
Hereditary insensitivity to pain with anhidrosis
Hereditary insensitivity to pain with anhidrosis

MedGen
C0020074[conceptid] (1)
MedGen
MIR765 microRNA 765 [Homo sapiens]
MIR765 microRNA 765 [Homo sapiens]
Gene ID:768220

Gene

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RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotrophic tyrosine kinase receptor type 1; AltName: Full=TRK1-transforming tyrosine kinase protein; AltName: Full=Tropomyosin-related kinase A; AltName: Full=Tyrosine kinase receptor; A...

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