U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Long QT syndrome, drug-associated

MedGen UID:
808159
•Concept ID:
CN221566
•
Disease or Syndrome

Recent clinical studies

Etiology

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine.
Suppa M, Marino L
Curr Drug Saf 2022;17(1):13-16. doi: 10.2174/1574886316666210629150105. PMID: 34212831
COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels.
Szendrey M, Guo J, Li W, Yang T, Zhang S
J Pharmacol Exp Ther 2021 May;377(2):265-272. Epub 2021 Mar 5 doi: 10.1124/jpet.120.000484. PMID: 33674391
QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.
Hasnain M, Vieweg WV
CNS Drugs 2014 Oct;28(10):887-920. doi: 10.1007/s40263-014-0196-9. PMID: 25168784
Drug- and non-drug-associated QT interval prolongation.
van Noord C, Eijgelsheim M, Stricker BH
Br J Clin Pharmacol 2010 Jul;70(1):16-23. doi: 10.1111/j.1365-2125.2010.03660.x. PMID: 20642543Free PMC Article
hERG: protein trafficking and potential for therapy and drug side effects.
Staudacher I, Schweizer PA, Katus HA, Thomas D
Curr Opin Drug Discov Devel 2010 Jan;13(1):23-30. PMID: 20047143

Diagnosis

Comprehensive characterization of long QT syndrome-associated genes in cancer and development of a robust prognosis model.
Xu J, Wen Z, She Y, Li M, Shen X, Zhi F, Wang S, Jiang Y
J Cell Mol Med 2024 Sep;28(18):e70094. doi: 10.1111/jcmm.70094. PMID: 39317949Free PMC Article
Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine.
Suppa M, Marino L
Curr Drug Saf 2022;17(1):13-16. doi: 10.2174/1574886316666210629150105. PMID: 34212831
Development of a predictive model for drug-associated QT prolongation in the inpatient setting using electronic health record data.
Hincapie-Castillo JM, Staley B, Henriksen C, Saidi A, Lipori GP, Winterstein AG
Am J Health Syst Pharm 2019 Jul 2;76(14):1059-1070. doi: 10.1093/ajhp/zxz100. PMID: 31185072
Moving towards better predictors of drug-induced Torsade de Pointes. 2-3 November 2005, Crystal City, Virginia, USA.
Cavero I, Crumb W
Expert Opin Drug Saf 2006 Mar;5(2):335-40. doi: 10.1517/14740338.5.2.335. PMID: 16503753

Therapy

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine.
Suppa M, Marino L
Curr Drug Saf 2022;17(1):13-16. doi: 10.2174/1574886316666210629150105. PMID: 34212831
COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels.
Szendrey M, Guo J, Li W, Yang T, Zhang S
J Pharmacol Exp Ther 2021 May;377(2):265-272. Epub 2021 Mar 5 doi: 10.1124/jpet.120.000484. PMID: 33674391
QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.
Hasnain M, Vieweg WV
CNS Drugs 2014 Oct;28(10):887-920. doi: 10.1007/s40263-014-0196-9. PMID: 25168784
Cardiac arrest during laparoscopic Roux-en-Y gastric bypass in a bariatric patient with drug-associated long QT syndrome.
Woodard G, Brodsky JB, Morton JM
Obes Surg 2011 Jan;21(1):134-7. doi: 10.1007/s11695-010-0137-8. PMID: 20383601
hERG: protein trafficking and potential for therapy and drug side effects.
Staudacher I, Schweizer PA, Katus HA, Thomas D
Curr Opin Drug Discov Devel 2010 Jan;13(1):23-30. PMID: 20047143

Prognosis

Comprehensive characterization of long QT syndrome-associated genes in cancer and development of a robust prognosis model.
Xu J, Wen Z, She Y, Li M, Shen X, Zhi F, Wang S, Jiang Y
J Cell Mol Med 2024 Sep;28(18):e70094. doi: 10.1111/jcmm.70094. PMID: 39317949Free PMC Article
Development of a predictive model for drug-associated QT prolongation in the inpatient setting using electronic health record data.
Hincapie-Castillo JM, Staley B, Henriksen C, Saidi A, Lipori GP, Winterstein AG
Am J Health Syst Pharm 2019 Jul 2;76(14):1059-1070. doi: 10.1093/ajhp/zxz100. PMID: 31185072
Psychiatric medications and sudden cardiac death: putting the risk in perspective.
Howland RH
J Psychosoc Nurs Ment Health Serv 2015 Feb;53(2):23-5. doi: 10.3928/02793695-20150122-01. PMID: 25654571
QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.
Hasnain M, Vieweg WV
CNS Drugs 2014 Oct;28(10):887-920. doi: 10.1007/s40263-014-0196-9. PMID: 25168784
Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study.
Goutelle S, Sidolle E, Ducher M, Caron J, Timour Q, Nony P, Gouraud A
Drugs Aging 2014 Aug;31(8):601-9. doi: 10.1007/s40266-014-0188-y. PMID: 24923384

Clinical prediction guides

Comprehensive characterization of long QT syndrome-associated genes in cancer and development of a robust prognosis model.
Xu J, Wen Z, She Y, Li M, Shen X, Zhi F, Wang S, Jiang Y
J Cell Mol Med 2024 Sep;28(18):e70094. doi: 10.1111/jcmm.70094. PMID: 39317949Free PMC Article
Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine.
Suppa M, Marino L
Curr Drug Saf 2022;17(1):13-16. doi: 10.2174/1574886316666210629150105. PMID: 34212831
Development of a predictive model for drug-associated QT prolongation in the inpatient setting using electronic health record data.
Hincapie-Castillo JM, Staley B, Henriksen C, Saidi A, Lipori GP, Winterstein AG
Am J Health Syst Pharm 2019 Jul 2;76(14):1059-1070. doi: 10.1093/ajhp/zxz100. PMID: 31185072
Psychiatric medications and sudden cardiac death: putting the risk in perspective.
Howland RH
J Psychosoc Nurs Ment Health Serv 2015 Feb;53(2):23-5. doi: 10.3928/02793695-20150122-01. PMID: 25654571
QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.
Hasnain M, Vieweg WV
CNS Drugs 2014 Oct;28(10):887-920. doi: 10.1007/s40263-014-0196-9. PMID: 25168784

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...