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Advanced sleep phase syndrome 3(FASPS3)

MedGen UID:
909447
Concept ID:
C4225169
Disease or Syndrome
Synonym: Advanced sleep phase syndrome, familial, 3
 
Gene (location): PER3 (1p36.23)
 
Monarch Initiative: MONDO:0014814
OMIM®: 616882

Definition

Advanced sleep phase syndrome is characterized by early sleep time (sleep onset) and early morning awakening (sleep offset) (summary by Zhang et al., 2016). For a discussion of genetic heterogeneity of advanced sleep phase syndrome, see FASPS1 (604348). [from OMIM]

Clinical features

From HPO
Depression
MedGen UID:
4229
Concept ID:
C0011581
Mental or Behavioral Dysfunction
Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.
Early chronotype
MedGen UID:
1646349
Concept ID:
C4703587
Finding
A tendency towards rising very early in the morning and going to bed early in the evening.

Professional guidelines

PubMed

de Bergeyck R, Geoffroy PA
Rev Neurol (Paris) 2023 Oct;179(7):767-781. Epub 2023 Aug 22 doi: 10.1016/j.neurol.2023.08.008. PMID: 37620177
Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
J Psychopharmacol 2019 Aug;33(8):923-947. Epub 2019 Jul 4 doi: 10.1177/0269881119855343. PMID: 31271339
Bhargava S
Pediatr Rev 2011 Mar;32(3):91-8; quiz 99. doi: 10.1542/pir.32-3-91. PMID: 21364012

Recent clinical studies

Etiology

Kishman EE, Reutrakul S, Broussard JL
Trends Endocrinol Metab 2025 Mar;36(3):199-201. Epub 2024 Sep 18 doi: 10.1016/j.tem.2024.08.008. PMID: 39299858Free PMC Article
Di H, Guo Y, Daghlas I, Wang L, Liu G, Pan A, Liu L, Shan Z
JAMA Netw Open 2022 Nov 1;5(11):e2240788. doi: 10.1001/jamanetworkopen.2022.40788. PMID: 36346632Free PMC Article
Duffy JF, Wang W, Ronda JM, Czeisler CA
J Pineal Res 2022 Aug;73(1):e12801. Epub 2022 May 13 doi: 10.1111/jpi.12801. PMID: 35436355Free PMC Article
Boivin DB, Boudreau P, Kosmadopoulos A
J Biol Rhythms 2022 Feb;37(1):3-28. Epub 2021 Dec 30 doi: 10.1177/07487304211064218. PMID: 34969316Free PMC Article
Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K
Lancet Neurol 2019 Mar;18(3):307-318. Epub 2019 Feb 12 doi: 10.1016/S1474-4422(18)30461-7. PMID: 30784558Free PMC Article

Diagnosis

Mason IC, Qian J, Adler GK, Scheer FAJL
Diabetologia 2020 Mar;63(3):462-472. Epub 2020 Jan 8 doi: 10.1007/s00125-019-05059-6. PMID: 31915891Free PMC Article
Abbott SM
Neurol Clin 2019 Aug;37(3):545-552. Epub 2019 Apr 30 doi: 10.1016/j.ncl.2019.03.002. PMID: 31256788
Gulia KK, Kumar VM
Psychogeriatrics 2018 May;18(3):155-165. doi: 10.1111/psyg.12319. PMID: 29878472
Magee M, Marbas EM, Wright KP Jr, Rajaratnam SM, Broussard JL
Sleep Med Clin 2016 Sep;11(3):389-401. Epub 2016 Jul 16 doi: 10.1016/j.jsmc.2016.05.004. PMID: 27542884
Sateia MJ
Chest 2014 Nov;146(5):1387-1394. doi: 10.1378/chest.14-0970. PMID: 25367475

