U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clonal hematopoiesis

MedGen UID:
1694554
Concept ID:
C5206406
Finding
Synonyms: Clonal Hematopoiesis; Hematopoiesis, Clonal
SNOMED CT: Clonal hematopoiesis (1240416002)
 
Monarch Initiative: MONDO:0100542

Definition

Cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage. [from NCI]

Professional guidelines

PubMed

Heimlich JB, Bhat P, Parker AC, Jenkins MT, Vlasschaert C, Ulloa J, Van Amburg JC, Potts CR, Olson S, Silver AJ, Ahmad A, Sharber B, Brown D, Hu N, van Galen P, Savona MR, Bick AG, Ferrell PB
Blood Adv 2024 Jul 23;8(14):3665-3678. doi: 10.1182/bloodadvances.2023011445. PMID: 38507736Free PMC Article
Krebs MG, Malapelle U, André F, Paz-Ares L, Schuler M, Thomas DM, Vainer G, Yoshino T, Rolfo C
JAMA Oncol 2022 Dec 1;8(12):1830-1839. doi: 10.1001/jamaoncol.2022.4457. PMID: 36264554
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Recent clinical studies

Etiology

Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Evans MA, Walsh K
Physiol Rev 2023 Jan 1;103(1):649-716. Epub 2022 Sep 1 doi: 10.1152/physrev.00004.2022. PMID: 36049115Free PMC Article
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA Jr, Levine RL, Morton LM, Zehir A, Papaemmanuil E
Nat Genet 2020 Nov;52(11):1219-1226. Epub 2020 Oct 26 doi: 10.1038/s41588-020-00710-0. PMID: 33106634Free PMC Article
Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL
N Engl J Med 2017 Jul 13;377(2):111-121. Epub 2017 Jun 21 doi: 10.1056/NEJMoa1701719. PMID: 28636844Free PMC Article

Diagnosis

Luque Paz D, Kralovics R, Skoda RC
Blood 2023 Apr 20;141(16):1909-1921. doi: 10.1182/blood.2022017578. PMID: 36347013Free PMC Article
Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL
J Exp Med 2021 Dec 6;218(12) Epub 2021 Oct 26 doi: 10.1084/jem.20211872. PMID: 34698806Free PMC Article
Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA Jr, Levine RL, Morton LM, Zehir A, Papaemmanuil E
Nat Genet 2020 Nov;52(11):1219-1226. Epub 2020 Oct 26 doi: 10.1038/s41588-020-00710-0. PMID: 33106634Free PMC Article
Wang L, Liu H
Hematology 2019 Dec;24(1):559-566. doi: 10.1080/16078454.2019.1642548. PMID: 31315542
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Therapy

Vlasschaert C, Robinson-Cohen C, Chen J, Akwo E, Parker AC, Silver SA, Bhatraju PK, Poisner H, Cao S, Jiang M, Wang Y, Niu A, Siew E, Van Amburg JC, Kramer HJ, Kottgen A, Franceschini N, Psaty BM, Tracy RP, Alonso A, Arking DE, Coresh J, Ballantyne CM, Boerwinkle E, Grams M, Zhang MZ, Kestenbaum B, Lanktree MB, Rauh MJ, Harris RC Jr, Bick AG
Nat Med 2024 Mar;30(3):810-817. Epub 2024 Mar 7 doi: 10.1038/s41591-024-02854-6. PMID: 38454125Free PMC Article
Sébert M
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):59-64. doi: 10.1182/hematology.2023000520. PMID: 38066862Free PMC Article
Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S
Nat Med 2023 Jul;29(7):1662-1670. Epub 2023 Jun 15 doi: 10.1038/s41591-023-02397-2. PMID: 37322115Free PMC Article
Agashe RP, Lippman SM, Kurzrock R
Mol Cancer Ther 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. PMID: 36252553Free PMC Article
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Prognosis

Wachter F, Pikman Y
Acta Haematol 2024;147(2):229-246. Epub 2024 Feb 16 doi: 10.1159/000536152. PMID: 38228114
Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Luque Paz D, Kralovics R, Skoda RC
Blood 2023 Apr 20;141(16):1909-1921. doi: 10.1182/blood.2022017578. PMID: 36347013Free PMC Article
Marnell CS, Bick A, Natarajan P
J Mol Cell Cardiol 2021 Dec;161:98-105. Epub 2021 Jul 21 doi: 10.1016/j.yjmcc.2021.07.004. PMID: 34298011Free PMC Article
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Clinical prediction guides

Weeks LD, Ebert BL
Blood 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. PMID: 37931207Free PMC Article
Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT Jr, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S
Nat Med 2023 Jul;29(7):1662-1670. Epub 2023 Jun 15 doi: 10.1038/s41591-023-02397-2. PMID: 37322115Free PMC Article
Belizaire R, Wong WJ, Robinette ML, Ebert BL
Nat Rev Immunol 2023 Sep;23(9):595-610. Epub 2023 Mar 20 doi: 10.1038/s41577-023-00843-3. PMID: 36941354Free PMC Article
Stone PH, Libby P, Boden WE
JAMA Cardiol 2023 Feb 1;8(2):192-201. doi: 10.1001/jamacardio.2022.3926. PMID: 36515941Free PMC Article
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL
N Engl J Med 2014 Dec 25;371(26):2488-98. Epub 2014 Nov 26 doi: 10.1056/NEJMoa1408617. PMID: 25426837Free PMC Article

Recent systematic reviews

Xie Y, Kazakova V, Weeks LD, Gerber JM, Tai J, Zhang TY, Lowsky R, Wu X, Yang C, Patel SA
Bone Marrow Transplant 2024 Nov;59(11):1585-1593. Epub 2024 Aug 25 doi: 10.1038/s41409-024-02403-2. PMID: 39183321Free PMC Article
Singh J, Li N, Ashrafi E, Thao LTP, Curtis DJ, Wood EM, McQuilten ZK
Blood Adv 2024 Jul 23;8(14):3771-3784. doi: 10.1182/bloodadvances.2024013228. PMID: 38838228Free PMC Article
Ma J, Zhang B, Song H, Wu D, Song T
Int J Implant Dent 2023 Dec 6;9(1):48. doi: 10.1186/s40729-023-00517-8. PMID: 38055096Free PMC Article
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Nowakowska MK, Kim T, Thompson MT, Bolton KL, Deswal A, Lin SH, Scheet P, Wehner MR, Nead KT
Am J Hematol 2022 Apr;97(4):411-420. Epub 2022 Jan 19 doi: 10.1002/ajh.26465. PMID: 35015316Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...