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Advance sleep phase syndrome, familial, 4(FASPS4)

MedGen UID:: 1823977
•Concept ID:: C5774204
•: Disease or Syndrome

Synonym:	FASPS4

Gene (location): Gene(s) directly associated with this condition or phenotype.	TIMELESS (12q13.3)

Monarch Initiative:	MONDO:0031044
OMIM®:	620015

Definition

Familial advanced sleep phase syndrome-4 (FASPS4) is an autosomal dominant condition in which individuals wake and sleep early (summary by Kurien et al., 2019). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348). [from OMIM]

Clinical features

From HPO

Early chronotype

MedGen UID:: 1646349
•Concept ID:: C4703587
•: Finding

A tendency towards rising very early in the morning and going to bed early in the evening.

See: Feature record | Search on this feature

Abnormality of the nervous system
- Early chronotype

Recent clinical studies

Diagnosis

Advanced sleep phase syndrome: Role of genetics and aging.

Silvestri R, Guarnieri B
Handb Clin Neurol 2025;206:61-70. doi: 10.1016/B978-0-323-90918-1.00005-8. PMID: 39864932

Sleep phenotype of individuals with autism spectrum disorder bearing mutations in the PER2 circadian rhythm gene.

Hoang N, Yuen RKC, Howe J, Drmic I, Ambrozewicz P, Russell C, Vorstman J, Weiss SK, Anagnostou E, Malow BA, Scherer SW
Am J Med Genet A 2021 Apr;185(4):1120-1130. Epub 2021 Jan 20 doi: 10.1002/ajmg.a.62086. PMID: 33474825

Sleep and circadian schedule disorders.

Labyak S
Nurs Clin North Am 2002 Dec;37(4):599-610, v. doi: 10.1016/s0029-6465(02)00036-1. PMID: 12587363

Clinical prediction guides

Advanced sleep phase syndrome: Role of genetics and aging.

Silvestri R, Guarnieri B
Handb Clin Neurol 2025;206:61-70. doi: 10.1016/B978-0-323-90918-1.00005-8. PMID: 39864932

Two pedigrees of familial advanced sleep phase syndrome in Japan.

Satoh K, Mishima K, Inoue Y, Ebisawa T, Shimizu T
Sleep 2003 Jun 15;26(4):416-7. doi: 10.1093/sleep/26.4.416. PMID: 12841366

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Related information

ClinVar
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Advance sleep phase syndrome, familial, 4
Advance sleep phase syndrome, familial, 4

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C5774204[conceptid] (1)
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C1868512[trait identifier] AND "Genomic Medicine Center of Excell... (2)
C1868512[trait identifier] AND "Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre"[submitter]
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C0268413[trait identifier] AND "Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre"[submitter]
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