Therapy

Boivin DB, Boudreau P, Kosmadopoulos A
J Biol Rhythms 2022 Feb;37(1):3-28. Epub 2021 Dec 30 doi: 10.1177/07487304211064218. PMID: 34969316Free PMC Article
Lalanne S, Fougerou-Leurent C, Anderson GM, Schroder CM, Nir T, Chokron S, Delorme R, Claustrat B, Bellissant E, Kermarrec S, Franco P, Denis L, Tordjman S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031490. PMID: 33540815Free PMC Article
Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A
J Psychopharmacol 2019 Aug;33(8):923-947. Epub 2019 Jul 4 doi: 10.1177/0269881119855343. PMID: 31271339
Ganesan S, Magee M, Stone JE, Mulhall MD, Collins A, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL
Sci Rep 2019 Mar 15;9(1):4635. doi: 10.1038/s41598-019-40914-x. PMID: 30874565Free PMC Article
Miles LE, Dement WC
Sleep 1980;3(2):1-220. PMID: 7010506

Prognosis

Kishman EE, Reutrakul S, Broussard JL
Trends Endocrinol Metab 2025 Mar;36(3):199-201. Epub 2024 Sep 18 doi: 10.1016/j.tem.2024.08.008. PMID: 39299858Free PMC Article
Huang T, Mariani S, Redline S
J Am Coll Cardiol 2020 Mar 10;75(9):991-999. doi: 10.1016/j.jacc.2019.12.054. PMID: 32138974Free PMC Article
Torquati L, Mielke GI, Brown WJ, Burton NW, Kolbe-Alexander TL
Am J Public Health 2019 Nov;109(11):e13-e20. Epub 2019 Sep 19 doi: 10.2105/AJPH.2019.305278. PMID: 31536404Free PMC Article
Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I, Gilad S, Harmelin A, Shapiro H, Halpern Z, Segal E, Elinav E
Cell 2014 Oct 23;159(3):514-29. Epub 2014 Oct 16 doi: 10.1016/j.cell.2014.09.048. PMID: 25417104
Scheer FA, Hilton MF, Mantzoros CS, Shea SA
Proc Natl Acad Sci U S A 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2 doi: 10.1073/pnas.0808180106. PMID: 19255424Free PMC Article

Clinical prediction guides

Kishman EE, Reutrakul S, Broussard JL
Trends Endocrinol Metab 2025 Mar;36(3):199-201. Epub 2024 Sep 18 doi: 10.1016/j.tem.2024.08.008. PMID: 39299858Free PMC Article
Wang X, Xu Y, Li X, Mansuri A, McCall WV, Liu Y, Su S
Sleep Health 2023 Dec;9(6):940-946. Epub 2023 Aug 28 doi: 10.1016/j.sleh.2023.07.018. PMID: 37648648Free PMC Article
Reid KJ
Neurol Clin 2019 Aug;37(3):505-526. doi: 10.1016/j.ncl.2019.05.001. PMID: 31256786Free PMC Article
Erren TC, Groß JV, Lewis P
J Sleep Res 2018 Jun;27(3):e12630. Epub 2017 Nov 20 doi: 10.1111/jsr.12630. PMID: 29159867
Scheer FA, Hilton MF, Mantzoros CS, Shea SA
Proc Natl Acad Sci U S A 2009 Mar 17;106(11):4453-8. Epub 2009 Mar 2 doi: 10.1073/pnas.0808180106. PMID: 19255424Free PMC Article

Recent systematic reviews

Arab A, Karimi E, Garaulet M, Scheer FAJL
Obes Rev 2024 Mar;25(3):e13664. Epub 2023 Dec 10 doi: 10.1111/obr.13664. PMID: 38072635
Hester L, Dang D, Barker CJ, Heath M, Mesiya S, Tienabeso T, Watson K
Chronobiol Int 2021 Oct;38(10):1375-1383. Epub 2021 May 24 doi: 10.1080/07420528.2021.1930029. PMID: 34030534
Kang J, Noh W, Lee Y
Appl Nurs Res 2020 Apr;52:151227. Epub 2019 Dec 26 doi: 10.1016/j.apnr.2019.151227. PMID: 31902652
Torquati L, Mielke GI, Brown WJ, Burton NW, Kolbe-Alexander TL
Am J Public Health 2019 Nov;109(11):e13-e20. Epub 2019 Sep 19 doi: 10.2105/AJPH.2019.305278. PMID: 31536404Free PMC Article
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670

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